0 projects

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STAMCELLER-Stamcelleforskning

STEM CELL DNA INTEGRITY AND PLURIPOTENCY

Stem cell metabolism is characterized by low respiratory activity and high glycolytic flux, which maintain cells in a reductive state. This is important to prevent damage to cellular genomes (nuclear and mitochondrial DNA). In addition and like differenti ated cells and other somatic cells, stem ...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Oslo

GLOBHELS-Global helse

Novel vaccine candidates against meningococcal disease

Meningococcal disease is a leading cause of meningitis and septicaemia globally, most often striking small children and teenagers. Due to the lack of efficient vaccines, serogroup B meningococcal disease is currently emerging on a worldwide basis. The rat ional design of outer membrane protein-ba...

Awarded: NOK 4.0 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EUROCORES: The functions of phosphoinositides in tissue morphogenesis and cancer

Membrane dynamics modulate cell polarity, vesicular trafficking, migration, growth, proliferation, differentiation, and more. Of all membrane lipids, phosphoinositides play a central role in these processes (Wymann & Marone 2005 Curr Opin Cell Biol; Lindm o & Stenmark 2006 J Cell Sci; Simonsen & ...

Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanisms that couple chromosome replication rate to cellular metabolism

Vi har kartlagt endringer i cellesyklus som følge av endringer i vekstmedium for E.coli bakterien og utformet et simuleringsverktøy til bruk i studier av cellesyklus hos bakterier. Vi har funnet ut at initiatorproteinet DnaA ikke er den eneste begrens ende faktoren i oppstarten av DNA kopiering...

Awarded: NOK 2.6 mill.

Project Period: 2010-2017

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

SOBER 2 - Sex On Brain European Research 2 Effects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour

This study is designed to enhance our understanding of sex specific brain development during puberty and adolescence and its implication for the aging process of the brain. Gonadotropin Releasing Hormone receptor (GnRHR) blockage pauses not only reproduct ive ability, but may also have significan...

Awarded: NOK 1.5 mill.

Project Period: 2010-2013

Location: Oslo

PSYKISK-Psykisk helse

Co-morbid Diabetes and Eating Disorders - an exploration of prevalence, psychological correlates and diabetic control

Dette prosjektet er en delstudie av Barnediabetesregisteret og har undersøkt spiseproblemer ved type 1 diabetes. Forekomsten av spiseproblemer hos 770 gutter og jenter med type 1 diabetes i alderen 11-19 år var 18% i hele utvalget, 9% blant guttene og 28% blant jentene. Vi fant at forekomsten økt...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

KREFT-Offentlig kreftprogram

CD20-specific T cell receptors in gene therapy of leukemia and lymphoma

T-cellereseptorer kan sammenlignes med målstyrte raketter, og utgjør den delen av T-cellene som gjør dem i stand til å gjenkjenne og drepe virusinfiserte celler med stor effektivitet og spesifisitet. Derfor kan T-celler effektivt kurere influensa uten bivirkninger. Prosjektet utnytter disse egens...

Awarded: NOK 7.6 mill.

Project Period: 2009-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

Molecular differences between embryonal carcinomas and embryonic stem cells: Implications for cancer

We see comparative and experimental studies involving embryonic stem (ES) cells and embryonal carcinoma (EC) cells in tandem as important in understanding both stem cell and germ cell tumour biology, and as potentially important as a source of stemness/pl uripotency markers relevant to other type...

Awarded: NOK 2.0 mill.

Project Period: 2009-2013

Location: Oslo

KREFT-Offentlig kreftprogram

Molecular and biological characterization of cancer metastases

Purpose: Metastasis is the principal cause of cancer death, and for most tumor types staging, prognostication and therapy is inadequate. Hence, new knowledge on how to prevent metastasis and identification of predictive markers is among the most important challenges in cancer research. Our strat...

Awarded: NOK 6.7 mill.

Project Period: 2009-2013

Location: Oslo

STAMCELLER-Stamcelleforskning

Epigenetic and genetic programs of mesenchymal stem cell differentiation: a genome-wide integrative approach

The progression from a stem cell state to a more differentiated progeny is determined by the specific activation of transcriptional programs, as a consequence of orchestrated epigenetic and genetic events. The current application aims to identify and char acterise transcriptional programs active ...

Awarded: NOK 3.5 mill.

Project Period: 2009-2014

Location: Oslo

PETROMAKS2-Stort program petroleum

Chemical exposures and cancer incidence in Norwegian offshore oil industry workers

Epidemiological studies have shown associations between work in the oil related industry and a variety of adverse health outcomes. Less knowledge is ,however, available on health effects among workers on installations. The few reports that exist indicate an excess of certain diseases among oil an...

Awarded: NOK 3.4 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Evaluation of functional Magnetic Resonance in the Diagnosis of Brain Tumors for Assessment of Clinical Efficacy (EMBRACE)

In patients suggestive of intra-cranial brain tumors, Magnetic Resonance (MR) is the imaging modality of choice for tumor characterization prior to, during and after surgical intervention. At Rikshospitalet (Oslo, Norway), a multi-disciplinary project has been established with the aim of develop...

Awarded: NOK 7.1 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation and organization of chromosome replication and segregation in Escherichia coli.

