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Covid19

From the SEA to the SOLution. An integrative assessment of marine pollution in a changing Arctic

Marine chemical pollution poses known threats to human health and to biodiversity, ecosystem and societal services. The Arctic is a major sink of global mercury (Hg) pollution. Arctic sediments, sea and glacial ice constitute vast Hg reservoirs. Recent studies raise concerns about their increasing role as local Hg sources. In a rapidly warming Arctic, the consequences of potentially increased environmental Hg on marine biota remain unknown. The objective of SEASOL is to identify the pathway(s) of Hg bioaccumulation in marine food webs of the High Arctic Kongsfjorden (Svalbard). This changing glacial fjord is recognised as a ‘natural laboratory’ of climate change in the Arctic. The fellow’s earlier research has shown the sole measurement of Hg levels as insufficient to connect biotic Hg dynamics to environmental change, whereas the analysis of Hg stable isotopes proved to be a promising tool for source discrimination and biotic transfer. SEASOL will build on the novel application of stable isotope analysis to identify the sources of Hg within the fjord system and the pathways to Hg accumulation within sentinel marine species. On the short-term, the study will provide fundamental knowledge to help understand how emerging sources of Hg from rapid environmental change will impact Arctic marine predators. On the long-term, SEASOL will contribute to the development of early-warning, adaptive management strategies, including modelling, for mitigating the cumulative impact of pollutants and climate change on Arctic marine species. This multidisciplinary approach and the central position of the host institution (Norwegian Polar Institute) in the field of Polar Research will equip the Fellow with a broad set of new skills and lay the foundation for building her specific niche as a future leader in marine pollution science.

Optimization of Free Space Optical Communication Link based Drones for Search and Rescue Operations in the Arctic Region

The Arctic region is witnessing more frequent shipping accidents than ever which require accurate search and rescue operations. The existing communication systems use drones with radio frequency (RF) technology, which has limited bandwidth and cannot offer 4G/5G connectivity due to harsh weather constraints. It further limits the capacity of drones and affects the resolution of images and videos. The current research proposes to design free space optical communication (FSOC) link-based drones that can enhance connectivity between multiple drones and rescue ships as well as the capacity of drones to produce high resolution images and videos. The proposed FSOC-based drones can provide highspeed connectivity than the existing RF technology. The research will collect atmospheric turbulences data from the Arctic region and use it for designing the FSOC link. Furthermore, to enhance the capacity of FSOC-based drones, the research will design advanced multiplexing schemes (Mode Division Multiplexing and Orthogonal Code Division Multiple Access) and to ensure link stability, omnidirectional receiver will be designed. The research will further evaluate the performance of proposed FSOC link under the impact of various atmospheric turbulences. The expected outcomes of this research will lead to the optimisation of FSOC-based drones in expanding search areas and improving communication systems for SAR operations in the Arctic region.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal. 

AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact. 

To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.  

To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

Aqua Research Infrastructure Services for the health and protection of our unique, oceans, seas and freshwater ecosystems

AQUARIUS will provide a highly comprehensive suite of integrated research infrastructures appropriate to addressing significant challenges for the long-term sustainability of our unique oceans, seas and freshwater ecosystems. For the first time, diverse research infrastructures will be combined to facilitate the work of researchers and key stakeholders focused on challenges and opportunities for both marine and freshwater systems. An impressive range of 57 research infrastructure services will be made available to include research vessels, mobile marine observation platforms, aircraft,  drones, satellite, sensors, fixed freshwater and marine observatories and test sites, experimental facilities, and sophisticated data infrastructures. AQUARIUS will support the development phase of the EU Mission to Restore our Ocean and waters by 2030, the Sustainable Blue Economy Partnership, the European Green Deal, and international climate initiatives. It will also be an essential component in achieving the European Digital Twin of the Ocean and the UN Decade for Ocean Sciences. The needs of researchers will be met through a robust and transparent system of transnational access funding Calls, facilitated by centralised user-friendly access portal. The Call programme will be informed through stakeholder engagement and brokerage events. Projects to be selected for Access must convincingly integrate multiple infrastructures and contribute to the core policy objectives of Mission Ocean, that is, to protect and restore marine and freshwater ecosystems and biodiversity; to prevent and eliminate pollution of our oceans, seas and waters; and to ensure a sustainable, carbon-neutral and circular blue economy. A thematic and geographic focus will be the hallmark of the proposed transnational Calls, aligning with the Lighthouse Regions, that is, the Baltic and the North Sea Basins, Black Sea, Atlantic/Arctic, and Mediterranean Sea along with their associated rivers.

