FRIMEDBIO-Fri prosj.st. med.,helse,biol

Molecular control of differentiation of multipotent stem cells in simple marine animals

The maintenance of stem cells and the regulation of their differentiation are still poorly understood. Interstitial stem cells are easily accessible in the simple animal Hydra and give rise to different neuronal cell fates, gametes and gland cells. In con trast, no interstitial stem cells have be...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Awarded: NOK 2.3 mill.

Project Period: 2006-2012

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cell cycle regulation: the role of replication clamps and interacting proteins

DNA replication is executed by enzymes called polymerases. The polymerases are tethered to the DNA template by binding to so-called clamps, which are doughtnut-shaped protein complexes encircling the DNA. The clamps are being loaded onto the DNA by clamp loaders, another protein complex. All orga...

Awarded: NOK 2.3 mill.

Project Period: 2006-2013

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structural Glycobiology

The aim of the present research project is to structurally and functionally characterize the basis of protein carbohydrate recognition, with the long-term goal of engineering the carbohydrate specificity of carbohydrate binding proteins. This research fie ld is central to many cellular processes ...

Awarded: NOK 3.4 mill.

Project Period: 2006-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Therapeutic approaches for the correction of misfolding mutations in pterin-dependent enzymes

Many inherited diseases are caused by the enhanced tendency of the mutant variant proteins to misfold and to either undergo proteasomal degradation or deleterious aggregation with plaque formation. For several of these diseases evidence has been accumulat ed that chemical or pharmacologic chapero...

Awarded: NOK 3.2 mill.

Project Period: 2006-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Novel modulators and downstream targets of the cAMP receptors Epac and PKA

I: Obtain genomic DNA suitable for recombinant deletion of Epac1 in ES cells, produce Epac1 null mice. II: a) Use mapping data of more than 100 cAMP analogs for PKA type I,II and Epac to predict effect of cAMP modifications on binding. Design new discriminating analogs. b) Identify new ATP-site...

Awarded: NOK 4.0 mill.

Project Period: 2005-2012

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Epidemiology of antibiotic resistance in clinical and envirionmental settings: prevalence, host diversity, and transfer of blaTEM genes

This study seeks to determine the prevalence, allele diversity, mobility and epidemiology of blaTEM (ampicillin) resistance genes and their hosts in a broad range of clinical and environmental settings. Recent studies suggest that environmental population s of bacteria can be an important reservo...

Awarded: NOK 1.9 mill.

Project Period: 2003-2012

Location: Troms - Romsa - Tromssa

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Betydningen av apolipoprotein E polymorfismen for sykdomsutvikling

Apolipoprotein E (apoE) er et molekyl som er viktig for kolesteroltransport mellom celler. Molekylet produseres og skilles ut i blodet fra leveren, men dannes også i andre organer. Tre varianter, apoE2, apoE3 og apoE4, kodes av allelene e2, e3 og e4 i et lokus på kromosom 19. I forhold til det "...

Awarded: NOK 1.8 mill.

Project Period: 2003-2014

Location: Oslo

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