2015

2014

2013

2012

2011

2010

2009

2008

2007

2006

Portefølje Naturvitenskap og teknologi ikon

The research system

Portefølje Humaniora og samfunnsvitenskap ikon

Ground-breaking research

Portefølje Samisk ikon

Sámi society and culture

Portefølje Demokrati, styring og fornyelse ikon

Democracy and global development

Portefølje Velferd, kultur og samfunn ikon

Welfare, culture and society

Portefølje Helse ikon

Health

Portefølje Klima- og polarforskning ikon

Climate and environment

Portefølje Landbasert mat, miljø og bioressurser ikon

Land-based food, the environment and bioresources

Portefølje Energi, transport og lavutslipp ikon

Energy and transport

Portefølje Muliggjørende teknologier ikon

Enabling technologies

Portefølje Industri og tjenestenæringer ikon

Innovation

LTP Climate, environment and environmentally friendly energy

Climate and loss of natural diversity

Internationalization

Societal security and civil preparedness

Renewal in the public sector

Velferdstjenester

Frontpage Image

Marine icon

Petroleum og mineraler

LTP Hav ikon

Oceans and coastal areas

LTP2 Muliggjørende og industrielle teknologier ikon

Enabling and industrial technologies

Trust and community

Professional environment

High quality and accessibility

LTP Climate

Strengthened competitiveness and innovation capacity

LPT Health

 An innovative business community

LTP3 Helse

Portefolje Petroleum Ikon

Portefølje Hav ikon

Portefølje Utdanning og kompetanse ikon

Portefølje Global utvikling og internasjonale relasjoner ikon

Portefølje Livsvitenskap ikon

LTP2 Styrket konkurransekraft og innovasjonsevne ikon

LTP2 Utvikle fagmiljøer av fremragende kvalitet

LTP2 Samfunnssikkerhet og samhørighet ikon

LTP2 Fornyelse i offentlig sektor ikon

LTP2 Klima, miljø og miljøvennlig energi ikon

Forsidebilde optimalisert

project-bank-technical

Et innovativt næringsliv ikon

Muliggjørende teknologier bakgrunn

Marin bakgrunnsbilde

Marin ikon

Forsidebilde

Statistics

Prosjektbanken presenterer statistikk og informasjon om prosjekter med finansiering fra Forskningsrådet fra 2004. Statistikken er fordelt på blant annet tema, år, geografi og organisasjon. Prosjektbanken gir også detaljert informasjon om de enkelte prosjektene.

...or see the summary and other information about the projects you have selected

Portfolios

En god beskrivelse av denne siden for søkemotoroptimalisering

Forside

How the grants are distributed between organisations, counties, subject areas etc....

Here are some examples of searches you can perform in the Project Databank

All long term plan objectives

About Text Queries

No thematic area or topic related to the project

has received funding in the programme period

No popular science description is available

have received funding in the programme period

The project with project number {{project number}} was not found

Technical description

Woops, something went wrong. Please refresh the page. If the error persists, please contact us.

We could not find what you were looking for

See statistics related to this LTP objective

See projects related to this LTP objective

related to this LTP objective have received grants

has been granted to projects related to this LTP objective

has been granted to projects related to this portfolio

related to this portfolio have received grants

About Prosjektbanken

Kunnskapsdepartement

Helse- og omsorgsdep

Kultur- og likestill

Medisin og helsefag

Samfunnsvitenskap

Oslo

Vestland

Trøndelag - Trööndelage

Troms - Romsa - Tromssa

Ukjent Fylke

Rogaland

Buskerud

Akershus

LTP3 Høy kvalitet og tilgjengelighet

LTP3 Rettede internasjonaliseringstiltak

LTP3 Muliggjørende og industrielle teknologier

LTP3 IKT og digital transformasjon

LTP3 Tillit og fellesskap

LTP3 Velferdstjenester

LTP3 Utenforskap, inkludering, kulturmøter og migrasjon

UoH-sektor

Instituttsektor

Helseforetak

Øvrige

Næringsliv

Portefølje Helse

Portefølje Forskningssystemet

Portefølje Banebrytende forskning

Portefølje Velferd og utdanning

Portefølje Muliggjørende teknologier

Handlingsrettede programmer

Programmer

Frittstående prosjekter

Nettverkstiltak

Infrastruktur og institusjonelle tiltak

Forvaltning

Diverse FoU-relaterte aktiviteter

Felleskostnader

Ukjent

Storbritannia

Østerrike

Island

Danmark

Frankrike

Nederland

New Zealand

Tyskland

Forskerprosjekt

Diverse personlige stipend (t.o.m. 2018)

