0 projects

Date from new to old

RUSMIDDEL-Rusmiddelforskning

VALIDAD Pilot - Development of a valid test battery for assessing driving ability when influenced by drugs

Road traffic safety is a significant issue for society. In the European Union there are approximately 45 000 traffic fatalities annually. The majority of these accidents are caused by human error, and the use of drugs (both prescribed and illegal compound s) is a significant contributor in this r...

Awarded: NOK 1.00 mill.

Project Period: 2008-2009

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanism of mammalian DNA repair

DNA repair prevents cancer and early aging and is essential for the immune system. Our objective is to obtain a detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair. BER is a template-dependent multistep proc ess initiated by a DNA glycosylase. The U...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular basis for control of the heartbeat by Na+

Contraction of the heart is triggered by an increase in Ca2+ within cardiac muscle cells, as Ca2+ ions bind to contractile proteins. The rise in Ca2+ results primarily from release from the sarcoplasmic reticulum which is the main intracellular store of C a2+. Therefore, the pumping ability of th...

Awarded: NOK 5.4 mill.

Project Period: 2008-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Workshop on Dynamics of Cell Signal Systems (cofunded with FEBS)

There is a need for European and international scientists in the area of cell signaling to get together and bring attention to new subjects such as spatiotemporal organization and modeling of signaling. Furthermore, European scientists should get togethe r for networking to strengthen and increa...

Awarded: NOK 0.15 mill.

Project Period: 2008-2008

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Unmasking the Interplay between Pathogenic Neisseria Species and Host Cells by Quantitative Proteomic Analysis

This proposal aims to investigate the interaction between pathogenic Neisseria gonorrhoeae and Neisseria meningitides with host cells during infection using in vitro and in vivo models (cell culture and mouse model). A quantitative proteomic approach usin g in vitro and in vivo metabolic labeling...

Awarded: NOK 3.8 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation of competence for natural transformation in Streptococcus pneumoniae

Bacteria that have the ability to take up naked DNA from the environment and incorporate this DNA into their genomes by homologous recombination are said to be naturally competent for genetic transformation. About 70 species of bacteria have been reported to possess this property. One of the bes...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Akershus

FRIBIO-Biologi og biomedisin

Dietary antioxidants and oxidative stress: Novel technologies for assessing oxidative stress in blood samples

Oxidative stress is intimately involved in pathophysiology many chronic degenerative diseases such as cancer, cardiovascular diseases, diabetes, cataract as well as neurodegenerative diseases. Oxidative stress is also central to the theory of aging. We ar e therefore investigating the role of die...

Awarded: NOK 3.1 mill.

Project Period: 2008-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

GENETIC MOUSE MODELS TO STUDY GASTRIC PHYSIOLOGY AND DISEASES

Genetic mouse models include introduction of exogenous gene into the mouse genome (the so-called transgenic mouse) and targeted disruption of endogenous gene (knockout mouse). Up to date, ~10% of the known mouse genes have been knocked out, 21 transgenic/ knockout mouse strains have been studied ...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors (TcRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cell s that recognize common cancer proteins, ...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A novel checkpoint regulating the cell cycle of fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle. Cancer development is frequently associated with the lack of checkpoints an...

Awarded: NOK 5.3 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Advanced MR imaging, MR metabolomics, proteomics and genetic mapping of breast cancer - Clinical tools for personalized patient treatment

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 5.2 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

IS-DAAD-Forskerutveksl. Norge-Tyskland

Tho, Ingunn DAADppp 2008-09 Tysk-norsk forskerutveksling

...

Awarded: NOK 90,000

Project Period: 2008-2010

Location: Troms - Romsa - Tromssa

IS-AUR-Samarb.progr. Norge Frankrike

Reuter, Nathalie Aurora 2008-09 Fransk-norsk forskerutveksling

...

Awarded: NOK 44,589

Project Period: 2008-2010

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Pathogenesis of complex genetic diseases, using pre-eclampsia as a model

Pre-eclampsia (PE) is the most common pregnancy-associated complication in the Western world. The syndrome is a major contributor to maternal and fetal illness/death. No therapeutic treatment exists. The mechanisms involved in development of PE remain to be elucidated. Observations suggest immu...