Advance Marine Research Infrastructures Together

The European Ocean Observing System (EOOS) is the foundation of European ocean knowledge. The core Marine Research Infrastructures (MRIs) focused on ocean observing (EMSO, EURO-ARGO and ICOS ERICs; EuroFleets+, EuroGoShip, GROOM RI, JERICO RI and MINKE as INFRA projects) are the main providers of in situ ocean data for the EOOS and Copernicus, and the primary managers of instrumental capacity supporting fundamental research.
These MRIs are aware that the lack of effective cross coordination prevents them from fully supporting frontier research, while the lack of integration makes it difficult to reach a critical mass for EOOS and results in significant cost duplication. Accordingly, AMRIT gathers these MRIs together with OceanOPS/WMO international coordination experience with the objective to:
- ensure seamless operation of marine observation platforms ;
- ensure the full nominal use of sensors and accelerate their evolution ;
- exploit the complementarity of the various observation platforms ;
- ensure the overall coherence of the ocean data value chain.
To achieve these objectives, AMRIT will design and implement an EOOS Technical Support Center (EOOS TSC) for
- a fully integrated information service across the data value chain from early planning stages to final delivery to users;
- a cross-platform fully standardised data acquisition methodology for Essential Ocean Variables;
- a collaborative federal structure to operate these services, relying on the ERIs and their members.
The EOOS TSC will be the cornerstone in establishing and maintaining the EOOS, upon which European ocean observing can be strengthened in the coming decades. AMRIT will provide a catalyst for the development and consolidation of MRIs throughout Europe, providing a benchmark for operational coordination and collaboration. AMRIT will advance EOOS in line with its 2023-2027 Strategy and beyond, and the European Commission's ambitions for sharing responsibility in ocean observing across Europe.

Improve offshore infrastructure resilience against geohazards towards a changing climate

POSEIDON brings together an interdisciplinary and intersectoral team to deliver a professionally trained next-generation network of Doctoral Candidates to develop a step change in our capacity to identify, map, assess and predict offshore geohazards and in turn produce ground-breaking methods to prevent, mitigate and boost the resilience of current offshore infrastructure under a changing climate. The consortium is formed by experts across EU countries with universities, research institutions, industry partners and a government body to cover a full training programme on scientific and transferable skills. 

The programme will undertake critical research across scales (from micro to macro) for seeking the inner links and differences, with an eventual aim to ascertain the pathways and grow our capacity for the enhancement of the existing and the robust development of new offshore infrastructure in the frame of safety and resiliency. In addition to the informed design and implementation of the novel physical/numerical modelling and lab studies, our approach is unique in the solid integration and utilisation of state-of-the-art data science technologies (e.g., data mining, machine learning, etc.) to their full potential. Only through this systematic approach, we can achieve the objectives of understanding the impact of offshore geohazards on our offshore critical infrastructures (OCIs) and developing novel models, tools and designs for future OCIs, such as, wind turbines, pipelines and cables. 

The Doctoral Candidates will enjoy a highly integrated, interdisciplinary and intersector training environment, enriched through secondments with the network of non-academics. POSEIDON enables critical learning across all training aspects to ensure that comprehensive, robust and implementable solutions are obtained and validated to face the OCIs climate-resilient building.

POLARIN: POLAR RESEARCH INFRASTRUCTURE NETWORK

The polar regions play a key role in the Earth’s system. They are essential for our climate and are sentinels of climate change, human expansion, and the hunt of new resources. The polar regions are losing ice, and their oceans and land are changing rapidly. The consequences of this polar transition extend to the whole planet and are affecting people in multiple ways. Evidence-based policy recommendations are needed, but the polar regions are difficult to reach, and research infrastructures able to operate in these regions are scarce. To understand and predict key processes in the polar regions and provide evidence-based information, the polar research community needs access to world-class research infrastructure operating in these regions.
POLARIN is an international network of polar research infrastructures and their services, aiming at addressing the scientific challenges of the polar regions. The network includes a wide array of complementary and interdisciplinary top level research infrastructures: Arctic and Antarctic research stations, research vessels and icebreakers operating at both poles, observatories, data infrastructures and ice and sediment core repositories. POLARIN will provide integrated, challenge-driven, and combined access to these infrastructures to facilitate interdisciplinary research on complex processes. 
POLARIN will:
1.	Provide challenge-driven transnational access to a large portfolio of research infrastructures. 
2.	Improve the access to data by improving data availability and interoperability between data infrastructures. 
3.	Provide virtual access to data and data services. 
4.	Provide data products for the scientific community and decision makers.
5.	Train the young generation of polar researchers in optimally exploiting the infrastructures for their research.
6.	Duly advertise the services offered by POLARIN and engage the infrastructure users to share their research outcomes with society.


Land-Sea interface: Let’s observe together!

