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2018

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EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries. 

CULTUral heritage in RurAL remote areas for creative tourism and sustainabilITY

The main objective of the project is to contribute to the promotion of cultural and creative tourism activities, considering the different capacities, resources, and specificities (material, creative, human...) of the territories, as a mean to help with the sustainable development of peripheral rural areas, favoring job creation and population settlement. For this, the potential of its cultural heritage will be researched, taking into account both the artisan material culture (techniques, materials, patterns and decorative elements), as well as the intangible culture (music, oral knowledge and culinary traditions) as a resource.   To promote non-seasonal tourism as a form of sustainable development with a stable population settlement we are going to research the crafts linked to the territory and their implications, but we will also carry out a documentation of the productive processes. First and foremost, we are going to cater to the necessities of the local communities and pay attention to aspects related to societal groups at risk of exclusion, such as women, the elderly and the youth.  All this will be developed from a multidisciplinary perspective, for which we will count on the various teams —most of them linked to different countries— that will be part of the consortium. Each of these partners will contribute to the development, as well as to the final result of the project through input directly related to their area of ??expertise: for example, among the collaborators we have intellectual teams specialized in the digitalization of heritage, research, or communication and dissemination, as well as as various institutions that will act as a testing ground for the more practical parts of the proposal. However, if something will characterize our work, it will be the constant collaboration between all parties, as well as the exchange of advice and experiences that will help to enrich collective knowledge and guarantee optimal results.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal.   AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact.   To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.    To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective. DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain.  

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis.  Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks. EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows. Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud. 

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.  Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.  The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation.   S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work programme, S4R will support the development of resilient health systems in European elderly care through improved leadership capabilities, governance structures, and adaptive capacities.

UNIVERSAL SENSOR BASED ON ELECTRICALLY-PUMPED MID-INFRARED SPECTROMETER ON SILICON CHIPS

High resolution optical spectroscopy in the mid-infrared (mid-IR) spectral range (3-12 µm wavelength) is an unambiguous way to detect and quantify small traces of greenhouse and toxic gases down to sensitivities of parts-per-billion. Such sensitivities are a prerequisite to safeguard low-pollution and toxic-free environment defined by the EU Action Plan: "Towards a Zero Pollution for Air, Water and Soil.” However, size, cost, and general complexity of the commercially available instruments limits their use to a small number of highly specialized applications, and prevents their deployment with sufficient coverage e.g. in networks, wearable electronics, etc. Particularly in the context of Internet of Things (IoT) devices, on chip integration of spectroscopic systems would constitute a game changer for mid-IR high-precision and portable sensors. The objective of UNISON is to address this challenge and demonstrate a highly scalable platform for infra-red spectroscopy that has both high-end performance and is compact. UNISON sensing scheme relies on dual comb spectrometers obtained by leveraging on electrically pumped cascade lasers (QCL and ICL) and on silicon-germanium (SiGe) mid-IR photonic circuits to surpass current spectroscopic systems in terms of detection bandwidth, point spacing and system compactness. UNISON is organized around 3 main cornerstones each of them relying on ambitious physical and technological challenges: (i) tunable large bandwidth frequency combs will be generated on SiGe photonics circuits  by combining electro-optical comb generation, non-linear effects and dispersion engineering ; (ii) the comb sources will be pumped by novel electrically-driven cascade laser sources integrated with the SiGe photonics circuits ; (iii) compact, broadband, and sensitive interaction region for trace gas detection, designed and optimized for the SiGe platform, will be integrated with the dual comb source to showcase the sensing capability of the spectrometer. 

Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal.   For each area, the consortium will work collaboratively to produce seven sets of resources:  i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets;   ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;  iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;  iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;  v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;  vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;  vii)	Comprehensive training materials related to all project outputs. 

Cooperation and AgReements enhancing Global interOperability for Aerosol, Cloud and Trace gas research infrastructures

The goal of CARGO-ACT is to deliver a clear roadmap for sustainable global cooperation between key ground-based aerosol, cloud and trace gas research infrastructures, each having invested in infrastructure and services to support their observing networks with a long-term perspective, with a view to consolidating into a sustainable global research infrastructure in the future. There is a strong desire for global integration from the research community, including weather, climate, and air quality monitoring and modelling,  and in particular from space agencies, since global networks of ground-based observations are an essential component complementing Earth Observation from space, providing calibration and validation of the remote sensing information collected by current and future satellite missions. The integration of the current ground-based networks, which may have different interests and priorities, requires cooperation and agreements at the global level, including engagement with relevant stakeholders. Their service provision is not limited to data services, but includes access to the measurement facilities, reference instruments, reference standards and laboratories, all of which are topics to be assessed in CARGO-ACT.    The specific objectives of CARGO-ACT are to, develop sustainable partnerships and decision making processes with relevant partners, demonstrate the benefits of converging interoperability and standards to stakeholders and the global research community, establish the mechanisms for providing  international access to distributed research infrastructures and develop a roadmap for upscaling towards an integrated global research infrastructure for aerosol, cloud and trace gases. 

