0 projects

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FUGE-Funksjonell genomforskn.i Norg

Global gene expression of human and rat brain: an integrative genomics study of CNS functions and genetic susceptibility in schizophrenia

Schizophrenia (SCZ) is a serious psychotic disorder ranked among the 10 most disabilitating disesases worlwide (WHO) with a lifetime risk of 1% in the general population. Despite decades of research, the understanding of underlying biological mechanism re mains inadequate and fragmentary and trea...

Awarded: NOK 5.3 mill.

Project Period: 2008-2012

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Opioid activated NMDA and opioid receptor mechanisms: studies of rodent and human brain using PET

The scope of the proposed project is to study the molecular mechanisms of opioid exposure. Within the financial framework, it will be focused on preclinical testing and validation as well as first human studies. Further studies depend on additional fundin g. Intentionally, opioid analgesia in p...

Awarded: NOK 1.8 mill.

Project Period: 2007-2011

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

THE PATHOPHYSIOLOGY OF AUDITORY HALLUCINATIONS IN SCHIZOPHRENIA - BRAIN IMAGING STUDIES

The present proposal attempts to respond to the challenges for neuroscience research in Norway and stated in the Nevronor Programme announcement January 2007. We specify six empirical , hypothesis-driven studies wher we attempt to: a) use fMRI and other MRI brain imaging measures to advance know...

Awarded: NOK 4.5 mill.

Project Period: 2007-2013

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The role of activity in synaptic development and plasticity in motor pathways: A multi-methodological dynamic imaging approach

This project addresses a major question in neuroscience: How activity in the nervous system regulates the organization of synaptic connections. It poses this question in the motor system, where activity-dependent regulation is less well understood than in sensory systems. To address this questio...

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mitochondrial Health and Neuronal Life

Lars Eide and Magnar Bjørås are joint applicants for this project. Mitochondria have central roles in neuronal homeostasis as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is th ought to underlie the progressive neurona...

Awarded: NOK 4.0 mill.

Project Period: 2007-2011

Location: Oslo

SAM-EU-Samfinansiering EU-kontoret

SmartHEALTH: Smart Integrated Biodiagnostic Systems for Healthcare

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Awarded: NOK 1.7 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

SFF-Sentre for fremragende forskn

Centre for Immune Regulation, CIR

Senter for immunregulering har hatt som mål å identifisere og karakterisere årsaker til feilregulering av immunsystemet. En slik feilregulering kan gi autoimmunitet og allergi. Forskerne i senteret har studert hva som går galt i samspillet mellom immuncellene både på cellulært og molekylært nivå...

Awarded: NOK 109.3 mill.

Project Period: 2007-2018

Location: Oslo

PSYKISK-Psykisk helse

Utilizing the Internet to deliver mental health self-help interventions to underserved populations in rural areas

The overall objective of this project is to contribute to the knowledge necessary in developing effective Internet-based self-help programs for preventing mental health problems and new episodes. This will be accomplished through two complementary PhD sub -projects based on data from a randomized...

Awarded: NOK 4.5 mill.

Project Period: 2007-2014

Location: Troms - Romsa - Tromssa

PSYKISK-Psykisk helse

Social Change, Health Care Intervention and Suicidality. - A Longitudinal Prospective Study of Suicidal behaviour.

1) Background Due to the lack of national statistics on suicide attempts in Norway, few studies have been published regarding the development of suicide attempts in the population. Since a main suicide prevention strategy in Norway is to provide follow-up for suicide attempters, there is a need ...

Awarded: NOK 2.2 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Functional magnetic resonance imaging (fMRI) for the study of brain mechanisms in schizophrenia (NEVROMENT)

We propose a new Bergen-Oslo collaborative fMRI (and related MR measures, VBM, DTI, MRS) research project on auditory hallucinations and delusions in schizophrenia. We believe that a focus on restricted research questions, with a priori hypotheses and str ict experimental designs has a better pot...

Awarded: NOK 4.5 mill.

Project Period: 2007-2011

Location: Vestland

YFF-Yngre, fremragende forskere

Lipocalin 2 - a novel antimicrobial protein: Role in mycobacterial disease, urinary tract infection and in wound healing

Infectious diseases remain the main cause of premature death worldwide and antimicrobial resistance is increasing. Consequently, the WHO stresses that there is an urgent need for new drugs and supplementary treatment regimens against infectious agents. We have recently discovered a novel mechani...

Awarded: NOK 8.2 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

EMBLNODE-Nord EMBLsenter i molekylærmed

Norsk senter for molekylærmedisin (NCMM) - Centre for Molecular Medicine Norway - Nordic EMBL Partnership

Norsk Senter for Molekylærmedisin (NCMM) er et nasjonalt forskningssenter og fungerer som drivhus for unge, talentfulle forskere innen molekylærmedisin, bioteknologi og translasjonsforskning. Senterets overordnede visjon er å forbedre den molekylære forståelsen av helse og sykdom for å kunne forb...

Awarded: NOK 182.8 mill.

Project Period: 2007-2025

Location: Oslo

PSYKISK-Psykisk helse

Mental disorders and developmental deviations in children (6-36 months) with congenital heart disease (CHD): a prospective case-control stud

Background: Congenital heart disease (CHD) occurs among 0.5-1.0% of newborns. Treatment possibilities have been dramatically improved during the past decade, leading to increased survival rates. How-ever, previous studies in CHD survivors suggest a higher risk of mental disorders, such as anxiet...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The genetically-defined Parkinson's disease. A study of biomarkers in patients and healthy carriers of the Park8 G2019S mutation.

