0 projects

Date from new to old

FRIPRO-Fri prosjektstøtte

Aberrant Oxidative DNA Modifications and DNA Structures in Genome Regulation

DNA-glykosylaser er enzymer som initierer reparasjon av små skader på DNA baser, som er bygge stenene i arveanleggene våre. Hvis de skadede DNA basene ikke blir fjernet kan de forårsake celledød eller mutasjoner og til slutt kreft. Imidlertid brukes DNA-glykosylaser også i medfødt og adaptiv immu...

Awarded: NOK 6.5 mill.

Project Period: 2022-2026

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

KSP: A platform for development of peptide-based antimicrobials for treatment of infections with drug-resistant bacteria

Antimikrobiell resistens (AMR) er en av de mest presserende helseutfordringene verden står overfor. Situasjonen rundt AMR er kompleks, men har ført til at relativt få offentlige eller private ressurser er brukt til å takle utfordringen. Vi foreslår å løse denne utfordringen ved å bygge en innovat...

Awarded: NOK 30.0 mill.

Project Period: 2021-2025

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Novel roles of Neil DNA glycosylases in genome dynamics

Epigenetiske DNA baser er dynamiske modifikasjoner på arveanleggene (genomisk DNA). Epigenetisk regulering og DNA-reparasjon er grunnleggende biologiske prosesser som er viktige for utvikling og god helse, som anerkjent av Nobelpriser (2012, 2015). DNA-glykosylaser initierer reparasjon av skadet ...

Awarded: NOK 9.9 mill.

Project Period: 2019-2023

Location: Trøndelag - Trööndelage

IS-AUR-Samarb.progr. Norge Frankrike

Role of PARP3 in normal continuos and stress-induced neurogenesis in brain.

Poly(ADP-ribosyl)ation is a post-translational modification of proteins mediated by Poly(ADP-ribose) polymerases (PARPs). PARPs catalyse the transfer and polymerisation of ADP-ribose units from NAD+ to form a ramified polymer, the poly(ADP-ribose) (PAR), covalently linked to acceptor proteins or...

Awarded: NOK 50,000

Project Period: 2015-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Modulation of epigenetic phenotypes by oxidative DNA base repair

DNA glykosylaser er en familie av proteiner/enzymer som reparerer skader på arveanleggene/DNA. Det er kjent at DNA glykosylasene har en viktig rolle for vedlikehold av DNA i cellen slik at man unngår varige endringer, såkalte mutasjoner. Nylig har det blitt foreslått at visse typer DNA glykosylas...

Awarded: NOK 9.0 mill.

Project Period: 2015-2018

Location: Trøndelag - Trööndelage

BIOTEK2021-Bioteknologi for verdiskaping

Small transmembrane peptides for treatment of pathogenic bacteria.

The business concept of this project is the introduction of a new concept of antimicrobial treatment with a novel method of action to treat infectious diseases and the evolution of antibiotic resistance. The invention is a new class of small and extremely toxic peptides that rapidly kill the bac...

Awarded: NOK 2.1 mill.

Project Period: 2013-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neil3, a novel function for self-renewal and proliferation of neural progenitor cells

The major cell types comprising the mammalian central nervous system arise from neural stem cells (NSC) and progenitor cells (NPC), including neurons, astrocytes and oligodendrocytes. In this proposal we aim to characterize a novel gene function, Neil3, r equired for neural stem/progenitor cell m...

Awarded: NOK 3.8 mill.

Project Period: 2011-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

STEM CELL DNA INTEGRITY AND PLURIPOTENCY

Stem cell metabolism is characterized by low respiratory activity and high glycolytic flux, which maintain cells in a reductive state. This is important to prevent damage to cellular genomes (nuclear and mitochondrial DNA). In addition and like differenti ated cells and other somatic cells, stem ...

Awarded: NOK 3.0 mill.

Project Period: 2010-2013

Location: Oslo

FORNY20-FORNY2020

Small toxic membrane peptides to treat bacterial infections

...

Awarded: NOK 2.0 mill.

Project Period: 2010-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

DNA glycosylases initiating removal of oxidative DNA base lesions in mammalian cells

Most mutagenic and carcinogenic agents induce covalent changes in the DNA structure and a large number of gene functions have evolved to effectuate repair or tolerance of such alterations without loss of viability or development of disease. DNA repair mec hanisms are probably the most important c...

Awarded: NOK 5.9 mill.

Project Period: 2009-2012

Location: Oslo

FORNY-3-Kommersialisering av FoUresultater

A new therapeutic strategy to combat antibiotic resistance

...

Awarded: NOK 1.4 mill.

Project Period: 2009-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Cellular responses to DNA damage in Schizosaccharomyces pombe

see attachments: Projectdescription and program

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Oslo

FORNY-3-Kommersialisering av FoUresultater

A new therapeutic strategy to combat antibiotic resistance

...

Awarded: NOK 2.2 mill.

Project Period: 2007-2008

Location: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Awarded: NOK 5.0 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

1st Seeberg Symposium on DNA repair

...

Awarded: NOK 99,999

Project Period: 2006-2006

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

1st Seeberg Symposium on DNA repair

...

Awarded: NOK 0.15 mill.

Project Period: 2006-2006

Location: Oslo