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Algebraic Theory of Information Quantities

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

EOSC Beyond: advancing innovation and collaboration for research

EOSC Beyond overall objective is to advance Open Science and innovation in research in the context of the European Open Science Cloud (EOSC) by providing new EOSC Core capabilities allowing scientific applications to find, compose and access multiple Open Science resources and offer them as integrated capabilities to researchers. To do so, EOSC Beyond supports a new concept of EOSC: a federated and integrated network of Nodes operated at different levels, national, regional, international and thematic, to serve the specific scientific missions of their stakeholders. Further specific objectives of the project are to accelerate ‘time to product’ of new scientific applications with software adapters, enable Open Science with machine composability and dynamic deployment of shared resources, support innovation in EOSC with a testing and integration environment, and align the EOSC Core architecture and specifications to integrate with European dataspaces. The project extends the state of the art of the EOSC Core and adopts a co-design methodology, including requirements elicitation, software development and validation in collaboration with different use cases from EOSC national and regional initiatives (e-Infra CZ, Czechia, NFDI, Germany, and NI4OS, South East Europe region), thematic research infrastructures from Social Sciences and Humanities (CESSDA), Life Sciences (CNB-CSIC and Instruct-ERIC), Environmental Science (ENES and LifeWatch), and Health and Food (METROFood-RI). EOSC Beyond builds on the capacities of prospective EOSC Nodes and partners with multi-annual experience in developing solutions for large-scale federated digital infrastructures and aligns with the technical architecture and requirements of data spaces from different business sectors. Ultimately, EOSC Beyond supports Open Science in modern, data-intensive, and multidisciplinary research, facilitating resource discovery, access, and reuse across scientific communities, organisations, and countries.


Harmonization of Advanced Materials Ecosystems serving strategic Innovation Markets to pave the way to a Digital Materials & Product Passport

The overarching objective of DigiPass is to enhance the digital maturity of the European communities that develop materials and intermediate products. The project will develop recommendations and clear routes toward digitalized circular business models. The overarching key result of DigiPass is to create a sustainable platform which includes support for Digital Materials & Product Passport and for collaborative innovation-by-design processes in a circular economy served by advanced materials. A business model for operating such a platform completes the overarching objective.
DigiPass is harmonizing and synergizing collected materials data sources and digital infrastructures. This will enable interoperability of data exchange, and standardization of advanced materials knowledge representation at all maturity levels. Accelerating the design, development, and production of advanced, safe, and sustainable chemicals and materials, as they are necessary for innovative products, calls for a collaborative approach involving different stakeholders to support durability, repair and overhaul, reuse, and recyclability of products. DigiPass project impacts all materials development communities over the whole circular value chain. 


Enhanced X(cross)-disciplinary Community-driven Imaging Technologies for Earth and Environmental material research

The EXCITE² Network is revolutionizing Earth and environmental material science research by consolidating a critical mass of 18 research facilities in 12 European and associated partner countries into a unified infrastructure and providing transnational access to advanced imaging technologies. This enables scientists to decipher complex processes within Earth materials at scales from nanometres to hundreds of centimetres, gaining unparalleled insight into the chemical and physical processes that govern, among others, environmental toxicity and its impact on human health, critical metal extraction for renewable energies, and the utilisation of Earth materials as long-term storage for climate-altering gases. The consortium fosters knowledge-sharing and talent attraction, bolstering the problem-solving capacity of the European Research Area. Moreover, EXCITE² is driving interdisciplinary collaboration and cross-fertilisation across academic institutions, scientific disciplines, and industry, propelling Europe towards a sustainable future. The initiative offers dedicated training programmes to a new generation of researchers within the European open science landscape, paired with access to world-class imaging facilities and expertise for problem-solving research and innovation. EXCITE² is introducing innovative service developments, such as artificial intelligence and leading-edge imaging experiments, to increase the user's problem-solving capacity. In addition, the consortium is implementing customised project valorisation strategies to maximize the impact of research outcomes in academia, society, and the economy. Citizen science projects allow the public to participate directly within the EXCITE² Network, contributing to solving EU challenges. As such, EXCITE² is paving the way towards a sustainable future, driving scientific excellence, and creating positive societal impact.

