0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Congenital heart defects in Norway - A nation-wide study

Vi har benyttet nasjonale helse- og populasjonsregistre for å undersøke risikofaktorer for medfødte hjertefeil i Norge. Epidemiologiske studier av medfødte hjertefeil har tidligere ikke vært utført på ett nasjonal nivå grunnet manglende data. Slike studier er viktige fordi medfødte hjertefeil er ...

Awarded: NOK 5.2 mill.

Project Period: 2009-2017

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure, Function and Regulation of NAD Kinases

The availability of NADP represents a key prerequisite for cellular functions. Besides its role in bioenergetic conversions, this nucleotide also serves in signalling pathways. The reduced form, NADPH, plays a pivotal role for the maintenance of cellular integrity, because it provides the reduci...

Awarded: NOK 6.1 mill.

Project Period: 2009-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The muscle excitation-transcription coupling

The composition of muscle is related to the risk of developing life style diseases such as obesity and type II diabetes. Muscle is a permanent tissue, but the phenotype can nevertheless be changed by changing the pattern of activity such as by exercise. C hanges in the pattern of action potential...

Awarded: NOK 6.2 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular mechanisms of androgen action

Androgens are essential for a wide range of important biological processes. These include the development and maintenance of male reproductive organs, hair cycle and skeletal muscle, as well as regulation of lipid metabolism and bone remodelling. Androgen s are implicated in pathological processe...

Awarded: NOK 6.2 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EXPLORATION AND VALIDATION OF ANGIOGENESIS MARKERS IN HUMAN CANCERS

Nydanning av blodårer og interaksjon mellom svulstceller og blodkar er viktige faktorer for svulsters vekst og spredning. Endel svulster kan behandles ved å blokkere deres blodsirkulasjon, slik det ble foreslått av Folkman i 1971. Medikamenter som motvirker nydanning av blodårer er godkjent for k...

Awarded: NOK 7.6 mill.

Project Period: 2009-2016

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The genetic basis of response to selection in natural bird populations - insight from state-of-the-art genomics analyses.

The natural environment of most natural plant and animal species is today changing fast as a consequence of human activities. Examples include environmental threats due to global warming, habitat fragmentation, and introduction of alien species. To cope w ith such threats and persist, populations...

Awarded: NOK 4.6 mill.

Project Period: 2009-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Hepatocyte Growth Factor in the Pathogenesis of Multiple Myeloma

Since our publications in 1996 showing that malignant plasma cells (MM cells) usually express both HGF and its receptor c-Met, a growing number of reports have implicated HGF/c-Met in the biology of MM. For instance, high levels of HGF in serum of MM pati ents predict a bad prognosis and correlat...

Awarded: NOK 3.3 mill.

Project Period: 2009-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Gene-environment interactions in childrens social competence: Differential susceptibly or differential vulnerability?

Starting in 2002 a series of findings has demonstrated that some individuals, also children, who share common polymorphisms, primarily related to the serotonergic and dopaminergic systems face greater risk of developing psychopathology when exposed to neg ative environments (e.g. negative life ev...

Awarded: NOK 8.6 mill.

Project Period: 2009-2014

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neurogenetics of aging: impact of DNA repair on Alzheimer disease

The genetic background for cognitive loss, dementia and aging processes is poorly described, and multidisciplinary research is needed to increase this knowledge. Alzheimer disease (AD) is by far the most important contributor to cognitive decline and deme ntia worldwide. Incidence may quadruple s...

Awarded: NOK 4.1 mill.

Project Period: 2009-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Reconstruction of past ecosystems by barcoding DNA preserved in permafrost

Recent advances in ultra-high-throughput DNA sequencing technology and in species identification (?barcoding?) tools based on ancient DNA preserved in permafrost soils are opening up a novel research avenue for paleoecological reconstruction. In this proj ect, we will develop new DNA barcoding ma...

Awarded: NOK 9.5 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Coral Reef Fish Coloration: Sexual Selection, Diversity and Speciation [revised Jan. 09]

Tropiske korallrev er blant verdens mest truete livsmiljøer. Korallrevene er samtidig "havets regnskoger", med et større biologisk mangfold enn noe annet havmiljø. Bare et fåtall av dyr og planter på korallrevene er studert - de aller fleste vet vi ingenting om. Prosjektet CoralFish har hatt som ...

Awarded: NOK 6.6 mill.

Project Period: 2009-2016

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Awarded: NOK 4.4 mill.

Project Period: 2009-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

State-dependent control of LTP consolidation

REM sleep is essential for normal cognitive function and required for long-term memory formation in both humans and rodents. Deprivation of REM sleep after LTP induction impairs LTP consolidation. Thus, REM sleep may represent a preferred off-line state o f neural networks for the modulation of s...

Awarded: NOK 3.1 mill.

Project Period: 2009-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cytokine- and stress-induced myocardial hypertrophy

Myocardial hypertrophy can be induced through hormonal factors or stress-sensing molecules. Hence, it is necessary to study the activation and function of such hypertrophic mediators to completely understand the biological processes occurring during devel opment of heart failure. We will combine ...

