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BOLD MINDS aspires to enhance the understanding of vulnerability factors underlying the emergence of borderline personality disorder (BPD), with an ultimate aim of increasing the potential for young individuals to receive early, evidence-based help when their mental health is at risk. BOLD MINDS will achieve this by investigating whether disruptions in two aspects of autobiographical memory (AM), narrative identity (NI) and involuntary AM (IAM), are associated with BPD features and problem behaviours in adolescents concurrently and over time. In doing so, BOLD MINDS will strengthen the understanding of mechanisms underlying the emergence of BPD in adolescence and lay a groundwork for developing evidence-based early interventions for BPD. While currently limited, the study of AM in this field is essential for two reasons. Firstly, because the aspects of AM under investigation, NI and IAM, are known to be involved in identity formation and emotion regulation which represent two key psychological processes that are disrupted in adults with BPD and are linked to problem behaviours such as self-harm and suicidality. Secondly, because promising research is emerging on the use of AM targets in the treatment of emotional disorder in adults, and provides a strong model for future treatment development with vulnerable adolescents. In addition, this timely research program aligns with calls from international organizations to prioritize early interventions to promote adolescent mental health. BOLD MINDS will adopt and adapt state-of-the-art ecological momentary assessment and analytical techniques and work at the crossroads of clinical and cognitive psychological perspectives, allowing for a multidimensional approach to understanding BPD vulnerability. Training-through-research and formalized training of the experienced researcher will prepare her for a permanent academic position and the founding of her own research lab specializing in AM and early interventions for BPD.

Borderline Personality Disorder: Memory and Identity in Adolescence

Bilingual Experiences, Cognitive Ageing and underlying Mechanisms

The goal of the Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME) project is to examine the functional neuroplastic mechanisms underlying mitigatory effects of bilingual experience on age-related cognitive decline. While evidence is available for structural brain changes supporting bilingualism-induced effects on cognitive aging (CA), functional mechanisms underlying such effects are not yet well understood. BECAME aims to fill this gap by investigating the trajectory of bilingualism-induced functional neuroplasticity across the adult lifespan (ages 18-85), crucially adopting an individual differences approach related to measurable degree of bilingual engagement. Importantly, although such benefits are thought to be rooted early in the lifespan, evidence for the timeframe and conditions of their early emergence is scarce. The choice of including the whole adult lifespan allows us to investigate these mechanisms and their emergence more directly from a lifespan perspective. I combine behavioral testing with brain recordings via electroencephalography (EEG). EEG is widely used in cognitive neuroscience to assess brain activity and the degree of communication between brain regions (functional connectivity) in response to stimuli and at rest. Combining behavioral and EEG modalities will allow me to test bilingualism’s effect on functional connectivity, as well as its consequences for functional efficiency, the minimum required neural activation to successfully perform a task. This will enable a detailed, evidence-based account of the protective effects observed in older-aged bilinguals, and how they are built from earlier life stages. By illuminating the relationship between multilingualism and resulting neurocognitive adaptations, BECAME will enable to capitalize on it as a health initiative, with manifold societal implications and the potential to be translated into actionable policies exploiting multilingualism to ameliorate effects of CA.

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Longitudinal Investigation of Visual and Numerical Perception in Preterm and Full-term Infants

The number of preterm births is on the rise -now more than 1 in 10 babies- and being born preterm is associated with having difficulties in two very important and related cognitive skills that we rely on daily: numerical and visual perception. However, a knowledge gap exists on neural and behavioural associations of numerical and visual perception in full-term and preterm infants. PrePER aims to uncover the underlying neural signatures of the cognitive dysfunctions that preterm infants might display in the first year of their lives and the role of parent-baby interaction to predict preterm infants that are at risk of developing these cognitive difficulties in the second year of their lives. The purpose is to establish criteria to identify infants (especially preterm) at-risk of having cognitive difficulties in numerical and visual perception. Shedding light on normal and impaired cognitive functions in infancy is an essential stepping stone that will pave the way for early diagnostic tools and interventions that would correct the cognitive dysfunctions more efficiently while the brain is still developing. The activities in PrePER will lead to original and innovative outcomes that are beneficial for four parties: 1) Scientific communities will be interested in the results as the ambitious research objectives address questions that have not been asked before. 2) Parents of preterm infants, health-care providers, and policy makers will be interested in the results as the overall aim is to establish criteria to identify infants at-risk of having cognitive-developmental difficulties in the first year of their lives. 3) The researcher will be accelerating her career progression as the training objectives meet her specific needs. 4) The supervisor will be enlarging her research interest and network as the research objectives include a topic within the researcher’s expertise.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal. 

AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact. 

To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.  

To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.

Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.

The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation. 

S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work programme, S4R will support the development of resilient health systems in European elderly care through improved leadership capabilities, governance structures, and adaptive capacities.

NEXT GENERATION IMAGING FOR REAL-TIME DOSE VERIFICATION ENABLING ADAPTIVE PROTON THERAPY

The NOVO project will address a fundamental issue in proton radiotherapy (PT) of cancer, namely the lack of real-time dose verification (RDV) that significantly limits the potential of PT due to uncertainties in the precise delivery of the prescribed dose. In the NOVO project, we will develop the first proof-of-concept of an RDV technology adaptable to any PT treatment and bring the concept to TRL 4 by also considering integration into the PT clinical workflow. The RDV technology will be pivotal for enabling the next generation of adaptive PT therapy, i.e., dose-guided real-time adaptive therapy. Real-time measurement of the dose to targeted and non-targeted tissues will be the key to truly empower patient-centered, personalized cancer treatment, important to improve curation and quality-of-life post-treatment. As a high-risk/high-gain project, NOVO aims at a first-of-its-kind RDV technology through the unique synergy between (1) cutting-edge, inexpensive organic scintillator technology that can detect secondary radiation during treatment for non-invasive measurements, (2) novel and fast image reconstruction, artificial intelligence (AI)-accelerated models and AI-enhanced image reconstruction to allow simultaneous detection of multiple radiation species and tissue compositional analysis, (3) tumor-tracking and imaging of tissue radio-sensitivity based on oxygen levels, (4) intelligent automation of decision-making schemes for real-time dose-guided adaptive therapy. The project will essentially open a new era in PT that enables curing more cancer patients and reducing toxicity from treatment. The NOVO consortium covers the entire value chain of RDV development (technology providers, theory and modelling, technology integration and PT clinics) and optimally engages nuclear, medical, and high-energy physicists, chemists, mathematicians, computer scientists, oncologists, biologists, as well as European PT centers. 


Development of innovative proton and neutron therapies with high cancer specificity by 'hijacking' the intracellular chemistry of haem biosynthesis.

Deep-lying cancers, such as glioblastoma multiforme (GBM) brain cancer, are very difficult to access and incurable by the current standards of care. The fluorescence of photosensitive molecules (PSs) can precisely guide surgical resection of GBM. Nevertheless, photomedical treatments like photodynamic therapy (PDT) show limited efficacies due to the low penetration of light into tissue. Proton radiotherapy can reach deep-lying disease through therapeutic energy deposition in a spatially confined region called Bragg peak. Current neutron-based therapies, like Boron Neutron Capture Therapy (BNCT), have sufficient penetration depth but lack cancer specificity.
In NuCapCure, we propose to 'hijack' intracellular biosynthetic pathways and use them to produce custom-made drugs that will facilitate two genuinely new cancer treatments: i) "NuCapCure Proton", combining proton radiotherapy, protondynamic therapy through PS proton activation, and proton capture therapy (BPCT) through three produced alpha particles; and ii) "NuCapCure neutron", combining GBM specific BNCT and PS neutron activation as demonstrated in our FET-open project FRINGE.
The main scientific breakthroughs of NuCapCure will be to demonstrate the custom production of novel compounds through native intracellular biosynthesis but also to establish experimental proof-of-principle, both in vitro and in vivo, of the proposed two novel therapies. Our highly interdisciplinary project team comprises world-renowned experts from a unique combination of disciplines: proton and neutron physics, synthetic chemistry, photochemistry, photobiology, radiobiology, medical physics, nuclear reactor and particle accelerator technology and radio-oncology to lay the foundations for novel, targeted and curative therapies against currently fatal cancer indications like GBM.