Midlene fra INFRA-Research infrastructures fordelt på år

Midlene fra INFRA-Research infrastructures fordelt på fylker

Midlene fra INFRA-Research infrastructures fordelt på fagområde

European Research Infrastructure for Marine Bioprospecting

The main objective of the EUREMAP consortium is to optimise the marine bioprospecting pipeline in Europe to enable state-of-the-art research and capacity for both academia and industry. The ambition is to leverage strengths available within European Research Infrastructures (RIs) and to align capacities and resources of the multidisciplinary field of marine bioprospecting. Hence, to increase the competitiveness of marine natural products in the field of drug discovery and to strengthen the blue bioeconomy in Europe, we will assemble a new pipeline that aligns and integrates the existing technical capacities and multidisciplinary expertise of the three European RIs - EU-OPENSCREEN (EU-OS), EMBRC and ELIXIR - in the field of marine natural products discovery. EUREMAP will develop a unique trans-RI integrated service in an European priority area, the blue economy. The pipeline will be an important part of the European blue growth strategy to stimulate economic growth through innovations in marine biotechnology. The potential for innovations and value creation in the blue biotechnology sector is high, and the sector is characterised by being multidisciplinary, knowledge-intensive and built on technology. Building a new European transnational RI service platform to support the competitiveness of an academic and industrial community in all aspects of this multidisciplinary field. EUREMAP will bring together an experienced, multidisciplinary consortium across three RIs to support and enable the discovery of novel bioactive natural products from marine organisms by utilizing novel technology to improve the capacity of European RIs.

The aDDRess Innovaiting Training Network is focused on providing training for individual PhD students in research on DNA damage and DNA repair ranges from characterising genes and pathways involved in the maintenance of DNA structure in healthy cells to analysing the physiological, cellular and molecular responses that occur upon DNA damage and molecular analysis of diseases associated with DNA damage. Our training program is of direct relevance to the call: we will prepare a proposal focused on training of Early Stage Researchers (ESRs) delivered via interdisciplinary networking and arranging joints doctorates. We plan to enrol 12 ESRs with a scientific focus on the functional role of DNA damage response and DNA repair mechanisms in development and disease. Each ESR will have an individual research project, which will be combined with shorter research trainings in the Partner organisations, attendance of networking events and courses. We will create an excellent European research network for ESRs training in key technologies, that will enable them to achieve their scientific goals and enhance their future employment prospects.

Innovative Training Network - DNA damage responses in Development and Disease, aDDRess

Project to be established: Developing a novel diagnostic tool for assessing DNA repair capability.
DNA repair is a crucially important player in preventing mutations and therefore cancer. It is also important as a factor in determining individual patients ' response to cancer therapy. We will develop a diagnostic tool for DNA repair assessment based on novel, high throughput, miniaturized, automated techniques. Till now, such a tool has not been available, since DNA repair assays have been very labour-inte nsive. 
Our tool will be based on the comet assay - a sensitive, well-established method for measuring DNA breaks. Electrophoresis of lysed, gel-embedded nuclei gives comet-like fluorescent images in which the relative tail fluorescence indicates the leve l of DNA damage. We have developed high throughput versions of the assay, and now plan to adapt these for measuring repair, using three distinct approaches: a cellular repair assay, in which cells are treated with DNA damaging agent, incubated, and remain ing damage measured at intervals; an in vitro assay, based on incubation of cell extract with DNA substrate containing specific lesions; and an assay for accumulated repair Intermediates when repair synthesis is blocked.
The new tool will be validated aga inst existing methods, and applied in a pilot clinical study. Our aim is that the method should become available as a standard tool for use in hospitals, and also in human biomonitoring studies, for example monitoring DNA repair in subjects occupationally  exposed to DNA damaging agents. Another possible application is in personalising healthcare.
Challenges: Defining role of partners, allocating workpackages, agreeing finances. R&D challenges: Miniaturising the repair assay to make use of small numbers of  cells; applying robotic technology to automate the assay; devising a rapid scoring method; validating the new methods in clinical studies.

High Throughput Estimation of DNA Repair Capability

A compact comet assay for versatile biomedical testing

Novel and emerging contaminants in Europe: Sources, occurrence, fate and impact for humans and the environment.

Molecular epidemiology is a discipline in which the methods of molecular biology are applied to human populations. We have developed a battery of methods for measuring diverse kinds of DNA damage, and capacities for DNA repair, in human lymphocytes. These  biomarkers allow us to investigate the impact of environmental factors, lifestyle, nutrition, sex and genetic polymorphisms on genomic instability, which is assumed to be causally related to aging and cancer. First, we need to establish mean baseline val ues for the various biomarkers, and the range found in a normal healthy population. To this end, we have collected and stored samples from about 300 subjects in the 'Norwegian Baseline Study'. These samples await analysis. The Yggdrasil scholar will learn  the necessary techniques, carry out certain method development (to optimise the DNA repair assays), and then analyse as many stored samples as possible in the time available. The ultimate aim is two-fold: first, to investigate associations between the pa rameters we measure and the anthropometric and nutritional information gathered by colleagues involved in this study; and second, to contribute to the database being established under ComNet, a new project to validate the comet assay as a biomonitoring to ol, and to establish reference values of biomarkers for future comparisons.

