0 projects

FUGE-Funksjonell genomforskn.i Norg

Functional genomics in ascidians through insertional mutagenesis and homologous recombination

Ascidians, or sea squirts, are marine invertebrate chordates. Their critical evolutionary position as basal chordates and the simplicity of their embryogenesis have attracted great attention from developmental and evolutionary biologists. Recently, ascid ians have become one of the most promisin...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

From comparative genomics to systems biology - unravelling novel principle virulence mechanisms in pathogenic spore-forming bacteria

In the past decade, our research group has been involved in the characterization of virulence mechanisms in Bacillus cereus group bacteria. Here we propose to study two processes connected to development of resistance to antimicrobial compounds - the func tion and cellular response of multidrug r...

Awarded: NOK 8.0 mill.

Project Period: 2007-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Signal transduction in cell separation processes- A novel, important signaling module in plants possibly involving RLKs, RopGEFs and RAC/ROP

Cell-to-cell communication is a necessity in plants during development and differentiation. Small peptides can function as signaling molecules. To function in cell-to-cell signaling theses small peptides must have properties that allow them to be transpor ted from the cytoplasma and out across th...

Awarded: NOK 8.6 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Temperature compensation and temperature regulation of metabolic flux

First nalysis is performed on different types of networks in terms of their ability to show temperature compensation and temperature adaptation. Static and dynamic compensation adaptation is considered: in the ?static? approach activation energies for the catalyzing steps are thought to be fixed...

Awarded: NOK 1.9 mill.

Project Period: 2007-2009

Location: Rogaland

FUGE-Funksjonell genomforskn.i Norg

The roles of microRNAs and transcription factors in gene regulation and tissue specific expression

MicroRNAs (miRNAs) were identified as a large group of regulatory genes in 2001, and increasing research has revealed these genes to be important in development, including differentiation, proliferation, and apoptosis. Many miRNAs seem to have tissue-spec ific expression patterns, which suggest t...

Awarded: NOK 7.0 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

The Interactomics of DNA Repair

The single most important factor for the correct functioning of genomes is that their coding information is maintained intact and transferred unperturbed to future generations. DNA repair is highly coordinated- and integrated with other fundamental cellul ar processes such as transcription, repli...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

SYSTEMS BIOLOGY IN THE MARINE TUNICATE OIKOPLEURA DIOICA

Gene regulatory modules are central to the coordination of an organism's developmental program and responses to its environment and understanding of them is a key objective of modern molecular biology and medicine. The sophisticated cis-regulation of gene expression in higher metazoans often ext...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Alkaline shock and excitotoxicity in epilepsy: RNAi in vivo - tools for investigation and prospects for therapy

Epilepsy is one of the most common forms of brain disorders, affecting about 1 % of the population. Alkaline shock, the rise of intracellular pH, is one of the few basic explanations of seizures that are now gaining a clear mechanistic description. Very r ecently a direct link between seizures, C...

Awarded: NOK 6.0 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Understanding brain systems by cell type-specific changes in gene expression

Despite impressive advances in almost every field of neuroscience, our understanding of brain function remains largely confined to its building blocks at the microscopic level, and to phenomenological descriptions at the macroscopic level. The introductio n of transgenic mice has provided neurosc...

Awarded: NOK 10.0 mill.

Project Period: 2007-2010

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

A systems biology approach to for modelling of plant signalling and host defence.

The whole-systems approches have created new opportunities for studying and modelling how cellular processes are regulated/coordinated to meet the organism/cell demands. We propose to use a whole-system approach to develop methods for modelling of plant c ellular processes. In addition to generat...

