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Hovedmålet med kreftbehandling er å eliminere kreftceller og dette er tradisjonelt oppnådd ved kirurgi, bruk av giftige medikamenter (cellegift) og stråling. En ny og betydningsfull tilnærming til kreftbehandling kalt immunterapi, har derimot fått mye oppmerksomhet det siste tiåret; Her forsøker leger og forskere å utnytte immunsystemet vårt for å målrettet  ødelegge kreftceller. En nøkkelaktør i denne banebrytende tilnærmingen er en gruppe «drapsmenn» i immunsystemet kjent som cytotoxiske T-lymfocytter (CTL-er). Disse cellene har en bemerkelsesverdig evne til å oppdage kreftceller ved å gjenkjenne unormale molekyler på overflaten av kreftcellene - molekyler som friske celler ikke har. Når CTL-er gjenkjenner kreftcellene ødelegger de dem ved å frigjøre giftige molekyler som initierer kreftcellenes selvdestruksjon. 
 
Selv om betydelige innsats har blitt dedikert til å forstå hvordan CTL-er aktiveres og hvordan de gjenkjenner kreftceller, vet vi mindre om de påfølgende hendelsene inne i kreftcellene som fører til deres død. Fra før vet vi at CTL-er kan initiere to forskjellige typer celledød i kreft: den første, kalt apoptose, er en stille og ordnet prosess der kreftcellene krymper og brytes opp uten å varsle immunsystemet; den andre, kalt pyroptose, er en mer dramatisk prosess som involverer dannelse av åpninger i cellemembranen, noe som fører til at cellene svulmer opp og sprekker. Under denne cellebristen blir innholdet inne i cellene frigitt i omgivelsene, og dette kan fungere som 'faretegn' som kan stimulere en sterkere immunrespons mot kreftcellene. Betydningen av denne cellebristen for å forsterke anti-tumorresponsene vil bli undersøkt i dette prosjektet. 
 
Videre er vi fascinert av muligheten for å avdekke ytterligere, ennå ukjente, former for celledød indusert av CTL-er. Utforsking av disse dødsrelaterte prosessene i kreftcellene kan potensielt øke effektiviteten av immunterapi og bidra betydelig i den pågående kampen mot kreft.

The primary goal of most cancer therapies is to induce cancer cell death. Immunotherapy relies on the cytotoxic activity of lymphocytes such as natural killer cells (NKs) and cytotoxic T lymphocytes (CTLs) to achieve this. While a significant amount of research in immunotherapy focuses on the events within cytotoxic lymphocytes or at the interface between cytotoxic lymphocytes and cancer cells, less is known about the molecular mechanisms that orchestrate cancer cell death, particularly in the case of CTL-mediated death.
CTLs are known to induce two types of cell death in cancer: non-inflammatory apoptosis and proinflammatory pyroptosis. Pyroptotic cancer cells release proinflammatory signals that attract immune cells to the tumor site, thereby enhancing the anti-tumor response. Cell lysis is a common outcome of pyroptotic cell death. It is unclear whether lysis can be decoupled from pyroptosis in cancer cells and whether the proinflammatory properties of pyroptotic cancer cell death depend on lysis. Moreover, it remains unknown whether CTLs can induce other forms of cell death in cancer, apart from apoptosis and pyroptosis.
Studying the mechanisms of CTL-mediated cancer cell death is challenging because CTLs selectively target cells expressing specific antigens. However, given the critical role of CTLs in immunotherapy, it is essential to deepen our understanding of CTL-induced cancer cell death.
This project aims to develop novel methodologies to investigate the death mechanisms that are initiated by CTLs. In addition, we will identify new pathways and mediators involved in CTL-induced cancer cell death. Furthermore, we will assess the contribution of proinflammatory cell death and lysis in promoting anti-tumor responses in vivo. Overall, this research will improve our knowledge of the molecular mechanisms of CTL-mediated cancer cell death and potentially reveal novel targets to enhance the efficacy of cancer immunotherapy.

T-cell-mediated proinflammatory cell death and lysis in cancer

En av de vanligste, men minst studerte, utfordringene med å bli eldre er problemer med å kommunisere. Mange eldre sliter spesielt med pragmatiske ferdigheter, som å forstå undertekst, eller tilpasse det de sier til personen de snakker med. 

La oss si at en lege må gi en alvorlig beskjed til en pasient. For å gjøre det litt lettere å takle, bruker legen vagere språk, som "kanskje" i stedet for "sannsynligvis". Mens yngre voksne ofte tar hensyn til høflighetsstrategier i måten de tolker det som blir sagt på, har eldre ofte vanskelig for å forstå når noen snakker indirekte. Mange eldre voksne har vanskelig for å forstå ikke-bokstavelig språk og kan misforstå alvorlighetsgraden av diagnosen. Dette kan påvirke beslutningen deres om behandling, noe som kan føre til utilsiktede konsekvenser. 

