0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

4th EU-US meeting on Endogenous genome damage

The main scientific focus of this meeting will be on DNA repair mechanisms and mutagenesis. Most mutagenic and carcinogenic agents induce covalent changes in the structure of the DNA and living organisms have evolved a large number of gene functions speci fically designed to repair or tolerate su...

Awarded: NOK 0.15 mill.

Project Period: 2011-2012

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

International Confernce on discovery based translational research

Following very successful meetings in recent years, the European Association for Cancer Research (EACR) will be staging its biennial conference EACR 21 in Oslo to discuss the latest developments in cancer research and science. The conference will be broad and balanced, and will include Gene Expr...

Awarded: NOK 0.25 mill.

Project Period: 2010-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Conference on "Membrane Dynamics in Endocytosis"

This is a proposal for the eleventh in a series of highly successful biannual European meetings on Endocytosis. The meetings have been alternating between European countries, and the most recent ones were organized in Spain in September 2005 and in Switze rland in September 2007. It is custom tha...

Awarded: NOK 49,999

Project Period: 2009-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DNA glycosylases initiating removal of oxidative DNA base lesions in mammalian cells

Most mutagenic and carcinogenic agents induce covalent changes in the DNA structure and a large number of gene functions have evolved to effectuate repair or tolerance of such alterations without loss of viability or development of disease. DNA repair mec hanisms are probably the most important c...

Awarded: NOK 5.9 mill.

Project Period: 2009-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

The AlkB family of demethylases; putative roles in embryonic stem cell identity and epigenetic reprogramming of the germ line.

This project is initiated primarily based upon the intriguing phenotype and breeding pattern of Alkbh (AlkB homologs) targeted mice. Targeting of mouse Alkbh's (8 in total) cause various degree of sex-ratio distortion and developmental abnormalities incl uding asymmetric left-right eye developme...

Awarded: NOK 6.0 mill.

Project Period: 2009-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Analysing the function of CIN85 in development and carcinogenesis using Drosophila melanogaster as model organism

The aim of this project is to understand molecular processes governing epithelial and neuronal functions during normal development and in carcinogenesis using the fruit fly Drosophila melanogaster as a model system. We will analyze the function of the mul tiadaptor protein CIN85 and its associate...

Awarded: NOK 3.2 mill.

Project Period: 2009-2012

Location: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Waldminghaus, Torsten DAADppp 2009 Tysk-norsk forskerutveksling

...

Awarded: NOK 8,203

Project Period: 2009-2010

Location: Oslo

STAMCELLER-Stamcelleforskning

Principles of stem cell pathway heterogeneity in tumor sub-populations

There is an ongoing debate on heterogeneity of stem cell parameters in tumor cells and the existence of tumor stem cells. The enclosed project proposal uses cell cycle parameters and stem cell pathways to analyze and determine mechanisms for creating and maintaining cell heterogeneity in tumors....

Awarded: NOK 3.0 mill.

Project Period: 2009-2012

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Protein aggregation and degradation in aging and disease: Role of polyubiquitination and autophagy

Neurodegenerative disorders such as Alzheimer's, Huntington's and Parkinson's disease are characterized by the deposition of polyubiquitinated protein aggregates. Recent results suggest that autophagy may have a protective effect in protein aggregation di seases. p62 and ubiquitin are well known ...

Awarded: NOK 0.13 mill.

Project Period: 2008-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

EMBO Conference on the replication and segregation of chromosomes

We will organise a high-quality scientific meeting to exchange information in the field of chromsome replication and segregation. This field of research is important for many reasons, for the fundamental understanding of the basic aspects of cellular grow th and proliferation as well as for an un...

Awarded: NOK 0.20 mill.

Project Period: 2008-2008

Location: Oslo

IS-STP-Statsstipendprogram, utlendinger

Suetterlin, Stefan, GB, statsstip 2008-09

...

Awarded: NOK 43,000

Project Period: 2008-2008

Location: Oslo

YFF-Yngre, fremragende forskere

The Function of Cyclin Dependent Kinases in the DNA Damage Response and Maintenance of Genome Stability

Project Summary Genome instability is one of the hallmarks of cancer. However, the mechanisms that protect the genome against spontaneous gross chromosomal rearrangements (GCRs) are not well understood. In recent years several pathways have been identifi ed that protect the genome against sponta...

Awarded: NOK 9.5 mill.

Project Period: 2008-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Regulation of Autophagy through two Big Protein Complexes; TORC1 and class 3 PI3K

The mammalian target of rapamycin (mTOR), a master regulator of both growth and catabolic processes, plays a central role in signal transduction pathways mediated by a variety of stress factors. Consequently, dysregulation of mTOR is found in many cancers . Recently, much attention has been focus...

