0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Spatiotemporal Regulation of cAMP Signalling in Health and Disease

Signalling networks involving the signal molecule cAMP and protein kinase A (PKA) are involved in regulation of a multitude of body functions involving most organ systems of the body. An emerging principle is that function of the cAMP signal pathway in th ese settings requires subcellular anchori...

Awarded: NOK 6.0 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Maturation of the electrophysiological and intracellular signaling systems in teleost gonadotropes during puberty

Hovedmålet til dette prosjektet er å belyse hvordan reguleringsmekanismen til de hormonproduserende gonadotrope cellene i hypofysen modnes under pubertetsutviklingen, med fokus på komponenter som deltar i elektrofysiologisk signalisering trigget av frigjø ringshormonet GnRH. Vi bruker torsk og me...

Awarded: NOK 6.6 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cytokine- and stress-induced myocardial hypertrophy

Myocardial hypertrophy can be induced through hormonal factors or stress-sensing molecules. Hence, it is necessary to study the activation and function of such hypertrophic mediators to completely understand the biological processes occurring during devel opment of heart failure. We will combine ...

Awarded: NOK 6.3 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Entorhinal circuits and memory functions

Several decades of research has convincingly indicated that the entorhinal-hippocampal system is a key component of circuits in the brain mediating episodic memory. Using rats as models, we have learned how memories may become encoded, stored and retrieve d. Focus has been on the hippocampus and ...

Awarded: NOK 5.0 mill.

Project Period: 2009-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Coral Reef Fish Coloration: Sexual Selection, Diversity and Speciation [revised Jan. 09]

Tropiske korallrev er blant verdens mest truete livsmiljøer. Korallrevene er samtidig "havets regnskoger", med et større biologisk mangfold enn noe annet havmiljø. Bare et fåtall av dyr og planter på korallrevene er studert - de aller fleste vet vi ingenting om. Prosjektet CoralFish har hatt som ...

Awarded: NOK 6.6 mill.

Project Period: 2009-2016

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Neoadjuvant Avastin in Breast Cancer (Neo-Ava) - an integrated molecular approach to treatment biology.

I kliniske studier hvor en ønsker å avdekke hvilke pasienter som har nytte av en spesifikk behandling, er detaljerte analyser av svulstvevet både i forkant, under og etter behandling, av stor betydning. Likeledes kan andre analyser også kaste lys over effekten av en slik behandling, slik som fors...

Awarded: NOK 4.4 mill.

Project Period: 2009-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure, Function and Regulation of NAD Kinases

The availability of NADP represents a key prerequisite for cellular functions. Besides its role in bioenergetic conversions, this nucleotide also serves in signalling pathways. The reduced form, NADPH, plays a pivotal role for the maintenance of cellular integrity, because it provides the reduci...

Awarded: NOK 6.1 mill.

Project Period: 2009-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

EXPLORATION AND VALIDATION OF ANGIOGENESIS MARKERS IN HUMAN CANCERS

Nydanning av blodårer og interaksjon mellom svulstceller og blodkar er viktige faktorer for svulsters vekst og spredning. Endel svulster kan behandles ved å blokkere deres blodsirkulasjon, slik det ble foreslått av Folkman i 1971. Medikamenter som motvirker nydanning av blodårer er godkjent for k...

Awarded: NOK 7.6 mill.

Project Period: 2009-2016

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The genetic basis of response to selection in natural bird populations - insight from state-of-the-art genomics analyses.

The natural environment of most natural plant and animal species is today changing fast as a consequence of human activities. Examples include environmental threats due to global warming, habitat fragmentation, and introduction of alien species. To cope w ith such threats and persist, populations...

Awarded: NOK 4.6 mill.

Project Period: 2009-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Reconstruction of past ecosystems by barcoding DNA preserved in permafrost

Recent advances in ultra-high-throughput DNA sequencing technology and in species identification (?barcoding?) tools based on ancient DNA preserved in permafrost soils are opening up a novel research avenue for paleoecological reconstruction. In this proj ect, we will develop new DNA barcoding ma...