Siden god kommunikasjon er viktig både i viktige medisinske samtaler og i hverdagen, er det viktig at vi finner ut hva som gjør at eldre kan ha vansker med å forstå og bli forstått. RESILIENCE skal hjelpe til med denne utfordringen ved å samle data om praktiske, kognitive og språklige ferdigheter hos voksne i alderen 18-90 år over tid. Dette vil gi oss en stor mengde data om pragmatiske, kognitive og språk ferdigheter og gjøre det tilgjengelig for forskning. Med denne dataen som grunnlag har vi følgende mål: 

• Forstå hvordan praktiske evner endrer seg generelt gjennom voksenlivet. 
• Finne ut hvilke mekanismer som påvirker pragmatiske evner på forskjellige tidspunkter i livet.
 • Utvikle en teoretisk modell som forklarer hvordan pragmatiske ferdigheter endrer seg med alderen.
 • Lage algoritmer som kan forutsi hvordan pragmatiske evner vil utvikle seg for enkeltpersoner i årene som kommer. 
• Utvikle og teste et verktøy som kan måle pragmatisk helse (både pragmatiske ferdigheter og deres underliggende mekanismer), noe som kan åpne  for å iverksette tiltak. 

Dette vil gi oss muligheten til å forstå bedre hvordan folk kan utvikle pragmatisk resiliens gjennom livsløpet.

A cornerstone of human communication is our reliance on pragmatic skills to guide linguistic interactions (e.g., reasoning about others' mental states to bridge the gap between what is said and intended in conversation). However these skills are highly sensitive to age-related decline, leading to miscommunication and uninformed decision making in the older adult population. This raises an important question, one which has puzzled linguistics and psychologists for decades: if pragmatic competence is fundamental to communication, why do individuals vary so much in this capacity? 

Traditionally, psychologists have approached pragmatic competence from a cognitive angle, reasoning that individual differences in executive functions (i.e., the cognitive skills associated with goal-directed actions) are what underlie effective pragmatic behavior. In a similar vein, language scientists have taken a linguistic approach, reasoning that one’s language background (e.g., the frequency with which individuals shift between languages) shapes pragmatic skills by enhancing sensitivity to the communicative context. This focus on either cognitive or linguistic influences has resulted in two expansive yet disparate areas of research.

RESILIENCE will unite these disciplines to pursue a longstanding debate on what underlies pragmatic resilience and decline using a large-scale, interdisciplinary and longitudinal approach. By gathering data on adults' (ages 18-90) pragmatic, cognitive and language skills over multiple time points, we will develop a comprehensive theoretical model that explains how cognitive and linguistic systems interact to shape pragmatic competence as we age, and create algorithms that predict the trajectory of an individual’s pragmatic abilities in upcoming years. Based on these results we will design a multidimensional tool that detects the earliest signs of pragmatic deficits, leading to future interventions, allowing us to uncover the paths to pragmatic resilience.

Uncovering the paths to pragmatic resilience

Noen av oss tåler stressende livshendelser godt. Andre derimot utvikler vedvarende fysiske og psykiske plager som følger av stress. Hvor godt vi håndterer stress avhenger av et komplekst samspill mellom miljøfaktorer, sosiale forhold, biologisk sårbarhet og indre motstandskraft. Forskning på stressreaksjonene til dyr og pasientgrupper som til vanlig lever under mye stress viser at en gruppe signalstoffer i kroppen som aktiverer det samme hjernesystemet som cannabis – endocannabinoidene – kan begrense styrken på stressreaksjoner og bidra til at man raskere kommer seg til hektene. I dette prosjektet skal vi undersøke hvordan mestring av stress på kort og lang sikt henger sammen med nivåer av endocannabinoider i kroppen for å forstå hvorfor noen personer er mer motstandsdyktige mot stress enn andre. I den ene studien følger vi pasienter som skal gjennomgå en stressende, men veldig vanlig, situasjon: kirurgi. Her måler vi pasientenes opplevelse av stress, samt mentale og fysiske helse, fra tiden før til to år etter operasjonen og undersøker hvordan dette henger sammen med nivåene deres av endocannabinoider og andre stresshormoner. I den andre studien bruker vi data fra et eksperiment hvor deltakerne har blitt utsatt for psykososialt stress til å undersøke om endocannabinoidnivået deres påvirker hvordan de reagerer på stress, og om stresset i seg selv kan påvirke kroppens produksjon av endocannabinoider. Til syvende og sist er målet med studien å vurdere hvorvidt målinger av endocannabinoidnivåer kan brukes til å forebygge helseplager og til å evaluere behovet for økt oppfølging etter alvorlig stressende påkjenninger i livet.

In the face of major life stressors, some individuals cope well whereas others develop ill health and long-term adverse outcomes. Predicting who needs additional support in response to major life stressors is essential for targeted prevention and more efficient allocation of resources. The endocannabinoid system is emerging as a promising target for understanding vulnerability and resilience to stress. This system appears to buffer stress in two ways: by limiting the magnitude of the stress response, and by facilitating recovery after a stressful event. While the early findings are intriguing, they mainly stem from studies in rodents and small clinical groups with high stress burden. What role endocannabinoids have more globally for human resilience, health and well-being remains elusive. 

