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NANO2021-Nanoteknologi og nye materiale

Norwegian Marine Biopolymers as Injectable Hydrogels for Tissue and Organ Repair – TUNIGUIDE

Alternativ tittel: Norske marine biopolymerer som injiserbare hydrogeler til reparasjon av vev og organ - TUNIGUIDE

Tildelt: kr 12,0 mill.

Prosjektnummer:

317790

Søknadstype:

Prosjektperiode:

2021 - 2023

Geografi:

The project is developing injectable, in situ gelling hydrogel formulations based on Norwegian marine biopolymers, tunicate nanocellulose fibrils and alginate, for tissue and organ repair and regeneration. Donor organ shortages are a serious global problem resulting in high mortality rates of people on transplant waiting lists and leads some people to obtain organs through illegal, unethical pathways. Tissue engineering, in which biomaterials are combined with cells, offers an alternative to help resolve this healthcare problem. We are generating hydrogels, materials composed of a hydrophilic polymer network capable of high hydration that can be tuned to deliver therapeutic agents or cells to damaged sites. We have found that tunicate nanocellulose/alginate hydrogels are biocompatible in a Wistar rat study and were found to be non-irritant in comparison to controls of commonly used Gortex surgical meshes. We are currently developing different variants of these nanocellulose/alginate hydrogels and assessing their rheological properties, injectability, and, at site retention. In contrast to surgically implanted materials, injectable hydrogels provide new avenues of minimally invasive delivery that will reduce healing time, reduce scarring and decrease the risk of post-operative infections. Realization of this approach will significantly lower costs for hospitals and result in less pain for patients. These are important translational aspects in bringing regenerative treatments into the clinic and will involve development of biocompatible, medically certified biopolymers with application-specific, tunable properties. Studies are ongoing to optimize flow and diffusion properties for different, specific tissue applications.

This project will develop biocompatible, injectable, in situ gelling hydrogel formulations based on Norwegian marine biopolymers, tunicate nanocellulose fibrils and alginate, for tissue and organ repair and regeneration. Donor organ shortages are a serious global problem resulting in high mortality rates of people on transplant waiting lists and leads some people to obtain organs through illegal, unethical pathways. Tissue engineering, in which biomaterials are combined with cells, offers an important alternative to help resolve this global healthcare problem. Hydrogels, materials composed of a hydrophilic polymer network capable of high hydration, yet retaining structural integrity, are attractive biomaterials in that they are biocompatible and can be tuned to deliver therapeutic agents or cells to damaged sites. Biocompatible hydrogels can act as scaffolds supporting growth of cells to promote tissue or organ repair. In contrast to surgically implanted materials, injectable hydrogels provide a new avenue of minimally invasive delivery that will reduce healing time, reduce scarring and decrease the risk of post-operative infections. Realization of this approach would significantly lower costs for hospitals and result in less pain for patients. These are important translational aspects in bringing regenerative treatments into the clinic and will involve development of biocompatible, GMP accredited biopolymers with application-specific, tunable properties. The project focus will be in tuning the injectability, in situ gelling properties and release rates to guide bioactive components for specific therapeutic applications. Studies designed to control fibril lengths, orientation/alignment, surface modifications and crosslinking kinetics, will be carried out to optimize flow and diffusion properties for specific tissue applications. Selected preclinical assessments will be carried out in 3 different tissue types.

Aktivitet:

NANO2021-Nanoteknologi og nye materiale