Ingen søknadstype

Koordinerings- og støtteaktivitet

Annen støtte (t.o.m. 2019)

Annen prosjektstøtte (t.o.m. 2014)

Helse

Internasjonalisering

Politikk- og forvaltningsområder

Anvendt forskning

Innovasjon i offentlig sektor (utgår 2014)

Velferd, arbeidsliv og utdanning

Grunnforskning

Utviklingsarbeid

Hovedmålet med kreftbehandling er å eliminere kreftceller og dette er tradisjonelt oppnådd ved kirurgi, bruk av giftige medikamenter (cellegift) og stråling. En ny og betydningsfull tilnærming til kreftbehandling kalt immunterapi, har derimot fått mye oppmerksomhet det siste tiåret; Her forsøker leger og forskere å utnytte immunsystemet vårt for å målrettet  ødelegge kreftceller. En nøkkelaktør i denne banebrytende tilnærmingen er en gruppe «drapsmenn» i immunsystemet kjent som cytotoxiske T-lymfocytter (CTL-er). Disse cellene har en bemerkelsesverdig evne til å oppdage kreftceller ved å gjenkjenne unormale molekyler på overflaten av kreftcellene - molekyler som friske celler ikke har. Når CTL-er gjenkjenner kreftcellene ødelegger de dem ved å frigjøre giftige molekyler som initierer kreftcellenes selvdestruksjon. 
 
Selv om betydelige innsats har blitt dedikert til å forstå hvordan CTL-er aktiveres og hvordan de gjenkjenner kreftceller, vet vi mindre om de påfølgende hendelsene inne i kreftcellene som fører til deres død. Fra før vet vi at CTL-er kan initiere to forskjellige typer celledød i kreft: den første, kalt apoptose, er en stille og ordnet prosess der kreftcellene krymper og brytes opp uten å varsle immunsystemet; den andre, kalt pyroptose, er en mer dramatisk prosess som involverer dannelse av åpninger i cellemembranen, noe som fører til at cellene svulmer opp og sprekker. Under denne cellebristen blir innholdet inne i cellene frigitt i omgivelsene, og dette kan fungere som 'faretegn' som kan stimulere en sterkere immunrespons mot kreftcellene. Betydningen av denne cellebristen for å forsterke anti-tumorresponsene vil bli undersøkt i dette prosjektet. 
 
Videre er vi fascinert av muligheten for å avdekke ytterligere, ennå ukjente, former for celledød indusert av CTL-er. Utforsking av disse dødsrelaterte prosessene i kreftcellene kan potensielt øke effektiviteten av immunterapi og bidra betydelig i den pågående kampen mot kreft.

The primary goal of most cancer therapies is to induce cancer cell death. Immunotherapy relies on the cytotoxic activity of lymphocytes such as natural killer cells (NKs) and cytotoxic T lymphocytes (CTLs) to achieve this. While a significant amount of research in immunotherapy focuses on the events within cytotoxic lymphocytes or at the interface between cytotoxic lymphocytes and cancer cells, less is known about the molecular mechanisms that orchestrate cancer cell death, particularly in the case of CTL-mediated death.
CTLs are known to induce two types of cell death in cancer: non-inflammatory apoptosis and proinflammatory pyroptosis. Pyroptotic cancer cells release proinflammatory signals that attract immune cells to the tumor site, thereby enhancing the anti-tumor response. Cell lysis is a common outcome of pyroptotic cell death. It is unclear whether lysis can be decoupled from pyroptosis in cancer cells and whether the proinflammatory properties of pyroptotic cancer cell death depend on lysis. Moreover, it remains unknown whether CTLs can induce other forms of cell death in cancer, apart from apoptosis and pyroptosis.
Studying the mechanisms of CTL-mediated cancer cell death is challenging because CTLs selectively target cells expressing specific antigens. However, given the critical role of CTLs in immunotherapy, it is essential to deepen our understanding of CTL-induced cancer cell death.
This project aims to develop novel methodologies to investigate the death mechanisms that are initiated by CTLs. In addition, we will identify new pathways and mediators involved in CTL-induced cancer cell death. Furthermore, we will assess the contribution of proinflammatory cell death and lysis in promoting anti-tumor responses in vivo. Overall, this research will improve our knowledge of the molecular mechanisms of CTL-mediated cancer cell death and potentially reveal novel targets to enhance the efficacy of cancer immunotherapy.

T-cell-mediated proinflammatory cell death and lysis in cancer

Prosjektet «Wheelchair Activity Monitoring» (WHAM) sikter både på å øke fysisk aktivitet blant rullestolbrukere, og på å bidra til bredere mål om mangfold og inkludering av personer med nedsatt mobilitet, ved å fremme større tilgjengelighet og deltakelse gjennom innovativ teknologi og forskning.