In this project we address this gap by leveraging comprehensive experimental and clinical data on two potent stress models: psychosocial stress and surgery. Drawing on these unique datasets, which combine experimental control with ecological validity, we will decipher how endocannabinoid levels influence people’s stress response and recovery across minutes, days, weeks and years. The project represents a novel directional shift for endocannabinoid research and will (i) determine the value of endocannabinoid levels as a biomarker to predict outcomes after surgery, (ii) quantify sex differences, (iii) assess endocannabinoid interplay with opioid analgesics, sex hormones and other stress markers (iv) spearhead open and reproducible science practices in endocannabinoid research, and (v) make this fine-grained and novel data available through an interactive web application. 

This project represents an ambitious effort to understand endocannabinoids’ role in stress resilience and will determine the value of endocannabinoids as a predictive biomarker and potential target for individualized treatment.

Deciphering endocannabinoid stress buffering in humans: 
Mechanistic and clinical investigations

BOLD MINDS aspires to enhance the understanding of vulnerability factors underlying the emergence of borderline personality disorder (BPD), with an ultimate aim of increasing the potential for young individuals to receive early, evidence-based help when their mental health is at risk. BOLD MINDS will achieve this by investigating whether disruptions in two aspects of autobiographical memory (AM), narrative identity (NI) and involuntary AM (IAM), are associated with BPD features and problem behaviours in adolescents concurrently and over time. In doing so, BOLD MINDS will strengthen the understanding of mechanisms underlying the emergence of BPD in adolescence and lay a groundwork for developing evidence-based early interventions for BPD. While currently limited, the study of AM in this field is essential for two reasons. Firstly, because the aspects of AM under investigation, NI and IAM, are known to be involved in identity formation and emotion regulation which represent two key psychological processes that are disrupted in adults with BPD and are linked to problem behaviours such as self-harm and suicidality. Secondly, because promising research is emerging on the use of AM targets in the treatment of emotional disorder in adults, and provides a strong model for future treatment development with vulnerable adolescents. In addition, this timely research program aligns with calls from international organizations to prioritize early interventions to promote adolescent mental health. BOLD MINDS will adopt and adapt state-of-the-art ecological momentary assessment and analytical techniques and work at the crossroads of clinical and cognitive psychological perspectives, allowing for a multidimensional approach to understanding BPD vulnerability. Training-through-research and formalized training of the experienced researcher will prepare her for a permanent academic position and the founding of her own research lab specializing in AM and early interventions for BPD.

Borderline Personality Disorder: Memory and Identity in Adolescence

The goal of the Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME) project is to examine the functional neuroplastic mechanisms underlying mitigatory effects of bilingual experience on age-related cognitive decline. While evidence is available for structural brain changes supporting bilingualism-induced effects on cognitive aging (CA), functional mechanisms underlying such effects are not yet well understood. BECAME aims to fill this gap by investigating the trajectory of bilingualism-induced functional neuroplasticity across the adult lifespan (ages 18-85), crucially adopting an individual differences approach related to measurable degree of bilingual engagement. Importantly, although such benefits are thought to be rooted early in the lifespan, evidence for the timeframe and conditions of their early emergence is scarce. The choice of including the whole adult lifespan allows us to investigate these mechanisms and their emergence more directly from a lifespan perspective. I combine behavioral testing with brain recordings via electroencephalography (EEG). EEG is widely used in cognitive neuroscience to assess brain activity and the degree of communication between brain regions (functional connectivity) in response to stimuli and at rest. Combining behavioral and EEG modalities will allow me to test bilingualism’s effect on functional connectivity, as well as its consequences for functional efficiency, the minimum required neural activation to successfully perform a task. This will enable a detailed, evidence-based account of the protective effects observed in older-aged bilinguals, and how they are built from earlier life stages. By illuminating the relationship between multilingualism and resulting neurocognitive adaptations, BECAME will enable to capitalize on it as a health initiative, with manifold societal implications and the potential to be translated into actionable policies exploiting multilingualism to ameliorate effects of CA.

Bilingual Experiences, Cognitive Ageing and underlying Mechanisms

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Per- og polyfluorerte stoffer (PFAS) er en stor gruppe menneskeskapte kjemikalier med høyt fluorinnhold som antas å ha negative helseeffekter. Kilder til PFAS kan være produksjon av vann-, varme- og flekkbestandige produkter og disse kjemikaliene er en del av hverdagen vår. PFAS påvirkning av biologiske systemer er ikke fullstendig forstått. Noen PFAS er antatt å øke risikoen for å utvikling av ikke-alkoholisk fettleversykdom (NAFLD) og øke risikoen for diabetes. 

For å forstå hvordan PFAS påvirker organene våre ønsker vi å bruke små laboratoriedyrkede organmodeller, kalt organoider. Disse miniatyrorganene kan dyrkes fra menneskelige stamceller og tilbyr et kontrollert miljø for å studere hvordan PFAS påvirker f.eks lever og bukspyttkjertelen vår, uten bruk av dyreforsøk.

