Safety Issues Associated with Antibiotic Resistance Hazards and Discovery of Safer Antibiotics Targeting Bacterial Purine Biosynthetic pathw

The rapid increase in resistance to current antibiotics strongly motivates the development of new antimicrobials with alternate modes of action. In eukaryotic systems, PurK and Class I PurE are substituted by a Class II PurE, which directly converts AIR i nto CAIR. Bacterial PurE and PurC also di...