In Escherichia coli, reinitiation at new origins is prevented by two different control systems. First, a process called sequestration makes newly formed origins unavailable to the initiation apparatus. The sequestration process involves membrane component s, SeqA protein and methylation at GATC s...

Awarded: NOK 3.0 mill.

Project Period: 2009-2013

Location: Oslo

KREFT-Offentlig kreftprogram

Understanding Breast Cancer Genomics; Towards combined molecular profiles for better diagnosis and treatment

We seek to reach a more fundamental understanding of the biological dynamics of breast cancer. High-throughput molecular data at multiple levels (eg DNA, mRNA, miRNA and protein level) have become available on increasing numbers of patients, and various m olecular profiles have been associated wi...

Awarded: NOK 10.5 mill.

Project Period: 2009-2012

Location: Oslo

GLOBHELS-Global helse

Improved vaccination responses and optional immunomodulating therapy by adjuvant administration of COX-2 inhibitor in HIV-infected patients

This Proposal results from translational HIV research by the Applicants, ranging from basic research on signal transduction in lymphocytes that has firmly established cyclic AMP (cAMP) / protein kinase A type I alpha as a major inhibitor of antigen-specif ic activation; to basic clinical studies ...

Awarded: NOK 4.2 mill.

Project Period: 2009-2015

Location: Oslo

IS-NAD-Samarbeid med NORAD-land

Yosry, Mohammed. Egyptisk spesialist 2009

...

Awarded: NOK 20,515

Project Period: 2009-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Lung cancer - characterization of biological factors for use in diagnosis, prognostication and therapy

Lung cancer is the leading cause of cancer-related death. Treatment results depend on stage, but are overall poor, due to the fact that most patients are diagnosed with advanced disease, but also lack of understanding of involved cellular and molecular di sease mechanisms. From 2005, all lung can...

Awarded: NOK 5.6 mill.

Project Period: 2009-2014

Location: Oslo

KREFT-Offentlig kreftprogram

Somatic, translational and psychosocial research in long-term cancer survivors

Background: The number of long-term cancer survivors (LTCSs) (>5 years after primary treatment) is rapidly increasing and currently concerns >100,000 patients in Norway. Although frequently cured by their disease, the treatments and the cancers have late effects that impair the physical and ment...

Awarded: NOK 5.2 mill.

Project Period: 2009-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

Tissue engineering of hyaline cartilage

Cartilage injuries are frequent and lead to pain and disability. Unfortunately, articular cartilage shows a limited capacity for selfhealing and often goes on to osteoarthritis. Several surgical techniques have been developed to fill the cartilage defects , but so far none of them have been able ...

Awarded: NOK 7.7 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Awarded: NOK 4.4 mill.

Project Period: 2009-2015

Location: Oslo

HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester

Implementing Online Patient-Provider Communication into Clinical Practice: Translational Research

Den internettbaserte Spørsmål og Svartjenesten (SoS) i denne studien er en tjeneste der pasientene kan sende meldinger til og motta svar fra sykepleiere, leger, ernæringsfysiologer og sosionomer etter sykehusinnleggelse eller poliklinisk konsultasjon. Meldingen fra pasienten mottas i en postkasse...

Awarded: NOK 4.5 mill.

Project Period: 2009-2015

Location: Oslo

VERDIKT-Kjernekomp.og verdiskaping IKT

MEDICAL SENSING, LOCALIZATION, AND COMMUNICATION USING ULTRA WIDEBAND TECHNOLOGY

The project will develop ultra wideband (UWB) technology for improved wireless health technology, for both improved network communication and improved and possibly novel medical applications. Three major research directions are pursued, namely short range sensing and imaging, improved sensitivit...

Awarded: NOK 28.8 mill.

Project Period: 2008-2013

Location: Oslo

SYKEFRAVÆR-Forskn.om årsaker til sykefrav

Facilitating and inhibiting factors and effect of interventions in return to work for patients with neck- and low back pain

Fremmende og hemmende faktorer og effekt av intervensjon for tilbakegang til arbeid hos pasienter sykemeldt for nakke- og ryggsmerter. Hensikten med prosjektet var å undersøke faktorer som påvirker sykefravær og tilbakegang til arbeid samt effekt av intervensjon sett fra et arbeidsrelatert, b...

Awarded: NOK 10.0 mill.

Project Period: 2008-2015

Location: Oslo

IS-NAD-Samarbeid med NORAD-land

Yosry, Mohammad egyptisk spes 2008

...

Awarded: NOK 38,100

Project Period: 2008-2008

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

A novel cell cycle checkpoint in fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle and cancer development is frequent ly associated with the lack of checkpoint...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors that recognize cancer cells. DNA encoding the receptors form basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) A large number of T cell clones recognizing common canc...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular characterization and functional studies of human B cell lymphoma

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. Our group aims at identifying genes/signalling pathways with prognostic, diagnostic or therapeutic potential in B cell lymphomas. We are one of 7 groups that co nstitute the newly established Centre for...

Awarded: NOK 3.2 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Oslo

PES-INST-Prosjektetablererstøtte EU (FoU)

Embedded sensing platform for medical

...

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Oslo

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