For å studere helseeffekter må vi kunne måle nivået av biomolekyler som fettstoffer i leveren og hormoner i bukspyttkjertelen. Til dette trenger vi å utvikle analytiske verktøy for å måle effektene. Først vil vi bekrefte at når leverorganoidene eksponeres for enkelte PFAS-forbindelser utvikles det NAFLD-lignende sykdom ved å sammenligne den biokjemiske profilen (proteiner og metabolitter) til organoider av lever med PFAS-eksponerte organoider. Deretter vil vi utvide den analytiske verktøykassen for å undersøke hvilke metabolske veier som påvirkes, og om effekten er den samme i NAFLD-induserte og PFAS-eksponerte organoider. Vi vil også eksponere insulinproduserende bukspyttkjertelorganoider for PFAS for å undersøke effekten av PFAS på hormonproduksjon. Når effektene av PFAS-eksponering på lever- og bukspyttkjertel-organoider er etablert, vil organoidene bli samkultivert i en chip, og effektene av PFAS-eksponering vil bli undersøkt og sammenlignet med individuelle organoider.

Persistent organic pollutants (POPs) are believed to contribute to metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD) and type 1 diabetes. HE-POP aims to investigate the effects of per- and polyfluoroalkyl compounds (PFAS), a type of POPs), on organ function in a controlled environment.

Organoids are multicellular laboratory-grown miniature organs, that are grown from stem cells. HE-POP will use organoids to examine how PFAS affects our organs and develop cutting-edge bioanalytical tools and methodology to measure these effects using liquid chromatography-mass spectrometry. HE-POP hypothesizes that PFAS negatively affects organ function, as evidenced by changes in hormone and lipid levels characteristic of NAFLD and type 1 diabetes. 

Organoids offer a controlled environment to study the effects of PFAS on the liver and pancreas, without the use of animal models. HE-POP aims to gain evidence of the negative effects of PFAS on organ function through controlled experiments on organoids and aid in understanding the biological mechanisms underlying NAFLD and type 1 diabetes.

HE-POP has fundaments in UN sustainable development goals, specifically #3, #12, and #14/15, seeking an understanding of diseases with worldwide prevalence, and understanding how POPs affect our life and surroundings and help enable the right regulatory actions and replacement chemicals.

HE-POP: Studying the Health Effects of Persistent Organic Pollutants, Using Mass Spectrometry, Organoids, and Organ-On-A-Chip

Rundt 7% av norske 4-åringer har så store psykiske vansker at de kvalifiserer for en diagnose, men det tar ofte lang tid fra vanskene oppstår, til de blir oppdaget og barna får rett hjelp. Myndighetene har derfor lagt tydelige føringer for at de som jobber med barn, må vite hva de skal se etter og hvordan de skal gå frem for at barna skal få den hjelpen de trenger. I Norge går over 95% av barna i barnehage hvor pedagogene blir godt kjent med barna over tid i deres naturlige miljø og har utviklingssamtaler med de foresatte 1-2 ganger i året. Barnehagen skulle derfor være en ideell arena for tidlig oppdagelse av psykiske vansker. Det har imidlertid ikke vært tilgjengelig noen tilpasset metode for de arbeidsformene og terminologi som er vanlig i barnehagene. Vi har derfor utviklet metoden Dialogbasert tidlig oppdagelse (DBTO) i nært samarbeid med pedagoger og foreldre i 8 ulike barnehager. Metoden går ut på å bruke utviklingssamtalen mer systematisk ved at både foreldre og barnehagelærer på forhånd fyller ut et spørreskjema om mulige bekymringer de har hatt for barnets utvikling og trivsel de siste månedene. I samtalen kan de så utforske og forsøke å enes om forståelsen av barnet og om det er behov for ytterligere vurdering eller andre tiltak. Tilbakemeldingene under utviklingen og tidlig utprøving tyder på at metoden fungerer godt og oppleves som et nyttig verktøy i foreldresamarbeidet. For å få tydeligere dokumentert kunnskap om hvordan DBTO fungerer i barnehagene, har vi utviklet forskningsprosjektet PRO-DIALOG. Vi ønsker med det å få kunnskap om (1) hvordan DBTO fungerer som et screening-instrument, (2) hvor brukervennlig den er, (3) hvordan den påvirker tidspunkt for igangsetting av tiltak og (4) hvordan den påvirker utviklingen av den psykiske helsen til barna over tid. 12 barnehager er plukket tilfeldig ut til å gjennomføre metoden, mens 11 skal fungere som kontroller. Foresatte til rundt 300 barn som har tre år igjen av barnehagen, vil bli spurt om å delta.

There is an unambiguous call for early interventions at the municipal level for children at risk of developing mental health problems. However, there is a surprisingly absence of socially valid methods for detecting children in need of early support.
        The aim of the project is to establish the properties of such a novel method; Dialogue Based Early Detection (DBED). We will study its properties as a mental health screener, how well it is adapted in an ordinary kindergarten context, and whether it affects activation of interventions for mental health concerns and children’s future mental health.
        The novel aspect of DBED is the systematic assessment of the child’s development and well-being by the kindergarten teacher and his/her parents, and the subsequent dialogue that aims to explore and converge their understanding of the child and conclude whether there is a need for further assessment or supportive actions.
        Parents of approximately 300 children in 23 different kindergartens aged 2-3 years will be invited to participate for the three last years before school start and follow-up the next two years. The kindergartens will be randomized to an implementation group or a control group. Parents’ socio-demographic characteristics and data from parent-teacher meetings, initiated interventions, user satisfaction, parental stress, and child mental health will be collected biannually, as well as tape recordings from interviews about user experiences of parents and teachers.
        The most critical challenges of the project will be participation rate of the invited parents in addition to attrition due to the time pressures in a busy workday in the kindergartens, and willingness of the control parents to complete the repeated questionnaires. Appropriate measures are made to take those risks into account.

