0 projects

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IS-AUR-Samarb.progr. Norge Frankrike

Functional mapping of brainstem-spinal motor circuits

Understanding how specific groups of neurons contribute to behaviour is a formidable challenge which in mammals requires studying extensive networks. Many motor networks encompass large areas of the central nervous system, mostly due to the presence of lo ng axonal connections such as those conne...

Awarded: NOK 60,943

Project Period: 2011-2013

Location: Oslo

IS-AUR-Samarb.progr. Norge Frankrike

MODULATING AQUAPORIN FUNCTION WITH PEPTIDE APTAMERS

The objective of this proposal is to facilitate the exchange between the CNRS/ENS Lyon Team and the University of Oslo Team to investigate the effect of specific peptide aptamers on aquaporin (AQP) function while investigating the expression and fate of A QP-interacting proteins. A fortuitous obs...

Awarded: NOK 80,000

Project Period: 2011-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Brain energy deprivation in epilepsy

«The Brain and Muscle energy group» har i perioden» 2011-2014 arbeidet med prosjektet-Brain energy deprivation in epilepsy- hvor vi har undersøkt energisituasjonen i hjernen ved epilepsi. Vi har tatt utgangspunkt i melkesyre som en viktig energikilde for hjernen, og vi har vist at hjernens melkes...

Awarded: NOK 6.5 mill.

Project Period: 2011-2014

Location: Oslo

IS-AUR-Samarb.progr. Norge Frankrike

Inhibiting protein-membrane interactions: towards new therapeutic strategies

The goal of the present proposal is to find compounds able to hinder the binding of Proteinase 3 to the neutrophil plasma membrane in vitro. Proteinase 3 is a neutrophil enzyme, present at the surface of the neutrophil plasma membrane and which has been i dentified as a drug target for a number o...

Awarded: NOK 28,700

Project Period: 2011-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Localisation, regulation and functional significance of the SMC-loading complex during eukaryotic cell division.

The strucural maintenance of chromosome (SMC)-complexes organise and stabilise higher order chromosomal conformations during normal cell division, e.g. condensation of chromosomes cell division or generation of inactive chromatin, cohesion of newly replic ated sister chromatids and stabilisation ...

Awarded: NOK 1.5 mill.

Project Period: 2011-2015

Location: Ukjent Fylke

IS-DAAD-Forskerutveksl. Norge-Tyskland

Dissecting the developing vestibulo-ocular reflex circuit: Pharmacogenetic and optogenetic manipulation

A fundamental question in neuroscience is how neuronal circuits are assembled during embryonic and fetal development. Critical features include the establishment of functionally appropriate patterns of synaptic connections and a proper balance between exc itatory and inhibitory connections. Senso...

Awarded: NOK 34,661

Project Period: 2011-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Arc and the molecular control of LTP consolidation in vivo

The brain extracts information about the world that shapes our behavior and ultimately influences who we are as individuals. The immense capacity and specificity of memory storage in the mammalian central nervous system is thought to depend on the plastic ity of synaptic connections. Recent break...

Awarded: NOK 8.0 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic Strategies to Interfere with Inhibition of Anti-tumor Immune Activity Mediated by Regulatory T cells

Prosjektet undersøker en type hvite blodlegemer (regulatoriske T celler) som hemmer andre T celler i immunforsvaret og justerer immunresponser. Disse regulatoriske cellene er normalt viktige for å forhindre autoimmunitet og reumatiske sykdommer. Hvis de derimot virker for sterkt kan det bidra ...

Awarded: NOK 7.8 mill.

Project Period: 2011-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Defining the role of Axl in normal and malignant mammary stem cells

Metastasis accounts for >90% of cancer-related mortality. Malignant cells carry oncogenic mutations that engender uncontrolled growth and epigenetic activation of stem cell features, chemotherapeutic resistance, immune modulation and metastasis. Tumor cel l epithelial-to-mesenchymal transition (E...

Awarded: NOK 4.8 mill.

Project Period: 2011-2015

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The complement system and the CD14/TLR4/MD2 complex as targets for therapy in sepsis.

