0 projects

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BIA-Brukerstyrt innovasjonsarena

Industrialisert produksjon av digital terapi.

Changetech AS er et norsk selskap som industrialiserer tjenester innen psykologi, nærmere bestemt psykologiske endringer. Dette skjer ved bruk av digitale kanaler (mobiltelefon, internett, mv.). De sentrale fagpersonene bak Changetech har tidligere laget en ikke-industrialisert løsning for røykes...

Awarded: NOK 5.7 mill.

Project Period: 2008-2011

Location: Oslo

PSYKISK-Psykisk helse

Long term effects of early intervention in psychosis: Ten year follow-up of the TIPS study.

Mental illness is now the largest cause of disability in the developed countries, and schizophrenia is ranked among the leading causes of the total burden of disease worldwide. In addition to personal suffering, the disorder also represents a major proble m to society In spite of more than 75 000...

Awarded: NOK 1.9 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Development of a peptide-based therapeutic vaccine to combat HIV disease (chronic immune stimulation)

This project aims to develop a novel therapeutic vaccine that induces nonneutralising antibodies to human immunodeficiency virus (HIV) to modulate disease rather than inhibit infection. Much evidence has now accumulated supporting the concept that acquire d immunodeficiency syndrome (AIDS) is an ...

Awarded: NOK 7.9 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utveckling av analysmetod för kvantitativ bestämning av blodlipider i helblod.

Ett flertal epidemiologiska undersökningar har påvisat ett klart orsakssamband mellan nivåerna av vissa blodfetter och risk för hjärtkärlsjukdom. LDL (det dåliga kolesterolet) är den viktigaste riskfaktoren och höga LDL-nivåer ökar risken för att drabbas av hjärtkärlsjukdom. HDL (det goda koleste...

Awarded: NOK 2.9 mill.

Project Period: 2008-2010

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Utvikling og bruk av nye seleksjons og high throughput screeningsverktøy for effektiv stammeforbedring i prosesser for produksjon av antib

Prosjektet er et samarbeid mellom Alpharma AS, SINTEF materialer og kjemi og Institutt for Bioteknologi ved NTNU. Prosjektdeltagerne har arbeidet sammen i en rekke prosjekter de siste 15 årene og har i felleskap utviklet flere kommersielt lønnsomme biopro sesser for produksjon av ulike antibiotik...

Awarded: NOK 10.3 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bioinformatics platform for the pharmacogenomic analysis of sequence variation in complex diseases

Traditional studies of complex disease and drug response have utilized a one gene one drug strategy. However because of highthroughput technology , the future trend of personalized medicine lies in understanding and modulating the complex responses involv ing many genes, their sequence variation ...

Awarded: NOK 3.5 mill.

Project Period: 2008-2011

Location: Oslo

BIA-Brukerstyrt innovasjonsarena

Nyrefunksjonsmåling basert på måling av cystatin C i en enkelt fullblodsprøve

Gode rutinemetoder for klinisk målinger av nyrenes filtrasjonshastighet er etterspurt. Gullstandardmetodene baserer seg på injeksjoner av fremmede substanser og/eller urinsamlinger over ett døgn, og egner seg spesielt dårlig hos barn. Som surrogatmarkør a nvendes måling av kreatinin i blodet, som...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Østfold

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Awarded: NOK 4.5 mill.

Project Period: 2008-2015

Location: Oslo

GLOBHELS-Global helse

The Immunogenicity and Protective Efficacy of Plant-Derived Influenza H5N1 Vaccine in Preclinical Models.

Influenza epidemics remain a burden to both human health and national economies, and parenteral influenza vaccines are the most effective prophylactic measure. The global spread of highly pathogenic avian influenza H5 virus, causing the largest and most s evere avian outbreaks in history, poses a...

Awarded: NOK 5.0 mill.

Project Period: 2008-2012

Location: Vestland

FORNY-3-Kommersialisering av FoUresultater

Obtaining in vivo data to judge the commercial potential of marine diatome apoptogen and marine cyanobacterial organic anion channel blocker

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Awarded: NOK 1.4 mill.

Project Period: 2008-2010

Location: Vestland

RUSMIDDEL-Rusmiddelforskning

Konferanser (SERAF)

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Awarded: NOK 2.3 mill.

Project Period: 2008-2015

Location: Oslo

FORNY-3-Kommersialisering av FoUresultater

Immobilization of sperm cells with prolonged shelf life in vitro and in vivo

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Awarded: NOK 1.7 mill.

Project Period: 2008-2009

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Development of high througput affinity protemics to search for drug targets in cancer.

Antibody array technology, mass-spectrometry and molecular biology techniques are combined to develop a new platform for screening of drug targets in cancer. The technology allows large-scale analysis of protein networks with high sample throughput. The p roject will develop large-scale analysis ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2012

Location: Oslo

RUSMIDDEL-Rusmiddelforskning

VALIDAD Pilot - Development of a valid test battery for assessing driving ability when influenced by drugs

Road traffic safety is a significant issue for society. In the European Union there are approximately 45 000 traffic fatalities annually. The majority of these accidents are caused by human error, and the use of drugs (both prescribed and illegal compound s) is a significant contributor in this r...

Awarded: NOK 1.00 mill.

Project Period: 2008-2009

Location: Trøndelag - Trööndelage

PSYKISK-Psykisk helse

Resource-oriented music therapy for psychiatric patients with low therapy motivation: Randomised controlled trial

Background Previous research has shown positive effects of music therapy for people with schizophrenia and other mental disorders. In clinical practice, music therapy is often offered to psychiatric patients with low therapy motivation, but little resear ch exists about this population. The aim ...