Promoting mental health in young children – a sustainable dialogue based approach in kindergartens (PRO-DIALOG)

Dette prosjektet, kalt Hukommelse for musikk, fokuserer på det økende antallet mennesker over hele verden som lever med demens, spesielt Alzheimer's sykdom (AD). AD starter typisk med hukommelsesproblemer og påvirker etter hvert daglige aktiviteter. Aktive musikkintervensjoner, spesielt sang, har vist positive effekter på humør, atferd og livskvalitet for personer med demens, men deres innvirkning på kognisjon er ikke godt forstått. Prosjektet har som mål å fylle dette kunnskapsgapet ved å studere effektene av å lære nye sanger på kognitiv, atferdsmessig og hjernemessig funksjon.

Studien vil omfatte hjemmeboende voksne over 65 år med AD fra Argentina, Østerrike og Norge. Deltakerne vil gjennomgå 5 måneder med intensiv musikalsk opplæring (to ganger i uken) og 5 måneder med minimal opplæring (en gang i måneden) i tilfeldig rekkefølge, med en to måneders pause imellom. Intervensjonene inkluderer å lære nye sanger med en personlig musikklærer. Generell kognisjon vil bli målt ved bruk av Alzheimer's Disease Assessment Scale - Cognitive (ADAS-cog), og hukommelse for musikk vil bli vurdert gjennom ulike metoder, inkludert atferdsoppgaver og hjerneaktivitet (EEG). Humør vil også bli evaluert i hver økt.

Målet er å inkludere 113 deltakere for å sikre pålitelig påvisning av meningsfulle effekter. Studien vil utforske hvordan humør og hukommelse for musikk bidrar til endringer i kognitive evner, og om disse effektene varierer basert på faktorer som kjønn, alder, AD-stadium, eller tidligere musikalsk opplæring og generell utdanning. Prosjektet vektlegger samarbeid mellom forskere, tjenesteytere og brukere for å sikre studiens relevans og anvendelighet.

The number of people living with dementia is increasing and is high in low, middle, and high-income countries. Alzheimer’s disease (AD), the most common type of dementia, manifests itself initially with cognitive impairment in memory domains, and later affects all activities of daily living. Active music interventions, particularly singing, can help to improve mood, behaviour problems, and quality of life. Too little is known about their effects on cognition, although some promising studies exist. The M4M project aims to fill this gap by measuring effects of learning new songs on clinical, behavioural and brain functioning. Specifically, M4M aims to examine changes in general cognitive functioning and memory for music in non-musician adults with AD undergoing intensive individual musical training based on singing novel songs, compared to minimal training.
        Home-dwelling adults with AD, 65 years or older, in 3 countries (Argentina, Austria, Norway), will receive 5 months of intensive intervention (2x/week) and 5 months of minimal intervention (1x/month), in random order, with a 2-month break in between. Interventions will entail learning new songs with an individual music teacher. At the end of each intervention period, general cognition will be measured with the Alzheimer's Disease Assessment Scale – Cognitive (ADAS-cog) by a person who is unaware of the intervention received. Memory for music will be tested with observations, behavioural tasks, and brain responses (EEG). Mood will be assessed in each session. We aim to include 113 participants; this will help us to reliably detect clinically meaningful effects. We will also examine how mood and memory for music lead to changes in cognitive abilities, and whether effects depend on sex, age, AD stage, or previous musical training or general education. M4M will be conducted in close collaboration between academic researchers, service providers, and service users to ensure relevance and applicability.

Memory for Music: Effects of individual intensive musical training based on singing in non-musicians with Alzheimer’s disease

InterNASH - An intercellular-pathway therapeutic for non-alcoholic steatohepatitis

Midlene fra ICT-1.03 Information and Communication Technologies fordelt på år

Midlene fra ICT-1.03 Information and Communication Technologies fordelt på fylker

Midlene fra ICT-1.03 Information and Communication Technologies fordelt på fagområde

European Schoolnet Living Schools Lab

The PES funds will be key to maximize the chances of succeeding with the application to the Horizon Europe call (topic entitled “Piloting emerging Smart IoT Platforms and decentralized intelligence”). The funding will enable ONiO to actively support the Coordinator organization (a research institute based in Sweden) and other partners in writing and submitting a very competitive proposal on a complex and challenging R&D topic. ONiO will contribute to writing parts of the proposal that concern our R&D work and specific tasks in the project, as well as to the exploitation of results and other complementary parts. The project proposal will focus on advancing the so-called edge-to-cloud continuum, unifying technologies through a common operating system and open platforms. The project will implement several pilots, and ONiO's contribution will focus on providing batteryless IoT sensor nodes for selected pilots.