Rullestolbrukere er tre til fem ganger mindre aktive enn den generelle befolkningen, noe som øker risikoen for å utvikle forebyggbare sykdommer. Selv om det finnes retningslinjer for fysisk aktivitet som er tilpasset rullestolbrukere, trenger vi fortsatt effektive måter å implementere disse på samt nøyaktig teknologi for å spore mulige endringer i fysisk aktivitet. WHAM har som mål å bidra til økt fysisk aktivitet blant rullestolbrukere ved å lage digitale verktøy for å monitorere og gi tilbakemelding på rullestolbrukerens aktivitet. WHAM består av tre faser: to år ved University of British Columbia (UBC), som inkluderer et samarbeid med eksperter innen atferdsendrings-intervensjoner for rullestolbrukere; ett år ved Norges teknisk-naturvitenskapelige universitet (NTNU) og et halvt år ved Maastricht Instruments - de to siste fasene er viet til å utvikle de digitale teknologiene. 

WHAMs mål er:
1)	Å teste effekten av et treningsprogram på fysisk aktivitetsnivå og fitness blant rullestolbrukere,
2)	Å utvikle nøyaktige algoritmer for monitorering av fysisk aktivitet blant rullestolbrukere,
3)	Å lage et system som både monitorerer og gir tilbakemelding på fysisk aktivitet blant rullestolbrukere.

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioral intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create
a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Topfinancing - WHeelchair Activity Monitoring project (WHAM)

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Algebraic Theory of Information Quantities

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

Per- og polyfluorerte stoffer (PFAS) er en stor gruppe menneskeskapte kjemikalier med høyt fluorinnhold som antas å ha negative helseeffekter. Kilder til PFAS kan være produksjon av vann-, varme- og flekkbestandige produkter og disse kjemikaliene er en del av hverdagen vår. PFAS påvirkning av biologiske systemer er ikke fullstendig forstått. Noen PFAS er antatt å øke risikoen for å utvikling av ikke-alkoholisk fettleversykdom (NAFLD) og øke risikoen for diabetes. 

For å forstå hvordan PFAS påvirker organene våre ønsker vi å bruke små laboratoriedyrkede organmodeller, kalt organoider. Disse miniatyrorganene kan dyrkes fra menneskelige stamceller og tilbyr et kontrollert miljø for å studere hvordan PFAS påvirker f.eks lever og bukspyttkjertelen vår, uten bruk av dyreforsøk.

For å studere helseeffekter må vi kunne måle nivået av biomolekyler som fettstoffer i leveren og hormoner i bukspyttkjertelen. Til dette trenger vi å utvikle analytiske verktøy for å måle effektene. Først vil vi bekrefte at når leverorganoidene eksponeres for enkelte PFAS-forbindelser utvikles det NAFLD-lignende sykdom ved å sammenligne den biokjemiske profilen (proteiner og metabolitter) til organoider av lever med PFAS-eksponerte organoider. Deretter vil vi utvide den analytiske verktøykassen for å undersøke hvilke metabolske veier som påvirkes, og om effekten er den samme i NAFLD-induserte og PFAS-eksponerte organoider. Vi vil også eksponere insulinproduserende bukspyttkjertelorganoider for PFAS for å undersøke effekten av PFAS på hormonproduksjon. Når effektene av PFAS-eksponering på lever- og bukspyttkjertel-organoider er etablert, vil organoidene bli samkultivert i en chip, og effektene av PFAS-eksponering vil bli undersøkt og sammenlignet med individuelle organoider.

Persistent organic pollutants (POPs) are believed to contribute to metabolic diseases, such as non-alcoholic fatty liver disease (NAFLD) and type 1 diabetes. HE-POP aims to investigate the effects of per- and polyfluoroalkyl compounds (PFAS), a type of POPs), on organ function in a controlled environment.

Organoids are multicellular laboratory-grown miniature organs, that are grown from stem cells. HE-POP will use organoids to examine how PFAS affects our organs and develop cutting-edge bioanalytical tools and methodology to measure these effects using liquid chromatography-mass spectrometry. HE-POP hypothesizes that PFAS negatively affects organ function, as evidenced by changes in hormone and lipid levels characteristic of NAFLD and type 1 diabetes. 

Organoids offer a controlled environment to study the effects of PFAS on the liver and pancreas, without the use of animal models. HE-POP aims to gain evidence of the negative effects of PFAS on organ function through controlled experiments on organoids and aid in understanding the biological mechanisms underlying NAFLD and type 1 diabetes.