Engineering carbon quantum dots for zinc ion hybrid capacitors

Zinc ion hybrid capacitors (ZIHCs) integrate two energy storage mechanisms of battery-type electrode and capacitive electrode, bearing the advantages in energy density, power density, and safety. Until now, the cycle retention rate of ZIHC's capacity reported is still not more than 80%, restricting its development and commercial application severely. Focusing on the issue, the project aims at overcoming the limitation of traditional electrode materials and re-defining the designing concept to construct Carbon Quantum Dots (C-QDs) for ZIHCs. Advanced methods will be used to harvest carbon quantum dots from coal tar pitch (a sort of industrial solid castoff). The bulk sp2-carbon network, innumerable edge sites, profuse surface functional groups, and regular size ensures that as-synthesis C-QDs have high electrical conductivity, sufficient ion transport channels and rich adsorption sites. Moreover, the new concept of dynamic evolution is introduced for insight into the structure and interface failure of ZIHC's electrode. The interface-reconstruction mechanism and the attenuation model of capacity will be established for the first time. Further, the methods to strengthen structures of C-QD electrode will be developed based on a trade-off strategy. The ultimate goal is to improve the energy storage efficiency of ZIHCs by 20% and to increase their cycle performance more than 95% unprecedentedly. This research will develop long-running high performance ZIHCs, for contributing European energy storage industry. The ER will achieve abundant research experience and scientific skills from the project and the capability to launch her own research group in future.

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Aqua Research Infrastructure Services for the health and protection of our unique, oceans, seas and freshwater ecosystems

AQUARIUS will provide a highly comprehensive suite of integrated research infrastructures appropriate to addressing significant challenges for the long-term sustainability of our unique oceans, seas and freshwater ecosystems. For the first time, diverse research infrastructures will be combined to facilitate the work of researchers and key stakeholders focused on challenges and opportunities for both marine and freshwater systems. An impressive range of 57 research infrastructure services will be made available to include research vessels, mobile marine observation platforms, aircraft,  drones, satellite, sensors, fixed freshwater and marine observatories and test sites, experimental facilities, and sophisticated data infrastructures. AQUARIUS will support the development phase of the EU Mission to Restore our Ocean and waters by 2030, the Sustainable Blue Economy Partnership, the European Green Deal, and international climate initiatives. It will also be an essential component in achieving the European Digital Twin of the Ocean and the UN Decade for Ocean Sciences. The needs of researchers will be met through a robust and transparent system of transnational access funding Calls, facilitated by centralised user-friendly access portal. The Call programme will be informed through stakeholder engagement and brokerage events. Projects to be selected for Access must convincingly integrate multiple infrastructures and contribute to the core policy objectives of Mission Ocean, that is, to protect and restore marine and freshwater ecosystems and biodiversity; to prevent and eliminate pollution of our oceans, seas and waters; and to ensure a sustainable, carbon-neutral and circular blue economy. A thematic and geographic focus will be the hallmark of the proposed transnational Calls, aligning with the Lighthouse Regions, that is, the Baltic and the North Sea Basins, Black Sea, Atlantic/Arctic, and Mediterranean Sea along with their associated rivers.

EOSC-ENTRUST: A European Network of TRUSTed research environments

The mission of EOSC-ENTRUST is to create a European network of trusted research environments for sensitive data and to drive European interoperability by joint development of a common blueprint for federated data access and analysis. 
Countries and institutions have made significant investments in secure and trusted data environments to meet the need for research and policy-driven analysis of sensitive datasets such as people's health and socio-economic status, the habitats of vulnerable species and geo-spatial locations of protected sites. There are now a large number of such secure environments in operation - linked to national centres, individual organisations or specific research communities. This fragmented landscape poses challenges for both users and providers: researchers are faced with a large number of different systems and access procedures; providers need to manage federated access across multiple, potentially incompatible, technology and governance frameworks.
EOSC-ENTRUST brings together providers of operational Trusted Research Environments from 15 European countries with a shared goal to implement, validate and promote their capabilities through a common European framework using shared standards and common legal, operational and technical language. This blueprint for interoperability is anchored in the EOSC Interoperability Framework spanning the four dimensions of Legal, Organisational, Technical and Semantic interoperability. EOSC-ENTRUST has identified four driver projects covering Genomics, Clinical trials, Social science, and public-private partnerships to benchmark capabilities, inform blueprint design and demonstrate secure  data analysis using federated workflows.
Targeted outreach activities will expand this open network with further providers and develop policy papers and guidelines for the full range of stakeholders to create a long-term operational TRE framework within the European Open Science Cloud.


