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FUGE-Funksjonell genomforskn.i Norg

Genome sequencing of cod by exclusive use of ultra-high-throughput sequencing technology

We propose a project characterized by exclusive use of new ultra-high-throughput sequencing technology combined with state-of-the art bioinformatics algorithms designed for maximal exploitation of this technology. The project will be carried out in close collaboration with 454 Life Sciences, the...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Identification of key antiviral and inflammatory modulators in Atlantic cod (Gadus morhua L.)

Atlantic cod has recently been introduced into aquaculture in Norway and is expected to constitute a major part of Norwegian fish farming within few years. Expansion of this industry faces many challenges, including disease problems. From farming of salmo nids we know that vaccination has been a ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Information material for public health care professionals

We would like to produce information material for physicians, midwives and other health care workers who meet the couples before, during and after their pregnancy. We would like to make information folders and also write in journals read by the health car e professionals. We would also like to ma...

Awarded: NOK 0.15 mill.

Project Period: 2008-2010

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

An integrative genomics approach to identify genes and biochemical pathways underlying complex traits in Atlantic salmon

Identifying the genes and biochemical pathways in salmon that are responsible for economically important traits is the primary focus of this application. While a wealth of phenotypic data is available (e.g. the salmon biobank) the ability to resolve causa tive genes and loci has been technology l...

Awarded: NOK 5.0 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Tissue Factor siRNA for treatment of melanoma metastasis

The project described herein covers the research and initial preclinical part of the project of developing a drug based on small interfering RNAs (siRNA) targeting Tissue Factor, a molecule known to be involved in the processes of blood clotting, metastas is and angiogenesis. The project has emph...

Awarded: NOK 1.9 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Development of a male contraceptive - from hit to drug candidate

The primary objective of the present project is to perform a hit-to-lead program (H2L) and further to develop a preclinical drug candidate. The outcome of the project is expected to be a preclinical drug candidate. Lead-backups will also be secured in cas e of future failure in a downstream proce...

Awarded: NOK 4.9 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Awarded: NOK 3.5 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Developing the next generation of oral vaccines for salmonids using plastids in plants

The following programme will develop a new concept of oral vaccines for fish using plastids as bio-factories in plants. The technology will allow the insertion of any gene or combination of genes into a plant plastid genome, resulting in a high level prot ein expression (approx 20% of total cellu...

Awarded: NOK 5.4 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

The Norwegian plant transcriptional profiling centre

The Norwegian Arabidopsis Centre (FUGE-NARC) was established as a part of FUGE I. NARC provided national service in plant functional genomics and the service activity was shared between Univeristy of Life Sciences (UMB, transformation/genotyping), Univers ity of Oslo (Y2H, in situ hyb) and Norwe...

Awarded: NOK 2.3 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Pathogenesis of complex genetic diseases, using pre-eclampsia as a model

Pre-eclampsia (PE) is the most common pregnancy-associated complication in the Western world. The syndrome is a major contributor to maternal and fetal illness/death. No therapeutic treatment exists. The mechanisms involved in development of PE remain to be elucidated. Observations suggest immu...

Awarded: NOK 8.5 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Aleström Zebrafish Lab - activities beyond the research projects 2007-2011

The major focus of the AZLab services are two-fold: 1) Being a regional center, in an national and international network of transgenic zebrafish laboratories, with capacity to offer access to the zebrafish model for academic and commercial partners. 2) Es tablish a unique training program in zebr...

Awarded: NOK 4.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Spontaneous preterm birth: a systems biology approach in the Norwegian Mother and Child Cohort Study

sPTB is an unresolved common complex condition in perinatal medicine and is related to long-term disabilities such as cerebral palsy, cognitive and respiratory problems, which will affect the infant in every day life situations. The pathophysiology of sPT B remains poorly understood. Infection an...