Awarded: NOK 5.3 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Contextual Regulation of Cell Proliferation & Differentiation in Angiogenesis: Integrated Functional Genomic Discovery &Validation Approach

Angiogenesis, the formation of new blood vessels from extant vasculature, is a fundamental homeostatic process and a key factor in the progression of many pathological conditions. Angiogenesis is defined by the growth and differentiation of endothelial ce lls. We conceptualize angiogenesis as a c...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

O-LINKED PROTEIN GLYCOSYLATION IN BACTERIA

Protein glycosylation is a pivotal element of biological systems not only because it is one of the major post-translational modifications but also because it has significant effects on protein properties and functions. We have recently discovered, and par tially characterized, the first general O...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Genomic Readout Platform

Project summary As scientists gain knowledge from mapping the Human Genome, they will also find new ways to treat and even prevent disease. To build the library of information necessary to advance the field of genomic medicine, it is imperative that we de velop DNA sequencing technology that is f...

Awarded: NOK 2.1 mill.

Project Period: 2007-2009

Location: Vestfold

FUGE-Funksjonell genomforskn.i Norg

Epigenetic surveying in immune-mediated diseases. A twin study.

Background: Genetically complex diseases, e.g. immune-mediated diseases are caused by a complex interplay between susceptibility genes and environment. The impact of environmental factors is clearly demonstrated in twin studies showing concordance rates i n MZ twins well below 100%. One impact of...

Awarded: NOK 8.0 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Regulation of Nuclear Receptor Function by Posttranslational Modifications

Nuclear receptors (NRs), together with coregulatory proteins, coordinate the transcription of gene networks in response to ligand binding and cellular signaling in such diverse biological programs as reproduction, development, nutritent uptake, metabolism and excretion. PMTs have proven to be es...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Understanding the System of Neurotransporters

The proposed project is a system-biology approach to transport across brain plasma membranes focusing on neurotransmitter inactivation and water transport. The primary aim is to prepare the ground for a large scale approach to understand what all the hund reds of transporter and ion channels do t...

Awarded: NOK 5.3 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

FUGE - Øst II - Funksjonell genomforskning i Østlandsregionen Handlingsplan 2007 - 2011 - Søknad om regional støtte

Foreliggende femårsplan og søknad fra FUGE-region Øst er utarbeidet av FUGE-Øst med medlemmer fra Universitetet i Oslo (UiO), Universitetet for miljø- og biovitenskap (UMB) og Norges veterinærhøgskole (NVH). Planen tar sikte på realisere hovedmålene angit t over. Sentrale virkemiddel for å nå d...

Awarded: NOK 5.0 mill.

Project Period: 2007-2012

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Multiple stress responses and adaptations

Farmers and breeders know that combinations of biotic and/or abiotic stresses in the field (e.g. disease and drought or high-light and cold) cause the greatest losses to crop productivity worldwide. Responses and tolerance to stress combinations are rarel y addressed in genomics research because ...

Awarded: NOK 1.8 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Søknad om regional FUGE-støtte 2007 - 2011, Midt-Norge

FUGE Midt-Norges arbeid i FUGE I perioden og de planer som er lagt for FUGE II (2007-2011) bygger på det mandat som er gitt av FUGEs styre i referat fra møte 04.11.2002. FUGE Midt-Norge har gjennom egenvurdering målt innsats og oppnådde mål i FUGE I peri oden opp mot overnevnte mandat og de måls...

Awarded: NOK 5.0 mill.

Project Period: 2007-2013

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Bacillus ACT 2007 - International Conference on Bacillus anthracis, B. cereus and B. thuringiensis

We apply for financial support from the Norwegian Research Council to help us organize the Bacillus ACT 2007 Conference in Oslo. The Conference will gather scientists from around the world (Europe, Americas, Asia) studying the group of closely related pat hogenic bacteria encompassing Bacillus an...

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Søknad om regionale midler til FUGE-N for perioden 2007-2011

Det regionale fagrådet for FUGE-N har hatt et budsjett på ca. 6,8 mill kroner i perioden 2002-2006 for å støtte regionale tiltak som bl.a. et kompetanseprosjekt, støtte til reiser for å øke kompetanse, lokale arbeidssamlinger og professor II-stillinger. E tableringen av FUGE-N har styrket og heve...

Awarded: NOK 5.0 mill.