Awarded: NOK 1.00 mill.

Project Period: 2008-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Copy number variants and predisposition to autoimmune diseases like rheumatoid arthritis.

A novel form of genetic variation has during the last two years been recognized to be important for human phenotypes and diseases, namely copy number variations (CNVs). CNVs have so far generally been overlooked in searches for susceptibility variants for common multifactorial diseases, however ...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

KLINISK-Klinisk forskning

Rehabilitation after severe traumatic brain injury. A national multicentre study

In Norway, the annual rate of hospital admission caused by head trauma is around 200 per 100 000 inhabitants. About 15 % of the patients admitted to a neurosurgical department with traumatic brain injury, are in the severe group according to the Glasgow C oma Scale score. These patients demand in...

Awarded: NOK 3.1 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Role of AlkB homologs 1 and 7 (ABH1 and 7) in epigenetic reprogramming

This project is primarily based upon the intriguing phenotype and breeding pattern of mABH1 (mouse AlkB homolog 1) targeted mice. As outlined below, this dioxygenase is required for faithful embryonic development. Major developmental defects include failu re of eye, nose and limb development (Fig...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Frontal lobe injury and cognitive control

The main goal of this project is to investigate the neural substrate and cognitive mechanisms that are involved in a set of higher-order "executive" functions that are necessary for goal-directed thinking and behavior. At present there is no unitary model that accounts for all aspects of executi...

Awarded: NOK 4.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Development of high througput affinity protemics to search for drug targets in cancer.

Antibody array technology, mass-spectrometry and molecular biology techniques are combined to develop a new platform for screening of drug targets in cancer. The technology allows large-scale analysis of protein networks with high sample throughput. The p roject will develop large-scale analysis ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A novel checkpoint regulating the cell cycle of fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle. Cancer development is frequently associated with the lack of checkpoints an...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Basic and clinical studies of peptide-based immunotherapy in chronic HIV-1 infection

Immune based therapies represent new, promising approaches to the treatment of chronic HIV infection, aiming to enhance the patients own specific immune response against HIV and delay the immune impairment caused by the HIV-infection. The basis for this a pplication is two patient cohorts that ha...

Awarded: NOK 0.76 mill.

Project Period: 2007-2010

Location: Oslo

IS-RUS-Stipendprogram for NVRussl.

Iyevleva, A RUS06/07-37

...

Awarded: NOK 30,000

Project Period: 2007-2007

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Modeling human disease in mice;DNA repair and genomic (in)stability.

Our research is currently focused on two classes of enzymes involved in repair, and possible regulation, of DNA and RNA species; flap endonuclease 1 (FEN1) and mammalian alkB homologs (ABHs). Genetic models are generated in order to elucidate the contribu tion of single gene deletions in genomic ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2011

Location: Oslo

NANOMAT-Nanoteknologi og nye materialer

Uptake and toxicity of quantum dots in cancer cells

Most of the work on quantum dots has so far been focused on their production and fluorescence imaging. The possibility to use quantum dots as photosensitizers remains unexplored: Can these nanoparticles generate reactive oxygen species in biological envir onments? Such a potential of quantum dots...

Awarded: NOK 5.6 mill.

Project Period: 2007-2011

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

Objective: The main purpose is to identify and characterize novel antibodies recognizing specific antigens on colorectal cancer cells. Interesting candidates will be thoroughly examined for their specificity and their ability to be used as diagnostic and/ or prognostic markers. Their potential as...

Awarded: NOK 2.2 mill.

Project Period: 2007-2011

Location: Oslo

FOLKEHELSE-Folkehelse

Energy Balance and Breast Cancer Aspects. A randomised clinical trial with physical activity interventio

Breast cancer requires intense and prolonged treatments often associated with significant side effects, also influencing their levels of physical activity after diagnosis. New evidence from large cohort studies supports a role of physical activity in redu cing recurrence and improving survival. A...

Awarded: NOK 2.6 mill.

Project Period: 2007-2011

Location: Oslo

KLINISK-Klinisk forskning

Does fusion lead to increased adjacent level disc degeneration in patients with chronic low back pain. An international collaborate project.

There is controversy as to whether fusion of one or more motion segments of the spine results in accelerated degeneration of the adjacent segment over time. Some argue that adjacent segment is exposed to increased mechanical stress, which accelerates disc degeneration, whilst others maintain tha...

Awarded: NOK 3.9 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Targeting occult tumor cell dissemination in localised breast cancer

For the future, a better treatment of patients with breast cancer is dependent upon a better assessment of the individual risk of harbouring minimal residual disease after the completion of the surgical treatment. The aim is to separate very low risk pati ents from high risk patients for future m...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Awarded: NOK 5.0 mill.

Project Period: 2007-2010

Location: Oslo