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POS-ERC-Støtte til ERC søkere som oppnår god evaluering

Støtte for ERC-CoG-2017: Nat-enzymer

Alle sider ved livet til en menneskecelle er kontrollert av proteiner. Ulike kjemiske grupper kan kobles på proteiner og disse fungerer som merkelapper som styrer proteinenes funksjoner. En kjemisk gruppe kalt acetyl er påkoblet nesten hvert eneste protein i cellene våre. Forskningsgruppen ved Ui...

Awarded: NOK 0.48 mill.

Project Period: 2016-2017

Location: Vestland

EVITA-eVitenskap

ISQBP2016 President's Meeting

The ISQBP, International Society of Quantum Biology and Pharmacology, is a is a society founded in 1970 to provide a forum for chemists, pharmacologists and biologists to discuss and extend the impact of computational methodologies in the fields of biology, chemistry, medicinal chemistry, chemica...

Awarded: NOK 79,842

Project Period: 2016-2016

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dynamics and reversibility of protein N-terminal acetylation

Livet til en menneskecelle er kontrollert av proteiner. Ulike kjemiske grupper kan kobles på proteiner og fungere som merkelapper som styrer proteinenes funksjoner. En kjemisk gruppe kalt acetyl er påkoblet nesten hvert eneste protein i cellene våre. Forskningsgruppen vår ved UiB har kartlagt mas...

Awarded: NOK 3.9 mill.

Project Period: 2014-2017

Location: Vestland

IS-AUR-Samarb.progr. Norge Frankrike

Inhibiting protein-membrane interactions: towards new therapeutic strategies

The goal of the present proposal is to find compounds able to hinder the binding of Proteinase 3 to the neutrophil plasma membrane in vitro. Proteinase 3 is a neutrophil enzyme, present at the surface of the neutrophil plasma membrane and which has been i dentified as a drug target for a number o...

Awarded: NOK 28,700

Project Period: 2011-2013

Location: Vestland

IS-TOPP-Toppfinans. av M.Curie-stipend

NUCLEOSOME 4D Toppfinansiering av Marie Curie stipendiat

Søknad om toppfinansiering av Marie Curie stipendiat for å kompensere for differansen mellom Marie Curie-ordningens 'Living allowance' og norsk tarifflønn.

Awarded: NOK 0.53 mill.

Project Period: 2010-2015

Location: Vestland

MILJØ2015-Norsk miljøforskning mot 2015

FORURENS: 3rd Norwegian Environmental Toxicology Symposium - Emerging solutions for emerging challenges

The 3rd Norwegian Environmental Toxicology Symposium is planned to be held in Bergen in April 14-16, 2010. It follows in the succesful path of the two previous meetings in Oslo (2004) and Trondheim (2008). The University of Bergen and the Norwegian Societ y for Pharmacology and Toxicology are joi...

Awarded: NOK 79,999

Project Period: 2010-2010

Location: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure, Function and Regulation of NAD Kinases

The availability of NADP represents a key prerequisite for cellular functions. Besides its role in bioenergetic conversions, this nucleotide also serves in signalling pathways. The reduced form, NADPH, plays a pivotal role for the maintenance of cellular integrity, because it provides the reduci...

Awarded: NOK 6.1 mill.

Project Period: 2009-2013

Location: Vestland

SUP-NHD-Strategiske UoH-progr.fin.NHD

iCod: integrative environmental genomics of cod (Gadus morhua)

The aim of this project is to develop a deeper understanding of transcriptional and translational responses of the cod genome to environmental insults, and integrating these into mechanistic insights using a systems biology approach. The project will expl oit established activities and competence...

Awarded: NOK 9.0 mill.

Project Period: 2009-2013

Location: Vestland

IS-BILAT-Mobilitet Norge-USA /Canada

Characterization of human protein N-terminal acetyltransferases and N-terminal acetylation

Even though blocking of the N-terminal end of proteins by the addition of an acetyl group has been known for more than thirty years, only limited information is available describing the mechanism and biological importance of human protein N-terminal-acety lation and protein N-terminal-acetyltrans...

Awarded: NOK 0.15 mill.

Project Period: 2007-2007

Location: Vestland

TU-Tungt utstyr

Instrumentering av "High Quality Protein Facility" ved Molekylærbiologisk institutt (MBI), UiB

Molekylærbiologisk institutt (MBI), Universitetet i Bergen, har dentifisert utforsking av proteinstruktur og -funksjon som et av sine hovedsatsingsområder. Internasjonalt utvikles nå mange metoder for "high-throughput" analyse av enkelt-parametre av prote iners funksjon i en forskningstilnærming ...

Awarded: NOK 3.5 mill.