Despites dental pulp capping materials should meet the certain requirements, the available materials have one or more shortcomings—poor biocompatibility and rheological properties, fail to maintain pulp vitality and to simulate reparative dentine formation and expensive etc. Mineral trioxide aggregate (MTA) is widely used material because of its beneficial properties. However, its composition bismuth oxide, which is suspectable to toxicity, has an impact on rheological properties. This emphasizes the necessity of looking for inexpensive alternatives to materials that meet the specifications. This project's goal and novelty are to investigate the potential processing of the dental pulp capping cement, which is made of strontium silicate (SrSiO3), strontium fluoride (SrF2), piezoelectric material (PZM) and tricalcium silicate (Ca3O5Si) and its rheological properties and hemocompatibility. Because SrSiO3, SrF2, PZM and Ca3O5Si have the promising properties. This project's work packages are split into four categories based on the interdisciplinary approach since it involves the synthesis and characterization of PZM, the processing and characterization of cement, the identification of rheological parameters utilizing ISO standardizations, and hemocompatibility, and acquiring new transferrable skills. Additionally, the interactions among the selected compounds will be determined. The scientific impact of this project is comprehending the physical properties and the immune system's response to evaluate the cement's suitability as a replacement for existing materials, as well as resulting in further uses in dentistry and medicine. The societal impact is providing millions of patients in Europe with predictable and outstanding treatment outcomes each year to maintain pulp vitality and health. Eventually, it will ease the financial load on millions of patients who need dental care, will be avoiding inflated medical expenses and misuse of the patent (economic impact).

SrSiO3-based Dental Pulp Capping Cement

VisMeg: How to communicate medical registry data to citizens in an understandable manner?

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på år

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på fylker

Midlene fra HELSEVEL-Gode og effektive helse-, omsorgs- og velferdstjenester fordelt på fagområde

Research Scientist

Cervical cancer can be prevented through regular screening of cell samples from the cervix. However, regular updates in sample types and screening intervals may cause uncertainty in sample interpretation and selection of appropriate follow-ups among screening participants and medical practitioners. The project goal is to develop digital services for participants and health professionals. VisMeg will develop models and methods to present complex medical data to diverse groups in a precise and understandable manner.

To date, the Cancer Registry's routines for delivery of data are manual and time consuming. The public and medical professionals expect digital, immediate access to sample results and history. However, registry data may not be readily understood by the participants and cause unjustified worry. Communicating registry data and sample results to diverse groups in a precise and understandable manner is the greatest research challenge. 

A decision support system will facilitate that samples are taken at appropriate intervals. Screening participants will gain insight into how their data is stored, who can access it, and how it is secured. This may improve user trust and stimulate increased sharing of medical data. The data can then be utilized for the benefit of women and the health services.

VisMeg is a collaboration between the Norwegian Cancer Registry, SINTEF, and the Norwegian Cancer Society. SINTEF contributes competence in data modelling, visual communication, and user-centric development. The Norwegian Cancer Society will, through its large network and user panels, contribute to gaining user insight and evaluating the projects outputs.

Researchers expect that VisMeg will reduce the time the Cancer Registry requires to deliver health data. An optimally timed screening program will improve resource use in the public health system and improve the overall health of the public. Models, methods, and tools will be made public so that results can be reused.

Livmorhalsprogrammet (LP) i Kreftregisteret har ansvaret for å forvalte og videreutvikle screening mot livmorhalskreft, og har helsedata om nesten 2 millioner kvinner. Hvert år sender LP påminnelse til ca 450 000 kvinner om at det er tid for ny prøve. Mye endringer med nye tester og nye retningslinjer i LP fører til at fastleger og pasienter blir usikre på hva prøvesvarene betyr, og hvordan kvinner med unormal prøver skal følges opp. 

Kvinner og deres behandlende leger har en lovfestet rett til innsyn i helsedata i LP. Per i dag finnes ingen rask tilgang til data i LP. Rutiner for innsyn er svært ressurskrevende. Innsyn går via fastlege og kan ta opp mot 30 dager. Manglende oversikt over tidligere prøver kan føre til unødvendig prøvetaking, og til feil utredning.