HE-POP has fundaments in UN sustainable development goals, specifically #3, #12, and #14/15, seeking an understanding of diseases with worldwide prevalence, and understanding how POPs affect our life and surroundings and help enable the right regulatory actions and replacement chemicals.

HE-POP: Studying the Health Effects of Persistent Organic Pollutants, Using Mass Spectrometry, Organoids, and Organ-On-A-Chip

Norge har under Parisavtalen påtatt seg en forpliktelse til å redusere klimautslippene sine med minst 55 prosent innen 2030 sammenlignet med nivået i 1990. Hittil har vi kun oppnådd 5 prosent av dette målet; vi har følgelig kun syv år på å redusere de resterende 50 prosent for å imøtekomme målene. For 2050 har vi satt oss enda større mål: å redusere klimautslippene med hele 90 prosent. Bakgrunnen for målene er at vi prøver å unngå de verste scenarioene FNs klimautvalg skisserer opp i sine rapporter. I tillegg har energiforbruket økt, og prognosene fra Statnett for ulike scenarier viser at energiforbruket skal fortsette å øke. Vi trenger følgelig mer energi. Dette har bidrat til at diskusjoner rundt kjernekraft i Norge er høyaktuelle og pågående. Norsk Kjernekraft AS har blitt opprettet med formål om å bygge Norges første kjernekraftverk. I tillegg ble det i fjor også bevilget 200 millioner kroner fra Regjeringen til et nytt senter som skal drive med nukleær forskning. Målet er å styrke den norske kunnskapsberedskapen på det nukleære området. Dette betyr at vi beveger oss i en retning hvor kjernekraft en dag kan bli aktuelt i Norge, og noen mener at dette er den eneste veien å gå hvis vi skal nå målene våre for 2050. Men i dag sitter vi med flere spørsmål enn svar, blant annet: Hvilken teknologi og leverandør burde vi velge? Er regelverket for snevert og strengt? Hvordan kan dette gjøres og samtidig ivareta sikkerhet? Hvordan tjener et kjernekraftverk penger?

Dette prosjektet skal svare på samtlige av disse spørsmålene i en detaljert og omfattende analyse. Her bruker vi grunnlagsdata til å vurdere dagens forskning opp mot hvordan industrien i andre land opererer, og ut ifra dette forsøke estimere hva risikoen knyttet til å bygge kjernekraft som industri i Norge er. Prosjektet sikter på å gi et så helhetlig bilde som mulig slik at vi kan gjøre oss opp en mening basert på fakta; om kjernekraft passer inn i miksen av det som utgjør norsk energi.

Denne prosjektbeskrivelsen skisserer forskningen Vala Maria Valsdottir (omtales herunder som stipendiaten) skal utføre innenfor sin doktorgradsavhandling. Prosjektet skal være en del av Senter for nukleær forskning (SNF) som fikk midler vinteren 2023.
Ph.d.-prosjektet er initiert av Inmeta Consulting AS, som igjennom denne ph.d.-stillingen vil bli en del av SNF. Inmeta planlegger en prosjektperiode på fire år, hvor stipendiaten arbeider 75 % med ph.d.-prosjektet og 25 % med vanlig virksomhet hos Inmeta. 
Prosjektet skal undersøke muligheten for kjernekraft som industri i Norge. Dette er både en samfunnsaktuell problemstilling samt en som medlemmene i SNF er interessert i å utforske. Stipendiaten kommer derfor til å samarbeide med alle aktørene som er involvert i senteret og benytte forskningsdata fra dem. Dette gjelder da spesielt Institutt for energiteknikk (IFE) som har mest grunnlagsdata som er relevant for dette prosjektet.
Kandidaten ferdigstilte en masteroppgave høsten 2020 i kjernefysikk på Universitetet i Oslo (UiO) og har derfor gode og relevante grunnkunnskaper for å ta på seg et slikt prosjekt. I tillegg har kandidaten tre års erfaring innenfor energibransjen, og er derfor oppdatert på industrien og forstår deres problemstillinger godt.

Er kjernekraft aktuelt for Norge?

