45 projects

Date from new to old

NYSKAPNING-NYSKAPNING

Reversing the Side Effects of Schizophrenia Treatment

Awarded: NOK 0.50 mill.

Project Period: 2025-2026

Location: Troms - Romsa - Tromssa

NYSKAPNING-NYSKAPNING

Liver uptake control

A new generation of large molecule drugs and nanoformulations (LMDs) is seeing an increased interest from the pharmaceutical industry. LMDs hold great promises for future development of therapeutics to treat diseases for which there are presently no cure. Among the most promising new generation o...

Awarded: NOK 4.7 mill.

Project Period: 2022-2025

Location: Troms - Romsa - Tromssa

FRIPROSJEKT-FRIPROSJEKT

Pack a pill in a PACA: PACA nanomedicines for targeting age-related changes in liver endothelium to prevent age-related diseases

When we age, we have numerous reduced, or even loss of, bodily functions. The liver is no exception - despite being one of the most robust organs in the body, the liver also ages. One such age-affected function is the communication between the blood and the liver's major cells, the hepatocytes. I...

Awarded: NOK 12.3 mill.

Project Period: 2021-2026

Location: Troms - Romsa - Tromssa

FORNY20-FORNY2020

KVAL: Pack a pill in a PACA

Awarded: NOK 0.50 mill.

Project Period: 2021-2022

Location: Troms - Romsa - Tromssa

POS-ERC-Støtte til ERC-søkere som oppnår god evaluering

Dissecting bacterial subpopulation physiology with activity-based probes

The long-terme aim of the ERC project is to establish a new biomarker system for bacterial physiology that is based on labeling with fluorescent chemical probes. To demonstrate the feasibility of this approach, we will perform an unbiased functional characterization (transcriptomic and growth ana...

Awarded: NOK 0.49 mill.

Project Period: 2020-2023

Location: Troms - Romsa - Tromssa

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Filter for plasmaspytt

Studies have shown dry mouth to be an extremely common problem. The condition affects not only teeth, oral mucosa and gums, but can also affect very basic functional aspects such as swallowing, digestion, talking and chewing. This results in a greatly reduced quality of life in the patients. Ther...

Awarded: NOK 31,999

Project Period: 2019-2020

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Early-life gut fungal dysbiosis in pediatric asthma development.

The microbial community that populates the lower gastrointestinal tract, gut microbiota, is a key player governing human health and disease. Perturbations of the microbiome at the earliest time in life during maximal physiological development have been associated with a risk of non-communicable d...

Awarded: NOK 3.3 mill.

Project Period: 2018-2022

Location: Troms - Romsa - Tromssa

FRIPRO-Fri prosjektstøtte

Sugar Crush: Metabolism-Induced Sinusoidal Endothelial Cell Defenestration as Critical Determinant of Fatty Liver Disease Progression

The buildup of excess fat in the liver when no alcohol consumption is involved is called Non-Alcoholic Fatty Liver Disease (NAFLD), a condition that can lead to progressive liver disease, cancer, and liver failure. The disease affects 1 in 3 people worldwide, and with no medication currently avai...

Awarded: NOK 7.9 mill.

Project Period: 2018-2024

Location: Troms - Romsa - Tromssa

FRIPROSJEKT-FRIPROSJEKT

Role of scavenger endothelial cells in elimination of virus

We are continuously exposed to contact with various types of viruses. Some of these penetrate our natural defense barriers and enter the bloodstream. Most types of viruses we encounter do not cause disease but must still be removed quickly and effectively from the blood. Much of this virus uptake...

Awarded: NOK 10.0 mill.

Project Period: 2017-2026

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Autophagy-regulated Signalosomes in Cellular Stress and Disease Pathways

Our project concerns a cellular process known as autophagy (greek for "self-eating"). Autophagy is a renovation or cleaning process in our cells that helps keeping us healthy and makes it possible for us to enjoy long lives. We are elucidating how autophagy can be targeted, or selective, and how ...

Awarded: NOK 12.5 mill.

Project Period: 2016-2021

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Stem Cell Metabolic Dysfunction in Myeloid Leukaemia and its Therapeutic Targeting

Acute myeloid leukaemia (AML) is the most common form of acute leukaemia occurring in adults. Its incidence increases with age and the prognosis for the older patient remains bleak. Overcoming these problems will require a better understanding of AML. Interestingly, cancer and normal cells differ...