LandSeaLot will link together in situ, model and earth observations (EO) and connect related communities, citizens and initiatives such as Copernicus, ESA, EEA, GEOSS, EMODnet and the European Digital Twin of the Ocean. These observations will be used in a gap analysis to co-design a common land-sea interface observation strategy and an implementation plan. LandSeaLot participants will simultaneously work on improving: in situ and EO capabilities, models to reduce the model/observations gap and the integration of model, in situ and satellite data. Observation capacity will be increased through tested, improved and guided use of low-cost technology by citizens, facilitated by the network of European marinas. The technologies selected will be piloted in Integration Labs (ILs) together with improved and integrated in situ and EO observation techniques and model outputs. LandSeaLot ILs will cover selected areas in the Black, Aegean, Mediterranean, Atlantic, North and Baltic Seas, with a range of catchment, tidal and meteorological regimes. Experts and citizen science leaders will work in the ILs together with JERICO-RI, DANUBIUS-RI and ICOS-ERIC, and with regional policy makers and managers to tailor integrated observations that will provide them with information to manage societal challenges. These will include assessment of the lateral carbon flux and stock, plastics transfer, nutrients impact on primary production and eutrophication, supporting biodiversity conservation, improving modeling capability and supporting climate change adaptation (storm surge, floods, heat waves, coastal erosion, saltwater intrusion). Data generated in the ILs will be made FAIR available via EMODnet and interoperability, and semantic solutions for existing, international data flows will be developed. Relevant communities will be engaged by workshops, conferences, training, a high-tech summit and by a communication strategy including videos and policy briefs to ensure LandSeaLot’s legacy.

Material Science Innovation for Accelerated, Sustainable and Safe Implementation of Carbon Capture and Storage

MISSION-CCS presents a timely and unique doctoral network designed to deliver the next generation of highly trained researchers and entrepreneurs in the field of material science, specifically focused towards accelerating implementation of carbon capture and storage CCS technologies worldwide and ensuring the sustainable and safe operation of existing and future CCS systems.

The training network combines unique experimental system design and modelling approaches, state-of-the-art analytical technologies and techno-economic analysis to deliver a new generation of researchers and entrepreneurs. The programme of research training centres of delivering Doctoral Candidate Researchers (DCRs) with world-leading technical expertise in material science and engineering relevant to the entire CCS process. MISSION-CCS ensures that the subject-specific technical knowledge of each DCRs is under-pinned by inter-sectorial knowledge whilst also promoting wider innovation skills and relevant training on the techno-economics of CCS, developing experts with breadth of knowledge.

A central aim of the network is to forge a strong cohort culture, by ensuring that peer-to-peer learning and mutual support become the norm, in order to enhance experience. Research-led training activities are strengthened through a dynamic and interactive education based programme delivered by an internationally renowned consortium of academics and industrialists with complementary skills. As part of the training programme, subsequent to an introduction to CCS systems and the specific material science challenges, DCRs will gain knowledge of system design and optimisation, state-of-the-art analytical methods, theoretical modelling, techno-economics, and understand the challenges of exploiting their research. They will also acquire proficiency in project management, communication, entrepreneurship, and innovation; all essential attributes for any modern technical professional.

Optimisation of digital catch monitoring and reporting in European Fisheries

 OptiFish will strive to provide technological solutions that will simultaneously improve the sustainability of fisher’s operations, enhance control processes and strengthen society’s trust in their products.
OptiFish will develop, test and recommend a set of innovative technologies and tools supported by artificial intelligence (AI) to provide the management, the fishing sector and the scientist with data on catch volumes, catch compositions and the fishing environment. 
The goal is to unlock the full potential of technologies such as electronic and genetic monitoring for automated species recognition based on AI and computer vision to reduce discards, unreported landings and unreported fishing activities, ultimately establishing  a fisheries control and enforcement system fit for the digital age. The technologies are not enough alone, it is also critical to consider the combination of technologies and the integration of computer vision models, the wide range of data sources and their subsequent formats, while also addressing stakeholders needs and acceptance. 
This goal cannot be achieved by a single project, which is why the aim of OptiFish is to lay a solid foundation for full technological development from which other projects and initiatives can be built. The project will place a strong focus on species recognition in different fisheries equipped with distinctly different catch handling facilities and in different European sea basins. 
To ensure that these innovations are relevant to fisheries management, OptiFish has participation from the Norwegian Directorate of Fisheries, and has received written support from the European Fisheries Control Agency (EFCA), the Basque, Danish and Belgian Fisheries authorities.