Project Period: 2007-2008

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Role of phosphorylation in regulation of redox-mediated events in apoptotic cell death

The blue-green algal toxins: nodularin and microcystin, induce apoptotic cell death in an ultrarapid manner (Fladmark et al., 1999). These toxins inhibit the general protein phosphatases (PP1 and PP2A) thereby resulting in Ca2+/calmodulin-dependent protei n kinase (CaMKII) hyperphosphorylation of...

Awarded: NOK 1.7 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Chromatin and differential gene regulation: The role of adjacent PHD fingers and bromo domains in epigenetic regulators

Correct differential gene expression is essential for proper development of tissues and organs. While the initial patterns of gene expression are established by classical transcription factors, the maintenance of correct gene expression relies on epigenet ic mechanisms, one of which relies on dif...

Awarded: NOK 3.2 mill.

Project Period: 2006-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

The Biosynthesis of NAD in Humans: Isozymes and Subcellular Compartmentation

NAD is essential for energy transduction. It is also a key molecule in a variety of central signaling pathways. Nevertheless, surprisingly little is not known about its biosynthesis. Our recent research has established that NAD biosynthesis is absent from the cytosol: the three human isoforms of...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Vestland

SUP-NHD-Strategiske UoH-progr.fin.NHD

Genes linked to normal development and survival of fish larvae

The present proposal combines the use of the newest retroviral-mediated trapping and mutagenesis techniques for zebrafish (Danio rerio) to investigate processes that are critical for growth and survival of fish larvae. Our research on the zebrafish model aims to study the development of essential...

Awarded: NOK 7.2 mill.

Project Period: 2006-2010

Location: Vestland

FRIBIO-Biologi og biomedisin

Functional sites in proteins: A combined proteomic and bioinformatical approach for improvement of a prediction system for linear motifs.

Functional sites in proteins are short stretches of amino acids that serve as binding sites, post-translational modification sites or proteolytic cleavage sites. Most functional features of proteins can be related to functional sites and/or globular domai ns. While there are several efficient met...

Awarded: NOK 3.1 mill.

Project Period: 2005-2009

Location: Vestland

FRIBIO-Biologi og biomedisin

Studies on Copper Homeostasis in Methylococcus Capsulatus based on the complete genomic sequence

Copper is an essential element required by all living systems. Copper can also cause serious cell damage through radical formation. Therefore, careful regulation of the intracellular copper concentration is required. Essentially no free copper is availabl e in the cytoplasm; the copper ions are b...

Awarded: NOK 2.6 mill.

Project Period: 2005-2009

Location: Vestland

HAVKYST-Havet og kysten

3 - Effects of produced water to Atlantic cod: Mechanistic studies and biomarker development with proteomics based methods.

Effects of contaminants on an organism start at the molecular level, and are transferred to higher levels of biological organization if the exposure is persistent and toxicological repair is overwhelmed. Long-term effects of produced water on the reproduc tion of Atlantic cod can therefore be stu...

Awarded: NOK 3.1 mill.

Project Period: 2005-2008

Location: Vestland

BIOBIOT-Biologi, bioteknologi, Mat. Nat.

Functional genomics - protein expression and functions related to a protein, MepE, secreted from Methylococcus capsulatus (Bath).

Methylococcus capsulatus (Bath) is able to obtain all its carbon and energy from methane. It is the main constituent of Bioprotein, a single cell protein product based on natural gas (Norferm DA), and represents. the first product to be commercialised fro m a methanotroph. Considering the low cos...

Awarded: NOK 1.3 mill.

Project Period: 2002-2004

Location: Vestland

GEN-Molekylærmedisin og genteknologi

The molecular biology of Ret tyrosine kinase growth factor receptor isoforms encoded by alternatively spliced c-ret RNA

...

Awarded: NOK 1.6 mill.

Project Period: 2002-2005

Location: Vestland

AB-MED1-Basal medisinsk forskning I

Dechiffrering av den epigenetiske kode: Karakterisering av spesifisitet i interaksjon mellom PHD-fingerproteiner og nukleosomer

Regulering av genuttrykking spiller en sentral rolle i utvikling av alle kroppens organer og vev. Feil genregulering kan være en medvirkende årsak til utvikling av f.eks. kreft og autoimmune sykdommer. Prosjektet bygger på tesen om at klassiske DNA-binde nde transkripsjonsfaktorer ikke alene kan...

Awarded: NOK 1.4 mill.

Project Period: 2001-2004

Location: Vestland

HAVKYST-Havet og kysten

Proteome ecotoxicology - a new strategy for developing biomarker tests for environmental monitoring, Postdr.stip.og utenlstip. til Danmark

Prosjektsammendrag: Inducible genes make attractive candidates for biomarkers, i.e. molecular and cellular responses to chemical exposure indicating adverse effects to organisms. The proteome represents the functional genome of a cell, i.e. that part of the genome expressed as proteins under a ce...

Awarded: NOK 1.8 mill.

Project Period: 2001-2006

Location: Vestland