0 projects

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FUGE-Funksjonell genomforskn.i Norg

Norwegian Proteomics Consortium - Bergen

PROBE, the Norwegian proteomic platform, was established in 2002 by the Norwegian Research Council under the Functional Genomics Initiative (FUGE) to provide the Norwegian scientific community access to the best in proteomic technologies and competence. Located within the Institute of Biomedicine...

Awarded: NOK 9.5 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

A FUGE Nor-MIC Node in Live Cell Imaging and Protein-Protein Interaction Analysis in Plants

There is a growing need to understand fundamental plant processes at the subcellular level. With respect to this it is of paramount importance to the Norwegian research community that a National Imaging Service and Training facility exists to meet these f uture demands. In addition a Molecular Im...

Awarded: NOK 1.0 mill.

Project Period: 2008-2012

Location: Rogaland

FUGE-Funksjonell genomforskn.i Norg

A National Service Platform for Global Analysis of Genome Structure and Function. The Norwegian Microarray Consortium (NMC)

The FUGE Microarray Platform is run by the Norwegian Microarray Consortium (NMC), based on a formal institutional collaboration between RR/UiO, NTNU, and UiB. We offer in-house production of standard and custom arrays, expression and genomic profiling ser vices (RNA or DNA in-DATA out) with diffe...

Awarded: NOK 9.7 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Norwegian plant transcriptional profiling centre

The Norwegian Arabidopsis Centre (FUGE-NARC) was established as a part of FUGE I. NARC provided national service in plant functional genomics and the service activity was shared between Univeristy of Life Sciences (UMB, transformation/genotyping), Univers ity of Oslo (Y2H, in situ hyb) and Norwe...

Awarded: NOK 2.3 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Pathogenesis of complex genetic diseases, using pre-eclampsia as a model

Pre-eclampsia (PE) is the most common pregnancy-associated complication in the Western world. The syndrome is a major contributor to maternal and fetal illness/death. No therapeutic treatment exists. The mechanisms involved in development of PE remain to be elucidated. Observations suggest immu...

Awarded: NOK 8.5 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Detection of gene products in cells; An advanced imaging FUGE2 platform node

We here propose the establishment of a FUGE node in Imaging. This node is based on the imaging expertise in the research groups at the Department of Molecular Biosciences (IMBV), the Institute of Basic Medical Sciences (IMB), and the Department of Biochem istry, the Radium Hospital, DNR/RH at the...

Awarded: NOK 6.9 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Spontaneous preterm birth: a systems biology approach in the Norwegian Mother and Child Cohort Study

sPTB is an unresolved common complex condition in perinatal medicine and is related to long-term disabilities such as cerebral palsy, cognitive and respiratory problems, which will affect the infant in every day life situations. The pathophysiology of sPT B remains poorly understood. Infection an...

Awarded: NOK 15.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Channel 2 application for continuation of FUGE MIC Trondheim in FUGE II period (2007-2011)

MIC Trondheim wants to continue in the FUGE II period with MR as the core technology, and will expand in capacity with acquisition of new MR equipment, and expand the high-level competence necessary for offering a wide variety of methods tailored to the u ser's research tasks. A goal is to establ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Host-virus interactions in Atlantic salmon

Infectious pancreatic necrosis virus (IPNV) and infectious salmon anemia virus (ISAV) are viruses causing threatening diseases in Norwegian aquaculture. Certainly, one of the most challenging problems in designing control strategies against these viruses is to define the specific factors, both in...

Awarded: NOK 12.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

The Bioinformatics Platform in the FUGE2 programme

The FUGE 2 Bioinformatics platform is designed in direct response to the demand for increased use of bioinformatics from the FUGE 1 evaluation. The platform will provide state of the art research based services in theoretical and applied bioinformatics to Norwegian research groups, in close coll...

Awarded: NOK 26.8 mill.

Project Period: 2008-2012

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Functional studies of tunneling nanotube-dependent cell-to-cell communication by high-throughput screening approaches

Intercellular communication is a major requirement for the development and maintenance of multicellular organisms. In the case of animals diverse mechanisms for the exchange of signals between cells have been established during evolution, including the se cretion of molecules as well as communica...

Awarded: NOK 4.0 mill.

Project Period: 2008-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Towards personalized therapy for breast cancer

Purpose of the project: Few protocols have so far been designed with attempts to characterize the systems biology of cancer. The objective of the project is to translate information obtained from integrative molecular analysis of material collected from i ndividual cancer patients, through valida...

Awarded: NOK 10.0 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

A proteomics node at Ås campus

As part of the NorProteomics FUGE network, Ås campus will develop expertise in the areas listed below and make this expertise available to on-campus and off-campus projects. Our key areas are: 1. Proteomics in difficult matrices, primarily related to food chemistry (meat, cereals; i.e. analysis ...

Awarded: NOK 1.5 mill.

Project Period: 2008-2012

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Advanced MR imaging, MR metabolomics, proteomics and genetic mapping of breast cancer - Clinical tools for personalized patient treatment

Breast cancer has the highest incidence and mortality of all malignant diseases among women globally. The heterogeneous nature of breast cancer results in different clinical presentations and outcomes, and patients show a diverse range of responses to a g iven treatment. Processes leading to more...