Awarded: NOK 9.5 mill.

Project Period: 2009-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Congenital heart defects in Norway - A nation-wide study

Vi har benyttet nasjonale helse- og populasjonsregistre for å undersøke risikofaktorer for medfødte hjertefeil i Norge. Epidemiologiske studier av medfødte hjertefeil har tidligere ikke vært utført på ett nasjonal nivå grunnet manglende data. Slike studier er viktige fordi medfødte hjertefeil er ...

Awarded: NOK 5.2 mill.

Project Period: 2009-2017

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Salmon lice as models for understanding life history evolution of parasites

Salmon lice represent an important problem both in relation to fish farming and to the conservation of wild salmonids. It is now estimated that at least 95 % of all salmon lice eggs in the sea come from farmed fish. The majority of salmon lice have ther efore changed their resource base from wi...

Awarded: NOK 3.4 mill.

Project Period: 2008-2014

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

B-cell lymphomagenesis in Ung-deficient mice: collaboration between chronic antigenic stimulation and DNA repair deficiency

The importance of responding appropriately to DNA damage is highlighted by the frequent development of human disease, most notably cancer, in cells where this response is compromised. Here, we ask whether endogenous DNA damage, such as uracil in DNA, can contribute to activation of the DNA damage...

Awarded: NOK 6.4 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Exploiting the plasticity in social life history; physiology of extreme longevity in honeybee diutinus workers

Our studies have documented direct effects of vitellogenin on stress resistance and longevity during summer. However, although vitellogenin RNAi in workers living under favorable ambient conditions provides functional insight, it does not directly address the role of vitellogenin in extreme work...

Awarded: NOK 3.4 mill.

Project Period: 2008-2013

Location: Viken

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Incipient speciation through ecological divergence in subarctic whitefish populations

The evolutionary processes that can create two species out of one are still under exploration and continuous debate. Recent developments have emphasised the potential of ecological speciation where species divergence may develop as an evolutionary consequ ence of ecological interactions within th...

Awarded: NOK 4.6 mill.

Project Period: 2008-2012

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Plastids as cellular reservoir for nuclear transcription factors

Transcription factors are responsible for the transcription of the genetic information and are therefore key molecules in any cell. In plant cells the genetic information is divided into three sub-genomes (nuclear, plastid, mitochondrial) that are depende nt on each other. The description of a eu...

Awarded: NOK 4.2 mill.

Project Period: 2008-2013

Location: Troms og Finnmark - Romsa ja Finnmárku - Tromssa ja Finmarkku

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Speciation processes in fungi examined through experimental and empirical approaches

Although more than 100.000 fungal species exist, fungi are largely missing in the speciation debate. Speciation theory is based mainly on research on animals and plants and little is known whether fungi conform to general models of speciation. Four differ ent boreal/nemoral wood-decay species com...

Awarded: NOK 3.3 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Identification of molecules involved in the generation of the MHC class II peptide loading compartment.

Visualization of vesicular trafficking has become possible by the rapid development of imaging techniques that utilize fast computers and fast on line imaging systems. Biologically we have developed a system for studying trafficking events in the immune specific intracellular pathway towards the...

Awarded: NOK 2.8 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Folate, Paternal Age and De Novo Genetic and Epigenetic Events.

De novo mutasjoner er endringer i arvematerialet (DNA) som oppstår i kjønnscellene eller tidlig i fosterutviklingen og som derfor er nye i den forstand at de ikke finnes hos foreldrene. Epigenetiske mekanismer er kjemiske endringer i arvematerialet som styrer hvorvidt et gen skrus av eller på, op...

Awarded: NOK 4.5 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Measuring Genetic Mating Systems and Sexual Selection Using a Sex-Role Reversed Pipefish.

Summary The interaction between molecular biology and animal behaviour has sparked a new understanding of mating systems and sexual selection. However, controversies remain, and at least ten different mating system metrics have been advocated to best meas ure patterns of mating. One aim of this p...

