0 projects

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FRIMEDBIO-Fri prosj.st. med.,helse,biol

A novel cell cycle checkpoint in fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle and cancer development is frequent ly associated with the lack of checkpoint...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Awarded: NOK 4.5 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Copy number variants and predisposition to autoimmune diseases like rheumatoid arthritis.

A novel form of genetic variation has during the last two years been recognized to be important for human phenotypes and diseases, namely copy number variations (CNVs). CNVs have so far generally been overlooked in searches for susceptibility variants for common multifactorial diseases, however ...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular mechanisms of LTP consolidation in vivo

The ability of the brain to store information stems from the fundamental plasticity of neuron-to-neuron communication at synapses. Rather than being static entities, synapses can undergo lasting increases or decreases in strength in response to specific i nput patterns. Synaptic plasticity is tho...

Awarded: NOK 5.5 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

GENETIC MOUSE MODELS TO STUDY GASTRIC PHYSIOLOGY AND DISEASES

Genetic mouse models include introduction of exogenous gene into the mouse genome (the so-called transgenic mouse) and targeted disruption of endogenous gene (knockout mouse). Up to date, ~10% of the known mouse genes have been knocked out, 21 transgenic/ knockout mouse strains have been studied ...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Match-mismatching of trophic levels as a structuring force of ecosystems

We intend to study ecosystem functioning using the match-mismatch hypothesis as a framework and three different marine ecosystems with focus on seabirds as examples. The marine ecosystems chosen - the Southern Ocean, the Barents Sea and the Benguela Upwel ling - are highly sensitive to climate va...

Awarded: NOK 6.5 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Surviving without oxygen: from mitochondrial function to ethanol production

While medical science has had a very limited success in counteracting the deleterious effects of ischemia/hypoxia in humans, evolution has repeatedly solved this problem. The best studied examples of anoxia tolerant animals are some North American freshwa ter turtles (genera Trachemys and Chrysem...

Awarded: NOK 5.2 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Prevention of cardiac inefficiency in type 2 diabetes by means of high-intensity exercise training

Type 2 diabetes is associated with altered myocardial metabolism, reduced cardiac performance and reduced cardiac efficiency (cardiac work per unit oxygen consumption). The long-term objective of the present project is to understand the mechanisms behind diabetic cardiomyopathy, an example of car...

Awarded: NOK 4.6 mill.

Project Period: 2008-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Phenotypic heterogeneity of glucokinase-diabetes mutations: Studies of structure, function and regulatory mechanisms leading to treatment

Glucokinase (GK) is the major glucose sensor in the pancreatic beta-cell where it catalyses the first step of glycolysis. Mutations in human GK (hGK) can be inactivating or activating. Heterozygous inactivating mutations lead to a mild form of diabetes, M ODY2, while homozygous inactivating mutat...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular therapy of maligngant glioma with lentiviral vectors and tumor infiltrating progenitor cells

The aim of the project is to establish a stable packaging cell line for lentiviral vectors based on bone marrow derived tumor infiltrating progenitor cells (BM-TIC) for the treatment of malignant glioma. In previous studies, we have shown that BM-TIC migr ate and distribute efficiently within mal...

Awarded: NOK 3.0 mill.

Project Period: 2008-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Frontal lobe injury and cognitive control

The main goal of this project is to investigate the neural substrate and cognitive mechanisms that are involved in a set of higher-order "executive" functions that are necessary for goal-directed thinking and behavior. At present there is no unitary model that accounts for all aspects of executi...

Awarded: NOK 4.0 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanism of mammalian DNA repair

DNA repair prevents cancer and early aging and is essential for the immune system. Our objective is to obtain a detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair. BER is a template-dependent multistep proc ess initiated by a DNA glycosylase. The U...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular basis for control of the heartbeat by Na+

Contraction of the heart is triggered by an increase in Ca2+ within cardiac muscle cells, as Ca2+ ions bind to contractile proteins. The rise in Ca2+ results primarily from release from the sarcoplasmic reticulum which is the main intracellular store of C a2+. Therefore, the pumping ability of th...

