0 projects

Selections based on text queries do not reflect the Research Council's published statistics. Read more...


Text queries provide an overview of all projects containing the specified text in either its title or summary. This may result in a different selection of projects than that used by the Research Council as presented in its various publications. The Research Council's statistics are normally based on selections in set categories. You will find these in the left menu, in the diagrams themselves or when selecting from the left column of autocomplete suggestions via the search field.

Les mer...

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Methylation supernegative colorectal cancers - a key to unlocking the secrets of the DNA (de)methylation machinery

...Cytosine methylation is essential for the proper...of a novel and intriguing subgroup of cancers, which have unusually little promoter...These tumors represent a unique opportunity for direct insight into the molecular and cellular...

Awarded: NOK 7.0 mill.

Project Period: 2015-2019

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Immunotherapy targeting genetic frameshift mutation in cancer cells

...unmet medical need for treatment of cancer the project entails...in microsatellite instability-high (MSI-H) cancer. MSI-H is known in many different cancer...particularly in colorectal cancer (CRC) (15%), stomach cancer (SC) (22%) and endometrial cancer...

Awarded: NOK 16.0 mill.

Project Period: 2021-2024

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

Data-driven Framework for Personalised Cancer Screening

...Cancer is a major cause of morbidity and mortality...proportion of the incidents are preventable. For example, mass-screening Nordic programs of...remains a major challenge. Existing automatic decision support systems for cervical...

Awarded: NOK 12.4 mill.

Project Period: 2019-2023

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

An integrative ICT platform for personalized medicine

...vision of VIRTMED is to advance ICT concepts and methods in order to...of complex information from multiple sources into an efficient form that easily can be used by...the research and development of a new ICT platform for integration and visualization of...

Awarded: NOK 0.50 mill.

Project Period: 2015-2016

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Impact of epithelial cell plasticity programs on the anti-tumor immune-response

...outlined as one of the emerging hallmarks of cancer. The proposed research project addresses the...Our preliminary results show that the receptor tyrosine kinase Axl plays a common role in...in normal epithelial stem cells and phenotypic plasticity in aggressive, therapy-resistant...

Awarded: NOK 3.3 mill.

Project Period: 2017-2020

Location: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Biomarkers of Cancer: Biocomputional analysis of data from population-based biobanks and health registries

...propose to build advanced biocomputational analysis...data, in collaboration with bioinformatics and biostatistical colleagues at...will apply this analysis capacity on specific cancer challenges. Cancer is the third-most common...

Awarded: NOK 7.0 mill.

Project Period: 2016-2021

Location: Oslo

INTPART-International Partnerships for Excellent Education and Research

Metabolic and signaling crosstalk of vitamin-derived cofactors - a training platform for systems medicine

...medicine has emerged as essential discipline to...dedicated study programs in systems medicine do net yet exist in Norway. This project...will develop a unique portfolio of systems medicine training – from molecular mechanisms to...

Awarded: NOK 4.5 mill.

Project Period: 2020-2026

Location: Vestland

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Defining relevant targets for personalizing gynecologic cancer treatment

...cancers have significant histologic, phenotypic and...We have already demonstrated the capacity to (1) build a team of clinical, para-clinical and...Lancet Oncology and JCO as driving investigators. (4) Gain confidence from national and...

Awarded: NOK 9.0 mill.

Project Period: 2015-2021

Location: Vestland

SYNKNØYT-Progr.f.synkrotron- og nøytron

Development, implementation and validation of a platform for structure-based automatic ligand screening

...present application seeks to develop, streamline, validate and build...methods for automatic fragment/ligand screening, data collection and crystal structure...using X-ray diffraction as an analytic tool, are sample preparation/mounting and data...

Awarded: NOK 3.2 mill.

Project Period: 2013-2017

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Subpopulation heterogeneitY and MicroenvironMental Engagement as predictors for Treatment Resistance in lYmphoma

...patients (inter-tumour heterogeneity) is known to affect treatment efficacy, most personalized...us, for the first time, with the opportunity to molecularly detect and characterise both...We will use viably frozen lymph node biopsies to thoroughly characterize lymphoma subpopulations...

Awarded: NOK 3.1 mill.

