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FUGE-Funksjonell genomforskn.i Norg

Genome sequencing of cod by exclusive use of ultra-high-throughput sequencing technology

We propose a project characterized by exclusive use of new ultra-high-throughput sequencing technology combined with state-of-the art bioinformatics algorithms designed for maximal exploitation of this technology. The project will be carried out in close collaboration with 454 Life Sciences, the...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Information material for public health care professionals

We would like to produce information material for physicians, midwives and other health care workers who meet the couples before, during and after their pregnancy. We would like to make information folders and also write in journals read by the health car e professionals. We would also like to ma...

Awarded: NOK 0.15 mill.

Project Period: 2008-2010

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Identification of key antiviral and inflammatory modulators in Atlantic cod (Gadus morhua L.)

Atlantic cod has recently been introduced into aquaculture in Norway and is expected to constitute a major part of Norwegian fish farming within few years. Expansion of this industry faces many challenges, including disease problems. From farming of salmo nids we know that vaccination has been a ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

An integrative genomics approach to identify genes and biochemical pathways underlying complex traits in Atlantic salmon

Identifying the genes and biochemical pathways in salmon that are responsible for economically important traits is the primary focus of this application. While a wealth of phenotypic data is available (e.g. the salmon biobank) the ability to resolve causa tive genes and loci has been technology l...

Awarded: NOK 5.0 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Development of a male contraceptive - from hit to drug candidate

The primary objective of the present project is to perform a hit-to-lead program (H2L) and further to develop a preclinical drug candidate. The outcome of the project is expected to be a preclinical drug candidate. Lead-backups will also be secured in cas e of future failure in a downstream proce...

Awarded: NOK 4.9 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Awarded: NOK 3.5 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Tissue Factor siRNA for treatment of melanoma metastasis

The project described herein covers the research and initial preclinical part of the project of developing a drug based on small interfering RNAs (siRNA) targeting Tissue Factor, a molecule known to be involved in the processes of blood clotting, metastas is and angiogenesis. The project has emph...

Awarded: NOK 1.9 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Developing the next generation of oral vaccines for salmonids using plastids in plants

The following programme will develop a new concept of oral vaccines for fish using plastids as bio-factories in plants. The technology will allow the insertion of any gene or combination of genes into a plant plastid genome, resulting in a high level prot ein expression (approx 20% of total cellu...

Awarded: NOK 5.4 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Development of high througput affinity protemics to search for drug targets in cancer.

Antibody array technology, mass-spectrometry and molecular biology techniques are combined to develop a new platform for screening of drug targets in cancer. The technology allows large-scale analysis of protein networks with high sample throughput. The p roject will develop large-scale analysis ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A National Service Platform for Global Analysis of Genome Structure and Function. The Norwegian Microarray Consortium (NMC)

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Awarded: NOK 9.7 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Norwegian plant transcriptional profiling centre

The Norwegian Arabidopsis Centre (FUGE-NARC) was established as a part of FUGE I. NARC provided national service in plant functional genomics and the service activity was shared between Univeristy of Life Sciences (UMB, transformation/genotyping), Univers ity of Oslo (Y2H, in situ hyb) and Norwe...

Awarded: NOK 2.3 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A NATIONAL SERVICE PLATFORM FOR GLOBAL ANALYSIS OF GENOME STRUCTURE AND FUNCTION: THE NORWEGIAN MICROARRAY CONSORTIUM

Awarded: NOK 7.2 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Towards a systems level understanding of responses to endogenous DNA damage in Caenorhabditis elegans

The impact of genomic instability on human health underscores the importance of understanding the mechanisms that coordinate responses to DNA damage in order to preserve genomic stability. There is a disparity between our knowledge of the cellular respons es to endogenous DNA damage and the impac...

Awarded: NOK 6.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Local NOR-MIC BioImaging node at the University of Tromsø

At the University of Tromsø we now establish a core facility for BioImaging. This core facility will be equipped with instruments aimed at imaging, flow cytometri, cell sorting and plate/membrane readers of fluorescent and chemiluminescent signals. For th is core facility we will have two full-ti...