Awarded: NOK 15.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

The CIGENE node of the Norwegian Sequencing and Genotyping Service Platform

CIGENE's mandate in the FUGE I period has been to: A. Establish and maintain a national core facility providing: (i) - a high-throughput SNP-typing service for human, animal, plant and microbial materials, (ii) - key competence concerning identification a nd methodological integration of experime...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Awarded: NOK 7.2 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Towards a systems level understanding of responses to endogenous DNA damage in Caenorhabditis elegans

The impact of genomic instability on human health underscores the importance of understanding the mechanisms that coordinate responses to DNA damage in order to preserve genomic stability. There is a disparity between our knowledge of the cellular respons es to endogenous DNA damage and the impac...

Awarded: NOK 6.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A proteomics node at Ås campus

As part of the NorProteomics FUGE network, Ås campus will develop expertise in the areas listed below and make this expertise available to on-campus and off-campus projects. Our key areas are: 1. Proteomics in difficult matrices, primarily related to food chemistry (meat, cereals; i.e. analysis ...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Awarded: NOK 8.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Salmon louse genome sequencing and functional studies on host parasite interactions

Copepods comprise the largest animal marine biomass but they have been poorly studied by molecular tools and no genome has so far been sequenced. Copepods are common as parasites on fishes and the salmon louse (Lepeophtheirus salmonis) is the most importa nt species in terms of economical signifi...

Awarded: NOK 6.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

National-wide service and competence from the Rikshospitalet-Radiumhospitalet Proteomics Core Facility in a Norwegian proteomics consortium

The Proteomics Core Facility at Rikshospitalet-Radiumhospitalet (RR-PCF) is a core facility platform organized jointly by Rikshospitalet-Radiumhospitalet HF (RR) and the University of Oslo (UiO) through "Felles Forskningsutvalg" at the hospital. The RR-PC F is engaged in the development of proteo...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Bergen

The present-day Molecular Imaging Center in Bergen (MIC) is an open facility that offers a collection of state-of-the-art microscopy equipment and image processing tools. MIC initiated its services in 2003 and was set up as a cooperation between NTNU in T rondheim and the University of Bergen to ...

Awarded: NOK 9.2 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Oslo Animal MRI unit - a node in the FUGE NorMIC consortium

The MR technology now allows for in vivo imaging to a resolution of microns which is even less than the size of many cell types. MRI has therefore become an invaluable tool for molecular imaging and translational research. Scientists in Oslo have used the FUGE MIC animal MR unit in Trondheim unt...

Awarded: NOK 1.00 mill.

Project Period: 2008-2012

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Awarded: NOK 9.3 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Proteomics Core Facility at the University of Tromsø as a node in the national consortium of proteomics platforms (NorProteomics)

The core facility for Proteomics in Tromsø has been fully operational since the end of 2004. The main purpose of the facility has been to serve research labs in the FUGE North region. The facility has 3 Mass spectrometer systems from Waters/Micromass. A M ALDI Micro MX, a Q-TOF Ultima Global with...

Awarded: NOK 1.3 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Local NOR-MIC BioImaging node at the University of Tromsø

At the University of Tromsø we now establish a core facility for BioImaging. This core facility will be equipped with instruments aimed at imaging, flow cytometri, cell sorting and plate/membrane readers of fluorescent and chemiluminescent signals. For th is core facility we will have two full-ti...

Awarded: NOK 0.45 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Protein-protein interactions at atomic levels

Our DNA is every day subjected to external and internal damaging agents and understanding the mechanisms of DNA repair at a molecular level is increasingly important in order to address future challenges for the human health. This project aims to reveal n ew information about molecular mechanisms...

Awarded: NOK 6.0 mill.

Project Period: 2008-2014

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Membrane trafficking in immunity and tumour suppression

Intracellular membrane trafficking plays key roles in cell signalling and innate and adaptive immunity. Endocytosis and subsequent endolysosomal trafficking of growth factor receptors constitute a crucial mechanism for receptor signal attenuation and tumo ur suppression. For innate immunity again...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Oslo

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