Awarded: NOK 6.9 mill.

Project Period: 2016-2023

Location: Troms - Romsa - Tromssa

IS-BILAT-Mobilitet Norge-USA /Canada

In silico and in vitro search for potential multidrug resistance therapeutics

Multidrug resistance is a particular limitation to medical treatment of diseases related to the major causes of mortality globally, e.g. chemotherapy, antibiotic treatment and HIV medication. The project involves basic research on ABC transporters involve d in multidrug resistance combining theor...

Awarded: NOK 0.10 mill.

Project Period: 2010-2011

Location: Troms - Romsa - Tromssa

IS-AUR-Samarb.progr. mellom Norge og Frankrike

Structure-function relation of Ferric uptake regulators and their new inhibitors

Globally, approximately one fourth of all human deaths are caused by bacterial infections. Overuse of antibiotics has induced the development of resistant pathogens, which is an increasing public health problem. The consequence is that new antibacterial c ompounds and new targets must be found Be...

Awarded: NOK 0.12 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

FRIMEDBIO-Fri prosjektstøtte for medisin, helse og biologi

Prevention of cardiac inefficiency in type 2 diabetes by means of high-intensity exercise training

Type 2 diabetes is associated with altered myocardial metabolism, reduced cardiac performance and reduced cardiac efficiency (cardiac work per unit oxygen consumption). The long-term objective of the present project is to understand the mechanisms behind diabetic cardiomyopathy, an example of car...

Awarded: NOK 4.6 mill.

Project Period: 2008-2013

Location: Troms - Romsa - Tromssa

IS-DAAD-Forskerutveksling Norge-Tyskland

Hanssen, Anne-Merethe DAADppp 2008 Tysk-norsk forskerutveksling

...

Awarded: NOK 50,000

Project Period: 2008-2009

Location: Troms - Romsa - Tromssa

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging and structural biology of molecular targets for psychotropic drugs

The research group has wide experience in using molecular graphics and other methods to study the molecular mechanisms of CNS active drugs. This application focuses on drugs acting on specific targets in brain, the serotonergic systems. The application wi ll enable further development and strengt...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Protein aggregation and degradation in aging and disease: Role of polyubiquitination and autophagy

Hundreds of proteins encoded by the human genome have the propensity to form cytoplasmic aggregates under certain conditions. Although the mechanisms of intracellular protein aggregation are poorly understood, it is well known that deposits of aggregatete d proteins are highly associated with agi...

Awarded: NOK 8.6 mill.

Project Period: 2007-2011

Location: Ukjent Fylke

IS-DAAD-Forskerutveksling Norge-Tyskland

Willassen, Nils Peder daadppp 0708

...

Awarded: NOK 70,000

Project Period: 2007-2008

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Host-pathogen interactions: In vitro and in vivo exploration of the quorum sensing system of the marine fish pathogen Vibrio salmonicida.

The genus Vibrio is among the most numerous and ubiquitous of marine bacteria and commonly found as etiological agents of diseases in both vertebrates and invertebrates throughout the world. Vibrio salmonicida, a halophilic and psychrophilic (cold adapted ) marine gram-negative bacterium, the eti...

Awarded: NOK 6.3 mill.

Project Period: 2006-2009

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Biological Role of Regulatory Catalytic RNA in Eukaryotic Protein Gene Expression

A new main category of catalytic RNA (the GIR1 ribozyme) has been discovered and is under investigation in our laboratory. The group I-like ribozyme (GIR1; approx. 200 nt) is a unique example of a naturally occurring ribozyme with an evolved biological fu nction. GIR1 generates the 5'-end of a nu...

Awarded: NOK 2.8 mill.

Project Period: 2006-2011

Location: Troms - Romsa - Tromssa

MILGENHEL-Miljø, gener og helse

Genome diversity and plasticity in Enterococcus faecium and E. faecalis with emphasis on pathogenicity and antibiotic resistance

Evidence for increased cost, morbidity and mortality caused by infections with bacteria resistant to antimicrobial compounds is accumulating. In hospitals, Enterococcus faecalis and E. faecium represent promiscuous reservoirs of antimicrobial resistance d eterminants. They are considered “difficu...