Awarded: NOK 8.5 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Stroma-targeting: a directed approached aimed at tumor stroma fibroblasts

In recent years the awareness about the importance of the stroma for normal tissue homeostasis and tumor growth has increased. Much of this progress has been in the field of angiogenesis and anti-angiogenesis approaches are currently receiving considerabl e attention. In contrast to the recent fo...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Spontaneous preterm birth: a systems biology approach in the Norwegian Mother and Child Cohort Study

sPTB is an unresolved common complex condition in perinatal medicine and is related to long-term disabilities such as cerebral palsy, cognitive and respiratory problems, which will affect the infant in every day life situations. The pathophysiology of sPT B remains poorly understood. Infection an...

Awarded: NOK 15.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Awarded: NOK 9.3 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Global gene expression of human and rat brain: an integrative genomics study of CNS functions and genetic susceptibility in schizophrenia

Schizophrenia (SCZ) is a serious psychotic disorder ranked among the 10 most disabilitating disesases worlwide (WHO) with a lifetime risk of 1% in the general population. Despite decades of research, the understanding of underlying biological mechanism re mains inadequate and fragmentary and trea...

Awarded: NOK 5.3 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Membrane trafficking in immunity and tumour suppression

Intracellular membrane trafficking plays key roles in cell signalling and innate and adaptive immunity. Endocytosis and subsequent endolysosomal trafficking of growth factor receptors constitute a crucial mechanism for receptor signal attenuation and tumo ur suppression. For innate immunity again...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Mitochondrial Health and Neuronal Life

Lars Eide and Magnar Bjørås are joint applicants for this project. Mitochondria have central roles in neuronal homeostasis as they actively participate in energy production, calcium buffering and apoptosis control. Erosion of mitochondrial function is th ought to underlie the progressive neurona...

Awarded: NOK 4.0 mill.

Project Period: 2007-2011

Location: Oslo

STAMCELLER-Stamcelleforskning

Factors predicting graft-versus host disease after allogeneic hematopoietic stem cell transplantation.

Allogeneic stem cell transplantation (ASCTx) represents the most commonly applied therapeutic use of stem cells from born individuals. The mortality and complication rate of ASCT is high, often preventing its use in less severe conditions than cancer. Th e aim of this project is to generate a be...

Awarded: NOK 3.4 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Opioid activated NMDA and opioid receptor mechanisms: studies of rodent and human brain using PET

The scope of the proposed project is to study the molecular mechanisms of opioid exposure. Within the financial framework, it will be focused on preclinical testing and validation as well as first human studies. Further studies depend on additional fundin g. Intentionally, opioid analgesia in p...

Awarded: NOK 1.8 mill.

Project Period: 2007-2011

Location: Akershus

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The role of activity in synaptic development and plasticity in motor pathways: A multi-methodological dynamic imaging approach

This project addresses a major question in neuroscience: How activity in the nervous system regulates the organization of synaptic connections. It poses this question in the motor system, where activity-dependent regulation is less well understood than in sensory systems. To address this questio...

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo

SFF-Sentre for fremragende forskn

Centre for Immune Regulation, CIR

Senter for immunregulering har hatt som mål å identifisere og karakterisere årsaker til feilregulering av immunsystemet. En slik feilregulering kan gi autoimmunitet og allergi. Forskerne i senteret har studert hva som går galt i samspillet mellom immuncellene både på cellulært og molekylært nivå...

Awarded: NOK 109.3 mill.

Project Period: 2007-2018

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of dendritic activity in thalamic neurons by use of 2-photon technique

Processing of information in nerve cells occurs mainly in their dendrites. However, due to lack of adequate methods there is today very little information available on mechanisms of dendritic signal processing. New and powerful imaging techniques based o n 2-photon microscopy and calcium imaging...

Awarded: NOK 0.70 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Structural characterization of neural network alterations in transgenic rat model of Huntington's disease

Huntingtons disease (HD) is an untreatable inherited neurodegenerative disease causing motor and cognitive dysfunction and premature death, due to loss of specific neurons in the basal ganglia. Having access to the first transgenic rat model of HD, the pr esent project seeks to conduct the first ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2010

Location: Oslo

EMBLNODE-Nord EMBLsenter i molekylærmed

Norsk senter for molekylærmedisin (NCMM) - Centre for Molecular Medicine Norway - Nordic EMBL Partnership

Norsk Senter for Molekylærmedisin (NCMM) er et nasjonalt forskningssenter og fungerer som drivhus for unge, talentfulle forskere innen molekylærmedisin, bioteknologi og translasjonsforskning. Senterets overordnede visjon er å forbedre den molekylære forståelsen av helse og sykdom for å kunne forb...

Awarded: NOK 182.8 mill.

Project Period: 2007-2025

Location: Oslo

1 3 4 5 6 7 39