Analysing DNA damage and repair in human population groups- Mobile researcher: Olena Bilyk, Ukraine

There is an increasing awareness of the potential risks from man-made chemicals to the environment and health. Regulations are coming into force that require rigorous testing of all chemicals above a certain level of usage. We will create a network of exp erts to provide research expertise and to apply selected state-of-the-art-assays in the field of environmental genotoxicity. Such assays are needed for basic research into genome damage and maintenance, for regulatory purposes (testing chemicals for possi ble health effects), for industry and for biomonitoring. Various well-established genotoxicity testing assays are available; some have been approved under recommendations from the European Commission, the International Conference on Harmonisation (ICH - p harmaceutical industry) or OECD. No single test is sufficient, and all tests have significant limitations. The emphasis in EcoGenoTox will be on providing a battery of high throughput, sensitive, validated assays. Among them, the comet assay (single cell  gel electrophoresis) is particularly versatile as a method for measuring different kinds of DNA damage as well as DNA repair. 
The network, while based in Norway, will encompass scientists of international renown from institutions in Europe and beyond. Ex isting links with regulatory bodies and potential end-users will be consolidated. Full project meetings will be held at the beginning of the project to formulate network activities, and at the end to decide future plans. Video conferences will be arranged  at regular intervals to discuss specific points, as well as meetings of partners whenever necessary.
The network will co-ordinate inter-laboratory validation trials of existing and modified assays, in close co-operation with regulatory organisations.

Coordinated approach to improved environmental genotoxicity testing

The Society for Free Radical Research (Europe) and the European Environmental Mutagen Society independently decided to hold their annual meetings in Oslo, and asked Andrew Collins (University of Oslo) and Gunnar Brunborg (Norwegian Institute of Public Hea lth) to organise the meetings back-to-back. Since the societies have certain interests in common, we decided to hold a joint symposium, on DNA Repair, with several notable speakers. DNA repair is an area of biological research in which Norwegian teams hav e excelled, and so this is an excellent opportunity to 'showcase' some of the best of Norwegian science, to a wider audience of environmental and other scientists. The conferences will be held during the week of September 12 to 18, 2010, in the Oslo Congr ess Centre (Folkets hus). 
The objective of the Society for Free Radical Research (Europe; SFRR) is to advance education in free radical processes, for the benefit of the public. Free radicals are species that contain an unpaired electron, making them, in  general, highly reactive and damaging to other molecules, with considerable industrial, biological and medical implications. In addition to their importance for industrial processes such as the formation of polymers, they play important roles in atmosphe ric and photochemical processes, and are involved in essential biological processes such as cell death, mutagenesis and tumour growth.
The European Environmental Mutagen Society, EEMS, is organized and operated to encourage the study of mutagens and subst ances of related biological activity in the human environment, particularly those agents that may be of concern to public health. EEMS is engaged in and sponsor research and dissemination of relevant information. EEMS is a meeting place for scientists and  students, from a wide area comprising experimental toxicology, molecular biology, DNA repair, epidemiology, exotoxicology and regulatory toxicology.

0 projects

PES2020-Prosj.etabl.støtte H2020

Innovative Training Network - DNA damage responses in Development and Disease, aDDRess

Awarded: NOK 56,999

Project Period: 2017-2018

Location: Oslo

PES2020-Prosj.etabl.støtte H2020

High Throughput Estimation of DNA Repair Capability

Awarded: NOK 21,219

Project Period: 2014-2014

Location: Oslo

PES-EUR-Prosjektetablererstøtte Eureka

A compact comet assay for versatile biomedical testing

Awarded: NOK 0.10 mill.

Project Period: 2013-2013

Location: Oslo

PES-EU-Prosjektetablererstøtte EU (bedrift)

Novel and emerging contaminants in Europe: Sources, occurrence, fate and impact for humans and the environment.

Awarded: NOK 42,000

Project Period: 2013-2013

Location: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Analysing DNA damage and repair in human population groups- Mobile researcher: Olena Bilyk, Ukraine

Awarded: NOK 0.11 mill.

Project Period: 2012-2013

Location: Oslo

DIV-INT-Annet internasjonalt samarbeid

Coordinated approach to improved environmental genotoxicity testing

Awarded: NOK 0.60 mill.

Project Period: 2010-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

2010 meetings of SFRR and EEMS in Oslo

Awarded: NOK 0.20 mill.

Project Period: 2010-2010

Location: Oslo

IS-RUS-Stipendprogram for NVRussl.

Collins, Andrew RUS04/05 pva 4 russiske forskere

Awarded: NOK 0.10 mill.

Project Period: 2004-2006

Location: Oslo