0 projects

Date from new to old

GLOBHELS-Global helse

Development of novel vaccine candidates to prevent primary or reactivated tuberculosis

Mycobacterium tuberculosis is among the major infectious pathogens in the world, and has a considerable impact on children and adults of disease endemic countries. Increasing spread of multi-drug-resistant tuberculosis and the general failure of the BCG v accine, have made vaccine development aga...

Awarded: NOK 78,999

Project Period: 2008-2010

Location: Vestland

GLOBHELS-Global helse

Development of an improved vaccine towards meningococcal disease in sub-Saharan Africa

Epidemics of meningococcal disease are a significant health problem in most African countries and there is a strong need for improved and affordable vaccines. We are here proposing a collaborative program between Norway and Cuba to provide a new approach for prevention of bacterial meningitis in ...

Awarded: NOK 0.20 mill.

Project Period: 2008-2008

Location: Oslo

GLOBHELS-Global helse

A rapid serological screening method for detecting tuberculosis disease and monitoring vaccine-induced immunity

The main project is to develop, evaluate and validate a rapid and inexpensive serological screening test for the detection of tuberculosis disease that is suitable for use in the developing world. Using an appropriate novel combination of antigens, we wil l develop a test that can detect and diff...

Awarded: NOK 0.12 mill.

Project Period: 2008-2008

Location: Oslo

GLOBHELS-Global helse

Improving Coverage of the EPI versus Inclusion of New Vaccines into the Existing Programme: Equity, efficiency and cost-effectiveness

We apply for NOK 200 000 through the GLOBVAC programme to establish a research project to look into equity, efficiency and cost-effectiveness implications of alternative policies to improve immunization in low income countries from a health systems perspe ctive. The main consortium members are U...

Awarded: NOK 0.20 mill.

Project Period: 2008-2010

Location: Vestland

GLOBHELS-Global helse

Evaluation of the Impact of the Integrated Management of Neonatal and Childhood Illness Strategy on Neonatal and Infant Mortality

This is a recently initied cluster-randomized trial in Haryana, North India. Eighteen geographical areas served by Primary Health Centres (PHCs) (average population 30,000) were randomized to intervention or comparison areas. The IMNCI intervention includ es three main components: a) improvements...

Awarded: NOK 7.4 mill.

Project Period: 2008-2012

Location: Oslo

GLOBHELS-Global helse

The Immunogenicity and Protective Efficacy of Plant-Derived Influenza H5N1 Vaccine in Preclinical Models.

Influenza epidemics remain a burden to both human health and national economies, and parenteral influenza vaccines are the most effective prophylactic measure. The global spread of highly pathogenic avian influenza H5 virus, causing the largest and most s evere avian outbreaks in history, poses a...

Awarded: NOK 5.0 mill.

Project Period: 2008-2012

Location: Vestland

GLOBHELS-Global helse

International workshop to discuss quality standards of indigenous and alternative medicine in multicultural settings in Meso-America

Background: Latin America has a thousand-year long culture in traditional medicine with fundamental ideas common to all the cultures. Treatment of diseases using herbs is part of their cultural heritage and traditional medicine is integrated in current be liefs about the causes of ill health. The...

Awarded: NOK 0.11 mill.

Project Period: 2008-2009

Location: Troms - Romsa - Tromssa

GLOBHELS-Global helse

Accessibility to health services among people with disabilities in southern Africa

This research project will study the availability and accessibility of health services to people with disabilities and the degree of inclusion of people with disabilities in health service delivery in South Africa and Malawi. By focusing on people with d isabilities in these two African countrie...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Oslo

GLOBHELS-Global helse

2nd generation Vaccibodies for infectious diseases

Aim: PI (Bjarne Bogen) and co-workers have recently reported on a novel vaccine technology, Vaccibodies, which appears very potent. The object of the present proposal is to further improve the design and immunogenicity of Vaccibodies (resulting in 2nd gen eration Vaccibodies). Background: New an...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Oslo

GLOBHELS-Global helse

Impact of a new and affordable conjugate meningococcal vaccine on carriage of serogroup A Neisseria meningitidis and disease transmission

Meningococcal meningitis is causing repeated massive epidemics in an area south of Sahara, termed the meningitis belt. The disease-causing bacteria are mainly serogroup A meningococci. These are transmitted between individuals by air-borne droplets and as ymptomatic carriers are the principal sou...

Awarded: NOK 11.1 mill.

