0 projects

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BIOTEK2021-Bioteknologi for verdiskaping

Optimization and application development of marine cold-adapted DNA polymerases - OptiZyme

Isothermal amplification (IA) methods are now increasingly being used for molecular detection of pathogens, and are considered an important contribution to improve both disease control and food safety analysis. In these methods, nucleic acid amplification takes place at constant (moderate) tempe...

Awarded: NOK 7.4 mill.

Project Period: 2013-2017

Location: Troms - Romsa - Tromssa

BIOTEK2021-Bioteknologi for verdiskaping

SYNTHESIS AND BIOLOGICAL EVALUATION OF THE POLYUNSATURATED NATURAL PRODUCT PROTECTIN D1 AND ANALOGS

This project will provide new lead compounds derived from marine natural products for the development of new remedies against inflammation. Inflammation is involved in numerous diseases such as cancer, cardiovascular diseases and inflammation. Our industr ial collaborator Pronova is conducting re...

Awarded: NOK 3.0 mill.

Project Period: 2013-2016

Location: Oslo

SIPHINIFES-SIP ved HI

Seafood Risk-benefit Methylmercury and nutrient interactions in the development of life style diseases.

Metylkvikksølv (MeHg) er en kontaminant og miljøgift som blant annet forekommer i maten vi spiser. MeHg er den formen av Hg som ansees som mest giftig for mennesker og deponeres i vann og akkumuleres oppover i næringskjeden. Fisk blir derfor viktigste eksponeringskilde til MeHg hos mennesker. Sel...

Awarded: NOK 14.0 mill.

Project Period: 2013-2018

Location: Vestland

SIPHINIFES-SIP ved HI

Inheritance of epigenetic patterns under the influence of diets and contaminants

Dette prosjektet ble etablert for å få dypere kunnskap om hvordan næringsstoffer og giftstoffer endrer epigenetisk DNA-metyleringsmønstre hos fisk. Prosjektet har vært delt inn i fire arbeidspakker (WP): WP1: I WP1 undersøkte vi hvordan arakidonsyre (ARA) i foreldrenes fôr påvirket avkommet (...

Awarded: NOK 16.0 mill.

Project Period: 2013-2018

Location: Vestland

BIOTEK2021-Bioteknologi for verdiskaping

A novel storage method for cultured retinal pigment epithelial cells for transplantation

The primary objective of the project is to develop better storage technology for cultured retinal pigment epithelial cells, due to the importance of such cells in the treatment of several retinal diseases, including age-related macular degeneration and St argardt disease. Age-related macular dege...

Awarded: NOK 4.6 mill.

Project Period: 2013-2016

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

A national research and innovation platform for personalized cancer medicine

Målsetningen for det Nasjonale KreftGenomikkprosjektet (NCGC, se http://kreftgenomikk.no) er å undersøke alle mutasjoner i ni ulike typer kreftsvulster for å identifisere hvilke av disse som er viktige i selve kreftutviklingen, og om noen av dem affiserer kreftmekanismer på en slik måte at det en...

Awarded: NOK 40.0 mill.

Project Period: 2013-2018

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Microvesicles as a Source of Prostate Cancer Biomarkers.

Prostate cancer is a global health problem and represents 12% of all cancer cases worldwide. Until now, prostate specific antigen has been extensively used as a biomarker for prostate cancer. However, this marker has serious limitations as a tumour marker since its use has lead to overdiagnosis ...

Awarded: NOK 2.8 mill.

Project Period: 2013-2016

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Systematic consideration of inhomogeneity at the large scale: towards a stringent development of industrial bioprocesses

Project Summary: The project aims to systematically elucidate the influence of increasing bioreactor inhomogeneity which occurs in industrial-scale bioreactor, with respect to microbial physiology and production performance of Corynebacterium glutamicum, a microorganism with broad industrial app...

Awarded: NOK 2.4 mill.

Project Period: 2013-2016

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Novel industrial bioprocesses for production of key valuable steroid precursors from phytosterol

Project MySterI (Mycobacterial Steroids for Industry) aims to produce high value steroid precursors using a novel bioconversion strategy resulting in lower production costs and less cost to the environment. The aim is to convert phytosterols in cheap wast e plant material to desired steroid precu...

Awarded: NOK 3.6 mill.

Project Period: 2013-2017

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Biology-Driven Synthesis - from Marine Natural Products to Commercial Lead Compounds

Stoffer som finnes i naturen er viktige inspirasjonskilder for utvikling av nye legemidler. Forskere i Norge benytter også naturens mangfold i jakten på nye virkestoffer til legemidler. Når et nytt stoff er oppdaget i naturen er det ofte nødvendig å utføre kjemiske modifikasjoner for å perfeksjon...