Project Period: 2022-2025

Location: Oslo

INTPART-International Partnerships for Excellent Education and Research

CapsNetwork – International Network for Capsule Imaging in Endoscopy

...system diseases like Crohn’s disease, inflammatory bowel disease, and cancer, are affecting a...across the world. Among them is the colorectal cancer the second most common cause of...In Norway, and around 4200 new cases of colorectal cancer and inflammatory bowel disease are...

Awarded: NOK 10.0 mill.

Project Period: 2021-2026

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Potent and selective protein kinase inhibitors from the sea

...a center for research-based innovation (CRI) of marine...protein kinase inhibition assays in its screening campaign of marine extracts. Through the...that inhibit the activity of kinases relevant for treatment of cancer. We have now identified a...

Awarded: NOK 8.2 mill.

Project Period: 2015-2017

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The Systems Biology of Breast Cancer

...Biology of Breast Cancer creates a world-class cancer research team,...of the biological dynamics of breast cancer. Breast cancer is a genetic disease; breast...individual characteristics, environmental factors. Our goal is to reach a comprehensive...

Awarded: NOK 9.0 mill.

Project Period: 2006-2010

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

...The main purpose is to identify and characterize novel antibodies...candidates will be thoroughly examined for their specificity and their ability to be used...potential as function-blocking moieties or for therapeutic targeting of cancer will be...

Awarded: NOK 2.2 mill.

Project Period: 2007-2011

Location: Oslo

RUSMIDDEL-Rusmiddelforskning

Alcohol consumption and the risk of coronary heart disease

...studies have found moderate alcohol consumption to be associated with reduced risk of coronary...and can specif ic genes or other risk factors interact with alcohol? Within the...that 200,000 participants have been followed for a long time, making it possible to adjust for...

Awarded: NOK 2.9 mill.

Project Period: 2010-2013

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Genetic and Process Optimizations for Effective Screening and Functional Production of Novel Therapeutic Antibody Fragments

...application range of antibodies in medicine and biotechnology is broad and there is a...and is still establish ed in the international forefront of discovering and developing the new...of drugs based on fully human antibodies for cancer and other key disease areas. This...

Awarded: NOK 4.0 mill.

Project Period: 2009-2011

Location: Oslo

BIOPROSP-Bioprospektering 2002 - 2006

Exploration of unique pharmaceutical activities of molecules isolated from Arctic and sub-Arctic marine organisms; The "Marbio" programme

...Part A (see below) in the Marbio programme is to establish a platform for the screening of new...organisms. This unit will have the capacity to collect, extract and by high-throughput...within the most important drug areas; to fight virus, bacteria and cancer, in addition...

Awarded: NOK 16.0 mill.

Project Period: 2003-2009

Location: Troms - Romsa - Tromssa

BIA-Brukerstyrt innovasjonsarena

Targeting Cancer Stem Cells with Axl inhibitors to Treat Advanced Metastatic Cancer

...Cancer is the leading cause of death in people under...While the detection and treatment of primary cancer has improved significantly, most fatality is...effective prognostic and therapeutic options for such disseminat ed disease remain scarce....

Awarded: NOK 11.7 mill.

Project Period: 2012-2015

Location: Vestland

FRIPRO-Fri prosjektstøtte

UNLOCKING THE POTENTIAL OF PRECISION MEDICINE TO PROMOTE DRUG SENSITIVITY IN LUNG CANCER

...evolution of drug resistance is the ultimate cause of most of...approaches, called fitness landscapes, together with computational models, to predict...More recently, a novel method has been derived to control evolution: that is, drive populations...

Awarded: NOK 3.9 mill.

Project Period: 2021-2024

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

Non-Invasive, Scalable, Algorithmic Automatic Screening of the Digestive System

...case lethal. There are several ways one can try to detect these, but regularly testing a...lack of enough high quality medical personnel. For example, colon cancer is the third most common...and female above 50 years are at risk, a screening is recommended on a regular basis. However,...

Awarded: NOK 0.48 mill.

Project Period: 2015-2016

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Prediction of antipsychotic drug response; a personalised medicine approach in schizophrenia

...gene discoveries in schizophrenia can lead to major health benefits, through better treatment...strategies - unleashing the large potential for personalised medicine in schizophrenia. We...schizophrenia that overlap with antipsychotic drug targets in protein-protein interaction...

