0 projects

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FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Subnode: Subcellular interactions and imaging - NTNU

Knowledge about protein-protein interactions as well as interactions between other molecules is of critical importance for functional genomics. By providing the state-of-the-art technologies to study inter-and intramolecular interactions, the national res earch community will be able to move func...

Awarded: NOK 7.4 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Aleström Zebrafish Lab - activities beyond the research projects 2007-2011

The major focus of the AZLab services are two-fold: 1) Being a regional center, in an national and international network of transgenic zebrafish laboratories, with capacity to offer access to the zebrafish model for academic and commercial partners. 2) Es tablish a unique training program in zebr...

Awarded: NOK 4.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Advanced MR imaging, MR metabolomics, proteomics and genetic mapping of breast cancer - Clinical tools for personalized patient treatment

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 5.2 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Norwegian Structural Biology Centre (NorStruct) Proposal for a continuation of the Centre for 2008-12

NorStruct will continue to offer state of the art services and collaboration in structural biology techniques to the Norwegian research community. The expertise and services will have a solid foundation in in-house research and national and international partners. The services will be organized i...

Awarded: NOK 23.0 mill.

Project Period: 2008-2013

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The Proteomics Core Facility at the University of Tromsø as a node in the national consortium of proteomics platforms (NorProteomics)

The core facility for Proteomics in Tromsø has been fully operational since the end of 2004. The main purpose of the facility has been to serve research labs in the FUGE North region. The facility has 3 Mass spectrometer systems from Waters/Micromass. A M ALDI Micro MX, a Q-TOF Ultima Global with...

Awarded: NOK 1.3 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Development of high througput affinity protemics to search for drug targets in cancer.

Antibody array technology, mass-spectrometry and molecular biology techniques are combined to develop a new platform for screening of drug targets in cancer. The technology allows large-scale analysis of protein networks with high sample throughput. The p roject will develop large-scale analysis ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

The Bioinformatics Platform in the FUGE2 programme

The FUGE 2 Bioinformatics platform is designed in direct response to the demand for increased use of bioinformatics from the FUGE 1 evaluation. The platform will provide state of the art research based services in theoretical and applied bioinformatics to Norwegian research groups, in close coll...

Awarded: NOK 26.8 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Spontaneous preterm birth: a systems biology approach in the Norwegian Mother and Child Cohort Study

sPTB is an unresolved common complex condition in perinatal medicine and is related to long-term disabilities such as cerebral palsy, cognitive and respiratory problems, which will affect the infant in every day life situations. The pathophysiology of sPT B remains poorly understood. Infection an...

Awarded: NOK 15.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Awarded: NOK 9.3 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A node of the FUGE platform for proteomics at the Biotechnology Centre of Oslo

Specialized proteomics service will be provided by the node at the Biotechnology Centre of Oslo for i.) quantitative proteomics ii.) clinical proteomics, and iii.) cell death proteomics. Quantitative proteomics will be performed either in cell culture by stable isotopic labeling of amino acids du...

Awarded: NOK 2.2 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Awarded: NOK 8.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

National-wide service and competence from the Rikshospitalet-Radiumhospitalet Proteomics Core Facility in a Norwegian proteomics consortium

The Proteomics Core Facility at Rikshospitalet-Radiumhospitalet (RR-PCF) is a core facility platform organized jointly by Rikshospitalet-Radiumhospitalet HF (RR) and the University of Oslo (UiO) through "Felles Forskningsutvalg" at the hospital. The RR-PC F is engaged in the development of proteo...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Membrane trafficking in immunity and tumour suppression

Intracellular membrane trafficking plays key roles in cell signalling and innate and adaptive immunity. Endocytosis and subsequent endolysosomal trafficking of growth factor receptors constitute a crucial mechanism for receptor signal attenuation and tumo ur suppression. For innate immunity again...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Norwegian Proteomics Consortium - Bergen

PROBE, the Norwegian proteomic platform, was established in 2002 by the Norwegian Research Council under the Functional Genomics Initiative (FUGE) to provide the Norwegian scientific community access to the best in proteomic technologies and competence. Located within the Institute of Biomedicine...