Hovedmålet er å utvikle en digital tjeneste, VisMeg, for innsyn og veiledning knyttet til registerdata på en forståelig måte. Prosjektet skal utvikle modeller, metoder, verktøy og prototyper for visuell presentasjon av heterogene helsedata. Prosjektet skal også tilby beslutningsstøtte og veiledning basert på data og prøvehistorikk, samt gi innsyn i dataforvaltningen for økt tillit. Prosjektet tar utgangspunkt i det nasjonale screeningprogrammet mot livmorhalskreft, og vil ha overføringsverdi til andre screeningprogram og helseregistre.

SINTEF, LP og Kreftforeningen vil i prosjektet innhente brukerinnsikt, kartlegge behov og barrierer, utvikle en semantisk modell og definere et grafisk språk for kommunikasjon av medisinske data, utvikle prototyper, og evaluere dem sammen med brukere.

En slik digital tjeneste vil bidra til å øke dekningsgraden, optimalisere forebygging av livmorhalskreft, redusere unødvendig prøvetaking og dermed spare store ressurser for innbyggere, Kreftregisteret og samfunnet. 

Flere pasientorganisasjoner og spesialistorganisasjoner vil være viktige støttespillere, og vil inviteres som studieobjekter samt ha en rådgivende funksjon for forskningen, men også realiseringsarbeidet.

VisMeg: Hvordan kommunisere medisinske registerdata til innbyggere på en forståelig måte?

Mange har historier å fortelle om at fordi de var sterke som unge, har de lett kunne trene seg opp igjen selv om de ikke har trent kontinuerlig og har mistet muskelmassen. Hittil har slike fenomener vært tilskrevet motorisk læring av tekniske ferdigheter, og man har ikke tenkt seg at det er noen hukommelse eller læringsmekanisme i musklene selv. Vi har imidlertid i dyreforsøk vist at det er en cellulær hukommelse i muskelcellene selv. I dette prosjektet viser vi at muskelcellene er DNA-fattige og at dette begrenser cellestørrelsen og dermed kraften. Vi viser at hukommelsen kan være basert dels på en permanent økning i antallet cellekjerner og dels på epigenetiske mekanismer som regulerer genenes tilgjengelighet.

The muscle fibres are the largest cells in the body, and the size generally determines the force.  While almost all other cells contain only one nucleus, muscle fibres have several hundred, and it is believed that each of them support a certain volume of cytoplasm. The textbook understanding is that during strength exercise fibres hypertrophy and new nuclei are added to pre existing fibres from fusing stem cells, while during disuse, fibres shrink and loose nuclei by apoptosis. We have developed in vivo imaging techniques where single nuclei can be followed in the animal with time-lapse microscopy. These techniques have suggested that the textbook model is wrong and that nuclei are not lost from muscle fibres during atrophy. Since we confirm that nuclei are added during hypertrophy, we suggest that the permanent increase in the number of nuclei after an hypertrophy episode could represent a form of cellular "memory". Our main goal is to provide convincing data for the existence of a "muscle memory", such that an elevated number of nuclei is beneficial in aiding later strength training. The ability to generate new muscle nuclei is impaired in the elderly; thus, the demonstration of a muscle memory should lead to a health advice for early exercise in order to counteract weakness in the elderly. We have observed that anabolic steroids generate new muscle nuclei in animals, similar experiments will be performed in humans, and might lead to changes in the worlds anti doping rules. In patients we will investigate muscle wasting with improved histological methods in order to find out if our new model also applies to humans, thus demonstrating that muscle wasting is not a degenerative disease. In animal models we will investigate the cellular dynamics of myonuclei and the molecular mechanisms underlying centronuclear myopathies. In addition to nucleic number as a novel memory mechanism we will investigate if genome imprinting also plays a role for the "memory.