Awarded: NOK 12.0 mill.

Project Period: 2020-2024

Location: Oslo

PES-HORISONT-EU-PES Horisont Europa

A targeted radiotherapy solution for hepatic and systemic cancer, delivering a potent alpha emitter directly to the tumor

...the pre-selection and treatment of liver cancer patients. Primary liver cancer is ranked as...occurring, and as the third most deadly cancer type as of 2022 (Globocan). Furthermore,...cancers, as pancreas, breast melanoma and colorectal cancer. Current therapies have limited...

Awarded: NOK 99,999

Project Period: 2024-2024

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Defining the role of Axl in normal and malignant mammary stem cells

...accounts for >90% of cancer-related mortality. Malignant...and metastasis. Tumor cel l epithelial-to-mesenchymal transition (EMT) is an embryonic...inappropriately evoked by microenviromental factors is strongly associated with...

Awarded: NOK 4.8 mill.

Project Period: 2011-2015

Location: Vestland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Personalized Clinical Management of Endometrial Cancer using Liquid Biopsy, Genomics and Artificial Intelligence

...the era of precision oncology, personalized management represents a challenge in...is favorable in early stages, the prognosis for advanced disease are still poor and...of EC patients with advanced disease. Thus, to improve the personalized treatment of poor...

Awarded: NOK 3.1 mill.

Project Period: 2022-2025

Location: Vestland

PES2020-Prosj.etabl.støtte H2020

A choice of medication in treatment of solid cancers based on screening of patient’s own live cancer cells.

...year 17 Mn people was diagnosed with cancer. The number is steadily increasing and the...organ, tissue or gland. Over half of all cancers are made up of just four cancers: bowel,...rare cancers have a huge unmet medical need for better treatment. Seald is a biotech company...

Awarded: NOK 49,999

Project Period: 2019-2020

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Imaging the breast cancer metabolome

...cancer has the highest incidence and mortality of...globally. The heterogeneous nature of breast cancer causes variable clinical presentation and...treatment response remains highl y inadequate. Drugs targeting oncogenic signaling in breast...

Awarded: NOK 8.8 mill.

Project Period: 2013-2017

Location: Trøndelag - Trööndelage

PROSBIO-Prosess- og biomedisinsk industri

Aided Interpretation of Quantitative Genomics via Literature Networks and High Throughput Screening Integration

...QTL (Quantitative Trait Loci) and array-CGH (Cytogenic Genomic Hybridization) is increasingly...functional genomics and pharmacogenomics (personalized medicine) in human and veterinary...genes in several chromosomal regions causative to the complex trait being studied. There is a...

Awarded: NOK 4.5 mill.

Project Period: 2005-2007

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Nordic PerMed: NorDCap Nordic implementation of personalized prostate cancer diagnostics

...overall idea of NorDCaP is to accelerate the spread of best practice...1. Transfer best-practice knowledge on personalized primary diagnostics of prostate cancer...2. Transfer best-practice knowledge on personalized follow up of low-risk cancers (Active...

Awarded: NOK 6.4 mill.

Project Period: 2019-2021

Location: Rogaland

BIOBANK-Humane biobanker og helsedata

Genome-wide miRNA profiling in prediagnostic samples from Janus Serum Bank for early diagnosis, improved therapy & surveillance of cancer

...in cancer management depends on timely detection,...miRNA expression profiles as early markers of cancer. Our focus will be on col orectal and lung...impact of early detection and treatment. We aim to identify miRNA expression profiles associated...

Awarded: NOK 5.0 mill.

Project Period: 2013-2015

Location: Oslo

IKTPLUSS-IKT og digital innovasjon

DoMore! : In silico Pathology - Improving diagnosis by utilizing Big Data and software-driven automation of pathology

...about researching and developing ICT solutions to supplement or replace methods in pathology to...and quality and hence treatment of cancer, based on analysis of Big Data produced by...prognostic studies suffer from undersampling. To account for heterogeneity most studies would...

Awarded: NOK 59.7 mill.

Project Period: 2016-2021

Location: Oslo