Awarded: NOK 6.3 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dissecting molecular properties of honey bee vitellogenin (Vg): a protein acting at the intersection between social behavior and aging

The honey bee provides opportunities for cutting-edge studies of the molecular basis for complex social traits. Our group has made substantial contributions to the understanding of honey bee behavior and aging by identifying a socially controlled pathway that affects social activities and aging r...

Awarded: NOK 4.1 mill.

Project Period: 2008-2012

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The development of attachment and social relations in young children: A transactional and contextual model

Establishing a secure attachment to caregiver(s) is considered one of the fundamental milestones in children's development. It is hypothesized that trough interaction with the caregiver the child forms mental representations of the self, others and the ou ter world, viz. inner working models. Mat...

Awarded: NOK 4.1 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Salmon lice as models for understanding life history evolution of parasites

Salmon lice represent an important problem both in relation to fish farming and to the conservation of wild salmonids. It is now estimated that at least 95 % of all salmon lice eggs in the sea come from farmed fish. The majority of salmon lice have ther efore changed their resource base from wi...

Awarded: NOK 3.4 mill.

Project Period: 2008-2014

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

B-cell lymphomagenesis in Ung-deficient mice: collaboration between chronic antigenic stimulation and DNA repair deficiency

The importance of responding appropriately to DNA damage is highlighted by the frequent development of human disease, most notably cancer, in cells where this response is compromised. Here, we ask whether endogenous DNA damage, such as uracil in DNA, can contribute to activation of the DNA damage...

Awarded: NOK 6.4 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Plastids as cellular reservoir for nuclear transcription factors

Transcription factors are responsible for the transcription of the genetic information and are therefore key molecules in any cell. In plant cells the genetic information is divided into three sub-genomes (nuclear, plastid, mitochondrial) that are depende nt on each other. The description of a eu...

Awarded: NOK 4.2 mill.

Project Period: 2008-2013

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Activity-dependent plasticity in visual cortex

A major question in neuroscience is how appropriate connections are formed when the brain develops. It is well established that neural circuits are fine-tuned by experience during 'critical periods' in early postnatal life. In the visual system, closing o ne eye for only a few days during a criti...

Awarded: NOK 2.7 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Speciation processes in fungi examined through experimental and empirical approaches

Although more than 100.000 fungal species exist, fungi are largely missing in the speciation debate. Speciation theory is based mainly on research on animals and plants and little is known whether fungi conform to general models of speciation. Four differ ent boreal/nemoral wood-decay species com...

Awarded: NOK 3.3 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Incipient speciation through ecological divergence in subarctic whitefish populations

The evolutionary processes that can create two species out of one are still under exploration and continuous debate. Recent developments have emphasised the potential of ecological speciation where species divergence may develop as an evolutionary consequ ence of ecological interactions within th...

Awarded: NOK 4.6 mill.

Project Period: 2008-2012

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Exploiting the plasticity in social life history; physiology of extreme longevity in honeybee diutinus workers

Our studies have documented direct effects of vitellogenin on stress resistance and longevity during summer. However, although vitellogenin RNAi in workers living under favorable ambient conditions provides functional insight, it does not directly address the role of vitellogenin in extreme work...

Awarded: NOK 3.1 mill.

Project Period: 2008-2013

Location: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular interactions underlying organization of cortical circuits

A major question in neuroscience is how appropriate connections are formed when the brain develops and how these connections are modified with experience. It is well established that neural circuits are fine-tuned by experience during 'critical periods' i n early postnatal life. In the visual sys...

Awarded: NOK 2.7 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Identification of molecules involved in the generation of the MHC class II peptide loading compartment.

Visualization of vesicular trafficking has become possible by the rapid development of imaging techniques that utilize fast computers and fast on line imaging systems. Biologically we have developed a system for studying trafficking events in the immune specific intracellular pathway towards the...

Awarded: NOK 2.8 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Copy number variants and predisposition to autoimmune diseases like rheumatoid arthritis.

A novel form of genetic variation has during the last two years been recognized to be important for human phenotypes and diseases, namely copy number variations (CNVs). CNVs have so far generally been overlooked in searches for susceptibility variants for common multifactorial diseases, however ...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Saxitoxin biosynthesis and genomics in organisms from two kingdoms - horizontal gene transfer or parallel evolution?

Paralytic shellfish poisoning is a potentially fatal affliction that results from the consumption of seafood or drinking water, which is infested with the neurotoxic alkaloid saxitoxin and its analogues (PSTs). Although PSTs are produced by a complex and unique biosynthetic pathway, distantly rel...

Awarded: NOK 3.9 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors that recognize cancer cells. DNA encoding the receptors form basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) A large number of T cell clones recognizing common canc...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Receptors controlling the innate immune system

Myeloid cells are activated quickly at the start of an immune response and play a central role in the orchestration of the secondary, adaptive immune response. The adaptive response is influenced both indirectly, through the secretion of cytokines that re gulate the type of immune response genera...

Awarded: NOK 3.2 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

A novel cell cycle checkpoint in fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle and cancer development is frequent ly associated with the lack of checkpoint...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Oslo