Project Period: 2008-2011

Location: Oslo

GLOBHELS-Global helse

Multi-disciplinary approach to Explaining Differential Immunization Coverage

Although there exist effective vaccines for many life-threatening diseases, access to these technologies remains limited in many low and middle income countries. The proposed project address the question: Why are some low-income countries and communities therein far more successful than others in...

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Oslo

GLOBHELS-Global helse

OMEVAC (Open Mobile Electronic Vaccine Trials), an interdisciplinary project to improve quality of vaccine trials in low-resource settings

Emerging international standards and regulations will in few years require complete electronic systems for management of a vaccine trials. Clinical trials conducted in low-income countries need to have the same level of quality and reliability as comparab le studies conducted in high-income count...

Awarded: NOK 10.0 mill.

Project Period: 2008-2013

Location: Vestland

GLOBHELS-Global helse

Phase IIb-Test of Concept Clinical Trial of the Peptide-based HIV-1 Therapeutic Vaccine Candidate Vacc-4x

Combination antiretroviral therapy (ART), the daily life long treatment for human immunodeficiency virus (HIV) infection is costly and associated with adverse side effects following long term use (e.g. metabolic toxicity). This study will further the cli nical development of the peptide-based HI...

Awarded: NOK 5.0 mill.

Project Period: 2008-2009

Location: Oslo

GLOBHELS-Global helse

Conference: Genetic vaccines - benefits and challenges

The Norwegian Biotechnology Advisory Board apply for financial support to arrange a state-of-the-art vaccine conference addressing the risks and benefits of new genetic vaccines, the need for these vaccines in developing countries and the regulatory chall enges Norwegian legislation puts on Norwe...

Awarded: NOK 0.20 mill.

Project Period: 2008-2009

Location: Vestland

GLOBHELS-Global helse

Right to health trough litigation? Can court enforced health rights improve health policy and priority setting in poor countries?

Background A majority of the world's governments are obliged through international treaties or national constitutions, or both, to respect, protect, promote and fulfill the human right to health. Cases regarding the right to health care are increasingly b rought before the courts in a number of l...

Awarded: NOK 9.7 mill.

Project Period: 2008-2012

Location: Vestland

GLOBHELS-Global helse

HIV vulnerability and HIV prevention needs among men who have sex with men in Tanzania

All over the world, sex between men has been associated with increased risk for HIV transmission. In Africa, however, the impact of the HIV epidemic on men who have sex with men (MSM) has not been well studied. In Tanzania, no previous study has been cond ucted. MSM have also not been a prominent...

Awarded: NOK 2.3 mill.

Project Period: 2008-2012

Location: Oslo

GLOBHELS-Global helse

IMPROVING DIAGNOSIS, TREATMENT AND CONTROL OF CHILDHOOD TUBERCULOSIS

Tuberculosis (TB) is a major public health problem. Despite strides in case detection and treatment, the prevalence of TB continues to rise at an alarming rate. Globally, childhood TB contributes to 15% of the total TB disease caseload, predominantly in d eveloping countries. More effective diagn...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Vestland

GLOBHELS-Global helse

Phase III double blind placebo-controlled trial of infant periexposure prophylaxis with 3TC to prevent HIV-1 transmission by breastfeeding

Postnatal transmission of HIV-1 through breast milk remains an unsolved problem in many resource-poor settings. In Sub-Saharan Africa, especially in the rural areas, replacement feeding has proven a problematic alternative because of social, cultural, eco nomic and hygienic constraints. Moreover,...

Awarded: NOK 12.5 mill.

Project Period: 2008-2014

Location: Vestland

GLOBHELS-Global helse

Indoor air pollution. A neglected poverty related cause of global ill health -impl. for health and society of promoting clean fuels in China

Smoke from solid fuels (biomass and coal) burned in households is among the leading health threats for people in developing countries, and is responsible for more than 1.6 million premature deaths annually - a quarter of which occur in China. Dependency o n these fuels thus constitutes a main str...

Awarded: NOK 6.7 mill.

Project Period: 2008-2012

Location: Oslo

GLOBHELS-Global helse

Immunity towards mycobacteria - identification of avirulent vaccine strains and therapeutic targets

Tuberculosis (TB) kills nearly 2 million people each year, and, together with HIV, Mycobacterium tuberculosis top the WHO list of deaths caused by infectious agents. In HIV infected individuals, Mycobacterium avium complex (MAC) is a major cause of second ary lethal infections. The only vaccine c...

Awarded: NOK 5.0 mill.

