0 projects

Date from new to old

FRIMED-Klinisk medisin og folkehelse

Genetic and environmental influences on reading development and reading disability: A longitudinal twin study

The proposed research will complete the first international longitudinal twin study of genetic and environmental influences on pre-reading and early reading and related skills from preschool (age 5) through the end of kindergarten, 1st, and 2nd grades, wh en children "learn to read", and at the e...

Awarded: NOK 2.1 mill.

Project Period: 2006-2010

Location: Rogaland

FRIBIO-Biologi og biomedisin

Chromatin and differential gene regulation: The role of adjacent PHD fingers and bromo domains in epigenetic regulators

Correct differential gene expression is essential for proper development of tissues and organs. While the initial patterns of gene expression are established by classical transcription factors, the maintenance of correct gene expression relies on epigenet ic mechanisms, one of which relies on dif...

Awarded: NOK 3.2 mill.

Project Period: 2006-2011

Location: Vestland

MATPROG-Matprogrammet: Norsk mat fra sjø og land

Health of mother and child in relation to consumption of organic food during pregnancy and infancy. The Norwegian Mother and child Study

Perceived positive health effects of organic food is a major motivation among consumers for buying organic food. Yet, relatively little is known about associations between organic food in the diet and health effects. This project uses data from The Norweg ian Mother and Child Cohort Study (MoBa),...

Awarded: NOK 4.0 mill.

Project Period: 2006-2012

Location: Oslo

FOLKEHELSE-Folkehelse

The Hordaland Homocysteine and Health Studies - biobanks and follow-up studies

This is a joint application to cover staff (0.5 position) for project and data management, statistical and laboratory services plus running project expences for the Hordaland Homocysteine Study and the Hordaland Health Study. The Norwegian Research Counci l has previously provided such support an...

Awarded: NOK 2.0 mill.

Project Period: 2006-2009

Location: Vestland

KLINISK-Klinisk forskning

Stimulated differentiation of native human acute myeloid leukemia (AML) blasts as a potential cancer-cell specific therapeutic target

Acute myeloid leukemia (AML) is an aggressive disorder characterized by accumulation in the bone marrow of large numbers of abnormal blood cells that fail to develop into normal functional blood cells. This is a life-threatening condition if not treated. Patients under the age of 60 are given int...

Awarded: NOK 2.2 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

The study of translocation of extragenous growth factors into cells- mechanisms and biological function of intracellular growth factors.

The growth, development and repair of cells and organs are controlled by a variety of hormones, growth factors and cytokines. Many of these factors are proteins that bind to specific molecules (receptors) at the cell surface. These receptors reside in the plasma membrane. Lipid membranes control...

Awarded: NOK 3.1 mill.

Project Period: 2006-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional Genomics of Regulatory T cells - Novel Therapeutic Strategies for Immunomodulation

The main goal of the research plan is to understand how the immune system controls immune reactivity and balances self-tolerance versus an efficient immune defence. This could potentially lead to new understanding of key factors in the pathogenesis of hum an disease. Specifically, we aim to inves...

Awarded: NOK 7.0 mill.

Project Period: 2006-2010

Location: Oslo

FOLKEHELSE-Folkehelse

Health Inequalities: Psychosocial Mechanisms in Childhood and Adolescence

Ingrid Leversen disputerte 10.desember 2012 for ph.d-graden med avhandlingen ?Adolescents? leisure activity participation and their life satisfaction: The role of demographic characteristics and psychological processes?. I sin avhandling tar Leversen for seg norske 15- og 16-åringers deltakel...

Awarded: NOK 3.8 mill.

Project Period: 2006-2015

Location: Vestland

PSYKISK-Psykisk helse

SUSCEPTIBILITY GENES FOR SCHIZOPHRENIA AND BIPOLAR DISORDER: TRANSLATING FUNCTIONAL GENOMICS TO CLINICAL PSYCHIATRY.

Schizophrenia (SCZ) and bipolar (BP) disorder are severe mental disorders, which are both ranked among the leading causes of the total burden of diseases worldwide. Despite decades of research devoted to psychotic illnesses, the understanding of underlyin g biological mechanisms is inadequate and...

Awarded: NOK 5.2 mill.

Project Period: 2006-2010

Location: Vestland

MILGENHEL-Miljø, gener og helse

Nano-sized versus larger particles: Does extremely small size introduce unique mechanisms for particle-induced toxicity?

Nanoparticles (NP) have been suggested to be important factors in inducing lung and heart disease of particulate air pollution (PM), and are also increasingly used in industry and medicine. Thus, there is an increasing concern for both public and occupati onal exposure. Generally, inflammation is...