InART is recognized as one of the main conference series in the field of Heritage Science and since its first edition in 2013 (Evora, Portugal) it mainly focused on the contribution of natural sciences to the field. A major change occurred after the COVID-19 pandemic, when a greater number of researchers from different branches of heritage science participated in InART 2022 (Paris, France). 
InART is an open platform for knowledge-sharing among professionals in the field of Heritage Science, including conservation.
These aspects are covered by the main conference topics:
•	Development of new tools (devices, technology, software, etc.), advanced data analysis and FAIR data management
•	Development and/or implementation of new methods and routines (diagnostic and conservation) for the understanding of heritage materials, techniques, and degradation processes (chemical, physical and biological)
•	Development, testing (includes mechanical testing), and characterization of new materials for conservation (special attention to green conservation treatments)
•	Application of non-invasive/non-destructive techniques
•	Preventive conservation: environmental monitoring techniques and climate/microclimate effects on the conservation of heritage sites and exposed objects.

Heritage science is a highly multidisciplinary research field. Consequently, topics covered during the InArt2024 conference can be approached from different points of view and the conference aims to merge natural sciences and conservation, providing a dynamic space for active interaction, scientific exchange, and debates on the central issues of heritage science research. InART2024 welcomes contributors from diverse fields to join and create an interdisciplinary discussion about cultural heritage conservation within the fields of archaeological objects, artworks, built heritage, etc.

6th International Conference on Innovation in Art Research and Technology

Potetskrell, et biprodukt fra industriproduksjon av potet (pommes frites, flak, chips mm.) er en råstoff ressurs som kan bli bedre utnyttet til nye formål. Skrellet er nemlig en rik kilde på antioksidanter, stoffer som planter naturlig har i seg for å beskytte mot skadelige UV-stråler og reaktive forbindelser som oksygen radikaler. Antioksidanter behøver vi også å tilsette i matvarer for å beskytte og ta vare på umettet fett så det ikke blir harskt og vondt i kontakt med luft. I dag brukes flere ulike syntetiske stoffer i matvarer for å hindre oksidasjon av fett og oljer. Men det er reist bekymring rundt sikkerheten for bruken av dem. Matvareindustrien, myndigheter og forbruker ønsker derfor å fjerne flere syntetiske antioksidanter og erstatte dem med naturlig alternativer. Det er imidlertid svært få slike produkter som er godkjent og tilgjengelig på markedet. Prosjektet Peel Preserve, som har et klart bærekraft mål, skal vise om et uttrekk av antioksidanter laget på industrielt potetskrell råstoff kan fungere som konserveringsmiddel og erstatte noen av de stoffene som brukes i dag. Tre næringsmiddelbedrifter skal teste potetskrell-ekstraktet i noen av sine produkter og utføre både interne og eksterne analyser på effekten. Men en viktig forutsetning for at potetantioksidant kan tas i bruk som nytt tilsetningsstoff i mat er at det blir godkjent av den Europeiske matsikkerhets myndigheten (EFSA) og gitt et E-nummer. Prosjektet skal igangsette denne lengre flertrinns godkjennings prosessen. Parallelt skal det utvikles en forretningsmodell og nødvendig beskyttelse rundt teknologien. Dersom industrien etter testingen av potetantioksidanten, vurderer denne som er god erstatning til konkurransedyktig pris, og en EFSA-godkjenning kan oppnås på sikt, åpner det for å kommersialisere et naturlig plante-basert produkt til beste for forbruker og for miljøet. Bak prosjektet Peel Preserve står Høgskolen i Innlandet i samarbeid med Nofima og Klosser Innovasjon.

Preserving foods with potato peels: Industry-relevant validation and first regulatory assessment of a new natural antioxidant

Applied Biocatalysis is the development through science and engineering of useful biological catalysts and their commercial applications. The BNCM 2024 conference has an intention to gather approx. 100 international and national scientists from academia and industry in addition to PhD students from the international community. BNCM 2024 will be the 7th in this series of meetings with attendees from both academia and industry presenting and discussing the newest research in enzyme catalysed reactions in other media than water. The conference series was started in 1986 by professors Hans Tramper and Urs von Stockar, University of Wageningen, the Netherlands, and has later been chaired in Russia, Italy and Germany before Elisabeth Jacobsen at NTNU was give the honor of chairing the conference.  Collaboration in biocatalysis research has been supported by EU Frameworks as three subsequent COST actions. The first action, COST Action D25 "Applied Biocatalysis. Stereoselective and environmentally friendly reactions catalysed by enzymes " (2001-2007) was initiated and chaired by professor Thorleif Anthonsen, NTNU, the founder of the Biocatalysis Group at NTNU, which the project leader of this conference now chair. The strategy of applied biocatalysis fits well under the definitions of white biotechnology and Sustainable chemistry (Suschem) and fits also well with the EU Green Deal Strategy.