Awarded: NOK 6.0 mill.

Project Period: 2013-2018

Location: Troms - Romsa - Tromssa

BIOTEK2021-Bioteknologi for verdiskaping

Novel thermostable enzymes for industrial biotechnology (THERMOGENE)

There is an increasing demand for new thermostable enzymes with enhanced performance and/or novel functionalities that provide savings in time, money and energy for industrial processes in the areas of high value chemical production and other "white" biot echnology applications. Enzyme chemistry ...

Awarded: NOK 2.2 mill.

Project Period: 2013-2016

Location: Vestland

BIOTEK2021-Bioteknologi for verdiskaping

The 4th Genome Maintenance Meeting (GMM4)

The 4th Genome Maintenance Meeting lasts from April 26 until April 29, 2013. 39 internationally recognized scientists from all over the world have confirmed their attendance as speakers. This is the fourth in line of a series of successful international m eetings, addressing genome instability an...

Awarded: NOK 0.15 mill.

Project Period: 2013-2013

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Functionalization of enzymes from Marine Bioprospecting

ArcticZymes (AZ) develop, produce and sell enzymes for use in molecular DNA technology applications and diagnostics. All enzymes originates from marine organisms in the Arctic oceans and have unique features shown to be useful in DNA technology applications. AZ have so far mainly sold stand-alone...

Awarded: NOK 5.0 mill.

Project Period: 2013-2016

Location: Troms - Romsa - Tromssa

BIOTEK2021-Bioteknologi for verdiskaping

Merging biology and materials! A conference for researchers and developers in public and private sectors.

There are rather limited number of meeting points for the Scandinavian bio-material industry and researchers. This conference attend to provide the setting for Scandinavian industry to meet researchers which are at the forefront of their field. The assemb ly will import some of the best scholars ...

Awarded: NOK 0.15 mill.

Project Period: 2013-2013

Location: Ukjent Fylke

BIOTEK2021-Bioteknologi for verdiskaping

Bioactive Interfaces II

Fouling represent a major challenge leading to increased costs for the marine and offshore industry. Toxic compounds are today employed to prevent ongrowth on marine surfaces. The development of "green" antifouling compounds from marine organisms has thus a huge potential as several marine organ...

Awarded: NOK 4.9 mill.

Project Period: 2013-2016

Location: Troms - Romsa - Tromssa

BIOTEK2021-Bioteknologi for verdiskaping

Kit to guide treatment management of patients with Inflammatory Bowel Disease

This is translation project with emphasis on chronic inflammatory bowel disease (IBD) where 2.2 million people in Europe suffer from the disease which for many can have devastating concequences. We have little knowledge of the etiology and inflammatory me chanisms in the early phase of the diseas...

Awarded: NOK 3.8 mill.

Project Period: 2013-2016

Location: Troms - Romsa - Tromssa

BIOTEK2021-Bioteknologi for verdiskaping

Rational Engineering of Advanced Clostridia for Transformational Improvements in Fermentation

Awarded: NOK 0.41 mill.

Project Period: 2013-2017

Location: Østfold

BIOTEK2021-Bioteknologi for verdiskaping

Developing Novel Application Routes for Chito-Oligosaccharides Produced from the Marine Biopolymer Chitin

Kitin er en lineær, 1,4-beta-linket uløselig marin karbohydrat biopolymer bestående av N-acetylglukosamin med en årlig produksjon på 100 gigatonn i naturen. Denne kan modifiseres til kitosan ved å endre mellom 0 til 100 % av N-acetylgrupper til fri amin og både kitin og kitosan kan spaltes til ki...

Awarded: NOK 5.4 mill.

Project Period: 2013-2017

Location: Akershus

BIOTEK2021-Bioteknologi for verdiskaping

The Development of Proprietary Targeted Inhibitors of DNA Replication and Repair in Bacteria as Novel Broad Spectrum Antibiotics

Forskere ved NTNU har utviklet et syntetisk peptid som blokkerer et nukleært protein nødvendig for DNA reparasjon og replikasjon i humane celler. Vi har funnet at dette peptidet har en antibakteriell aktivitet, og siden bindingssetet for dette peptidet er konservert mellom ulike bakterier, så ve...

Awarded: NOK 5.4 mill.

Project Period: 2013-2016

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Small transmembrane peptides for treatment of pathogenic bacteria.

The business concept of this project is the introduction of a new concept of antimicrobial treatment with a novel method of action to treat infectious diseases and the evolution of antibiotic resistance. The invention is a new class of small and extremely toxic peptides that rapidly kill the bac...

Awarded: NOK 2.1 mill.