Open edge to cloud continuum for EU digital sovereignty

The PES funds will be essential to maximising the chances of succeeding with the application to the Eurostars call. The funding will enable ONiO to lead the preparation (engaging international partners, writing and submission) of a solid proposal in challenging R&D topics and pitched towards a competitive European funding program. ONiO will take overall responsibility for writing the proposal, with contributions from partners in specific parts that concern their R&D work in the project, as well as the exploitation of the project results. The project proposal will focus on the development of a new scalable platform for energy harvesting applications based on ultra low power, sustainable electronic components.

Sustainable Electronics for Energy Harvesting Applications

ONiO er et innovativt teknologiselskap som skaper energihøstende, batteriløse løsninger til Tingenes Internett. Vårt mål er å ta de nyeste fremskrittene innen microchipteknologi, og putte dem i trådløse, smarte enheter drevet av vår nyeste batteriløse mikrokontroller. Disse nye enhetene kan brukes i sensorløsninger i industrielle og private områder som blant annet helse, produksjon, smarte bygg, kjøretøy etc.

Vi har utviklet ONiO.zero - en liten mikrokontroller som tar for seg energiflaskehalsen som for øyeblikket kveler veksten av Tingenes Internet. De små sensorene er avhengige av batterier som må byttes med jevne mellomrom, noe som øker materialkostnaden og hever terskelen for massiv produksjon og distribusjon. ONiO.zero er en supereffektiv, trådløs mikrokontroller som bruker innovativ energihøsting til å drifte seg selv og eventuelle andre komponenter. Energihøstingen trekker overskudd fra omgivelsene - fra strålingskilder som radio, mobilnett, lys og varme. Ingen batterier å bytte, og ingen strømledninger - kun pålitelig og uavbrutt operasjon.

Energioverskuddet skal være nok til å drive ultraeffektive sensorenheter som temperatur, trykk, lys, bevegelse mm. Uten batteri kan vi tillate oss å fokusere på komponenter som er mindre i størrelse og mer funksjonelle, der all plass blir brukt til sitt fulle potensial. Integrering i eksisterende løsninger blir lettere enn noen gang. ONiO.zero har innebygd Bluetooth for trådløs kommunikasjon.

I dette prosjektet ønsker vi å utvikle en ny mikrokontroller med nye verktøy for trådløs kommunikasjon; Ultra Wide Band (UWB) teknologi som kan fungere uten batterier. UWB er en form for radiokommunikasjon som bruker lavenergi radiobølger med rekkevidde på over det dobbelte av tradisjonell Bluetooth (BLE), og presisjon ned til en tiendedels nøyaktighet ved lokalisering og posisjonering. Dette gjør at UWB egner seg utmerket til sporing i sanntid av mennesker, last, ressurser og verktøy innendørs eller i industrielle omgivelser.

ONiO is a highly innovative Norwegian SME with a vision to bring self-powered solutions to the IoT market. ONiO’s core business is to translate the latest technical breakthroughs in wireless MCU (microcontroller units) into commercial solutions across a wide range of IoT market segments: healthcare, industrial, automotive, buildings, etc., replacing the need for a battery.

Our core technology platform is based on a highly flexible, ultra low power, compact chip designed for energy harvesting - i.e. capturing the available energy from the surroundings, primarily radio frequency (RF) energy but also capable of using external sources like solar, thermal or kinetic energy. The ONiO.zero chip is capable of powering multiple embedded sensors in a device, and is currently equipped with Bluetooth for wireless communication. 

With this project, we will develop a new chip with Ultra Wide Band (UWB) technology to unleash a prime space of applications/use-cases that rely on very accurate positioning (spatial and directional data), such as indoor navigation, tracking of people and assets, access control, social distancing, etc. The project will be implemented in collaboration with a global provider of indoor mapping and navigation services and with a research group within positioning algorithms.

Development of highly accurate asset location systems based on self-powered wireless transmitter devices

The PES funds will be key to maximize the chances of succeeding with the application to the Horizon Europe call (topic entitled “Advanced lightweight materials for energy efficient structures”). The funding will enable ONiO to actively support the coordinating organization and other partners in writing and submitting a very competitive proposal in a challenging R&D topic. ONiO will contribute in writing parts of the proposal that concern our R&D work and specific tasks in the project as well as exploitation of results and other complementary parts. The project proposal will focus on the development of new structural power materials based on sustainable constituents and respective green manufacturing processes. The consortium will aim at technological breakthroughs in structural batteries and supercapacitors for potential applications within a wide range of areas.

Multifunctional materials for sustainable structural power devices

The PES funds will be key to maximize the chances of succeeding with the application to the Horizon Europe call (topic entitled “Functional electronics for green and circular economy”). The funding will enable ONiO to actively support the coordinating organization and other partners in writing and submitting a very competitive proposal in a challenging R&D topic. ONiO will contribute in writing parts of the proposal that concern our R&D work in the project as well as exploitation of results and other complementary parts.

The project proposal will focus on the development of an integrated, self-powered, and wireless sensing platform for a range of applications. The consortium will aim at technological breakthroughs in energy harvesters, energy storage and sensing devices, as well as in computation and communication approaches. Focus on low-power, lightweight, low-cost and eco-friendly materials and fabrication approaches are prioritized.