7th International Conference on Biocatalysis in Non-Conventional Media

End-to-End Green House Gas (GHG) Monitoring Service

Midlene fra ENVIRONMENT-1.06 Environment (including Climate Change) fordelt på år

Midlene fra ENVIRONMENT-1.06 Environment (including Climate Change) fordelt på fylker

Midlene fra ENVIRONMENT-1.06 Environment (including Climate Change) fordelt på fagområde

Linked Open Data for environment protection in Smart Regions

The extent to which homecare or day-care for infants may be beneficial or detrimental for subgroups of infants may depend on the family environment. The primary goal of this project will be to provide new information on childcare and infants? adaptation d uring the first 18 months of life. The project, which will be part of the Norwegian Mother and Child Cohort Study, will answer crucial questions about the effects of care on infants. The study will be especially informative because of the potentially larg e sample size (n=34 000) and the study's prospective nature. 

Maternal leave and cash allowances program enable Norwegian mothers to choose to go back to work and use day-care or stay home and care continuously for their infants their first two years of life without loosing income. Surprisingly, no studies of large samples have investigated the associations between welfare programs and infant development. Does our welfare program protect children from developing behaviour difficulties at age 6 months and  18 months of age? In affluent families, in the richest country in the world, do infants pay a price or can we identify protective factors against infant behaviour difficulties in affluent as well as in less affluent families? Thus, in this project we wan t to investigate whether these welfare programs affect infants somewhat differently depending on the family environment, age and gender.

The results will indicate whether the family alone, or some combination of home care and group day-care might bring a bout benefits for young children and prevent them from developing behaviour difficulties at a very young age. In addition, this baseline study will provide crucial scientific knowledge for consecutive followups for the 7th wave planed at school entry.

"Maternal leave, cash benefit and infant psychological difficulties: 
a longitudinal baseline study of 34 000 0-18 months old"

Anxiety disorders (ADs) in childhood are common, may cause great suffering, and may persist into adulthood. Few children with an AD receive psychiatric treatment for their illness compared to children with ADHD and behavorial disorders. Knowledge of effec tive treatments and predictors of positive treatment outcome is essential. This study will examine the effects of individual and group delivered treatment, implementing a cognitive behavioral treatment program, compared with a wait-list control group. A f ollow-up at 12 months is included to examine the maintenance of treatment effects. At follow-up, selected data will be compared with a non-randomized sample receiving treatment as usual. The study will be conducted in cooperation with ordinary community c linics with ordinary clinicians conducting the treatment. Predictors of treatment outcome, such as parental involvement in therapy, parental psychopathology, parental rearing behavior, and therapeutic alliance will be studied. A pilot study was conducted in 2006 at three community clinics to ensure the feasibility of the planned effectiveness study. The study is a randomized controlled trial of children aged 7-12 diagnosed with separation anxiety disorder, social phobia, or generalized anxiety disorder. E xpected N = 150, which based on experiences from the pilot study and the existing research literature is a sufficient sample size to answer the primary research question. There is a great need to evaluate the effects of psychotherapy for children with ADs . This study has the potential to add important knowledge regarding the effects of treatment of ADs and making effective treatment available to ordinary clinicians in the community.

Effectiveness of group and individual treatment of childhood anxiety disorders in ordinary community clinics. A randomized controlled trial.

Although research on suicidal behaviour is quite abundant, we are still far from reaching a full understanding of the meaning(s) of such behaviour. In pursuit of this goal, we need to take cultural aspects into consideration. Two approaches to study the m eaning(s) of suicidal behaviour is to look at the intentionality involved in such behaviour, and to look at the attitudes towards suicidal behaviour. Building on research already conducted by this research group, the main aim of the present study is to en hance our understanding of the meaning(s) of suicidal behaviour in a cultural context by a) studying and comparing intentionality involved in nonfatal suicidal behaviour in Norway and Ghana, and b) studying and comparing attitudes towards suicidal behavio ur in various groups of students, professionals and lay people in Ghana and Uganda. Additional aims are to contribute to the development of research methodology and theory building in a cultural context. Methodological triangulation is employed in the stu dy. In the intentionality part of the study, semi-structured interviews consisting of a narrative and a problem-focused part will be conducted with patients admitted to hospital following an act of nonfatal suicidal behaviour. The interviews will focus on  the following circumstances: 1) the patient's own narrative about a) how he or she came to the suicidal act itself, b) which intention the patient him/herself had with the act, c) how the patient has experienced the surroundings' reactions to the act, an d, 2) the patient's body image and experience, and 3) the patient's communicative repertoire. In the attitude part of the study, first, qualitative interviews (semi-structured) of groups of students, professionals and lay people will be conducted, and, se cond, a quantitative questionnaire study in similar groups will be conducted. The results will provide a research base from which suicide preventive efforts can be developed and initiated.