The mechanisms behind the development of PD are still obscure, but it is clear that PD is heterogeneous both in terms of cause, phenotype, progression, and response to treatment. Reproducible biomarkers for PD susceptibility and/or progression that are se nsitive and specific have long been sough...

Awarded: NOK 1.2 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

IMAGING GENETICS OF SCHIZOPHRENIA. A WHOLE GENOME - BRAIN MRI STUDY

Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and is a major public health problem with a high cost for society. Brain imaging studies have shown structural abnormalities and dy sfunction in specific brain regions. The ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Senter for rus- og avhengighetsforskning - SERAF

Tildelingen fra NFR har gjennom 10 år gjort det mulig for SERAF å utvikle og å drive klinikknær rusmiddelforskning på høyt internasjonalt nivå. Vi har bidratt til en bedre, kunnskapsbasert behandling av rus- og avhengighetslidelser i Norge, gjennom å bidra til et lokalt basert og forankret kunnsk...

Awarded: NOK 100.9 mill.

Project Period: 2007-2020

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of memory circuitry to evaluate memory loss in Alzheimer's disease models

Memory loss is among the first signs of Alzheimer's disease, and it progresses to encompass all aspects of a person's past and present life experiences. The severity of Alzheimer's disease and its increasing incidence with changing demographics require a tremendous effort in finding treatments. P...

Awarded: NOK 1.00 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

DELAYED SLEEP PHASE SYNDROME. PREVALENCE, DEVELOPMENTAL HISTORY, PERSONALITY AND TREATMENT

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder assumed to peak in adolescence and young adulthood. It is characterized by a delay in the sleep wake-rhythm which causes prolonged sleep onset latency and problems getting up in the morning. The disorder often has negative i...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Brain and brain cell injury in newborn infants

The main objective of the proposed project is to investigate basic mechanisms for regulation of brain injury and brain cell death in newborn infants. Specifically, we propose to study these mechanisms as they relate to two common causes of brain damage in the newborn period, namely asphyxia (hyp...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo

SFF-Sentre for fremragende forskn

Centre for Cancer Biomedicine, CCB

Grunntanken bak dannelsen av CCB var å forene basalbiologisk forskning på mekanismer i kreftutvikling med pasientnær kreftforskning som tar sikte på å identifisere nye kjennetegn på kreft som kan brukes i diagnose, prognose og terapi. Dette har vist seg som en vellykket forskningsstrategi, og CCB...

Awarded: NOK 120.6 mill.

Project Period: 2007-2018

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Understanding the System of Neurotransporters

The proposed project is a system-biology approach to transport across brain plasma membranes focusing on neurotransmitter inactivation and water transport. The primary aim is to prepare the ground for a large scale approach to understand what all the hund reds of transporter and ion channels do t...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

PSYKISK-Psykisk helse

EARLY BIPOLAR DISORDER: CLINICAL AND BIOLOGICAL CHARACTERISTICS IN FIRST EPISODE MANIA

Bipolar disorder (BPD) is a severe psychiatric disorder characterized by manic and depressive episodes with periods of normal mood in between. Recent lines of evidence suggest that BPD is a more severe illness that previously believed and it is regarded as one of the most important factors contr...

Awarded: NOK 4.7 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Attention deficit /hyperactivity disorder (ADHD): Risk factors, comorbidity and gene-environment interactions.

Attention deficit hyperactivity disorder (hyperkinetic disturbance; ADHD) is a common condition in school age children (world-wide prevalence estimates 3-7 %). In addition most affected individuals will continue to show symptoms as adults. Still, it has l ong been considered a controversial diagn...

Awarded: NOK 3.0 mill.

Project Period: 2007-2011

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Combining electrophysiological recording and imaging in investigations of the rod pathway of the retina

The retina serves as an ideal model system for investigations that aim to bridge the gap between systems level descriptions and underlying mechanisms at cellular and molecular levels. The principal objective is to understand, at a molecular and microphysi ological level, the integrative dynamics ...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Vestland

FORNY-3-Kommersialisering av FoUresultater

Early diagnosis of diabetes

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Awarded: NOK 2.2 mill.

Project Period: 2007-2009

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Norwegian PET Conference and Seminar Series

This application is for fundiing for conference and seminar series to develop the Positron emission tomography (PET) method into an important tool in the study of the Brain and Brain-derived human disease. It is based on the Norwegian Medical Cyclotron Ce nter (NMS) in Oslo and the Bergen PET Cen...

Awarded: NOK 0.30 mill.

Project Period: 2007-2009

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Quantitative MR imaging used to gain new knowledge of perinatal brain injury- from newborns to young adults with very low birth weight

The neurological adult outcome of VLBW and ELBW survivors is of great interest to society. Perinatal brain injury has major impact both economically, for health care and emotionally for parents and children as they develop into adulthood. Combining quanti tative MRI and clinical research, may ser...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging and structural biology of molecular targets for psychotropic drugs

The research group has wide experience in using molecular graphics and other methods to study the molecular mechanisms of CNS active drugs. This application focuses on drugs acting on specific targets in brain, the serotonergic systems. The application wi ll enable further development and strengt...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

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