0 projects

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Potential clinical relevance of radiation-induced signaling pathways

Radiation therapy is a commonly used treatment modality for cancer. Although in the past decades radiation therapy has shown to be a very successful treatment form, it still can be improved. One problem is that some tumors are particularly resistant to th e cytotoxic effects of radiation and resp...

Awarded: NOK 3.1 mill.

Project Period: 2007-2013

Location: Oslo

FRIBIO-Biologi og biomedisin

Global expression of defence-related genes in Populus and transfer of knowledge to Norway spruce

Due to the great economic losses caused by the root and butt-rot pathogen Heterobasidion annosum, developments of efficient control measures are warranted. Considerable clonal variation has been recorded for Norway spruce in resistance towards H. annosum, but the defence mechanisms contributing ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Viken

FRIBIO-Biologi og biomedisin

Modeling human disease in mice;DNA repair and genomic (in)stability.

Our research is currently focused on two classes of enzymes involved in repair, and possible regulation, of DNA and RNA species; flap endonuclease 1 (FEN1) and mammalian alkB homologs (ABHs). Genetic models are generated in order to elucidate the contribu tion of single gene deletions in genomic ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2011

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

The role of mismatch repair proteins in origin sequestration

We have shown that DNA replication is tightly coupled to cell growth in wild type E. coli cells. Initiation of replication occurs precisely at the same point in the cell cycle, generation after generation. The molecular mechanisms behind the precise timin g of initiation of replication are not ye...

Awarded: NOK 2.9 mill.

Project Period: 2007-2014

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Applying advanced computational and experimental tools to explore surface electrostatics in chitinases

Understanding how proteins work is a major challenge in the post-genome era. Traditionally proteins have been studied by the use of numerous biochemical techniques, but as the number of proteins that needs to be characterized has increased, so has the num ber of in computo techniques to study pro...

Awarded: NOK 2.9 mill.

Project Period: 2007-2012

Location: Viken

FRIBIO-Biologi og biomedisin

cAMP signalling -novel downstream targets of PKA and Epac identified by phospho-proteomics.

I. Implement novel method for quantitative COFRADIC non-gel global phospho-proteomics through stay of candidate in the laboratory of prof. J. Vandenkerckhove at Univ. of Gent II. The phospho-proteome will be compared in cells in response to activation of PKA (by N6-MB-cAMP) or Epac (by 8-pCPT-2´-...

Awarded: NOK 3.2 mill.

Project Period: 2007-2011

Location: Vestland

BIOMOL-Molekylær biovitenskap og bioteknologi

Endocytic regulation of receptor signalling and trafficking

Internalization by way of endocytosis represents an important mechanism for modulation of receptor signalling. Endocytosis followed by recycling is a mechanism for short-term downregulation of receptor signalling whereas endocytosis followed by lysosomal degradation represent a mechanism for long...

Awarded: NOK 0.67 mill.

Project Period: 2007-2008

Location: Oslo

FRIBIO-Biologi og biomedisin

Contact meeting for the Norwegian Biochemical Society

The annual meeting of the Norwegian Biochemical Society has a world-wide reputation as an excellent meeting place for scientists, both on the scientific and the social level. They have been a tremendous success and is arguably the one meeting in Norway wh ich has contributed the most to the conta...

Awarded: NOK 0.36 mill.

Project Period: 2007-2010

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

Severe Streptococcus pyogenes infections in Norway - Molecular genetic analysis of antibiotic resistance and virulence determinants

Group A streptococci is one of the most common human pathogens that can produce a variety of diseases ranging from mild pharyngitis (strep throat) to life-threatening toxic shock syndrome and necrotizing fasciitis. The incidence of invasive streptococcal disease has been increasing in Norway in t...

Awarded: NOK 0.16 mill.