Suicidal behaviour in a cultural perspective

The aim of the research project is to improve the understanding of the social processes for developing mental health problems, such as depression and anxiety among Norwegian adolescents. Further, we want to examine the risk and protective factors such as social network, parental characteristica, personality and alcohol use on adolescetns depression and anxiety. In addition, we will investigate parents mental health and alcohol use and its impact on adolescents mental health problems. 

The prospective stu dy is based on the Young-HUNT study in the Nord-Trøndelag Health Study (HUNT), 1995-97. All the pupils in the county from 8th to 13th grade participated in the study (n=8984), 88% of all invited. A follow-up study was performed five years later among thos e still in 12th to 13th grade, (n=2714), 79% of all invited. Data from Young-HUNT was merged with parental mental health data reported in the adult HUNT study. The following measures were among others included in both these studies: anxiety and depression  (SCL-25), lifestyle, such as alcohol use, personality, self-esteem, and social network. This means that we have the opportunity to study for example the impact of parents mental health and lifestyle on the adolescents mental health.  

The most important  challenge of this study is that the measure of depression and anxiety can be rather crude. However, the measure has proven to be reliable in earlier studies. Likewise the measure on alcohol is brief, but the face validity is good and the measure has been  used successfully in earlier studies.

Scientific importance: Few earlier studies of this kind are based on data from both adolescence and their parents. This will give an important contribution to a better understanding of the impact of parental mental health and lifestyle on the adolescent mental health.

Adolescent Mental Health: A Prospective Family Study

The overall objective of this project is to contribute to the knowledge necessary in developing effective Internet-based self-help programs for preventing mental health problems and new episodes. This will be accomplished through two complementary PhD sub -projects based on data from a randomized control trial assessing a state-of-the-art program for prevention of depression relative to characteristics of users, adherence and efficacy. The Internet-based self-help programs could in the future be offered as  an unattended service as well a concept of therapy with minimal therapeutic assistance offered from the office of the local General Practitioner.

Internet based intervention programs mostly make use of cognitive behaviour therapy to increase self-help a bility. One of the unique qualities the Internet can offer in terms of interventions is that the therapeutic changes can occur in an anonymous. In addition, Internet based services are usually available at all hours and can be accessed from the privacy of  one?s own home. This implies that Internet services have a low threshold and possibly represents a low stress situation. 
The Internet-based self-help programs for promoting mental health and preventing depression is based on evidence-based facts about d epression and cognitive behavioural therapy.
Internet-based interventions has a potential option for bridging service gaps with regard to the availability of specialized services to people experiencing geographic and mobility constraints, such as people l iving in rural and underserved communities, and people with disabilities.

There will be recruited 380 participants through advertising. The target group is individuals 18?65 years of age with mild or moderate symptoms of depression, based on informed con sent. By random the volunteers are assigned to one of the intervention conditions (control condition, Internet intervention without follow-up, with tailored email follow-up, and with telephone-based follow-up)

Utilizing the Internet to deliver mental health self-help interventions to underserved populations in rural areas

1) Background
Due to the lack of national statistics on suicide attempts in Norway, few studies have been published regarding the development of suicide attempts in the population. Since a main suicide prevention strategy in Norway is to provide follow-up  for suicide attempters, there is a need for longitudinal studies of attempters. Few follow-up models have been scientifically evaluated. 
3) Aims: 1) To document the epidemiological development of suicidal behaviour in Bærum in a 22 year period. 2) To ex amine and measure if suicide-related structural changes in the period have affected the suicidal behaviour. 3) To measure possible effects of a community based suicide prevention team on the suicide attempt repetition rates and suicide rates among attempt ers in Bærum.
2) Methods. The main data set has been collected over a 22-year period and comprises information of 1535 unique suicide attempters and 2260 suicide attempts. Statistical measurements will be preformed using survival analysis. Trends over tim e will initially be estimated non-parametric using the Nelson-Aalen estimator. Trends over time adjusted for changes in risk factors will be estimated using proportional hazard models (Cox regression and Poisson regression)
4) Scientific relevance: By adr essing both descriptive epidemiological data, data on social explanations, and follow-up data, the present study aims to expand the knowledge base of suicidal behaviour on several levels. Further, due to the scarcity of well-conducted studies evaluating e ffects from systematic follow-up of suicide attempters on repetition of non-fatal suicide attempts as well as on suicide among suicide-attempters, the present study will be of great scientific as well as clinical value. Additionally, the investigation of mortality consequences of health care system changes will be of scientific as well as clinical importance for the establishment of national guidelines on treatment of suicidal patients in mental health care.

