0 projects

Date from new to old

SFF-Sentre for fremragende forskn

Centre for Immune Regulation, CIR

Senter for immunregulering har hatt som mål å identifisere og karakterisere årsaker til feilregulering av immunsystemet. En slik feilregulering kan gi autoimmunitet og allergi. Forskerne i senteret har studert hva som går galt i samspillet mellom immuncellene både på cellulært og molekylært nivå...

Awarded: NOK 109.3 mill.

Project Period: 2007-2018

Location: Oslo

PSYKISK-Psykisk helse

Social Change, Health Care Intervention and Suicidality. - A Longitudinal Prospective Study of Suicidal behaviour.

1) Background Due to the lack of national statistics on suicide attempts in Norway, few studies have been published regarding the development of suicide attempts in the population. Since a main suicide prevention strategy in Norway is to provide follow-up for suicide attempters, there is a need ...

Awarded: NOK 2.2 mill.

Project Period: 2007-2011

Location: Oslo

YFF-Yngre, fremragende forskere

Lipocalin 2 - a novel antimicrobial protein: Role in mycobacterial disease, urinary tract infection and in wound healing

Infectious diseases remain the main cause of premature death worldwide and antimicrobial resistance is increasing. Consequently, the WHO stresses that there is an urgent need for new drugs and supplementary treatment regimens against infectious agents. We have recently discovered a novel mechani...

Awarded: NOK 8.2 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

FRIMED-Klinisk medisin og folkehelse

Basic and clinical studies of peptide-based immunotherapy in chronic HIV-1 infection

Immune based therapies represent new, promising approaches to the treatment of chronic HIV infection, aiming to enhance the patients own specific immune response against HIV and delay the immune impairment caused by the HIV-infection. The basis for this a pplication is two patient cohorts that ha...

Awarded: NOK 0.76 mill.

Project Period: 2007-2010

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Functional magnetic resonance imaging (fMRI) for the study of brain mechanisms in schizophrenia (NEVROMENT)

We propose a new Bergen-Oslo collaborative fMRI (and related MR measures, VBM, DTI, MRS) research project on auditory hallucinations and delusions in schizophrenia. We believe that a focus on restricted research questions, with a priori hypotheses and str ict experimental designs has a better pot...

Awarded: NOK 4.5 mill.

Project Period: 2007-2011

Location: Vestland

EMBLNODE-Nord EMBLsenter i molekylærmed

Norsk senter for molekylærmedisin (NCMM) - Centre for Molecular Medicine Norway - Nordic EMBL Partnership

Norsk Senter for Molekylærmedisin (NCMM) er et nasjonalt forskningssenter og fungerer som drivhus for unge, talentfulle forskere innen molekylærmedisin, bioteknologi og translasjonsforskning. Senterets overordnede visjon er å forbedre den molekylære forståelsen av helse og sykdom for å kunne forb...

Awarded: NOK 182.8 mill.

Project Period: 2007-2025

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

The genetically-defined Parkinson's disease. A study of biomarkers in patients and healthy carriers of the Park8 G2019S mutation.

The mechanisms behind the development of PD are still obscure, but it is clear that PD is heterogeneous both in terms of cause, phenotype, progression, and response to treatment. Reproducible biomarkers for PD susceptibility and/or progression that are se nsitive and specific have long been sough...

Awarded: NOK 1.2 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Mental disorders and developmental deviations in children (6-36 months) with congenital heart disease (CHD): a prospective case-control stud

Background: Congenital heart disease (CHD) occurs among 0.5-1.0% of newborns. Treatment possibilities have been dramatically improved during the past decade, leading to increased survival rates. How-ever, previous studies in CHD survivors suggest a higher risk of mental disorders, such as anxiet...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Exploring the T cell receptor genome - the next generation cancer immunotherapeutics

We will generate recombinant T cell receptors (TCRs) that recognize cancer cells. DNA encoding the receptors forms basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) T cells that recognize telomerase have been isolated ...

Awarded: NOK 2.3 mill.