Mechanisms for a Novel Muscle Memory

The composition of muscle is related to the risk of developing life style diseases such as obesity and type II diabetes. Muscle is a permanent tissue, but the phenotype can nevertheless be changed by changing the pattern of activity such as by exercise. C hanges in the pattern of action potentials leads to a different set of genes being expressed in pre-existing fibres, and this will change physiological properties such as contraction speed and metabolism (glycolytic/oxidative). Recent evidence suggests th at a multitude of activity-correlates can serve as signals in this excitation-transcription coupling. We will study some of the putative pathways such as negative regulation of fast myosin heavy chain isoforms by the transcription factor NFAT; how calcium  regulate phosphorylation of muscle specific factors such as myogenin and myoD regulate myson heavy chain and metabolism; effects of lipid sensors such as PPARd; and factors related to low oxygen levels such as Hif-1a. We will also by genomics and proteom ics search for new pathways. The understanding of the signalling pathways related to activity opens up the possibility for drug intervention, and for one of the pathways (PPARd), we will test drug candidates directly. We will use several advanced special  methods that have been established in the lab such as somatic gene transfer, electrical stimulation with implanted electrodes and in vivo time lapse imaging of single cells over days and weeks in the intact animal.

The muscle excitation-transcription coupling

This project addresses a major question in neuroscience: How activity in the nervous system regulates the organization of synaptic connections. It poses this question in the motor system, where activity-dependent regulation is less well understood than in  sensory systems. To address this question in a way that can provide profound insight into the dynamic mechanisms of plasticity, the project will use cutting-edge imaging technology to follow synaptic changes both in vivo and in ex vivo preparations, in w hich activity patterns can be manipulated and synaptic structure and molecular composition can be assessed longitudinally at the same synapse.

Cutting-edge imaging technologies to be used include in vivo imaging of activity in muscle and motor neurons wi th calcium-sensitive and voltage-sensitive probes

The results obtained from this project will increase our understanding of the potential and limitations of motor plasticity in a clinical setting, most immediately in the context of functional recovery af ter spinal injury, but also with clear implications within the context of brain trauma that disrupts motor function, such as stroke, in which post-injury training is an important component of therapy. Lastly, the insight gained about synaptic plasticity i s expected to contribute to a better general understanding of  plasticity in the brain.

The role of activity in synaptic development and plasticity in motor pathways: A multi-methodological dynamic imaging approach

The project aims at developing nanocrystals or  Quantum dot (QD) technology for in vivo use in general, and for tracking single molecules in particular. Quantum dots emit fluorescence and have emission spectra that are orders of magnitude more intense tha n conventional dyes. An antibody is usually needed to ensure specific binding of the QD. To date however, the use of QDs in vivo has been limited since the conjugation of an antibody to the QD makes it relatively large. Project 1: Is aimed at the adaptati on of QDs. QDs conjugated to [a]-bungarotoxin to label acetylcholine receptors (AChRs) we will use the technology to track single molecules in the synapse, in order to elucidate basic mechanism for synapse formation, synapse maintenance, and synaptic comp etition. Project 2: Rapsyn is a synapse protein that binds AChRs and it is essential for synapse formation. We plan to clone dominant negative forms of rapsyn into plasmids and overexpress them in muscle cells by single cell injection of the plasmids. We will use modified QDs to track the fate of rapsyn and AChRs after transfection to investigate the effect of dominant negative forms of rapsyn at the adult NMJ. Project 3: Competition between neural inputs is one of the fundamental problems in neurobiology . This competition between active and less active synapses be recapitulated adult animals by the formation of ectopic synapses or by the partial blockade of single synapses. In both cases a "winning" and a "losing"synapse can be studied, and the receptor dynamics investigated using QDs. This will allow us to study early events in clusters in membrane regions where the ultimate fate of the clusters will be known.

0 projects

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Mechanisms for a Novel Muscle Memory

Awarded: NOK 9.0 mill.

Project Period: 2015-2020

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The muscle excitation-transcription coupling

Awarded: NOK 6.2 mill.

Project Period: 2009-2014

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The role of activity in synaptic development and plasticity in motor pathways: A multi-methodological dynamic imaging approach

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Adaptation of nanocrystals for in vivo use in tracking of single molecules at the neuromuscular junction

Awarded: NOK 3.1 mill.

Project Period: 2006-2008

Location: Oslo

AB-MED2-Basal medisinsk forskning II

How to change muscle phenotype: intracellular mechanisms studied in vivo

Awarded: NOK 1.5 mill.

Project Period: 2000-2004

Location: Oslo