Providing research infrastructure services to support Next Generation EU

This four-year project will harness outputs from key social science RIs in Europe and other reliable sources to support the aims of the ‘Next Generation EU’ programme and to inform EU youth policy. Virtual access will be provided to the outputs through special installations (portals) developed during the project. The core of the proposal is a set of existing research ‘services’, which will be re-purposed and customised to focus directly on the five themes: Make it Green; Make it Digital; Make it Healthy; Make it Strong; and Make it Equal. 

For each area, the consortium will work collaboratively to produce seven sets of resources:

i)	A searchable inventory of relevant variables drawn from multiple cross-national datasets; 

ii)	Analytical summaries, suitable for policy makers and analysts new to the field, as well as interactive resources available through the project portal;

iii)	Harmonised and merged extracts from these datasets that reduce the burden on analysts and increase sample sizes;

iv)	New data collected through the ESS’s established CRONOS web panel infrastructure. Eleven countries will field five waves of the panel, each one dedicated to a NextGenEU theme. Free and rapid access to the data will be available through the CRONOS portal alongside analytical summaries;

v)	In-person and virtual deliberative forums with young people (aged 18-34) in four countries covering the five Next Generation EU’ themes;

vi)	An educational tool (E-NextGen) channelling our data for use in classrooms and by the general public;

vii)	Comprehensive training materials related to all project outputs.


Storskala implementering av e-konsultasjoner med fastlegen: evaluering av effekter på helsesystemet, fastleger og pasienter.

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på år

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på fylker

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på fagområde

Senior Researcher

AIM
The aim of this project is to study the impact of e-consultations with the GP on the health system, General Practitioners (GPs) and patients.
METHODS
The project uses quantitative and qualitative methods to evaluate the large-scale implementation of e-consultations in Norway. Research is structured around three main activities.
1. Retrospective cohort study. Data from national health registries will be collected and analyzed to study changes in adoption and use of e-consultations with the GP over time. The relationships between utilization and patients’ characteristics will be explored to measure the impact of e-consultations on equitable access to care.
2. Prospective cross-sectional study. Focus groups and interviews will explore the topics of clinical appropriateness, safety, communication, doctor-patient relationship, organizational models and workload. A prospective cross-sectional study will be conducted to investigate the perspectives of gps and patients towards e-consultations. At least 100 gps and their patients will be asked to evaluate the perceived quality of 1,500 conducted e-consultations. Gps will also evaluate organizational models and workload.
3. Patient interviews and survey. In-depth interviews with elderly patients recruited through the Pensioners Association will be conducted as elderly patients are considered the main group of non-users. A national citizen survey will be conducted on the national health portal helsenorge.no to explore how e-consultations are used by patients.
RESULTS
1. Retrospective cohort study. Applications to the regional ethics committee and data protection officer were sent and approved 2022. An application was sent to helsedata at the end of 2022 and approved in may 2024. Data from helfo are expected to be delivered by the norwegian directorate of health in spring 2024 due to high demand and long processing times.
2. Prospective cross-sectional study. Five focus group interviews with gps have been conducted to explore how they perceive clinical appropriateness, safety, communication, doctor-patient relationship in e-consultations. Data have been analysed and two scientific papers focusing on quality of communication and impact on gp practice will be sent to the journal of medical internet research by the end of 2023. A course named “better quality in e-consultations” has been developed by the project team in collaboration with skil in 2022 and 2023. As part of this course, participating gps will answer two surveys focused on perceived quality of e-consultations and organizational models and workload. The course was launched in february 2023 and it is expected a recruitment of at least 100 gps by the end of 2023. Data from both surveys will be analyzed in 2024.
3. Patient interviews and survey. Semi-structured interviews were conducted in november-december 2022 with 16 patients over 65 years with experience of using text-based e-consultations. Data were analysed through thematic analysis. Four themes were identified: 1) the importance of digital health literacy and the fear of losing it, 2) the high availability of the service as the main advantage, 3) the importance of voluntary use of e-consultations, 4) the importance of a trusting relationship with the GP. A scientific paper has been published in 2023 in the Scandinavian Journal of Primary Health Care. A national citizen survey was conducted to explore: 1) when and for what purposes patients use e-consultations with the GP, 2) whether e-consultations replace a traditional GP appointment or create new demand, 3) which characteristics of the patients and e-consultations are associated with the different use of e-consultations. The survey was developed in collaboration with helsenorge and published in January-February 2023. Data have been analysed and a scientific paper submitted to the Journal of Medical Internet Research.
CONCLUSION
This project will provide key stakeholders, policymakers and practitioners with research-generated knowledge on the impact of e-consultations, thus supporting optimal use of the service in routine practice and maximize its benefits.