Self-powered functional electronics platform

The PES funds will be key to maximize the chances of succeeding with the application to the Horizon Europe Doctoral Networks (Industrial Doctorates) call. The funding will enable ONiO to lead the preparation (building the consortium, writing and submission) of a solid proposal in challenging R&D topics and pitched towards a highly reputed, very competitive European funding program. ONiO will take overall responsibility for writing the proposal, with contributions from partners in specific parts that concern their R&D work and training elements in the project.
 
The project proposal aims at preparing the next generation of researchers by providing cutting-edge training in the field of smart sensing technologies and its translation into wireless and self-powered devices for continuous health monitoring. It will involve close collaboration between ONiO (and other industrial organization) and leading academic partners in electronics micro- and nano-systems, printed/organic electronics, flexible substrates and med-tech/wearables technology.

Multi-sensor technology for continuous healthcare monitoring based on self-powered, wireless sensors

ONiO AS is a company focused on bringing self-powered battery free technology to the IoT market. The company is dedicated to empowering the innovative sensor and data driven transformation by developing and manufacturing innovative smart sensors and radio technology as ultra-low power solutions not requiring a battery. ONiO's key roadmap product is a wireless microcontroller with energy harvesting (ONiO.zero), capable of multi-sensor measurements of essential parameters (e.g. vital signs in the case of medical use). Alongside the ONiO.zero we hope to build a robust, elastic, scalable and easily deployable database and data analytics platform that will enable new products and massive growth in diverse segments (such as IoT, industrial and automation, automotive, etc.). 
The project will be carried out by ONiO AS, as the project coordinator and lead participant. ONiO AS is a Norwegian R&D performing SME. The major barriers for ONiO going forward relate to: 1) market awareness and acceptance by end-users; 2) access to clients and securing the best commercialization partners; 3) regulatory compliance / medical approvals for the healthcare sector. This project will enable to: 1) mature our core technology (hardware and software); 2) conduct operational demonstrations of our turnkey solutions with test-users; 3) plan the clinical trials for our medical solution; 4) acquire market intelligence and prepare strategic partnering with relevant stakeholders. 
The EIC Accelerator provides a unique opportunity for ONiO to showcase the potential of its technology to raise customer awareness and overcome the remaining challenges associated with the market adoption of our product. The project is therefore key to accelerate the monetization of the technology and know-how available in-house. In sum, the completion of the project’s goals is intrinsically linked with ONiO AS’ strategy for successful market launch and commercialization of our smart sensor-based products.

WISE project: Wireless self-powered technology for continuous and accurate smart sensing

ONiO AS is developing and manufacturing innovative smart sensors and radio technology as ultra-low power solutions not requiring a battery, disrupting the world of smart sensing. ONiO's key roadmap product is a sensor chip wireless micro-controller with energy harvesting (ONiO.zero), allowing multi-sensor measurements of essential parameters (e.g. vital signs in the case of medical uses). Alongside the ONiO.zero we hope building a robust, elastic, scalable and easily deployable database and data analytics will enable new products and massive growth in IoT, medical, automotive, industrial, smart cities, wearables/clothing and consumer electronics markets.

Currently, ONiO does not have in-house expertise in antenna design for farfield multiband RF energy harvesting. However, this hardware asset (and embedded know-how) is critical for the success of our product, so we need to internalize this expertise by recruiting a resource with a strong academic track-record in developing and testing fully integrated energy harvesting components. The SME Innovation Associate programme project is thus necessary for this plan. The final antenna design(s) to be led by the Innovation Associate will need to meet our current specification criteria for a battery-less chip, which are already stricter than the observed performance of state-of-the-art systems being developed for academic research.

ONiO self powered sensing

ONiO AS is developing and manufacturing innovative smart sensors and radio technology as ultra-low power solutions not requiring a battery, disrupting the world of smart sensing. ONiO's key roadmap product is a wireless micro-controller with energy harvesting (ONiO.zero), capable of multi-sensor measurements of essential parameters (e.g. vital signs in the case of medical uses). Alongside the ONiO.zero we hope to build a robust, elastic, scalable and easily deployable database and data analytics platform that will enable new products and massive growth in diverse segments (IoT, medical, automotive, industrial, smart cities, wearables/clothing and consumer electronics markets).

The overall objective of the EID project is to provide specialized and highly qualified training to a group of Early Stage Researchers (ESRs), giving them the competences and skills to address the current and future challenges within ONiOs technological development roadmap and to initiate R&D activities that will be crucial for ONiOs product development plans. Our main challenge is that we do not currently possess the resources and expertise that are essential for achieving the full length of the activities proposed in this project. Therefore, we are looking for a group of ESRs to whom we can provide the appropriate training through the EID programme, in cooperation with leading academic partner(s), in order to internalize the missing expertise and further advance the development of our technology. Acquiring these skills, through this mutually beneficial training programme is fundamental for ONiO to maintain a competitive advantage over the coming years, advancing the use of new material science and mechanical engineering technologies to improve our future smart sensor-based products.