Project Period: 2007-2007

Location: Oslo

FRIBIO-Biologi og biomedisin

Study of cellular distribution and biological functions of neonatal Fc receptor in immune cells

Immunoglobulin G (IgG) is the major class of immunoglobulins and the protein with the longest serum half-life. IgG is also actively transferred to the fetus, giving the full-term fetus IgG levels over maternal levels and protective immunity. The MHC class I related neonatal Fc receptor (FcRn) is...

Awarded: NOK 2.3 mill.

Project Period: 2007-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Mechanism of cargo selectivity in axonal transport Isolation and characterization of kinesin light chain associated vesicles

The aim of this project is to gain knowledge about how the motor protein kinesin-I interacts with its vesicle cargo, and what the nature is of the vesicles that are transported by kinesin-I through neurons. The role of neuronal transport in neurodegenerat ive diseases such as Alzheimer's disease,...

Awarded: NOK 2.7 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

EGF-induced Formation of Clathrin Coated Pits

Growth factor receptors control cellular growth and differentiation by transmitting signals from outside the cell to the cell interior, particularly the nucleus. Signal transmission can be modulated in several ways. To control signalling, down-regulation of receptors from the cell surface is impo...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Oslo

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Rogaland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Statistical tools for studying genetic architecture

Advances in molecular biology have revealed that most phenotypes are controlled by highly complex and interactive gene networks. This complex genetic basis is, however, not reflected in the rather simple genotype-phenotype maps postulated in population an d quantitative genetics. These models are...

Awarded: NOK 2.8 mill.

Project Period: 2007-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

A novel signal transduction pathway regulating cell separation processes in plants - the IDA/IDL network and their predicted partners.

Signaling mediated by small peptides is important in cell-to-cell communication. Few peptide ligands involved in cell signaling are known from plants and even less is known about the peptide-ligand-receptor pairs. A group of small putative peptide-ligands have recently been characterized by the ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

BIOMOL-Molekylær biovitenskap og bioteknologi

International conference on the biology and biotechnology of thermophilic microorganisms; Thermophiles 2007

Thermophilic microorganisms thrive at temperatures from about 60 to above 100 oC. Those growing optimally above 80 oC are termed hyperthermophiles. The most hyperthermophilic organism characterized so far is able to grow at temperatures up to 113 oC, but microbial growth has even been recorded at...

Awarded: NOK 49,999

Project Period: 2007-2007

Location: Vestland

FRIBIO-Biologi og biomedisin

Elucidation of downstream signaling events of cAMP using new tools distinguishing the roles of EPAC and PKA

The present project will receive Epac and PKA modulating cAMP analogs. I. We will test selected new analogs in a newly developed and unique assay for binding to PKA holoenzyme II. The best activators (current or novel) will be used, separately and jointl y, to define effect of Epac and PKA activ...

Awarded: NOK 3.1 mill.

Project Period: 2007-2011

Location: Vestland

FRIBIO-Biologi og biomedisin

The role of T cell specific adapter protein in T cell activation and autoimmunity

Genetic variation in genes controlling T cell activation may be responsible for individual differences in fine-tuning of the immune response. Such variability may account for part of the genetic susceptibility to develop autoimmune diseases. Having a majo r interest in elucidating the aetiology o...

Awarded: NOK 3.1 mill.

Project Period: 2007-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Characterization of Novel Insulin Regulated Pathways in Fat Synthesis in Liver and Adipose Tissue

Diets rich in lipids and carbohydrates together with a lack of physical exercise predispose individuals to multifunctional diseases such as atherosclerosis, hyperlipidemia, obesity, insulin resistance and diabetes type 2. Fat metabolism and glucose homeos tasis are inherently related, and insulin...

Awarded: NOK 2.2 mill.

Project Period: 2007-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Dynamics underlying astrocyte behaviour

For a long time astrocytes, the most abundant glial cell species, have been considered passive bystanders of neural activity. The picture that is now emerging is that astrocytes are critically involved in regulating brain function. Despite extensive exper imental efforts, a thorough understanding...

