0 projects

Date from new to old

SFF-Sentre for fremragende forskn

Centre for Embryology and Healthy Development (CRESCO)

Noen av de mest avgjørende hendelsene i en organismes liv skjer under befruktningen og i de aller tidligste stadiene av embryoutvikling. Disse hendelsene omfatter modning av kjønnsceller, befruktning og aktivering av gener. Genetisk reprogrammering er en forutsetning for befruktning og embryoutv...

Awarded: NOK 155.6 mill.

Project Period: 2023-2033

Location: Oslo

FRIPRO-Fri prosjektstøtte

Epitranscriptomic regulation and genome stability in meiosis and the preimplantation embryo

En av de mest inngående endringene i et liv til en organisme er reprogrammeringen av gener under modning av eggcellen og i det tidligere embryo. Under modning av egg blir gener skrudd av slik at de er helt avhengige av stabile mRNA (mRNA representerer et bindeledd mellom et gen på et kromosom og ...

Awarded: NOK 12.0 mill.

Project Period: 2021-2026

Location: Oslo

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Epitranscriptomic regulation of meiosis and the preimplantation embryo

Dynamiske modifikasjoner på DNA og protein er helt nødvendige for å regulere genuttrykk i cellene våre og det er slike modifikasjoner som gjørt at en hudcelle er så forskjellig fra f.eks en hjernecelle. Slike modifikasjoner har vært kjent i flere tiår. Dynamiske modifikasjoner på RNA er en mye ny...

Awarded: NOK 10.9 mill.

Project Period: 2018-2022

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Reversible 6-methyladenine (m6A) base modification in mRNA: molecular function and role in disease

Kjemiske modifikasjoner i DNA og protein har blitt studert i flere tiår og oppdagelsen av deres reverserbare potensial har endret vår forståelse av dynamisk genregulering.. Det er nettopp identifisert en modifikasjon som er dynamisk i mRNA. Foreløpige resultater indikerer at denne modifikasjonen ...

Awarded: NOK 9.3 mill.

Project Period: 2014-2018

Location: Oslo

STAMCELLER-Stamcelleforskning

Reversible methyl modifications in DNA and RNA: dynamics in stem cell growth and differentiation.

A broad repertoire of modifications is known to underlie adaptable coding and structural function of proteins, DNA and various RNA species. Methylations of mammalian DNA and histone residues are known to regulate transcription and the discoveries of demet hylases that remove methylation in DNA an...

Awarded: NOK 6.0 mill.

Project Period: 2013-2017

Location: Oslo

BIOTEK2021-Bioteknologi for verdiskaping

Method for identification of 5-hydroxymethylcytosine and 5-methylcytosine at single base resolution

Awarded: NOK 4.8 mill.

Project Period: 2013-2017

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

4th EU-US meeting on Endogenous genome damage

The main scientific focus of this meeting will be on DNA repair mechanisms and mutagenesis. Most mutagenic and carcinogenic agents induce covalent changes in the structure of the DNA and living organisms have evolved a large number of gene functions speci fically designed to repair or tolerate su...

Awarded: NOK 0.15 mill.

Project Period: 2011-2012

Location: Oslo

STAMCELLER-Stamcelleforskning

Mapping of histone modifications in totipotent and pluripotent cells in vivo and characterization of a novel epigenetic mark

This project focuses on revealing the epigenetic basis of in vivo pluripotency and totipotency, characterizing a putative novel epigenetic mark with relevance to pluripotency and the characterization of candidate enzymes for the regulation of this mark. Fertilization produces a totipotent zygo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The AlkB family of hydroxylases; unique roles in DNA, RNA and histone hydroxylation/demethylation.

This project is partly based upon the intriguing phenotype and breeding pattern of Alkbh1, Alkbh4 and Alkbh7 (AlkB homolog 1, 4 and 7) targeted mice. Alkbh1 targeting in mice cause sex-ratio distortion and asymmetric left-right eye development. Alkbh1 is highly expressed in embryonic stem (ES) c...

Awarded: NOK 6.8 mill.

Project Period: 2010-2015

Location: Oslo

STAMCELLER-Stamcelleforskning

The AlkB family of demethylases; putative roles in embryonic stem cell identity and epigenetic reprogramming of the germ line.

This project is initiated primarily based upon the intriguing phenotype and breeding pattern of Alkbh (AlkB homologs) targeted mice. Targeting of mouse Alkbh's (8 in total) cause various degree of sex-ratio distortion and developmental abnormalities incl uding asymmetric left-right eye developme...

Awarded: NOK 6.0 mill.

Project Period: 2009-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Role of AlkB homologs 1 and 7 (ABH1 and 7) in epigenetic reprogramming

This project is primarily based upon the intriguing phenotype and breeding pattern of mABH1 (mouse AlkB homolog 1) targeted mice. As outlined below, this dioxygenase is required for faithful embryonic development. Major developmental defects include failu re of eye, nose and limb development (Fig...

Awarded: NOK 5.1 mill.

Project Period: 2008-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Modeling human disease in mice;DNA repair and genomic (in)stability.

Our research is currently focused on two classes of enzymes involved in repair, and possible regulation, of DNA and RNA species; flap endonuclease 1 (FEN1) and mammalian alkB homologs (ABHs). Genetic models are generated in order to elucidate the contribu tion of single gene deletions in genomic ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2011

Location: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Klungland, Arne daadppp 0708

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Awarded: NOK 0.14 mill.

Project Period: 2007-2009

Location: Oslo

YFF-Yngre, fremragende forskere

Toppforskningsprogrammets prosjekt ledet av Arne Klungland

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Awarded: NOK 5.3 mill.

Project Period: 2004-2007

Location: Oslo

IS-DAAD-Forskerutveksl. Norge-Tyskland

Klungland;a. Norge DAADppp 04/05 bevilgning for 2004/05 utbet/bevilget i 04

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Awarded: NOK 0.10 mill.

Project Period: 2004-2005

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional genomics of antioxidant defence mechanisms and DNA repair: Relevance for aging and neurological disease.

The present prosject seeks to bring together a range of novel technologies and multidisciplinary expertise to broaden our understanding of DNA repair mechanisms. Specifically we will explore the hypothesis that deficient DNA repair plays a key pathogenet ic role in neurological disease and in ag...

Awarded: NOK 8.0 mill.

Project Period: 2004-2008

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

DNA repair deficiency

DNA repair deficiency Arne Klungland1, Hans Krokan2 and Erling Seeberg1 1Department of Molecular Biology, Institute of Medical Microbiology, Uni6ersity of Oslo, The National Hospital, 0027 Oslo, Norway 2UNIGEN Center for Molecular Biology, The Norwegian University of Science and Technology, Trond...

Awarded: NOK 4.0 mill.

Project Period: 2002-2006

Location: Oslo