0 projects

Date from new to old

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

The Norwegian national node of International Neuroinformatics Coordinating Facility (INCF-N) - Phase 2: 2011-2016

International Neuroinformatics Coordinating Facility, INCF, ble etablert i 2006 etter anbefaling fra OECD Global Science Forum. INCFs formål er å fremme utviklingen av infrastruktur for dataintegrasjon gjennom deling av data og analyse av data om hjernen, samt modellering og simulering av funksjo...

Awarded: NOK 4.0 mill.

Project Period: 2011-2017

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Life After STroke - The LAST study

LAST studien er en nasjonal randomisert kontrollert multisenter studie som har til hensikt å undersøke effekten av et langtidsoppfølgingsprogram etter hjerneslag. Personer som har vært innlagt ved slagenheten ved St. Olavs Hospital eller ved Bærum sykehus får tilbud om å delta i studien ved den p...

Awarded: NOK 5.7 mill.

Project Period: 2011-2016

Location: Trøndelag - Trööndelage

IS-TOPP-Toppfinans. av M.Curie-stipend

Neuroendocrine Immune Networks in Ageing - Ashish Shah

Se Annex 1 (vedlegg)

Awarded: NOK 0.50 mill.

Project Period: 2010-2013

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

What happens in the cerebral cortex through the life-span? Intra-cortical myelination, genes and cognition in development, aging and disease

Despite its huge impact on research in neuroscience, a major limitation of MR morphometry has been that little information is obtained about specific neurobiological mechanisms. Cortical thinning is seen throughout adolescence, adulthood and in early Alzh eimer's disease (AD), but the underlying ...

Awarded: NOK 2.6 mill.

Project Period: 2010-2013

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

brain and brain cell injury in newborn infants

Nyfødtasfyksi er fortsatt en viktig årsak til dødelighet og sykelighet både blant norske barn og internasjonalt. Årsaksmekanismene til skadene ved nyfødtasfyksi er fortsatt delvis ukjente. Vi har vist at det kan være skadelig å bruke 100 % oksygen i gjen oppliving av nyfødte. Grunnen til at oksy...

Awarded: NOK 2.6 mill.

Project Period: 2010-2015

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Modeling neural mapping and remapping in the hippocampus

Navigation and memory for every-day episodes are thought to depend on the hippocampus and associated brain networks, supported by the characteristic properties of the underlying neural networks. Considerable progress in uncovering the neural basis for spa tial cognition in the hippocampus and par...

Awarded: NOK 0.23 mill.

Project Period: 2010-2011

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

In vivo two-photon imaging of glial dysfunction in stroke

Prosjektet fokuserte på hvilke roller gliacellenes vannkanal aquaporin-4 (AQP4) har i hjernen ved hjerneslag. Et hovedfunn var at AQP4 påvirker gliacellenes Ca2+ signaler og volumregulering. Vi avdekket dermed mulige angrepspunkt for behandling av eksitotoksisk hjerneskade. Et annet funn var at A...

Awarded: NOK 2.6 mill.

Project Period: 2010-2014

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Functions of the dentate gyrus

The hippocampus is known to play an important role in various types of memory both in humans and rodents. The dentate gyrus is a sub-region of the hippocampus and one of two places in the adult brain where new neurons are continuously added to existing ne tworks. The function of these adult born ...

Awarded: NOK 0.15 mill.

Project Period: 2010-2011

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Motivation, dopamine and schizophrenia: A multi-modal functional neuroimaging approach.

Målet med studien var å undersøke mulige endringer i atferd og hjerneaktivitet på bakgrunn av enkeltdosebehandling av to forskjellige antipsykosemedikamenter: Aripiprazole og haloperidol, sammenliknet med placebo. Medikamentene ble undersøkt ved hjelp av funksjonell hjerneavbildnings tilnærming ...

Awarded: NOK 1.2 mill.

