FUGE-Funksjonell genomforskn.i Norg
Mouse models for studying oxidative demethylation of DNA and RNA
It was recently discovered that the AlkB protein from E. coli uses a novel mechanism, termed oxidative demethylation, to remove deleterious methyl lesions from DNA and RNA. Eight mammalian AlkB homologues, denoted ABH1 - ABH8 (mABH1-8 in mice), exist, and two of these, ABH2 and ABH3, have been s...