Awarded: NOK 9.5 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

A FUGE Nor-MIC Node in Live Cell Imaging and Protein-Protein Interaction Analysis in Plants

There is a growing need to understand fundamental plant processes at the subcellular level. With respect to this it is of paramount importance to the Norwegian research community that a National Imaging Service and Training facility exists to meet these f uture demands. In addition a Molecular Im...

Awarded: NOK 1.0 mill.

Project Period: 2008-2012

Location: Rogaland

FUGE-Funksjonell genomforskn.i Norg

A National Service Platform for Global Analysis of Genome Structure and Function. The Norwegian Microarray Consortium (NMC)

Awarded: NOK 9.7 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Norwegian plant transcriptional profiling centre

The Norwegian Arabidopsis Centre (FUGE-NARC) was established as a part of FUGE I. NARC provided national service in plant functional genomics and the service activity was shared between Univeristy of Life Sciences (UMB, transformation/genotyping), Univers ity of Oslo (Y2H, in situ hyb) and Norwe...

Awarded: NOK 2.3 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Bacterial flagellin: a novel adjuvant for vaccine strategies

The focus will be on development of strongly protective vaccines aimed primarily to fish, but the knowledge generated will be highly relevant within vaccine development to mammalian species - as fish possess very similar immune defence mechanisms compared to mammalian species. This will be achie...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

zEPISTEM: DEFINING STEMNESS BY ASSESSING THE EPIGENETIC BASIS OF PLURIPOTENCY IN EMBRYONIC STEM CELLS OF ZEBRAFISH

Chromatin organization around active or repressed genes starts to be elucidated, but the packaging of a gene into a chromatin structure compatible with potential for transcription, such as in a pluripotent cell, is largely unknown. The zEPISTEM research p rogram aims at identifying novel gene mar...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Structure based rules for protein kinase inhibitor selectivity

Protein kinase inhibitors are now emerging as a major class of new targeted drugs. Many diseases, especially cancers, are associated with disregulation of signalling pathways, and modulation of protein kinase activity is now a clearly validated approach f or therapy. Because there are over 500 pr...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Secretomes of lactobacilli and enterococci and their impact on bacterial adaptation and human health

Lactic acid bacteria belonging to the genera Lactobacillus and Enterococcus are normal inhabitants of fermented food products and of the human gastrointestinal tract. The impact of these bacteria on human health varies from beneficial to harmful. We will conduct genome-wide studies of surface-loc...

Awarded: NOK 5.3 mill.

Project Period: 2007-2014

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Dissection of Epigenetic Mechanisms and Transcriptional Networks in Seed Development

Seed development is the product of double fertilization of the egg cell and the central cell by two sperm cells from the pollen and requires a coordinated interplay of the transcriptional programmes in the embryo, the endosperm and the maternal seed coat. Parent of origin dependent expression pl...

Awarded: NOK 6.0 mill.

Project Period: 2007-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Epigenetic gene regulation: The 'conspiracy' between chromatin modification and transcription factors.

An important aspect of gene regulation involves the interconversion between transcriptionally permissive euchromatin and repressive heterochromatin, which in part is regulated by post-translational modifications of the nucleosomal histone tails. The patte rns of histone modification (the histone ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Awarded: NOK 10.0 mill.

Project Period: 2007-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Cellular responses to DNA damage in Schizosaccharomyces pombe

see attachments: Projectdescription and program

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional and structural characterization of the membrane-integrated plastid phosphate translocators

Atomic structures of proteins provided a wealth of information about the functioning of proteins at the molecular level, e.g. the catalytic mechanisms of enzymes, pointing to the enormous impact of X-ray crystallography on modern biology. Because of techn ical hurdles almost all of the more than ...

Awarded: NOK 5.2 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Awarded: NOK 8.0 mill.

Project Period: 2007-2012

Location: Oslo

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