Awarded: NOK 5.4 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Change in clinically significant behavior during pharmacological augmented treatment of anxiety disorders

There has been enormous progress in the treatment of anxiety disorders, yet about 40% patients with chronic posttraumatic stress disorder do not recover after receiving daily medication or psychotherapy. PTSD is characterized by hyperarousal, coupled with emotional avoidance. Non-reinforced expo...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Unmasking the Interplay between Pathogenic Neisseria Species and Host Cells by Quantitative Proteomic Analysis

This proposal aims to investigate the interaction between pathogenic Neisseria gonorrhoeae and Neisseria meningitides with host cells during infection using in vitro and in vivo models (cell culture and mouse model). A quantitative proteomic approach usin g in vitro and in vivo metabolic labeling...

Awarded: NOK 3.8 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular characterization and functional studies of human B cell lymphoma

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. Our group aims at identifying genes/signalling pathways with prognostic, diagnostic or therapeutic potential in B cell lymphomas. We are one of 7 groups that co nstitute the newly established Centre for...

Awarded: NOK 3.2 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Role of AlkB homologs 1 and 7 (ABH1 and 7) in epigenetic reprogramming

This project is primarily based upon the intriguing phenotype and breeding pattern of mABH1 (mouse AlkB homolog 1) targeted mice. As outlined below, this dioxygenase is required for faithful embryonic development. Major developmental defects include failu re of eye, nose and limb development (Fig...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation of competence for natural transformation in Streptococcus pneumoniae

Bacteria that have the ability to take up naked DNA from the environment and incorporate this DNA into their genomes by homologous recombination are said to be naturally competent for genetic transformation. About 70 species of bacteria have been reported to possess this property. One of the bes...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Computational models of aberrant attribution of salience in schizophrenia and the effects of medication: An event related fMRI study

It has been known for decades that dopamine abnormalities are relevant to the pathophysiology of schizophrenia (mainly psychotic symptoms) and that blocking the dopamine system is associated with improvements in symptoms. How one gets from this neurochemi cal change to the expressed behavior abno...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Improved individualized diagnosis and treatment monitoring of prostate and breast cancer by combining new MR and ultrasound technology

This project deals with combining new methods in medical ultrasound (US) and Magnetic Resonance (MR) imaging to improve individualized diagnosis and treatment monitoring of prostate and breast cancer. The project includes further development of new techno logy and taking this technology into clin...

Awarded: NOK 3.7 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The life history trade-off between immune function and brain development

As immunity has been proven to be costly in energetic terms, these investments are likely to conflict with other, important and energy-demanding fitness traits. Several studies have addressed trade-offs between the immune-system and other factors, like gr owth, development or reproductive investm...

Awarded: NOK 4.0 mill.

Project Period: 2007-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Medication assisted rehabilitation and crime; how do MMT affect crime rates and patterns?

It is still not known fully to which extent MMT offers crime reduction as a mean of harm reduction for heroin addicts in Norway. New knowledge of crime reduction patterns based on cross-registry studies and in-dept studies on crime patterns will give impo rtant new knowledge for program planners ...

Awarded: NOK 2.7 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Applying advanced computational and experimental tools to explore surface electrostatics in chitinases

Understanding how proteins work is a major challenge in the post-genome era. Traditionally proteins have been studied by the use of numerous biochemical techniques, but as the number of proteins that needs to be characterized has increased, so has the num ber of in computo techniques to study pro...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Targeting occult tumor cell dissemination in localised breast cancer

For the future, a better treatment of patients with breast cancer is dependent upon a better assessment of the individual risk of harbouring minimal residual disease after the completion of the surgical treatment. The aim is to separate very low risk pati ents from high risk patients for future m...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular control of differentiation of multipotent stem cells in simple marine animals

The maintenance of stem cells and the regulation of their differentiation are still poorly understood. Interstitial stem cells are easily accessible in the simple animal Hydra and give rise to different neuronal cell fates, gametes and gland cells. In con trast, no interstitial stem cells have be...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular and cellular mechanisms of the hippocampal memory system studied by in vivo recording in behaving animals

A major challenge in neuroscience is to explain behaviour in terms of molecular, cellular and neuronal network mechanisms. We will study mechanisms of the medial temporal lobe memory system by in vivo recording of hippocampal single unit and neuronal netw ork activity (EEG) in freely mowing rats ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Statistical tools for studying genetic architecture

Advances in molecular biology have revealed that most phenotypes are controlled by highly complex and interactive gene networks. This complex genetic basis is, however, not reflected in the rather simple genotype-phenotype maps postulated in population an d quantitative genetics. These models are...

Awarded: NOK 2.6 mill.

Project Period: 2007-2012

Location: Oslo

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