Safety of Covid-19 vaccination in pregnancy

I dette prosjektet undersøker vi sikkerheten av Covid-19 vaksinering av gravide kvinner. Vi undersøker svangerskapsutfall, kortidseffekter på kvinnen og fosteret og langtidseffekter hos barn av mødre som ble vaksinerte under graviditeten. COVID-19 gir fortsatt mye sykdom i samfunnet, og vi har studert infeksjon og vaksinasjon hos gravide. Gravide med COVID-19 infeksjon har økt risiko for alvorlig sykdom, komplikasjoner og sykehusinnleggelse. COVID-19 infeksjon under graviditeten er også forbundet med økt risiko for uheldige svangerskapsutfall. Vaksinasjon under graviditet beskytter de gravide kvinnene mot COVID-19-infeksjon, og vi har vist at mors vaksinasjon under graviditeten beskytter spedbarn mot COVID-19-infeksjon.Vi undersøker nå flere konsekvenser hos mor og barn etter COVID-19 infeksjon i svangerskapet og flere studier vaksinering av gravide. Alle våre studier tyder på at vaksinasjon hos gravide er trygt, og beskytter både moren og barnet mot COVID-19 og komplikasjoner.

It is difficult to predict how the current COVID-19 pandemic will progress, and what its final impact will be. Mutations continuously alter the virus’ ability to spread and the potentially the severity of infections, making it difficult to predict changes in risk groups, and whether the current vaccines will remain effective. Reassuring the general population regarding vaccine safety and effectiveness is crucial for keeping the trust and adherence to vaccine programs. Although data on COVID-19 infection during pregnancy is still limited, the available evidence points to increased risk of severe disease, complications and hospitalizations in pregnant women with COVID-19 infection. COVID-19 infection during pregnancy is also associated with increased risk of a range of adverse pregnancy outcomes. Vaccination during pregnancy will protect pregnant women from COVID-19 infections. There are also potential benefits to the child after birth of maternal vaccination during pregnancy as IgG antibodies are actively transferred through the placenta to the fetus. It is likely that maternal vaccinations during or pregnancy protect infants from COVID-19 infection The current COVID-19 vaccines have not been tested or approved for use in pregnant women, and thus, safety and effectiveness of these vaccines during pregnancy is unknown. Currently, it is difficult for pregnant women and care givers to make decisions about COVID-19 vaccination as empirical data to support decisions is lacking. Very few countries can address population risks related to safety of vaccination in pregnancy. With national linked Norwegian registry data our international team will study the safety of COVID-19 vaccination during pregnancy, addressing pregnancy outcomes, short term effects on the women and fetus, and longer term effects in children born after maternal pregnancy vaccination. Our team has broad expertise in using population-based data to study infections in pregnancy.