Project Period: 2007-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neurogenetics of attention in the aging brain

Aging was recently described as a ?neurocatastrophe? involving increased oxidative stress, disturbed energy homeostasis, accumulation of damaged proteins, and lesions in nucleic acids (Mattson & Magnus, 2006), making aging the primary risk factor for deve lopment of neurodegenerative diseases. Ag...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Oslo

SFF-Sentre for fremragende forskn

Centre for Cancer Biomedicine, CCB

Grunntanken bak dannelsen av CCB var å forene basalbiologisk forskning på mekanismer i kreftutvikling med pasientnær kreftforskning som tar sikte på å identifisere nye kjennetegn på kreft som kan brukes i diagnose, prognose og terapi. Dette har vist seg som en vellykket forskningsstrategi, og CCB...

Awarded: NOK 120.6 mill.

Project Period: 2007-2018

Location: Oslo

BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Senter for rus- og avhengighetsforskning - SERAF

Tildelingen fra NFR har gjennom 10 år gjort det mulig for SERAF å utvikle og å drive klinikknær rusmiddelforskning på høyt internasjonalt nivå. Vi har bidratt til en bedre, kunnskapsbasert behandling av rus- og avhengighetslidelser i Norge, gjennom å bidra til et lokalt basert og forankret kunnsk...

Awarded: NOK 100.9 mill.

Project Period: 2007-2020

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Brain and brain cell injury in newborn infants

The main objective of the proposed project is to investigate basic mechanisms for regulation of brain injury and brain cell death in newborn infants. Specifically, we propose to study these mechanisms as they relate to two common causes of brain damage in the newborn period, namely asphyxia (hyp...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Imaging of memory circuitry to evaluate memory loss in Alzheimer's disease models

Memory loss is among the first signs of Alzheimer's disease, and it progresses to encompass all aspects of a person's past and present life experiences. The severity of Alzheimer's disease and its increasing incidence with changing demographics require a tremendous effort in finding treatments. P...

Awarded: NOK 1.00 mill.

Project Period: 2007-2009

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

DELAYED SLEEP PHASE SYNDROME. PREVALENCE, DEVELOPMENTAL HISTORY, PERSONALITY AND TREATMENT

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder assumed to peak in adolescence and young adulthood. It is characterized by a delay in the sleep wake-rhythm which causes prolonged sleep onset latency and problems getting up in the morning. The disorder often has negative i...

Awarded: NOK 2.0 mill.

Project Period: 2007-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Awarded: NOK 8.0 mill.

Project Period: 2007-2011

Location: Oslo

FOLKEHELSE-Folkehelse

Physical activity and chronic pain in HUNT 3 - A prospective cohort study

Regular physical activity promotes health. An inactive lifestyle may alter gene expression, influence negatively on several organ systems and thereby cause chronic disease and increase mortality. These conditions may be reversed by regular activity and in creased level of physical fitness. Physic...

Awarded: NOK 5.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Anxiety disorders in children- association with neurodevelopmental delay/disorder and temperament/personality. A clinical case-control study

Anxiety disorders (AD's) in childhood are common and may cause great suffering.Childhood AD's may persist into adulthood and knowledge of important risk factors for development and maintenance of these disorders is essential.The development of AD's is due to a complex interaction between biologi...

Awarded: NOK 5.4 mill.

Project Period: 2007-2010

Location: Oslo

KLINISK-Klinisk forskning

Functioning disturbance in chronic back pain: Altered muscle activation pattern, muscle metabolism and pain-cognitions.

There is evidence that individuals with chronic non-specific back pain (CNSBP) show altered muscle activation patterns. It is unknown why these alterations in activation pattern occur, which consequences this may have for muscle metabolism and how they ar e linked to pain experience and developme...

Awarded: NOK 2.0 mill.

Project Period: 2007-2015

Location: Vestfold

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Attention deficit /hyperactivity disorder (ADHD): Risk factors, comorbidity and gene-environment interactions.

Attention deficit hyperactivity disorder (hyperkinetic disturbance; ADHD) is a common condition in school age children (world-wide prevalence estimates 3-7 %). In addition most affected individuals will continue to show symptoms as adults. Still, it has l ong been considered a controversial diagn...

Awarded: NOK 3.0 mill.

