0 projects

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FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Awarded: NOK 3.2 mill.

Project Period: 2007-2011

Location: Vestland

IS-BILAT-Mobilitet Norge-USA /Canada

Characterization of human protein N-terminal acetyltransferases and N-terminal acetylation

Even though blocking of the N-terminal end of proteins by the addition of an acetyl group has been known for more than thirty years, only limited information is available describing the mechanism and biological importance of human protein N-terminal-acety lation and protein N-terminal-acetyltrans...

Awarded: NOK 0.15 mill.

Project Period: 2007-2007

Location: Vestland

STAMCELLER-Stamcelleforskning

Tissue engineering in bone defects: Development of porous copolymer scaffolds stimulating stem cell growth and bone regeneration

For repair of bone defects, tissue engineering would be to combine cells capable of osteogenic activity with an appropriate scaffold. Mesenchymal stem cells are multipotential cells that are capable of differentiating into different type of cells dependin g on culture condition. The selection of ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2010

Location: Vestland

STAMCELLER-Stamcelleforskning

Genome plasticity of somatic stem cells

Chromatin organization in stem cells arises from distinct combinations of epigenetic marks resulting in genomic plasticity. Mesenchymal stem cells (MSCs) have received intense attention due to their perceived potential use in regenerative medicine. Nothin g is known, however, on epigenetic marks ...

Awarded: NOK 4.9 mill.

Project Period: 2007-2011

Location: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Klungland, Arne daadppp 0708

...

Awarded: NOK 0.14 mill.

Project Period: 2007-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

Impact of DNA base lesion repair for stem cell maintenance

DNA damage (mutations) are the fundamental cause of all forms of cancer and a number of different but integrated processes operate to prevent genetic changes from occurring. These include cell cycle regulation, DNA replication, transcription, DNA repair, regulation and sanitation of nucleotide po...

Awarded: NOK 5.0 mill.

Project Period: 2007-2010

Location: Oslo

STAMCELLER-Stamcelleforskning

Signaling in neural stem cells: implications for regenerative medicine and tumor biology

Stem cell biology is one of the most closely followed developments in biomedicine today. Stem cells may provide the foundation for rational regenerative therapeutics with far-reaching implications in the health sector, but give also new alleys in the unde rstanding of tumor biology. The central ...

Awarded: NOK 12.4 mill.

Project Period: 2007-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

Cancer and Mesenchymal Stem Cells

Mesencymal stem cells (MSCs) isolated from the human bone marrow, have been suggested, based on their differentiation potential, to be used in tissue regeneration and repair strategies. While these cells may have a considerable therapeutic potential, it i s also possible that they may have unwant...

Awarded: NOK 3.5 mill.

Project Period: 2007-2010

Location: Vestland

STAMCELLER-Stamcelleforskning

The role of HGF and other multiple myeloma cell products in osteoblastogensis from bone marrow stem cells.

Multiple myeloma, which is the second most frequent haematological cancer, is du to malignant transformation of antibody producing plasma cells. The tumour cells are found in the bone marrow, and severe bone degradation is characteristic for the disease. The presence of the malignant plasma cell ...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Awarded: NOK 2.5 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

1st Seeberg Symposium on DNA repair

...

Awarded: NOK 99,999

Project Period: 2006-2006

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

1st Seeberg Symposium on DNA repair

...

Awarded: NOK 0.15 mill.

Project Period: 2006-2006

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional characterisation of AlkB-like macromolecular demethylases

We have recently discovered a novel mechanism for repairing methylation damage in DNA and RNA. The repair reaction occurs by oxidative demethylation, and can be performed both by human and bacterial AlkB proteins. Eight different AlkB-like proteins are fo und in the human genome, and the project ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Opioidergic signaling mechanisms in pain and dependence: PET opioid receptor binding. I. animal studies.

We are all naturally dependent on opioids for our emotional health. The opioid system is activated during the experience of pain, and opioids are used as analgesia and for abuse. Intentionally, opioid analgesia in pain and opioid drug abuse are contrary t o each other, but there are several commo...

Awarded: NOK 2.8 mill.