SmartSense: Self-powered multi-sensor technology for on skin continuous and accurate sensing with wireless communication

Feedback from the market demonstrates a need for improvements in systems that are currently used to provide fever monitoring of patients; single measurements at discrete points in time, with non-repeatable accuracy. This is a grim contrast to possibilities made available and utilized by smart sensor technology in other areas of the medical field. Improved monitoring facilitates better diagnostics, which in turn ensures optimal treatment for patients, better working conditions for health professionals, peace of mind for parents, and a major impact on issues related to the senior wave
The gold standard in most hospitals is manual rectal measurements. As an example, the estimated time used for manual fever monitoring in Europe is equivalent to 126,841 FTEs and €261M in consumables, or €4,8bn in total cost. We estimate we can reduce the time spent by more than 95%.
ONIO will provide a solution at a cost 4 times lower (10 times after cost down) than the current products, and be accessible to both the consumer market as well as the professional healthcare market. Improved monitoring will facilitate better diagnostics and treatment, peace of mind for parents and caregivers, reduction of staff hours related to collecting and analyzing data. In turn, this will alleviate the pressure on health professionals as well as reduce expenditures.
The objective is to introduce the first product ONiO.temp for children on the consumer market by the end of 2020. With the ultimate target of global expansion, there will be a progressive escalation, starting in 2020 with Scandinavia as the home market, expanding to selected countries in the European market by early 2021. Based on sales estimates from pharmacies, we expect a positive ROI second half of 2021,  a 28 % market share of a €2348M market in Europe and a Gross profit of €195M after 5 years in the market. Growing from 15 employees in year 1 to more than 150 employees in year 5.

Informed fever care. Empowering health awareness, medical care, and diagnostics by changing the way we monitor and use body temperature data

Cura8 er i ferd med å utvikle en ny løsning for kontinuerlig, trådløs febermåling, med sikte på å introdusere produktet i 2019. Markedet er primært Europa, med Skandinavia som testmarked. Den primære brukermålgruppen er barn, mens eldre/helseinstitusjoner vil være et aktuelt delmarked noe senere. Produktet vil bli distribuert gjennom apotekkjeder, men også pr. internett.

En funksjonell prototype er nå under utvikling. Produktet vil være en løsning hvor et spesialplaster plasseres på pasientens panne. Riktig temperatur kan avleses kontinuerlig, og resultatene overføres til PC eller mobiltelefon via en leser ved hjelp av en app. 

Cura8 søkte 15.2.17 om EU-støtte gjennom SMB-instrumentets fase 1, og fikk en evalueringsscore på 13,82 poeng. Fase1-aktivitetene som nå er gjennomført legger grunnlaget for en fase 2-søknad til SMB-instrumentet (cut-off 10.1.18). Cura8 tar sikte på å gjennomføre dette prosjektet i 2018 og 2019. Dette vil omfatte nødvendige demonstrasjonsaktiviteter for å lykkes med kommersialiseringen av produktet CuraTemp (bl.a. videreutvikling, testing av prototype, oppskalering, gjennomføring av go-to-market plan). Prosjektet vil munne ut i en videreutviklet, investorklar forretningsplan.

CuraTemp 2018 - Utvikling og kommersialisering av kontinuerlig trådløs febermåling

Cura8 AS er i ferd med å utvikle en ny løsning for kontinuerlig, trådløs febermåling, med sikte på å introdusere produktet i 2018. Markedet er primært Europa, med Skandinavia som testmarked. Den primære brukermålgruppen er barn, mens eldre/helseinstitusjoner er et aktuelt delmarked noe senere. Produktet vil bli distribuert gjennom apotekkjeder, men også pr. internett.

En funksjonell prototype er nå under utvikling. Produktet vil være en løsning hvor et spesialplaster plasseres på pasientens panne. Riktig temperatur kan avleses kontinuerlig, og resultatene overføres til PC eller mobiltelefon via en leser ved hjelp av en app. Leseren er en engangsinvestering, mens spesialplasteret er forbruksvare (skiftes en gang pr. døgn). Spesialplasteret vil ha en passiv UHF RFID-tag med temperatursensor. Leseren som mottar data plasseres i nærheten av pasienten, og data kan sendes bruker/pårørendes mobilapp f.eks. via wifi og en skyløsning.

Prosjektet under SMB-instrumentets fase 1 vil ikke fokusere på den videre teknologiske utviklingen. De viktigste prosjektaktivitetene i fase 1 (6 måneder) vil være:
- Videreutvikling av forretningsmodell og forretningsplan
- Identifisering og valg av leverandører av produktkomponenter
- Design
- Immaterielle rettigheter
- Markeds- og kommersialiseringsplan
- Godkjenningsprosess (i samarbeid med Nemko)

Fase 1-prosjektet er i tråd med intensjonen med SMB-instrumentet og er klart relevant i forhold til topic 6 (IKT-løsninger for helse).

Prosjektet vil munne ut i en videreutviklet forretningsplan, som basis for videre drift og en eventuell prosjektsøknad til SMB-instrumentets fase 2.

ICT-1.03 Information and Communication Technologies

European Schoolnet Living Schools Lab

Awarded: NOK 0.55 mill.

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ICT-1.03 Information and Communication Technologies

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