Project Period: 2007-2011

Location: Vestland

PSYKISK-Psykisk helse

EARLY BIPOLAR DISORDER: CLINICAL AND BIOLOGICAL CHARACTERISTICS IN FIRST EPISODE MANIA

Bipolar disorder (BPD) is a severe psychiatric disorder characterized by manic and depressive episodes with periods of normal mood in between. Recent lines of evidence suggest that BPD is a more severe illness that previously believed and it is regarded as one of the most important factors contr...

Awarded: NOK 4.7 mill.

Project Period: 2007-2011

Location: Oslo

KLINISK-Klinisk forskning

Patient education in patients with chronic obstructive pulmonary disease (COPD) and rheumatic disease: effect, experiences and costs

This is (hopefully) an improved version of an earlier application to NFR that was reviewed as both "a high quality research program" and "poorly written and non-competitive". The comments from the reviewers have been used to revise the project. Patient e ducation has become a task that is dictat...

Awarded: NOK 3.9 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

KLINISK-Klinisk forskning

Spontaneous firing activity in motoneurones of cervical paraspinal musculature in healthy subjects and in patients with neck pain

I prosjektet "Spontan elektrisk aktivitet i nerveceller til nakkemuskler hos friske frivillige og nakkesmertepasienter" forsøker vi å forstå mer av årsakene til nakkesmerter, ved å studere hvordan nerveceller i ryggmargen styrer nakkemusklene i ro og ved bevegelser. Vi ønsker å finne ut om disse...

Awarded: NOK 4.3 mill.

Project Period: 2007-2014

Location: Oslo

GNBIO-Grunnleggende næringsrettet bioteknologi

Tumor Targeting Antibodies in Colorectal Cancer

Objective: The main purpose is to identify and characterize novel antibodies recognizing specific antigens on colorectal cancer cells. Interesting candidates will be thoroughly examined for their specificity and their ability to be used as diagnostic and/ or prognostic markers. Their potential as...

Awarded: NOK 2.2 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Computational models of aberrant attribution of salience in schizophrenia and the effects of medication: An event related fMRI study

It has been known for decades that dopamine abnormalities are relevant to the pathophysiology of schizophrenia (mainly psychotic symptoms) and that blocking the dopamine system is associated with improvements in symptoms. How one gets from this neurochemi cal change to the expressed behavior abno...

Awarded: NOK 2.5 mill.

Project Period: 2007-2012

Location: Oslo

KLINISK-Klinisk forskning

Genetic susceptibility and development of chronic sciatic pain - possible implications for future treatment

Previous findings suggest that development of chronic sciatic pain results from multiple functional changes in the peripheral and central nervous system. As described in this grant proposal, several recently described human genetic variants may affect suc h processes. Hence, individual genetic su...

Awarded: NOK 1.8 mill.

Project Period: 2007-2010

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Norwegian PET Conference and Seminar Series

This application is for fundiing for conference and seminar series to develop the Positron emission tomography (PET) method into an important tool in the study of the Brain and Brain-derived human disease. It is based on the Norwegian Medical Cyclotron Ce nter (NMS) in Oslo and the Bergen PET Cen...

Awarded: NOK 0.30 mill.

Project Period: 2007-2009

Location: Oslo

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Quantitative MR imaging used to gain new knowledge of perinatal brain injury- from newborns to young adults with very low birth weight

The neurological adult outcome of VLBW and ELBW survivors is of great interest to society. Perinatal brain injury has major impact both economically, for health care and emotionally for parents and children as they develop into adulthood. Combining quanti tative MRI and clinical research, may ser...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

NEVRONOR-Nasjonal satsing på nevrovitenskap f

Combining electrophysiological recording and imaging in investigations of the rod pathway of the retina

The retina serves as an ideal model system for investigations that aim to bridge the gap between systems level descriptions and underlying mechanisms at cellular and molecular levels. The principal objective is to understand, at a molecular and microphysi ological level, the integrative dynamics ...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Improved individualized diagnosis and treatment monitoring of prostate and breast cancer by combining new MR and ultrasound technology

This project deals with combining new methods in medical ultrasound (US) and Magnetic Resonance (MR) imaging to improve individualized diagnosis and treatment monitoring of prostate and breast cancer. The project includes further development of new techno logy and taking this technology into clin...

Awarded: NOK 3.7 mill.

Project Period: 2007-2012

Location: Trøndelag - Trööndelage

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