Awarded: NOK 4.0 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cancer-targeted T cell Receptors - the next generation immunotherapeutic drugs

The aim is to generate recombinant T cell receptors that recognize cancer cells. DNA encoding the receptors form basis for novel drugs for immunotherapy of cancer. Two strategies are followed to select T cells with the desired receptors: 1) A large number of T cell clones recognizing common canc...

Awarded: NOK 3.2 mill.

Project Period: 2008-2015

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Saxitoxin biosynthesis and genomics in organisms from two kingdoms - horizontal gene transfer or parallel evolution?

Paralytic shellfish poisoning is a potentially fatal affliction that results from the consumption of seafood or drinking water, which is infested with the neurotoxic alkaloid saxitoxin and its analogues (PSTs). Although PSTs are produced by a complex and unique biosynthetic pathway, distantly rel...

Awarded: NOK 3.9 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

A novel cell cycle checkpoint in fission yeast

In this project we shall further study and characterise a novel mechanism of checkpoint regulation that we have recently discovered (Tvegård et al, Genes Dev, 2007). Checkpoints are important regulators of the cell cycle and cancer development is frequent ly associated with the lack of checkpoint...

Awarded: NOK 3.0 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanism of mammalian DNA repair

DNA repair prevents cancer and early aging and is essential for the immune system. Our objective is to obtain a detailed understanding of the mechanism of base excision repair (BER) and direct base damage repair. BER is a template-dependent multistep proc ess initiated by a DNA glycosylase. The U...

Awarded: NOK 4.0 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Regulation of competence for natural transformation in Streptococcus pneumoniae

Bacteria that have the ability to take up naked DNA from the environment and incorporate this DNA into their genomes by homologous recombination are said to be naturally competent for genetic transformation. About 70 species of bacteria have been reported to possess this property. One of the bes...

Awarded: NOK 3.4 mill.

Project Period: 2008-2012

Location: Viken

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular basis for control of the heartbeat by Na+

Contraction of the heart is triggered by an increase in Ca2+ within cardiac muscle cells, as Ca2+ ions bind to contractile proteins. The rise in Ca2+ results primarily from release from the sarcoplasmic reticulum which is the main intracellular store of C a2+. Therefore, the pumping ability of th...

Awarded: NOK 5.4 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Unmasking the Interplay between Pathogenic Neisseria Species and Host Cells by Quantitative Proteomic Analysis

This proposal aims to investigate the interaction between pathogenic Neisseria gonorrhoeae and Neisseria meningitides with host cells during infection using in vitro and in vivo models (cell culture and mouse model). A quantitative proteomic approach usin g in vitro and in vivo metabolic labeling...

Awarded: NOK 3.8 mill.

Project Period: 2008-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapies for genetic diseases associated to aromatic amino acid hydroxylases

It is increasingly recognized that intracellular protein misfolding and aggregation are common to many disorders, notably associated to neurodegeneration. Many inherited diseases are also caused by the enhanced tendency of mutant proteins to misfold and t o undergo proteasomal degradation or dele...

Awarded: NOK 8.3 mill.

Project Period: 2008-2013

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Match-mismatching of trophic levels as a structuring force of ecosystems

We intend to study ecosystem functioning using the match-mismatch hypothesis as a framework and three different marine ecosystems with focus on seabirds as examples. The marine ecosystems chosen - the Southern Ocean, the Barents Sea and the Benguela Upwel ling - are highly sensitive to climate va...

Awarded: NOK 6.5 mill.

Project Period: 2008-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Change in clinically significant behavior during pharmacological augmented treatment of anxiety disorders

There has been enormous progress in the treatment of anxiety disorders, yet about 40% patients with chronic posttraumatic stress disorder do not recover after receiving daily medication or psychotherapy. PTSD is characterized by hyperarousal, coupled with emotional avoidance. Non-reinforced expo...

Awarded: NOK 3.6 mill.

Project Period: 2008-2012

Location: Trøndelag - Trööndelage