Awarded: NOK 2.6 mill.

Project Period: 2007-2009

Location: Viken

FRIBIO-Biologi og biomedisin

Competence-induced cell lysis in Streptococcus pneumoniae: Implications for horizontal gene transfer and virulence

Streptococcus pneumoniae have the ability to enter a transient phenotype termed competence for natural transformation, which enables the bacterial cells to take up free DNA from the surrounding environment. Recently, it was discovered that competent cells also aquire the ability to lyse neighbou...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Viken

FRIBIO-Biologi og biomedisin

Vaccine development for HIV and influenza

Aim: Based on the vaccibody principle developed by us, we wish to generate novel vaccines for important infectious diseases such as HIV and influenza. Background: Vaccination has had an enormous impact on health and longevity of humans world-wide. However , for some important diseases such as HIV...

Awarded: NOK 3.1 mill.

Project Period: 2007-2010

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Cellular responses to meningococcal meningitis

Meningococcal disease is a leading cause of meningitis and septicaemia worldwide. Among the serious consequences of meningitis are brain edema and disturbed neuronal excitability. These effects are often the direct cause of death. Despite the serious comp lications, the molecular basis for these ...

Awarded: NOK 3.4 mill.

Project Period: 2007-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional genetic networks that maintain genomic stability in mammalian cell lines and in Caenorhabditis elegans

The spontaneous formation of lesions in DNA is among the most significant threats to genomic integrity. We are using genetic and biochemical methods in the model organism Caenorhabditis elegans (C.elegans) and DNA repair deficient mouse cell lines to stud y the biological consequences of accumula...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Studies of growth control and gene expression in normal and neoplastic B-lymphoid cells

Malignant lymphomas represent a heterogeneous group of diseases with variable clinical course. The complex biology and the variety of genetic and epigenetic factors involved in the pathogenesis make lymphomas a challenging disease for translational resear ch. There a clear need for the developmen...

Awarded: NOK 2.5 mill.

Project Period: 2006-2012

Location: Oslo

FRIBIO-Biologi og biomedisin

Interplay between DNA repair mechanisms in yeast and their crosstalk with other cellular processes

DNA repair is essential for the maintenance of genomic integrity and defect repair is associated with diseases as cancer, neurological disorders and aging. Unraveling the mechanism of DNA repair is therefore of fundamental importance and the present proje ct seeks to broaden our understanding of ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2009

Location: Oslo

FRIBIO-Biologi og biomedisin

Endocytosis and intracellular transport of protein toxins

Errors in trafficking and signalling are associated with different diseases, including cancer. This project aims at increasing our knowledge about intracellular transport processes to provide a more rational basis for treatment and prevention of disease. Protein toxins such as Shiga toxin and the...

Awarded: NOK 4.3 mill.

Project Period: 2006-2011

Location: Oslo

BIOMOL-Molekylær biovitenskap og bioteknologi

1st Seeberg Symposium on DNA repair

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Awarded: NOK 0.15 mill.

Project Period: 2006-2006

Location: Oslo

FRIBIO-Biologi og biomedisin

Functional characterisation of AlkB-like macromolecular demethylases

We have recently discovered a novel mechanism for repairing methylation damage in DNA and RNA. The repair reaction occurs by oxidative demethylation, and can be performed both by human and bacterial AlkB proteins. Eight different AlkB-like proteins are fo und in the human genome, and the project ...

Awarded: NOK 3.1 mill.

Project Period: 2006-2010

Location: Oslo

FRIBIO-Biologi og biomedisin

Chromatin and differential gene regulation: The role of adjacent PHD fingers and bromo domains in epigenetic regulators

Correct differential gene expression is essential for proper development of tissues and organs. While the initial patterns of gene expression are established by classical transcription factors, the maintenance of correct gene expression relies on epigenet ic mechanisms, one of which relies on dif...

Awarded: NOK 3.2 mill.

Project Period: 2006-2011

Location: Vestland