Prosjektet tar sikte på å utvikle et nytt terapeutisk regime ved tilstander hvor det medfødte immunapparatet er over-aktivert og gir opphav til alvorlig sykdom, slik man ser det ved sepsis (blodforgiftning). Vi har i tidligere studier vist at hemming av to viktige grener av immunapparatet, komple...

Awarded: NOK 8.1 mill.

Project Period: 2011-2017

Location: Oslo

STAMCELLER-Stamcelleforskning

ziPS cells for Biomedicine: zebrafish induced pluripotent stem cells for disease modeling

Sebrafisk er en veldig god dyremodell for modellering av sykdommer fordi den er relativt lett og billig å holde i laboratoriet. Stamceller er en veldig nyttig celletype for modellering av sykdom på laboratoriet. Ved oppstart av prosjektet, var ingen stamceller fra Sebrafisk tilgjengelige. I dette...

Awarded: NOK 6.0 mill.

Project Period: 2010-2015

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

Molecular heterogeneity of breast carcinomas; clinical implication of tumor subclones.

Breast carcinomas are considered a heterogeneous tumor type both at the clinical, pathological and molecular level, and individual tumors can display a wide range of molecular variation. Recent work separating tumor cells into subfractions based on differ entially expressed cell surface markers h...

Awarded: NOK 0.21 mill.

Project Period: 2010-2011

Location: Oslo

IS-BILAT-Mobilitet Norge-USA /Canada

In silico and in vitro search for potential multidrug resistance therapeutics

Multidrug resistance is a particular limitation to medical treatment of diseases related to the major causes of mortality globally, e.g. chemotherapy, antibiotic treatment and HIV medication. The project involves basic research on ABC transporters involve d in multidrug resistance combining theor...

Awarded: NOK 0.10 mill.

Project Period: 2010-2011

Location: Troms - Romsa - Tromssa

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Mechanisms of memory retrieval in the hippocampus

The discovery that hippocampal cells have location-specific activation (place cells), which is extremely reliable and observable during almost any behaviour in a moving rat made the possibility to study neuronal processes and behaviour together. Recent ad vances suggest that place is represented ...

Awarded: NOK 93,999

Project Period: 2010-2011

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

cAMP-mediated regulation of proliferation and cell death in normal and malignant cells

I prosjektperioden 20111001-20161130 har vi publisert 8 artikler direkte knyttet til prosjektet. I prosjektet knyttet til effekten av cAMP på DNA-skadeindusert celledød i akutt lymfoblastiske leukemi-celler (ALL-celler), har vi vist at cAMP-signalering fører til reduserte nivåer av DNA-skadeindus...

Awarded: NOK 3.8 mill.

Project Period: 2010-2017

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Traffic through and around the Golgi apparatus in epithelia -determine the apical and basolateral surface glycoproteomes

The cell surface is decorated with glycans attached to lipids and proteins. Different plasma membrane regions display a specific composition of glycanated proteins and contribute to the definition of interactions at the cell boundary. For epithelial cells , glycans (particularly glycosaminoglycan...

Awarded: NOK 5.0 mill.

Project Period: 2010-2014

Location: Oslo

STAMCELLER-Stamcelleforskning

Production of hESCs for the study of human serotonergic neurons in health and disease

The neurotransmitter serotonin, one of the key modulatory neurotransmitters, is pivotally involved in myriad of neurological and behavioral disorders, including migraine, motor disorders, sleep disorders, eating disorders, and a spectrum of neuropsychiatr ic disorders including major depression, ...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

FORNY20-FORNY2020

Oxycare - Treatment for Bacteria Infected Wounds

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Awarded: NOK 2.8 mill.

Project Period: 2010-2013

Location: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

In silico drug discovery of Wnt signaling small molecule agonists and antagonists for normal and cancer stem cells

The studies of adult stem cells and stem cell niches regulation signals are among cutting edge research in modern molecular biology. The emerging field of research is devoted to the concept of "cancer stem cells" in which the lost of control on stem cells proliferation is considered as one of th...