Awarded: NOK 6.1 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Translational Research in Lung Cancer and Palliative Care - from genomics to symptom control

This project will perform functional genomic research with a translational approach that will bring new scientific knowledge into the health care system. The project will identify gene polymorphisms and gene expression profiles that may confer developmen t of lung cancer, and act as a prognostic...

Awarded: NOK 9.3 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Global gene expression of human and rat brain: an integrative genomics study of CNS functions and genetic susceptibility in schizophrenia

Schizophrenia (SCZ) is a serious psychotic disorder ranked among the 10 most disabilitating disesases worlwide (WHO) with a lifetime risk of 1% in the general population. Despite decades of research, the understanding of underlying biological mechanism re mains inadequate and fragmentary and trea...

Awarded: NOK 5.3 mill.

Project Period: 2008-2012

Location: Vestland

YFF-Yngre, fremragende forskere

EXERCISE IN MEDICINE: BIO-EPIDEMIOLOGY OF FITNESS AND CARDIOVASCULAR DISEASE

The western Society epidemic of life-style-related disease is an impending threat to public health, as well as economy, and calls thus for effective, affordable treatment and prevention strategies. The project has the potential to identify the key cellula r and molecular mechanisms underlying the...

Awarded: NOK 10.0 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

GLOBHELS-Global helse

Phase III double blind placebo-controlled trial of infant periexposure prophylaxis with 3TC to prevent HIV-1 transmission by breastfeeding

Postnatal transmission of HIV-1 through breast milk remains an unsolved problem in many resource-poor settings. In Sub-Saharan Africa, especially in the rural areas, replacement feeding has proven a problematic alternative because of social, cultural, eco nomic and hygienic constraints. Moreover,...

Awarded: NOK 12.5 mill.

Project Period: 2008-2014

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

PSYKISK-Psykisk helse

Effectiveness of group and individual treatment of childhood anxiety disorders in ordinary community clinics. A randomized controlled trial.

Anxiety disorders (ADs) in childhood are common, may cause great suffering, and may persist into adulthood. Few children with an AD receive psychiatric treatment for their illness compared to children with ADHD and behavorial disorders. Knowledge of effec tive treatments and predictors of positiv...

Awarded: NOK 6.4 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Phenotypic heterogeneity of glucokinase-diabetes mutations: Studies of structure, function and regulatory mechanisms leading to treatment

Glucokinase (GK) is the major glucose sensor in the pancreatic beta-cell where it catalyses the first step of glycolysis. Mutations in human GK (hGK) can be inactivating or activating. Heterozygous inactivating mutations lead to a mild form of diabetes, M ODY2, while homozygous inactivating mutat...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Vestland

FRIBIO-Biologi og biomedisin

Epigenetic and transcription factor patterns in regulation of cancer-stroma-vascular interactions of human urogenital cancer

In cancer increased cell proliferation outweighs apoptosis and the cancer cells lose contact inhibition and invade surrounding stroma. Genomic instability provides substrate for the evolution and selection of increasingly aggressive cells that invade and metastasize. We have previously reported p...

Awarded: NOK 5.0 mill.

Project Period: 2008-2011

Location: Vestland

GLOBHELS-Global helse

Impact of a new and affordable conjugate meningococcal vaccine on carriage of serogroup A Neisseria meningitidis and disease transmission

Meningococcal meningitis is causing repeated massive epidemics in an area south of Sahara, termed the meningitis belt. The disease-causing bacteria are mainly serogroup A meningococci. These are transmitted between individuals by air-borne droplets and as ymptomatic carriers are the principal sou...

Awarded: NOK 11.1 mill.

Project Period: 2008-2011

Location: Oslo

FORNY-3-Kommersialisering av FoUresultater

Treating blindness by stem cells. Culture, storage, transport and transplantation of corneal epithelium

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Awarded: NOK 4.0 mill.

Project Period: 2008-2009

Location: Oslo

FRIMED-Klinisk medisin og folkehelse

Diabetes and diabetes precursors: detection, classification, prediction, genetics, complications and prevention. The Tromsö Study.

The incidence and prevalence of diabetes mellitus are increasing in many populations, and diabetes is now one of the most prevalent chronic diseases worldwide. Diabetes carries a great disease burden in terms of morbidity, mortality and costs. Most cases are classified as Type 2 diabetes, which h...

Awarded: NOK 3.0 mill.

Project Period: 2008-2011

Location: Troms - Romsa - Tromssa

GLOBHELS-Global helse

Conference: Genetic vaccines - benefits and challenges

The Norwegian Biotechnology Advisory Board apply for financial support to arrange a state-of-the-art vaccine conference addressing the risks and benefits of new genetic vaccines, the need for these vaccines in developing countries and the regulatory chall enges Norwegian legislation puts on Norwe...

Awarded: NOK 0.20 mill.

Project Period: 2008-2009

Location: Vestland

PSYKISK-Psykisk helse

Immunity-linked genes in cognition and schizophrenia

Epidemiological data has clearly identified immune challenges during fetal and early life as a risk factor for developing psychiatric disorders such as schizophrenia and autism. Traditionally the brain was believed to be devoid of immunological responses as its ability to respond by the classical...

Awarded: NOK 5.0 mill.

Project Period: 2008-2010

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Spontaneous preterm birth: a systems biology approach in the Norwegian Mother and Child Cohort Study

sPTB is an unresolved common complex condition in perinatal medicine and is related to long-term disabilities such as cerebral palsy, cognitive and respiratory problems, which will affect the infant in every day life situations. The pathophysiology of sPT B remains poorly understood. Infection an...

Awarded: NOK 15.0 mill.

Project Period: 2008-2012

Location: Oslo

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