Awarded: NOK 2.0 mill.

Project Period: 2006-2010

Location: Oslo

RUSMIDDEL-Rusmiddelforskning

The Karolinska Project for Early Treatment of Women with Alcohol Addiction (EWA). Mortality and Morbidity 15-25 years after treatment

Summary: This is a unique, prospective longitudinal study of 420 women with alcohol addiction who were treated within a specialized woman only treatment program (EWA) that was started in 1981. Based on a randomised design, 100 of the eligible women were t reated at EWA, while another 100 were ref...

Awarded: NOK 3.8 mill.

Project Period: 2006-2011

Location: Ukjent Fylke

PENGESPILL-Kunnsk.gr.lag pengespill-probl

Treatment of pathological gambling: A comparative study between a cognitive behavioral program and a minimal intervention program

Aims. The study aims at recruiting and offering adequate help for persons with a primary gambling addiction in Helse Vest. A positive treatment outcome is defined as a reduction in a number of gambling addiction symptoms, psychologically, socially and eco nomically. Design and setting. This ran...

Awarded: NOK 4.3 mill.

Project Period: 2006-2010

Location: Vestland

RUSMIDDEL-Rusmiddelforskning

Alcohol problems and depression: A 15-year longitudinal, nationwide study of mental health among Norwegian doctors.

Background: Concurrent depressive disorder and abuse of alcohol is common in the general population, and longitudinal studies that clarify this interplay over time and identify risk factors are highly required. Health care workers and in particular doctor s show high levels of depressive symptoms...

Awarded: NOK 4.2 mill.

Project Period: 2006-2012

Location: Oslo

PSYKISK-Psykisk helse

Effects of integrated and comprehensive treatment to persons with mental disorders and substance use disorders.

Patients with co-occurring substance abuse and mental disorders are characterized by high suicide and treatment drop-out rates, and long-lasting interpersonal, work, school, health and legal problems. And because mental disorders and substance misuse inte ract and co-excists, it is important to p...

Awarded: NOK 4.7 mill.

Project Period: 2006-2009

Location: Trøndelag - Trööndelage

MILGENHEL-Miljø, gener og helse

Human exposure pathways of polyfluorinated compounds and brominated flame retardants used in consumer products as inputs to risk assessment

Recently, concerns have risen about the increasing occurrence of polyfluorinated alkyl compounds (PFCs) and brominated flame retardants (BFRs) in the environment, compounds that are widely used in consumer products. The exposure of humans to PFCs and BFRs and the potential associated health risk...

Awarded: NOK 2.9 mill.

Project Period: 2006-2010

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

The Systems Biology of Breast Cancer

Systems Biology of Breast Cancer creates a world-class cancer research team, working systematically towards understanding of the biological dynamics of breast cancer. Breast cancer is a genetic disease; breast tumor genomes are dynamic and tumors are com plex systems shaped by gene aberrations, ...

Awarded: NOK 9.0 mill.

Project Period: 2006-2010

Location: Oslo

RUSMIDDEL-Rusmiddelforskning

Development of heroin addiction: a consequence of heroin or of its metabolites?

The objective of the present project is to investigate if and how heroin metabolites contribute to the development and appearance of heroin addiction. Heroin abuse is a significant medical problem due to its damaging consequences, both social and individu al, and it is difficult to treat. Heroin ...

Awarded: NOK 1.5 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Protein - DNA interactions at atomic levels

The project aims at exploring protein-DNA interactions at atomic levels using novel DNA-binding proteins. Protein targets will be selected from the genomes of the extremophiles Deinococcus radiodurans and Vibrio salmonicida and produced recombinant in qua ntities necessary for structural and func...

Awarded: NOK 3.1 mill.

Project Period: 2006-2011

Location: Troms - Romsa - Tromssa

FOLKEHELSE-Folkehelse

The epidemiology of prescription drug use. A record-linkage study in Norway

Three surveys will form the basis of this project: a) The Cardiovascular Survey Progamme in Norway 1972-2004, b) The Youth part of a) 2000-2004, c) Norwegian Epidemiological Osteoporosis Studies (NOREPOS) 1994-2001. The information in these databases wil l be supplemented with information on soc...

Awarded: NOK 4.4 mill.

Project Period: 2006-2010

Location: Oslo

PSYKISK-Psykisk helse

Supporting Patient Communication and Coping with Illness in Childhood Cancer

Children with cancer experience complex physical, psychosocial, and behavioural symptoms/problems due to the illness treatment, uncertain diagnosis, and medical procedures. To help children cope with their problems and prevent psychological distress, we d eveloped the support system, Peds-CHOICE,...