Awarded: NOK 5.2 mill.

Project Period: 2008-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Postgenome glycomics: The structures, interactions, and functions of complex sugars attached to proteins and lipids

Glycome is a term meant to cover the whole set of glycans produced in a single organism (or tissue) in analogy to genome and proteome. This concept follows as a consequence of the development in the post-genome era, since glycans play critical roles in di verse biological phenomena. It seems evid...

Awarded: NOK 8.0 mill.

Project Period: 2008-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Establishment/Evaulation of a Biomolecular NMR Structure Platform and Instrumentation Requirements for Biomolecular NMR

All molecules function through their three-dimensional structures as well as through their chemical properties. Understanding the mode of action of proteins and other biomolecules as well as optimal medical and biotechnological exploitation of these molec ules therefore relies to a large extent o...

Awarded: NOK 0.50 mill.

Project Period: 2008-2009

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Population-based cohorts and biobanks in Norway. A national consortium for research on genes, environment and health

The Biohealth 2 proposal is based on CONOR (Cohort of Norway) and MoBa (the Norwegian Mother and Child Cohort Study), which together formed BioHealth 1 (Biobanks for Health in Norway). BioHealth I was funded by FUGE I and has five partners: the universiti es in Tromsø (UiT), Bergen (UiB) and Oslo...

Awarded: NOK 19.6 mill.

Project Period: 2008-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Stroma-targeting: a directed approached aimed at tumor stroma fibroblasts

In recent years the awareness about the importance of the stroma for normal tissue homeostasis and tumor growth has increased. Much of this progress has been in the field of angiogenesis and anti-angiogenesis approaches are currently receiving considerabl e attention. In contrast to the recent fo...

Awarded: NOK 5.3 mill.

Project Period: 2008-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Development of high througput affinity protemics to search for drug targets in cancer.

Antibody array technology, mass-spectrometry and molecular biology techniques are combined to develop a new platform for screening of drug targets in cancer. The technology allows large-scale analysis of protein networks with high sample throughput. The p roject will develop large-scale analysis ...

Awarded: NOK 5.6 mill.

Project Period: 2008-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Bacterial flagellin: a novel adjuvant for vaccine strategies

The focus will be on development of strongly protective vaccines aimed primarily to fish, but the knowledge generated will be highly relevant within vaccine development to mammalian species - as fish possess very similar immune defence mechanisms compared to mammalian species. This will be achie...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Awarded: NOK 8.0 mill.

Project Period: 2007-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Cellular responses to DNA damage in Schizosaccharomyces pombe

see attachments: Projectdescription and program

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Functional and structural characterization of the membrane-integrated plastid phosphate translocators

Atomic structures of proteins provided a wealth of information about the functioning of proteins at the molecular level, e.g. the catalytic mechanisms of enzymes, pointing to the enormous impact of X-ray crystallography on modern biology. Because of techn ical hurdles almost all of the more than ...

Awarded: NOK 5.2 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Mechanisms mediating transfer and persistence of antibiotic resistance, and dissemination of virulence genes in streptococci and enterococci

The present project will study mechanisms for genome variation and maintenance in two closely related groups of bacteria Streptocococcus pneumonia and Enterococcus (E. faecalis and E. faecium). While S. pneumonia is considered as a sole pathogen, though 4 0% of humans carry this species, the two ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

IMAGING GENETICS OF SCHIZOPHRENIA. A WHOLE GENOME - BRAIN MRI STUDY

Schizophrenia is a severe psychiatric disorder characterized by psychotic symptoms, cognitive dysfunction and poor outcome, and is a major public health problem with a high cost for society. Brain imaging studies have shown structural abnormalities and dy sfunction in specific brain regions. The ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

zEPISTEM: DEFINING STEMNESS BY ASSESSING THE EPIGENETIC BASIS OF PLURIPOTENCY IN EMBRYONIC STEM CELLS OF ZEBRAFISH

Chromatin organization around active or repressed genes starts to be elucidated, but the packaging of a gene into a chromatin structure compatible with potential for transcription, such as in a pluripotent cell, is largely unknown. The zEPISTEM research p rogram aims at identifying novel gene mar...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Structure based rules for protein kinase inhibitor selectivity

Protein kinase inhibitors are now emerging as a major class of new targeted drugs. Many diseases, especially cancers, are associated with disregulation of signalling pathways, and modulation of protein kinase activity is now a clearly validated approach f or therapy. Because there are over 500 pr...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Epigenetic gene regulation: The 'conspiracy' between chromatin modification and transcription factors.

An important aspect of gene regulation involves the interconversion between transcriptionally permissive euchromatin and repressive heterochromatin, which in part is regulated by post-translational modifications of the nucleosomal histone tails. The patte rns of histone modification (the histone ...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Single Cell Profiling of Phospho-Protein Networks in Health and Disease - From Signalling Profiles to Future Biomarkers

This proposal describes plans for a research project to be undertaken by a strong concortium of PI's (Gjertsen, Lorens, UoB; Torgersen, Aandahl, Tasken, UoO) and aiming to characterize key events in intracellular signalling networks that regulate cellular properties and behaviour in health and d...

Awarded: NOK 10.0 mill.

Project Period: 2007-2012

Location: Vestland

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