0 projects

Date from new to old

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Nuclear autophagy; Functions in neuroprotection and tumor suppression

Autophagy is a cytoplasmic renovation mechanism that causes degradation and clearance of macromolecules such as pathogens, defective organelles and protein aggregates. PML bodies, on the other hand, represent distinct nuclear compartments that are known t o function in apoptosis, differentiation ...

Awarded: NOK 6.4 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dual band-pass filtering of information within cortical pyramidal neurons

Pyramidal neurons are the principal cells the main 'computational units' - of the cerebral cortex, but how they function remains enigmatic. The present proposal aims at elucidating novel functional principles within these cells that are likely to be impor tant at two different levels: at the fund...

Awarded: NOK 10.0 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DECIPHERING EMBRYONIC SEGMENTATION: GENES THAT CONTROL THE REPEAT PATTERN OF THE VERTEBRAL COLUMN

The segmented or metameric aspect of the body axis is a basic characteristic of vertebrates, and segmentation has long thought to be a key aspect of the basic design. Previous studies from our group have shown that the notochord of teleosts nucleates vert ebral development by forming the initial ...

Awarded: NOK 6.0 mill.

Project Period: 2010-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: Genome-based analysis of C1 metabolism in bacilli and redesign of Bacillus subtilis into a methlotroph

One-carbon (C1) compounds such as methane and methanol are attractive, non-food and low-cost carbon and energy sources for microbial bioprocesses, which can be utilized by specialized groups of microorganisms; the methylotrophs. Research efforts with diff erent model strains revealed that methylo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The association between dietary intake and biomarkers for nutrients and disease

Dette er et prosjekt for å bedre forstå kosthold hos kvinner og hvordan det henger sammen med andre markører. Vi har undersøkt kostholdsmønstre hos kvinner, og i hvilken grad disse korrelerer med serumnivå av spesifikke ernæringsfaktorer. Kostmønstrene hos norske kvinner likner på mønstre funne...

Awarded: NOK 4.1 mill.

Project Period: 2010-2016

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Functional in vivo analysis of Protein Kinase Cs and related kinases

Awarded: NOK 7.4 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: The functions of phosphoinositides in tissue morphogenesis and cancer

Membrane dynamics modulate cell polarity, vesicular trafficking, migration, growth, proliferation, differentiation, and more. Of all membrane lipids, phosphoinositides play a central role in these processes (Wymann & Marone 2005 Curr Opin Cell Biol; Lindm o & Stenmark 2006 J Cell Sci; Simonsen & ...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

MOLECUALR CHARACTERISATION OF T CELL RECEPTORS IN COELIAC DISEASE

Formålet med prosjektet er å beskrive det spesifikke T cellesvaret mot gluten hos cøliakipasienter, helt ned på aminosyrenivå, og å designe et molekyl som kan detektere de cellene i tarm som stimulerer dette T cellesvaret. T cellesvaret driver betennelsen i tarmen og det er derfor viktig å finne ...

Awarded: NOK 3.9 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms that couple chromosome replication rate to cellular metabolism

Vi har kartlagt endringer i cellesyklus som følge av endringer i vekstmedium for E.coli bakterien og utformet et simuleringsverktøy til bruk i studier av cellesyklus hos bakterier. Vi har funnet ut at initiatorproteinet DnaA ikke er den eneste begrens ende faktoren i oppstarten av DNA kopiering...

Awarded: NOK 2.6 mill.

Project Period: 2010-2017

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EVOLUTIONARY PROCESSES IN AGE-STRUCTURED MOOSE POPULATIONS: TOWARDS SUSTAINABLE MANAGEMENT STRATEGIES IN FLUCTUATING ENVIRONMENTS

We consider the Fennoscandian harvest regime of moose to represent a large-scale population manipulation experiment, which can be used to study how changes in the age- and sex-composition infer with evolutionary processes within populations and their abil ity to adapt to future environmental chan...

Awarded: NOK 8.2 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Network functions of newly generated neurons and cellular mechanisms of place cell activity in adult hippocampus

In this proposed research program, we will combine state-of-art genetic and electrophysiological technologies to reveal mechanisms supporting adult hippocampus functions. The proposal is largely divided into two parts. 1) Network functions of newly gener ated neurons in adult dentate gyrus. New ...

Awarded: NOK 10.3 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Intrinsic limitation of the field metabolic rate in a free-ranging Arctic seabird: the role of oxidative stress

The rate of energy expenditure integrates nearly all aspects of the ecology of a species, and knowledge of the factors limiting energy expenditure is of paramount importance for a better understanding of the evolution of life-history traits in free-living species. One factor which may exert a po...

Awarded: NOK 3.9 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The pathogenic role of chemokines in atherogenesis and plaque destabilization

I korthet har prosjektet tatt utgangspunkt i kjemokiners betydning i utviklingen av aterosklerose. Kjemokiner er potente kjemoattraktanter av inflammatoriske celler inn til blant annet blodkarets vegg. Dette gjør at kjemokiner kan være spesielt viktig i utviklingen og destabilisering av aterosk...

Awarded: NOK 4.2 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Identifying molecular targets on cancer stem-like cells from human brain tumours

The overall objective of our laboratory is to determine the biological mechanisms underlying brain tumour development and identify novel therapeutic targets that will block or reduce tumour progression. Our research group has been able to isolate two diff erent phenotypes from human glioblastomas...

Awarded: NOK 7.2 mill.

Project Period: 2010-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Evolvability of allometry

In spite of a long-term interest of biologists and especially evolutionary biologists in allometry, biological and genetic models underlying the changes in relative dimensions of parts of the body that are correlated with changes in the overall size are s urprisingly few, and the evolution of all...