Social Change, Health Care Intervention and Suicidality. - A Longitudinal Prospective Study of Suicidal behaviour.

Background: Congenital heart disease (CHD) occurs among 0.5-1.0% of newborns. Treatment possibilities have been dramatically improved during the past decade, leading to increased survival rates. How-ever, previous studies in CHD survivors suggest a higher  risk of mental disorders, such as anxiety, depression, and ADHD as well as serious developmental deviations (motor, cognitive, and social).  
Objective: To screen children with CHD between the age of 6 and 36 months for early indicators of mental and dev elopmental disorders, and to determine the importance of diagnosis- and treatment-related risk factors. 
Method: Information from two data sources will be linked: 1. the Norwegian Mother and Child Cohort Study (MoBa) that aims at following 100 000 childre n from the fetal stage. 2.  the nationwide CHD-registry at Rikshospitalet, Oslo, Norway. Presently, around 75000 have been includen in the MoBa study. Among them, we expect to be able to identify around 500 infants with CHD. On all children in the MoBa st udy there is information about the course of pregnancy, the birth, diseases, and about mental health and development collected at 6, 18, and 36 months. For the assessment of mental health status and development, short versions of established questionnaire  measures have been used. Information on the CHD diagnosis and treatment is available from the CHD registry. This information will be used to determine the impact of medical risk factors on the infants' mental health and development.
Scientific importance : This will be the first population-based study following children with CHD from so early an age. The patient-control design will enable us to find early signs of mental and developmental disorders, to identify both medical and psychological predictors,an d to  study their course over time.

Mental disorders and developmental deviations in children (6-36 months) with congenital heart disease (CHD): a prospective case-control stud

We intend to study the relationship between intake of folate and fatty acids during early life and the risk of neurodevelopmental disorders (ND) such as autism and attention deficit/ hyperactivity disorder (ADHD). 

Having language problems at the age of three is a strong predictor for neurodevelopmental disorders. Therefore, language delay (LD) is our primary outcome. We will use two designs. For 50,000 children included in the Norwegian Mother and Child Cohort Study, we will estimate the risk of LD acco rding to the following exposures: maternal intake of folate and fatty acids during pregnancy; the childs intake of folate and fatty acids during the first year of life; maternal intake of folic acid antagonists during pregancy. 

In a nested case-parent s tudy from the same cohort we will analyse vitamins, metabolites and triad genes in the folate metabolic pathway with the aim to elucidate the interaction between folate and fatty acid intake and maternal and child genotypes on the risk of LD. The analyses  will be corrected for confounding variables such as diet, use of tobacco and alcohol in pregnancy and socioeconomic status.

Folate and fatty acids in early life and neurodevelopmental disorders: developmental language delay as an early marker

Anxiety disorders (AD's) in childhood are common and may cause great suffering.Childhood AD's may persist into adulthood and knowledge of important risk factors for development and maintenance of these disorders is essential.The development of AD's is due  to a complex interaction between biological and environmental factors.This study will examine the relationship between AD's and two biological risk factors:1.Neurodevelopmental delays/disorders (NDD`S) in motor and cognitive function and 2.Temperament/pe rsonality.To date a few studies have consistently found that motor impairment is associated with childhood anxiety and predicts persistent anxiety in adolescence.The association between AD's and NDD's in cognitive functions such as language and attention is far less studied. In contrast, there is a huge research literature on temperament as a risk factor for AD's.The temperamental trait "behavioural inhibition" has been shown to be particularly associated with AD's.However, very few studies have examined the interplay between NDD's, temperament and anxiety.The study is a clinical case-control study of children aged 7-12 years with AD's referred to three different out-patient clinics.The participants will be assessed by diagnostic interviews, neuropsycholo gical tests and temperament/personality instruments.Comparison groups are:1.children with ADHD (to compare AD's with another mental disorder related to NDD's) and 2.Non-referred children without a mental disorder. Follow-up at 6 months,1 and 5 years.A pil ot study at two of the three out-patient clinics to be included,showed a sufficient sample size.Anticipated implications of the study include increased knowledge of biological risk factors and comorbidity as well as treatment implications in AD's.Children  with NDD's are often met with demands they cannot cope with due to their neurodevelopmental immaturity.To adjust the demands to the child's actual level of functioning is important

ENVIRONMENT-1.06 Environment (including Climate Change)

Linked Open Data for environment protection in Smart Regions

Awarded: NOK 1.3 mill.

Popular Science Description

Summary

Funding scheme:

ENVIRONMENT-1.06 Environment (including Climate Change)

Funding Sources

Thematic Areas and Topics