Project Period: 2007-2012

Location: Troms - Romsa - Tromssa

FUGE-Funksjonell genomforskn.i Norg

Functional genomics and diabetes in Norway - Clinical, molecular, cellular and epidemiological analysis of monogenic diabetes

Diabetes is a common and severe disease. Maturity-onset diabetes of the young (MODY) is an inherited type of diabetes with decreased insulin secretion. Based on our national MODY Registry, we have recently identified a novel syndrome of exocrine and endoc rine pancreatic dysfunction caused by mut...

Awarded: NOK 8.5 mill.

Project Period: 2007-2012

Location: Ukjent Fylke

FUGE-Funksjonell genomforskn.i Norg

National resources for genomics, functional genomics and health reserach in Atlantic salmon and Atlantic cod. WP 2

The Norwegian School of Veterinary Science (NVH) aims to be at the forefront of international research in the field of aquatic medicine. During many years and through numerous national and international projects, NVH has built up substantial competence wi thin marine research/fish health and func...

Awarded: NOK 3.9 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

Seeds for growth - Identification of transcriptional programs controlling seed growth and development from Arabidopsis to rice

The last decades have brought about a tremendous increase in our understanding in molecular mechansims of seed development. However, further progress appears to be haltered by three major constraints. First, seeds are compound structures that harbour many tissues and cell types. Currently, a rel...

Awarded: NOK 1.3 mill.

Project Period: 2007-2011

Location: Oslo

FUGE-Funksjonell genomforskn.i Norg

FUGE II - Region West Application

This application is a response to the call for regional funding within the FUGE II program. Five professor II positions are requested to bring specific areas of expertise in support of systems biology, organelle biology, proteomics, microarray technology and marine functional genomic research. ...

Awarded: NOK 4.6 mill.

Project Period: 2007-2013

Location: Vestland

FUGE-Funksjonell genomforskn.i Norg

Global metabolic switching in Streptomyces coelicolor

Systems Biology aims at understanding and predicting the properties of a biological system under targeted perturbations (e.g. genetic changes or changes in the external environment) with the use of integrated data analyses and mathematical modelling. It r equires a multidisciplinary approach incl...

Awarded: NOK 3.2 mill.

Project Period: 2007-2010

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

A study of aging in the honey bee brain

The honey bee is a key neurobiological model for understanding learning and memory formation. As a highly social invertebrate, moreover, the bee provides unique opportunities for cutting-edge research on aging and frailty because it opens up the interface between the individual and the social en...

Awarded: NOK 7.0 mill.

Project Period: 2007-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

Systems Biology of a genetically engineered Pseudomonas fluorescens with inducible exo-polysaccharide production: analysis of the dynamics a

The biosynthesis of the industrially important exopolysaccharide alginate will be used as a model system for global analysis of the functioning of metabolic networks in genetically engineered strains of the unicellular bacterium Pseudomonas fluorescens. T he level of synthesis of the polymer can ...

Awarded: NOK 9.3 mill.

Project Period: 2007-2011

Location: Trøndelag - Trööndelage

FUGE-Funksjonell genomforskn.i Norg

Transcriptional and Metabolic Studies in Enterococcus faecalis

The study will be initiated by a thorough analysis of the metabolic pathways given by the genome sequence of Enterococcus faecalis V583. The project will investigat the metabolic characteristic of central carbon metabolism of E. faecalis with emhasis on s ugar utilisation. An important part of th...

Awarded: NOK 2.4 mill.

Project Period: 2007-2010

Location: Akershus

FUGE-Funksjonell genomforskn.i Norg

International conference on the biology and biotechnology of thermophilic microorganisms; Thermophiles 2007

Thermophilic microorganisms thrive at temperatures from about 60 to above 100 oC. Those growing optimally above 80 oC are termed hyperthermophiles. The most hyperthermophilic organism characterized so far is able to grow at temperatures up to 113 oC, but microbial growth has even been recorded at...

Awarded: NOK 99,999

Project Period: 2007-2007

Location: Vestland