Awarded: NOK 0.16 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

New transgenic mouse models for studies of integrin function in fibroblastic cells

Cells interact with the extracellular matrix via cell surface receptors called integrins. During the 10 past years we have systematically worked on one particular integrin that we have identified and characterized, the alpha11beta1 integrin. In 2007 we pu blished a paper describing a tooth erupti...

Awarded: NOK 4.3 mill.

Project Period: 2010-2014

Location: Vestland

STAMCELLER-Stamcelleforskning

Mapping of histone modifications in totipotent and pluripotent cells in vivo and characterization of a novel epigenetic mark

This project focuses on revealing the epigenetic basis of in vivo pluripotency and totipotency, characterizing a putative novel epigenetic mark with relevance to pluripotency and the characterization of candidate enzymes for the regulation of this mark. Fertilization produces a totipotent zygo...

Awarded: NOK 3.0 mill.

Project Period: 2010-2014

Location: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Medical Image Registration of 3D Datasets

This Yggdrasil proposal represents a truly multidisciplinary project consisting of two organ-specific applications - multimodal MR imaging and image registration in the study of brain-behavior relationships in cognitive aging, and motion correction of dyn amic contrast enhanced MRI for the quanti...

Awarded: NOK 0.13 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Development of new analytical and preparative techniques for enantioselective resolution of Stiripentol

The main goal of the work is the biocatalyzed kinetic resolution of stiripentol through three ways 1- Lipase mediated reaction (esterification or hydrolysis) 2- biocatalyzed reduction of the prochiral ketone 3- biocatalyzed oxidation of the racemic alc ohol. A mandatory prerequisite for the b...

Awarded: NOK 0.13 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Studying Molecular genetics of type-2 diabetes

Project title Studying Molecular genetics of type 2 diabetes Aim Major aim of the present research is to Investigate the functional role of novel gene mutants or variants associated with Maturity-onset diabetes of the young (MODY) in south Asian Indians Objective The main objective of this pr...

Awarded: NOK 45,999

Project Period: 2010-2010

Location: Ukjent Fylke

IS-BILAT-Mobilitet Norge-USA /Canada

The role of Alfy in neurodegeneration

The neurodegenerative disorders Alzheimer's and Huntington's disease are serious and fatal illnesses, currently with no treatments or clear diagnostic tools available. To be able to develop new drugs and diagnostic tools, detailed knowledge is crucial. Al though there have been a number of import...

Awarded: NOK 0.11 mill.

Project Period: 2010-2011

Location: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Quantification of peptides uptake by fluorescence techniques

Novel approaches to deliver either biologics (genes, RNAi...), or traditional therapeutics include cell penetrating peptides (CPPs) named due to an apparent endocytosis independent ability to enter cells. Interestingly, CPPs' concentration is key to uptak e and trafficking understanding with a th...

Awarded: NOK 57,999

Project Period: 2010-2011

Location: Ukjent Fylke

FORNY20-FORNY2020

New lead compound for tuberculosis treatment

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Awarded: NOK 2.1 mill.

Project Period: 2010-2013

Location: Troms - Romsa - Tromssa

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Site-directed mutagenesis to reveal essential residues for 5-HT7 receptor binding and activation

Serotonin (5-hydroxytryptamine, 5-HT) is a key neurotransmitter implicated in neuropsychiatric disturbances such as depression, anxiety and psychosis. Recent studies on knockout animals and using selective 5-HT7 receptor antagonists have provided strong s upport that the G-protein-coupled 5-HT7 r...

Awarded: NOK 0.13 mill.

Project Period: 2010-2011

Location: Ukjent Fylke

FORNY20-FORNY2020

New Drugs for Treatment of Cerebral Edema 2

...

Awarded: NOK 0.93 mill.

Project Period: 2010-2011

Location: Oslo

STAMCELLER-Stamcelleforskning

Neural patterning of the mammalian forebrain - in vitro generation of Hippocampal neurons from mouse and human ES cells.

The mammalian forebrain develops from a sheet of neuroepithelium that is flanked by distinct patterning centers. The Hippocampus, a part of the brain of crucial function for perception, memory and learning - which is disproportionally affected in diseases such as Alzheimers and epilepsy, arise f...

Awarded: NOK 0.46 mill.

Project Period: 2010-2016

Location: Oslo

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