Awarded: NOK 3.7 mill.

Project Period: 2006-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Modulation of a PKA-Csk-Lck inhibitory pathway in T cell lipid rafts by CD28-mediated recruitment of a b-arrestin/phosphodiesterase complex

The goal of this project is to understand the molecular mechanisms for cAMP inhibition of lymphocyte proliferation and immune functions. Specifically, we want to understand the molecular interactions and spatio-temporal regulation of the newly mapped PKA- type I-Csk inhibitory pathway regulating ...

Awarded: NOK 2.9 mill.

Project Period: 2006-2009

Location: Oslo

MILGENHEL-Miljø, gener og helse

Aryl hydrocarbon receptor mediated responses to environmental toxicants

A group of environmental pollutants, which may pose a potential health risk to humans, is the polycyclic aromatic hydrocarbons (PAHs). PAHs are found in urban air and occupational environments, and a very large part of the population is exposed to these c ompounds. An important source of PAH expo...

Awarded: NOK 2.2 mill.

Project Period: 2006-2009

Location: Oslo

FOLKEHELSE-Folkehelse

Food and eating among young Norwegians. A sociological analysis of teenagers' food ideologies and practices in an everyday context

The project will focus on the socio-cultural aspects of teen girls and boys food choice and eating patterns. In the qualitative part we will focus on how teenagers describe, explain and give reasons for their food and eating patterns, while the quantitati ve part will map eating behaviour, motiva...

Awarded: NOK 3.2 mill.

Project Period: 2006-2010

Location: Oslo

KLINISK-Klinisk forskning

MOLECULAR MR IMAGING OF BREAST CANCER Treatment monitoring and prognostic evaluation

Successful cancer treatment and recovery depends upon early diagnosis, but also important is the decision on which type of treatment each cancer patient should receive. Through a combination of new contrast agents and improved technology, MR is making adv ances in identifying the functional and m...

Awarded: NOK 5.3 mill.

Project Period: 2006-2010

Location: Trøndelag - Trööndelage

MILPAAHEL-Miljøpåvirkning og helse

The Nordic-Swiss Childhood Brain Tumour Study

During the last decade, the use of mobile telephones has increased dramatically in large parts of the world. It has been hypothesized, that children should be more vulnerable to radio frequency electromagnetic field exposures from mobile telephones than a dults, but no epidemiological studies of ...

Awarded: NOK 1.8 mill.

Project Period: 2006-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Molecular Pathogenetic Mechanisms of Heart Failure - Dissecting GRK Function in The Heart

Heart failure, the final outcome of many cardiovascular disorders, is a major cause of morbidity and mortality in the Western Hemisphere. Indeed, the incidence and prevalence of heart failure in the Western Hemisphere are increasing due to altered demogra phics with increased proportion of elderl...

Awarded: NOK 2.4 mill.

Project Period: 2006-2009

Location: Oslo

MILPAAHEL-Miljøpåvirkning og helse

Environmental noise

Det er tidligere dannet et konsortium av de sentrale norske støyforskningsmiljøene som gikk inn for en samordnet innsats for å nå det nasjonale støymålet: 25 % reduksjon av støyplagen frem mot 2010. Det er allerede klart at tidsaspektet i dette målet ikke vil oppfylles, men reduksjonsmålet anses...

Awarded: NOK 11.7 mill.

Project Period: 2006-2012

Location: Trøndelag - Trööndelage

FOLKEHELSE-Folkehelse

Promoting healthy weight among school children

Increasing rates of overweight and obesity is seen as a major public health problem. In Norway, the prevalence of overweight and obesity among school children has increased during the past decade. While the aetiology of obesity is not fully understood, ch ildren are seen as key target groups for ...

Awarded: NOK 5.9 mill.

Project Period: 2006-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

The role of regulatory T cells in allergy

A dramatic increase in prevalence of allergy observed within the last two decades has been associated with better hygiene, increased use of antibiotics and improved vaccination. Infections are important for the induction of regulatory elements within the immune system, and it has been suggested t...

Awarded: NOK 2.7 mill.

Project Period: 2006-2009

Location: Oslo

VAM-Velferd, arbeid og migrasjon

Tid for omsorg

Pleie- og omsorgstjenestene står overfor store utfordringer. Kommunene søker å møte disse ved dels å sette inn mer ressurser og dels ved å organisere seg slik at de får mer ut av ressursene. Omstillingstakten er stor, men mange kommuner ser ut til å innfø re nye forvaltningsformer uten forsknings...

Awarded: NOK 4.2 mill.

Project Period: 2006-2011

Location: Oslo

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