Project Period: 2007-2014

Location: Trøndelag - Trööndelage

GLOBHELS-Global helse

Further Developments of New Immunogenic Peptide-based HIV Vaccines Targeting Dendritic Cells

Therapeutic HIV vaccines targeting dendritic cells have so far shown more promising results than preventive HIV vaccines and may become an alternative even for prophylaxis. This Proposal describes plans for basic clinical studies on further characterizati on and developments of new immunization s...

Awarded: NOK 7.4 mill.

Project Period: 2007-2013

Location: Oslo

GLOBHELS-Global helse

Preparing for tuberculosis vaccine efficacy trials: Baseline epidemiology, improved diagnosis, markers of protection and phase I/II trials

This collaboration between scientists in Denmark, India, Norway, South Africa and the U. S. will conduct 3 large cohort studies of tuberculosis (TB) in Palamaner, India, using state of the art immunology to identify correlates of protective immunity and i ncipient disease. These cohorts will be a...

Awarded: NOK 18.5 mill.

Project Period: 2007-2014

Location: Vestland

GLOBHELS-Global helse

Project establishment: Development of vaccine(s) against infections with diarrheagenic Escherichia coli and Shigella

Diarrheal diseases are the second most common cause of death in children, accounting for 1/5 of the 10.6 million annual child deaths. In addition, repeated episodes of diarrhea, especially if prolonged and associated with growth faltering, are an importan t cause of malnutrition in developing cou...

Awarded: NOK 0.30 mill.

Project Period: 2007-2007

Location: Vestland

GLOBHELS-Global helse

Integrated Health Information Systems (HIS) for vaccination in developing countries

Improving immunisation coverage is seen as a cost effective and efficient means for improving the health of populations. However, increasing focus is being directed at populations where coverage is poor, and to populations who are marginalised and therefo re at risk. Identifying these groups is n...

Awarded: NOK 10.0 mill.

Project Period: 2007-2013

Location: Oslo

GLOBHELS-Global helse

Novel vaccine candidates and delivery systems for HIV and influenza

Aim: We wish to generate novel vaccines for important infectious diseases such as HIV (FRIBIOMOL)and influenza (GLOBVAC). Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However, for some important diseases such as HIV, there are no available vacc...

Awarded: NOK 2.0 mill.

Project Period: 2007-2011

Location: Oslo

GLOBHELS-Global helse

LAYVAC: Lay health worker programmes for vaccine uptake in low and middle income countries: Developing a global knowledge-base

Background: Lay health workers (LHWs), who carry out healthcare functions but have no professional healthcare qualifications, are used widely and have the potential to improve vaccination uptake in low and middle income countries (LMICs). However, data on their effects, cost-effectiveness and su...

Awarded: NOK 10.5 mill.

Project Period: 2007-2012

Location: Oslo

GLOBHELS-Global helse

Explaining Differential Immunization Coverage: a multi-disciplinary approach

The Universal Childhood Immunization campaign has been hailed as a success story. At the UNICEF summit in 1990 it was declared that the target had been achieved. Since then, however, immunization coverage has deteriorated. But coverage is highly uneven be tween different countries and regions. In...

Awarded: NOK 0.28 mill.

Project Period: 2007-2007

Location: Oslo

GLOBHELS-Global helse

New rotavirus vaccines: targeting childhood morbidity and mortality in low- and middle-income countries in Central Asia

The current project is aimed at reducing morbidity and mortality caused by rotavirus (RV) disease among young children in low- and middle-income countries in Central Asia. RV is the most common cause of severe acute gastroenteritis in young children and a major cause of childhood death in develo...

Awarded: NOK 8.8 mill.

Project Period: 2007-2012

Location: Oslo

GLOBHELS-Global helse

Development and validation of delivery technology for gene based prophylactic vaccines

While conventional vaccines have been instrumental in fighting a number of diseases, they have proven less successful against pathogens that require a strong cellular immune response for protection such as HIV, malaria and tuberculosis. A new and promisi ng vaccine technology is based on deliver...

Awarded: NOK 0.17 mill.

Project Period: 2006-2008

Location: Oslo

GLOBHELS-Global helse

Pectin products from Malian medicinal plants, can they combat ailments related to the immune system?

The objective of this proposal is to identify immunological active pectin polysaccharides from Malian medicinal plants, traditionally used for wound healing and combating infections such as malaria and schistosomiasis. The use of conventional medicines is too expensive for the majority of people...

Awarded: NOK 5.3 mill.

Project Period: 2006-2011

Location: Oslo

1 2 3