BACKGROUND
In Norway, e-consultations with the GP experienced a tremendous implementation pace following the COVID-19 pandemic. As a complex intervention, it is crucial to study the process of implementation, wider adoption and scale up. It is also important to understand whether the use of e-consultations ensures equity in access to care and assess the impact on the health system, GPs and patients.
METHODS
The project adopts a mixed-methods approach, combining quantitative and qualitative methods to evaluate the large-scale implementation of e-consultations in Norway. Research is structured around three working packages (WPs).
WP1. A retrospective cohort study will be conducted to study changes in adoption and use of e-consultations over time and explore the impact on equitable access to care. Data will be obtained from national health registries. Temporal trends  will be examined through time-series analysis. Multilevel regression models will be used to explore relationships between utilization and patient characteristics.
WP2. A prospective cross-sectional study will be conducted to study the perspectives of GPs and patients towards the perceived quality of video consultations. Focus groups will explore the topics of clinical appropriateness, safety, communication, doctor-patient relationship, organizational models and workload. 50-100 GPs will be recruited and asked to evaluate 1,500 video consultations through an online survey. Patients will evaluate the same video consultations. Interviews with GPs will be conducted to study how different organizational models affect workload and availability.
WP3. The perspectives of digitally active users and non-users will be explored through questions integrated into a national citizen survey conducted to explore citizens’ knowledge, use and attitudes towards digital health solutions. Additional interviews will be conducted on elderly as the main group of non-users who are not digitally active.

The large-scale implementation of e-consultations with the GP: a mixed-methods evaluation of the impact on health system, GPs and patients

Abscesser er en vanlig medisinsk tilstand i både human- og veterinærmedisin forårsaket av bakterielle infeksjoner, traumer eller postoperativt. Dagens behandling av abscesser er skylling og drenering, men denne prosessen kan ta lang tid og mange pasienter får snart tilbakefall.
Etter mange års erfaring på området har forskeren Sverre Nesvåg og legen Tore Tholfsen, begge tilknyttet Stavanger universitetssykehus (SUS), kommet med en ny type kateter for abscessdrenering. Dette kateteret kombinerer kunnskap fra medisin og olje og gass, og tilbyr en enkelt måte å automatisere abscess drenering, for å redusere behov og tid for å innlegge pasienter.
Løsninger har fått patent godkjent i Europa, og takk til dette kvalifiseringsprosjektet er første delen av kateteret bygget og testet med lovende resultater.

KVAL: MADS – Multiphase Abscess Drainage System

This project aims to provide a new treatment for the large number of adolescents with severe obesity who do not respond to current best practice in paediatric obesity treatment - lifestyle treatment. Based on our previous work revealing the important role of brain-gut signaling in regulating appetite and satiety, and our preclinical studies and phase IIa trial in adults with obesity, we attempt to fill this treatment gap by testing the efficacy of a novel treatment - Endoscopic Injection of Botulinum toxin A for Obesity (EIBO) - in a multinational, randomized, double blind, placebo-controlled phase II clinical trial. 
The present project is an extension of a submitted EU-proposal; "Repurposing Endoscopic injections of Botulinum toxin A in treatment of adolescents with severe obesity (EIBO)" (Topic H2020?SCI-PM-09-2016) with NTNU as coordinator of the consortium. The present extension lies in A) establishing a robust cooperation between the specialist - and municipality health services to strengthen the effect of the new treatment, and B) to establish an algorithm for prediction of response to the new EIBO treatment in order to maximize the success rate for those who are treated.
If the original project is not obtaining funding by EU (known by aug. 2016) the consortium intend to perform the project within the frames of separate national funding. The concepts of the present project is not influenced by the outcome of the EU proposal but in case of refusal more patients need to be included in Norway to secure the sufficient number of patient.

0 projects

FORNY20-FORNY2020

KVAL: MADS – Multiphase Abscess Drainage System

Awarded: NOK 0.50 mill.

Project Period: 2022-2023

Location: Rogaland

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Repurposing Endoscopic injections of Botulinum toxin A in treatment of adolescents with severe obesity.

Awarded: NOK 0.28 mill.

Project Period: 2016-2018

Location: Trøndelag - Trööndelage

IS-NAD-Samarbeid med NORAD-land

Mohsen, Amr egyptisk spes 2007

Awarded: NOK 21,203

Project Period: 2007-2007

Location: Trøndelag - Trööndelage