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BEHANDLING-God og treffsikker diagnostikk, behandling og rehabilitering

Repurposing in personalized leukemia therapy

Gjenbruk av medisiner til andre sykdommer enn opprinnelig tiltenkt kan gi oss effektive og sikre medisiner der de trengs som mest. Pasienter med agressive former for kreft, kanskje spesielt pasienter med kreftsykdom som har kommet tilbake etter den første behandlingen, trenger nye og mer effektiv...

Awarded: NOK 12.0 mill.

Project Period: 2020-2027

Location: Vestland

FRIMED2-FRIPRO forskerprosjekt, medisin og helse

Next generation leukemia diagnostics and therapy through p53 isoform analysis

Akutt myelogen leukemi (AML) er ein krefttype som utviklar seg frå dei kvite blodcellene i beinmargen og fører over tid til at kreftcellene fortrenger dei normale blodcellene. Leukemi blir tradisjonelt behandla med cellegift med stamcelletransplantasjon som støttande behandling for yngre pasienta...

Awarded: NOK 8.8 mill.

Project Period: 2015-2020

Location: Vestland

PETROMAKS2-Stort program petroleum

Individual health surveillance of workers exposed to petroleum products

På grunn av sin eksponering for benzen har norske oljearbeidere en økt risiko for å utvikle blodkreft. Det er fortsatt usikkerhet hvilken risiko lav eksponering for benzen forårsaker. Gjeldende metoder for vurdering av eksponering klarer ikke å fange opp tidlige celle-responser som svar på akutt ...

Awarded: NOK 8.9 mill.

Project Period: 2012-2018

Location: Vestland

PETROMAKS2-Stort program petroleum

Novel biomarkers for the prediction of health consequences from occupational exposure to benzene in 12 versus 8 h work shifts

There has recently been reported an increased risk of blood derived malignancies among Norwegian offshore workers. This could indicate that the exposure to carcinogenic benzene has been higher than published for this industry, or that the increased risk f or these malignancies can be found at low...

Awarded: NOK 9.2 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Awarded: NOK 10.0 mill.

Project Period: 2007-2012

Location: Vestland

INT-BILAT-BILAT-ordningen

USA - Phosphoproteomics in Bergen and Stanford applied on acute myeloid leukemia

The major cause of fatalities in acute myeloid leukemia (AML) is disease relapse, resulting in no more than 50% five-year survival even when the most intensive chemotherapy is used. These relapses reflect de novo or developed chemoresistance of the cancer cells. Acute myeloid leukemia (AML) cell...

Awarded: NOK 75,000

Project Period: 2006-2007

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Proteome analysis of acute myelogenous leukemia (AML). Molecular mechanisms of cell death regul. in AML rel. to cytogenetics and prognosis.

The malignant hematological disease acute myelogenous leukemia (AML) has an overall long-term survival of 50%, with far worse outcomes in patients over 60 years of age. AML material >90% pure will be collected from patients, before chemotherapy, during c hemotherapy and at disease relapse. Kryo...

Awarded: NOK 11.5 mill.

Project Period: 2002-2006

Location: Vestland

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