Project Period: 2006-2009

Location: Ukjent Fylke

IS-BILAT-Mobilitet Norge-USA /Canada

Cellular and physiological studies of mouse models of diabetes and exocrine deficiency due to mutations in carboxyl-ester lipase

We have recently discovered a novel monogenic diabetes syndrome with combined endocrine and exocrine pancreatic dysfunction, which is caused by mutations in the carboxyl-ester lipase gene (Ræder et al, Nature Genetics, in review). Our findings link diabet es to dysfunction of a lipase in the panc...

Awarded: NOK 60,000

Project Period: 2006-2006

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

The control of growth by insulin and TOR pathways in Drosophila: identification and characterisation of modifiers of starvation through a ge

This research projects aim to characterising some general mechanisms of growth control. Growth is a complex process, which depends both on internal cues, or genetic parameters, and external influences, like nutrition, exercise or temperature. It is well r ecognized that nutritional input is of gr...

Awarded: NOK 1.6 mill.

Project Period: 2006-2011

Location: Ukjent Fylke

FRIBIO-Biologi og biomedisin

Molecular characterization of embryonic microenvironment that stimulates adult human hematopoietic stem cells to differentiate into neurons

Recent research from the applicant and colleagues has shown that adult human hematopoietic stem cells, derived from bone marrow biopsies, can be stimulated to differentiate into nerve cells by placing them into the injured spinal cord of a chicken embryo. The injured embryonic spinal cord regen...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Studies of mesenchymal cell function during development and disease using transgenic techniques.

Cells interact with collagens using specific cell surface protein receptors belonging to a family called integrins. We have identified one collagen-binding integrin (alpha11beta1), characterized its structure and are studying its function using genetical ly modified mice lacking alpha 11 integri...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

PPAR activation and mitochondrial function in obesity related diseases.

Disorders of lipid metabolism are intimately connected to many common, life-style related diseases. Obesity and obesity-related disorders, often referred to as the metabolic syndrome, is a serious condition with the presence of a number of risk factors li ke overweight, dyslipidaemia, hypertensio...

Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Endothelial cell differentiation - a key to future therapy of chronic inflammation and cancer

Much attention is focused on understanding the role of vascular endothelial cells in disease. In several fields of medicine, there is great interest in understanding the mechanisms that regulate the generation of new vessels and endothelial cell different iation, because the future ability to man...

Awarded: NOK 1.8 mill.

Project Period: 2005-2009

Location: Oslo

STAMCELLER-Stamcelleforskning

EuroSTELLS Project: Translational Stem Cell Research: From Basic Biology to Regenerative Medicine

This project involves the joined forces of 13 research groups from 6 countries with common interests and complementary competence in developmental biology, stem cell biology and regenerative medicine and cancer biology. The consortium aims at elucidating the mechanisms that control self-renewal a...

Awarded: NOK 3.0 mill.

Project Period: 2005-2009

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Nasjonalt forskerkurs ved NCS

...

Awarded: NOK 52,999

Project Period: 2005-2005

Location: Oslo

FRIBIO-Biologi og biomedisin

Timing of initiation of replication in E. coli

The research project described here is aimed at understanding the molecular mechanisms that govern timing of DNA replication in E. coli. We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replica tion occurs precisely at the same point i...

Awarded: NOK 2.7 mill.

Project Period: 2005-2008

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Novel modulators and downstream targets of the cAMP receptors Epac and PKA

I: Obtain genomic DNA suitable for recombinant deletion of Epac1 in ES cells, produce Epac1 null mice. II: a) Use mapping data of more than 100 cAMP analogs for PKA type I,II and Epac to predict effect of cAMP modifications on binding. Design new discriminating analogs. b) Identify new ATP-site...

Awarded: NOK 4.0 mill.

Project Period: 2005-2012

Location: Vestland

STORFORSK-Store forskerinitierte prosjekter

Adipose Stem Cells: Molecular Basis of Pluripotency

Stem cells reside in many adult tissues and are responsible for maintaining tissue homeostasis. Adipose tissue-derived mesenchymal stem cells (ASCs) display sufficient plasticity to differentiate into cell types outside their predicted developmental linea ge. This might create opportunities for a...

Awarded: NOK 18.5 mill.

Project Period: 2005-2011

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Norwegian Center for Stem Cells, dekning av reiseutgifter

...

Awarded: NOK 31,499

Project Period: 2005-2006

Location: Oslo

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