Awarded: NOK 3.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Interactions between foreign DNA and SECs (scavenger endothelial cells) in vitro and in vivo

Nucleic acid (NA) molecules (DNA and RNA) in food/feed are taken up from the intestines and circulate in the bloodstream of mammals. Isogenic NA shed from apoptotic and necrotic cells are also released into the blood circulation. DNA is usually very rapid ly cleared from the bloodstream, and degr...

Awarded: NOK 1.3 mill.

Project Period: 2005-2010

Location: Troms - Romsa - Tromssa

BIOFYS-Fysiologiske og anatomiske fag

Neuronal mechanisms conveying hypoxic tolerance to diving birds and mammals

We propose to use the in vitro brain slice technique with cortical and medullary-based (cerebellar) neuronal networks, to unravel adaptive neuronal mechanisms to hypoxia in higher vertebrates. In this context, we will also investigate the possible role of the respiratory pigment neuroglobin in t...

Awarded: NOK 1.2 mill.

Project Period: 2005-2007

Location: Troms - Romsa - Tromssa

TU-Tungt utstyr

Oppgradering av EM ved Universitetet i Tromsø

Det har i flere år vært ytret ønske om anskaffelse av en ny fryse-ultramikrotom samt nytt digitalt billedhåndterings-utstyr. Nylig har det også fremkommet et uttalt ønske fra flere ved fakultetet om anskaffelse av en såkalt high pressure freezing enhet. S istnevnte apparatur representerer det ult...

Awarded: NOK 3.5 mill.

Project Period: 2005-2006

Location: Troms - Romsa - Tromssa

BIOMOL-Molekylær biovitenskap og bioteknologi

A study of homing endonucleases: Molecular evolution and gene discovery

Homing endonuclease genes (HEGs) encode highly specific DNases responsable for the mobility and spread of group 1 introns. They are divided into four families (His-Cys box, LAGLIDADG, GIY-YIG and HNH) based on conserved protein motifs. LAGLIDADG HEGs are most numerous and widespread, while the Hi...

Awarded: NOK 0.72 mill.

Project Period: 2004-2005

Location: Troms - Romsa - Tromssa

YFF-Yngre, fremragende forskere

Toppforskningsprogrammets prosjekt ledet av Terje Johansen

...

Awarded: NOK 4.5 mill.

Project Period: 2004-2007

Location: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Struktur og funksjon av SPBP ePHD: Avsløring av et protein-protein interaksjonsnettverk involvert i genregulering og DNA replikasjon

Prosjektgruppen har klonet og sekvensert full-lengde cDNA fra mus og menneske for SPBP (Stromelysin-1 PDGF-responsive element Binding Protein), som er et kjerneprotein på ca 220 kDa. Mus og humant protein er 92% identiske i aminosyresekvens. Genet uttrykk es i en rekke vev og alternativ spleising...

Awarded: NOK 0.49 mill.

Project Period: 2004-2008

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Envision - A molecular descriptor database and visualization tool for structural analysis of environmental adapted marine enzymes.

The project aims at building bioinformatics tools for identification, exploration and development of macromolecules of industrial and biotechnological importance. this will be achieved by developing methods and algorithms for identification of structural descriptors for a number of protein func...

Awarded: NOK 6.6 mill.

Project Period: 2004-2008

Location: Troms - Romsa - Tromssa

BIOMOL-Molekylær biovitenskap og bioteknologi

Interactions between the mitogen-activated protein kinase pathways and the cAMP-dependent protein kinase pathways

...

Awarded: NOK 2.3 mill.

Project Period: 2004-2007

Location: Troms - Romsa - Tromssa

BIOFYS-Fysiologiske og anatomiske fag

Lactoferricin derivater med høy antitumoral aktivitet og selektivitet for lymfomer og neuroblastomer

Det er et stort behov for å få utviklet nye behandlingsstrategier for å øke overlevelsesraten hos kreftpasienter. Kanoniske membranaktive peptider er en lovende stoffklasse som i den senere tid har fått øket fokus. Enkelte av disse peptidene er i stand ti l å drepe kreftceller ved konsentrasjoner...

Awarded: NOK 0.60 mill.

Project Period: 2004-2006

Location: Troms - Romsa - Tromssa

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