Awarded: NOK 7.3 mill.

Project Period: 2010-2015

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Was the DEK1 protein key to the development of differentiated multi cellular land plants?

DEK1 consists of a calpain cystein proteinase linked to a 21 transmembrane protein module. Dek1 is an essential gene for plant development that specify epidermal cell fate in all organs by a position dependant, cell autonomous mechanism. Its essential rol e in plant development is supported by th...

Awarded: NOK 4.7 mill.

Project Period: 2010-2014

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Exercise training as a treatment strategy for improved cardiac metabolism in patients with heart failure and with a transplanted heart

The search for an adequate treatment for heart failure is a major challenge, and even though the medical treatment has been improved substantially in recent years, the mortality rate remains high. During the last decades physical activity has been recogni zed as an important part in the rehabilit...

Awarded: NOK 2.5 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Biogenesis of plant photoautotrophy

Fotosyntetiserende organismer som planter og alger stammer fra fotosyntetiserende bakterier. De begynte å høste lys energi for å gi energi til sine metabolske behov og bli autotrofe for mer enn tre milliarder år siden. Sentralt i prosessen for fotosyntese og autotrofi er klorofyll. Molekylet er s...

Awarded: NOK 10.3 mill.

Project Period: 2010-2015

Location: Rogaland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Inflammasome activation by cholesterol crystals

Atherosclerotic lesions are focal thickenings of the innermost layer of the artery consisting of cells from the artery cell wall, connective tissue elements, liquid and crystalline lipids as well as blood-borne immune cells. Immune cells in atheroscleroti c lesions show signs of activation and pr...

Awarded: NOK 5.3 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The anatomy of memory: circuitry and functions of the hippocampal-parahippocampal region.

The human hippocampal-parahippocampal region plays an important role in memory. The relationship between the circuitry contained in this brain region and its contribution to memory is a topic of intense research, yet to date there is no complete and mecha nistic understanding of how the circuitry...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The Nordic-European Initiative on Colorectal Cancer (NordICC)

Colorectal cancer (CRC) is a major burden in western countries. The disease develops from precursor lesions. Colonoscopy can detect and remove CRC precursor lesions and may thus be effective for CRC prevention. According to European Union guidelines, evid ence from randomised trials to reduce inc...

Awarded: NOK 13.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Enhanced Minimally Invasive Therapy,- e-MIT

Prosjektet e-MIT (enhanced Minimally Invasive Therapy) har som hovedmålsetting å forbedre behandling av pasienter gjennom utvikling av minimal invasive teknikker. e-MIT har videre mål om å forbedre behandling av pasienter med utposning på hovedpulsåren (abdominalt aorta aneurysme), kreft i mage, ...

Awarded: NOK 13.0 mill.

Project Period: 2010-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Investigating social inequalities & determinants of weight development in youth: Applying longitudinal, environmental and experimental data

Forskerprosjektet "Investigating social inequalities & determinants of weight development in youth: Applying longitudinal, environmental and experimental data." baserer seg på data fra den longitudinell studien «Voksen i år 2000», den Europeiske tverrsnittsstudien fra EU-prosjektet ENERGY og inte...

Awarded: NOK 5.7 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cardiac stroke volume and its contribution to the circulation: Interaction of mechanical and nervous factors affecting the heart

Når du puster, påvirkes hjertet av både nervøse og mekaniske faktorer. Mitt prosjekt har som hovedfokus å se på samspillet mellom mekaniske og nervøse påvirkninger av hjertets slagvolum. I prosjektet har jeg utviklet og publisert en ny metode for å måle s lagvolum fra hjertets høyre og venstre si...

Awarded: NOK 2.9 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Can Cysteine Metabolism Provide a Target to Treat Obesity?

Framdriftsrapport. Rapporteringsfrist: 20121001. Mottatt: 20130211. 197195 - Can Cysteine Metabolism Provide a Target to Treat Obesity? Side: 8 begrenset. Flere av de beskrevne prosjektene vil nå bli utvidet til også å inkludere aminosyre- og fettsy reprofilen, noe som vil markert heve kvaliteten...

Awarded: NOK 9.4 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular Interactions with the Extracellular Matrix of Tumour Microenvironment

Interactions of cells (both tumour and stromal cells) with extracellular matrix (ECM) are an important part of the influence of the microenvironment on tumour progression. ECM interacts with cells via integrin receptors, as well as other receptors, and pr ovides signals for cell proliferation and...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Human protein N-terminal acetyltransferases: A protein-modifying enzyme family essential for cell survival and peptide hormone regulation

Acetylation is a very common protein modification occurring both at lysine residues within proteins (N-epsilon-acetylation or lysine acetylation) and at N-termini of proteins (N-alpha-acetylation or N-terminal acetylation). Lysine acetylation has been stu died extensively and it provides importan...

Awarded: NOK 10.9 mill.

Project Period: 2010-2014

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms of mammalian DNA Repair

DNA repair prevents cancer and early aging and is essential for adaptive immunity. Our objective is to obtain detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair by human AlkB homologs. In addition, we will now expand our research into possible epi...

Awarded: NOK 5.9 mill.

Project Period: 2009-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Fear of childbirth: causes and consequences

The Western world has an epidemic of self-perceived fear of childbirth. Between 5 and 10% of all pregnant women in the Oslo area are being treated for fear of childbirth. Steadily increasing numbers of pregnant women are requesting caesarean sections due to fear of giving birth. However, caesare...

Awarded: NOK 6.6 mill.

Project Period: 2009-2014

Location: Akershus

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