Project Period: 2010-2015

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

A systems biological approach to elucidate local protein synthesis code in synaptic plasticity and memory

This project is a systems biological approach to understanding how regulation of protein synthesis in neuronal subcompartments mediates long-lasting changes in synaptic communication and memory. The project consists of four interactive modules and 8 work packages (WPs). The experimental strateg...

Awarded: NOK 2.5 mill.

Project Period: 2010-2013

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Automated spike sorting of multielectrode recordings: Construction of test data as part of international methods development project

The project is a part of an international collaborative effort on developing and testing of methods for automated analysis of extracellular recordings of action-potentials. Several electrode types may be considered, but a focus will be on tetrodes, a type of multielectrode with four contacts. Su...

Awarded: NOK 1.1 mill.

Project Period: 2010-2013

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

SOBER 2 - Sex On Brain European Research 2 Effects of Gonadotropin Releasing Hormone Receptor blockage on brain development and behaviour

This study is designed to enhance our understanding of sex specific brain development during puberty and adolescence and its implication for the aging process of the brain. Gonadotropin Releasing Hormone receptor (GnRHR) blockage pauses not only reproduct ive ability, but may also have significan...

Awarded: NOK 1.5 mill.

Project Period: 2010-2013

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

CMT: Statistical analysis and revision of genetic diagnostics in a population, identification of the disease locus in a family with CMT2

Project summary CMT is the largest group of inherited polyneuropathies and a large number of genes are associated with the condition. The Department of Medical Genetics at the University Hospital of North-Norway is a part of the National Neuromuscular Cen tre. Patients with CMT constitute a signi...

Awarded: NOK 2.5 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

IS-BILAT-Mobilitet Norge-USA /Canada

The role of monocarboxylate transporters in mesial temporal lobe epilepsy

Epilepsy is a common serious neurological disorder. Unfortunately, the treatment of epilepsy has severe shortcomings. Many epilepsy patients become refractory to the drugs available. In more than 40 % of cases, the disorder cannot be controlled by medicat ion, and surgically removal of the hippoc...

Awarded: NOK 91,000

Project Period: 2010-2010

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Interactions Between Evoked And Intrinsic Brain Activity. Electrophysiology, Hemodynamics, Behavioral Consequences.

This project brings together an international and interdisciplinary team of recognized researchers with a common interest in how human behavior is influenced by intrinsic fluctuations of electrohysiologic and hemodynamic brian activity. Intrinsic activity has only recently been recognized as a r...

Awarded: NOK 1.2 mill.

Project Period: 2009-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neurogenetics of aging: impact of DNA repair on Alzheimer disease

The genetic background for cognitive loss, dementia and aging processes is poorly described, and multidisciplinary research is needed to increase this knowledge. Alzheimer disease (AD) is by far the most important contributor to cognitive decline and deme ntia worldwide. Incidence may quadruple s...

Awarded: NOK 4.1 mill.

Project Period: 2009-2013

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Properties of thin, unmyelinated axons in mammalian brain

In order to better understand and control how neurons work we need more knowledge about thin, unmyelinated axons. This is because: - They are the most common axonal type in the mammalian cortex. - They are the part of the neuron that we have least knowled ge about, which is mostly due to their ti...

Awarded: NOK 0.30 mill.

Project Period: 2008-2010

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Building national and international networks in aquaporin research: from in vivo two-photon imaging to gene analysis in patient cohorts

A number of neurological and psychiatric diseases for which current therapies are nonexisting or inadequate involve deficiencies in water homeostasis or cerebral blood flow regulation. Examples are headache disorders, epilepsy and Alzheimer`s disease. The recent Nobel-recognized discovery of aqu...

Awarded: NOK 3.1 mill.

Project Period: 2008-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

ESF - Stress and Mental Health (EuroSTRESS) - støttes av NevroNor

Repetitive and uncontrollable stress is known to be a powerful risk factor for mental disorders. Whether an individual will respond adaptively or maladaptively to a stressor is de?ned by his/her genetics, developmental history and the environment in adult hood. In particular traumatic experiences...

Awarded: NOK 2.8 mill.