Awarded: NOK 0.45 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The Proteomics Core Facility at the University of Tromsø as a node in the national consortium of proteomics platforms (NorProteomics)

The core facility for Proteomics in Tromsø has been fully operational since the end of 2004. The main purpose of the facility has been to serve research labs in the FUGE North region. The facility has 3 Mass spectrometer systems from Waters/Micromass. A M ALDI Micro MX, a Q-TOF Ultima Global with...

Awarded: NOK 1.3 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Protein-protein interactions at atomic levels

Our DNA is every day subjected to external and internal damaging agents and understanding the mechanisms of DNA repair at a molecular level is increasingly important in order to address future challenges for the human health. This project aims to reveal n ew information about molecular mechanisms...

Awarded: NOK 6.0 mill.

Project Period: 2008-2014

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

The CIGENE node of the Norwegian Sequencing and Genotyping Service Platform

CIGENE's mandate in the FUGE I period has been to: A. Establish and maintain a national core facility providing: (i) - a high-throughput SNP-typing service for human, animal, plant and microbial materials, (ii) - key competence concerning identification a nd methodological integration of experime...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Channel 2 application for continuation of FUGE MIC Trondheim in FUGE II period (2007-2011)

MIC Trondheim wants to continue in the FUGE II period with MR as the core technology, and will expand in capacity with acquisition of new MR equipment, and expand the high-level competence necessary for offering a wide variety of methods tailored to the u ser's research tasks. A goal is to establ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Ultra-high throughput sequencing platform

Recent technological breakthroughs making possible low cost ultra-high throughput gene sequencing (UTS) open up a new era within biology. It is now possible to sequence a bacterial genome in less than a week, a human chromosome in 3-4 weeks or generate m illions of metagenomic sequences in days....

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Host-virus interactions in Atlantic salmon

Infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in...

Awarded: NOK 12.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A novel checkpoint regulating the cell cycle of fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle. Cancer development is frequently associated with the lack of checkpoints an...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Subnode: Subcellular interactions and imaging - NTNU

Knowledge about protein-protein interactions as well as interactions between other molecules is of critical importance for functional genomics. By providing the state-of-the-art technologies to study inter-and intramolecular interactions, the national res earch community will be able to move func...

Awarded: NOK 7.4 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Aleström Zebrafish Lab - activities beyond the research projects 2007-2011

The major focus of the AZLab services are two-fold: 1) Being a regional center, in an national and international network of transgenic zebrafish laboratories, with capacity to offer access to the zebrafish model for academic and commercial partners. 2) Es tablish a unique training program in zebr...

Awarded: NOK 4.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Advanced MR imaging, MR metabolomics, proteomics and genetic mapping of breast cancer - Clinical tools for personalized patient treatment

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 5.2 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Awarded: NOK 8.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Salmon louse genome sequencing and functional studies on host parasite interactions

Copepods comprise the largest animal marine biomass but they have been poorly studied by molecular tools and no genome has so far been sequenced. Copepods are common as parasites on fishes and the salmon louse (Lepeophtheirus salmonis) is the most importa nt species in terms of economical signifi...

Awarded: NOK 6.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

National-wide service and competence from the Rikshospitalet-Radiumhospitalet Proteomics Core Facility in a Norwegian proteomics consortium

The Proteomics Core Facility at Rikshospitalet-Radiumhospitalet (RR-PCF) is a core facility platform organized jointly by Rikshospitalet-Radiumhospitalet HF (RR) and the University of Oslo (UiO) through "Felles Forskningsutvalg" at the hospital. The RR-PC F is engaged in the development of proteo...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Norwegian Molecular Imaging Consortium - Bergen

The present-day Molecular Imaging Center in Bergen (MIC) is an open facility that offers a collection of state-of-the-art microscopy equipment and image processing tools. MIC initiated its services in 2003 and was set up as a cooperation between NTNU in T rondheim and the University of Bergen to ...

Awarded: NOK 9.2 mill.

Project Period: 2008-2012

Location: Vestland

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