Project Period: 2013-2015

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

New one-step process for the preparation of targeting stealth nanoparticles for drug delivery and molecular imaging

For many diseases, there is a high need for novel disease site focused treatments, as the most efficient drugs are so potent that they also lead to severe systemic toxicity and side effects. Nanoparticles and -capsules can be used to encapsulate drugs and imaging agents for targeted treatment an...

Awarded: NOK 7.6 mill.

Project Period: 2013-2017

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Method for identification of 5-hydroxymethylcytosine and 5-methylcytosine at single base resolution

Awarded: NOK 4.8 mill.

Project Period: 2013-2017

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Optimization of a diagnostic hypoxia test for detection of aggressive cervical cancer

Siden siste rapport, dvs de siste månedene av prosjektet,har det vært arbeidet med å utvikle den nye oppfinnelsen som er generert i prosjektet og som beskriver en hypoksitest basert på genenes metyleringsnivå. Arbeidet har inkludert å evaluere styrken av en metyleringstest sammenliknet med den op...

Awarded: NOK 6.2 mill.

Project Period: 2013-2016

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Bioactive peptides in tunicate biomass

Fishmeal has traditionally been the major protein source for carnivorous fish. However, it is likely that the world's supply of fishmeal will not be sufficient to meet future demand. Globally there is acute need for new protein sources .This proof of prin ciple proposal intends to support the com...

Awarded: NOK 3.3 mill.

Project Period: 2013-2016

Location: Vestland

BIOTEK2021-Bioteknologi for verdiskaping

Extented biotarget validation studies for the specific inhibitor of Wnt/beta-catenin signaling OD270

Wnt/beta-catenin er en signalvei som er sentral i kreft. Til tross for biomedisinsk betydning av Wnt/beta-catenin signalveien innen kreft, i sær innen kreftmetabolisme og metastasering, finnes det ingen farmakologisk virkesubstans mot signalveien som er klarert for klinisk bruk. Vi har identifis...

Awarded: NOK 5.4 mill.

Project Period: 2013-2014

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Compounds that regulate phospholamban phosphorylation with possible cardioprotective effect in the post-infarction heart

Successful acute trombolytic treatment of myocardial infarction (MI, 1.2 mill cases i 7 markets) creates more damaged hearts and a medical need for better post-MI treatment. The adrenalin-beta-adrenergic receptor-cAMP-protein kinase A signalling pathway r egulates heart rate and contractility. Al...

Awarded: NOK 5.8 mill.

Project Period: 2013-2017

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Enzymatic modification and upgrading of marine polysaccharides

Fremdrift Aktivitet Fokuset påde PhD kandidatene som er i avslutningsfasen. Det gjelder arbeid med Fukoidan et sulfatert poysakkarid som utvinnes fra brunalger og er nå den andre polymer typen som fremstilles kommersiet fra stortare under betegnlesn ProtaSea Fucoidan godkjent som NDI av FDA. ...

Awarded: NOK 40.0 mill.

Project Period: 2012-2017

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Enzyme development for Norwegian biomass - mining Norwegian biodiversity for seizing Norwegian opportunities in the bio-based economy

I dette prosjektet jobber seks forskningsinstitusjoner og to bedrifter sammen for å utvikle konkurransedyktig enzymteknologi for å utnytte norsk biomasse. Målet er å øke verdiskapingen i norsk biobasert industri. Med naturens egne verktøy (her: enzymer) skal vi skape en god bioøkonomi, basert på ...

Awarded: NOK 40.0 mill.

Project Period: 2012-2019

Location: Akershus

BIOTEK2021-Bioteknologi for verdiskaping

Sterile salmon by targeting factors involved in germ cell survival: novel vaccination strategies for sustainable fish farming (Sketch 40)

Salmosterile prosjektet har utviklet nye metoder for å lage steril laks i oppdrett basert på knockdown og knockout teknologi. Prosjektet har utnyttet informasjonen fra laksens genom, og har funnet et protein, Dead end, som er essensiell for dannelse av kjønnsceller hos laks. Vi har i prosjektet l...

Awarded: NOK 38.4 mill.

Project Period: 2012-2018

Location: Vestland

BIOTEK2021-Bioteknologi for verdiskaping

Establishing the SINTEF/NTNU collection of marine bacteria as a national biobank resource

The SINTEF/NTNU collection of marine bacteria is mentioned in the strategy document "Strategiplan for marin bioprospektering 2010" (Norwegian research Council, Innovation Norway and SIVA) as one of the most important marine collections existing in Norway together with Marbank in Tromsø. The prop...

Awarded: NOK 2.3 mill.

Project Period: 2012-2017

Location: Trøndelag - Trööndelage

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