Project Period: 2008-2013

Location: Vestland

NEVRONOR-Nasjonal satsing på nevrovitenskap f

TOP Group in Psychiatric Genetics Consortium - Genome Wide Association Study

Schizophrenia (SCZ) and Bipolar disorder (BIP) are severe psychiatric disorders characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and are major public health problems with a high cost for society. The heritability is high, but d espite the clear genetic component, the p...

Awarded: NOK 0.30 mill.

Project Period: 2008-2009

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Common paths to neurodegeneration

Neurodegenerative diseases are a diverse group of disorders that are an ever-increasing social and economic burden on society. Design of drugs or therapeutic approaches to halt or slow the progression of these debilitating diseases will need to exploit kn owledge of pathogenic mechanisms. Protein...

Awarded: NOK 0.13 mill.

Project Period: 2008-2009

Location: Oslo

IS-STP-Statsstipendprogram, utlendinger

Amaral, Ana I. Porem, portugisisk stp 07/08

...

Awarded: NOK 41,500

Project Period: 2008-2008

Location: Trøndelag - Trööndelage

IS-NAD-Samarbeid med NORAD-land

Sallam, Abdelhamid Egyptisk stp 07/08

...

Awarded: NOK 41,500

Project Period: 2008-2008

Location: Oslo

KLINISK-Klinisk forskning

Understanding early events in Alzheimer disease (AD) pathogenesis: Integration of molecular, functional and structural imaging

This project will develop and employ integrated imaging techniques in the longitudinal study of patients with mild cognitive impairment (MCI). We aim to study mechanisms for Alzheimer disease induction, and to determine factors predictive for cognitive de cline and conversion to dementia. Fracti...

Awarded: NOK 3.1 mill.

Project Period: 2008-2011

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The genetically-defined Parkinson's disease. A study of biomarkers in patients and healthy carriers of the Park8 G2019S mutation.

The mechanisms behind the development of PD are still obscure, but it is clear that PD is heterogeneous both in terms of cause, phenotype, progression, and response to treatment. Reproducible biomarkers for PD susceptibility and/or progression that are se nsitive and specific have long been sough...

Awarded: NOK 1.2 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

TU-Tungt utstyr

MULTICHANNEL ELECTROPHYSIOLOGICAL RECORDING FROM CELL ASSEMBLIES IN GENETICALLY MODIFIED BRAIN CIRCUITS

Despite impressive advances in every field of neuroscience, our understanding of brain function remains largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. The introduction of tr ansgenic mice has provided neuroscience w...

Awarded: NOK 1.8 mill.

Project Period: 2007-2007

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Quantitative MR imaging used to gain new knowledge of perinatal brain injury- from newborns to young adults with very low birth weight

The neurological adult outcome of VLBW and ELBW survivors is of great interest to society. Perinatal brain injury has major impact both economically, for health care and emotionally for parents and children as they develop into adulthood. Combining quanti tative MRI and clinical research, may ser...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The Norwegian Multiple Sclerosis Registry and Biobank

Multiple sclerosis (MS) is an immune-mediated, inflammatory disease of the central nervous system (CNS) in genetically susceptible individuals. It is a disabling disease of young adults, with no curable treatment available. There is growing knowledge of s everal aspects of the disease, but the et...

Awarded: NOK 4.5 mill.

Project Period: 2007-2010

Location: Vestland

TU-Tungt utstyr

Functional Neuroanatomy of the Cortico-Parahippocampal-Hippocampal Memory System.

Memory is a property of distributed networks in the mammalian cortex. While the permanent storage of episodic memories is likely to take place at distributed locations in the neocortex, fast acquisition of such memories depends critically on the (para)hip pocampal system. This dependence reflects...

Awarded: NOK 6.8 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mother's neurological disease as a risk factor for the child

The neurological diseases myasthenia gravis (MG), multiple sclerosis (MS) and epilepsy can influence pregnancy, the process of giving birth and the child. Genetic factors, pathogenic mechanisms, disease symptoms and therapy can be responsible. The Medical Birth Registry of Norway contains inform...

Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Vestland

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