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32728 Lutefisk Filet

Konseptet med å bruke immunforsvaret til å bekjempe kreft - immunterapi - er basert på å stimulere T-celler for å drepe kreftceller. For å produsere T-celleterapi hentes T-celler ut fra pasientens blod. Disse cellene utstyres med spesifikke proteiner kalt reseptorer, som gjør det mulig for T-cellene å gjenkjenne kreftcellene. De modifiserte T-cellene dyrkes i stort antall i laboratoriet og føres tilbake til pasientens kropp hvor de finner og dreper kreftcellene. Kliniske resultater med slik celleterapi for solid tumor har vært skuffende sammenlignet med blodkreft. For å forbedre terapeutisk effekt og mer kostnadseffektiv behandling trengs det videreutvikling av produksjonsmetodene. Det er et stort behov for kunnskap om hvilke faktorer som kreves for å produsere klinisk optimale T-celler som ligner T cellene som normalt trenes i kroppen for å utføre et vellykket fysiologisk immunforsvar. Testing i stor skala er nødvendig for å identifisere disse faktorene. CellFit har en tverrfaglig tilnærming som kombinerer automatiserte high-throughput screening-teknologier med klinisk T-celleproduksjon og tilgang til innovative reagenser. Vi vil tilby optimale celleprodukter (mer aktive og som varer lenger i kroppen) og prosesser (mer effektive, mer strømlinjeformet). High throughput screeningmetoder brukes i dag til å identifisere og velge angrepsmål T-celleterapi, men ikke for å optimalisere produksjonsprosessen. Nyutviklede screeningssystemer vil muliggjøre rask evaluering av T-cellenes effekt i kreftcelledrap og andre ønskede egenskaper. Den samlede kompetansen til SINTEF, Oslo universitetssykehus og Thermo Fisher innen screening med high throughput, produksjon av celleterapi og ny utvikling av reagenser vil gi nye innovative screeningmetoder, forbedrede celleprodukter og prosesser som lett kan tas i bruk for å forbedre terapi og klinisk resultat. I samarbeid med Oslo Cancer Cluster vil vi sikre outreach og kunnskapsdeling for å fremme ansvarlig forskning og innovasjon.

Clinical outcomes reported for solid tumour adoptive cell therapy have been disappointing compared to liquid cancers. To improve therapeutic efficacy and treatment cost-effectiveness which depend on long-term clinical outcome, T-cell manufacturing methods require development. Standard, non-optimal, formulae are currently used in manufacture and a great knowledge gap exists for which factors are required to produce clinically optimal T cells in an artificial in vitro expansion versus a successful physiological in vivo T cell response. Large-scale testing is required to identify these factors. By merging automated high-throughput screening technologies with clinical T-cell manufacturing and the access to innovative reagents we will provide significantly improved cellular products (more active and in vivo persistent) and processes (higher yields, more streamlined). Although high-throughput screening approaches are used to identify and select targets or antigens in T-cell therapy, no one is currently using these techniques to screen culture conditions to advance the T-cell manufacturing process. Developed screening systems will enable rapid evaluation of ex vivo T-cell efficacy by direct testing of 2D and 3D tumour-cell killing, T-cell phenotype and metabolism. T-cell therapy can be combined with e.g. checkpoint inhibitors or metabolic drugs in this screening to enable identification of useful treatment combinations for patient groups or single patients in a personalized medicine approach. The combined competencies of SINTEF and Oslo University Hospital, and Thermo Fisher within high-throughput screening, cellular therapy production and novel reagents will provide innovative new screening methods, improved cellular products and processes readily translated to improve clinical therapy and outcome. In collaboration with Oslo Cancer Cluster we will ensure public outreach and knowledge-sharing to foster responsible research and innovation.

KSP: CellFit - T cells fit to fight cancer

Tre måneder etter den første bølgen av Covid i Norge, sommeren 2020, svarte over 100.000 av deltakerne i Koronastudien på et spørreskjema der vi spurte hvordan de følte seg. Vi ble overrasket over at så mange av de som hadde hatt covid sa at de følte at de hadde fått en dårligere helse enn tidligere. Likevel hadde de over 1000 covid pasientene og over 100.000 andre deltakerne omtrent like mye tungpust og plager fra luftveiene så vi måtte lete andre steder etter en forklaring på hvorfor en del av de som hadde hatt covid følte seg dårlige. 
Heldigvis hadde mange av deltakerne også beskrevet hvordan de følte seg og det vi fant overrasket oss: covid pasientene nevnte hukommelsesplager 100 ganger så ofte som de som ikke hadde hatt covid. 
Vi forsto med en gang at covid påvirker hjernen på en eller annen måte og at det ville bli viktig å utforske dette videre og det er dette vi gjør i dette prosjektet der vi vil se på hvordan covid påvirker hukommelsen i detalj og hvordan helsen til de som har hatt covid utvikler seg i tiden etter sykdommen.

The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) causes COVID-19, a potentially fatal disease. More than 100 million people have been infected, and 2 million deaths have been reported. The World Health Organization (WHO) declared COVID-19 a pandemic on March 11th, 2020. The long-term outcome of COVID-19 is not known, but the novelty of the disease, the severe symptoms in some patients, the dissemination of the virus throughout the body, and initial reports of medium-term negative health effects as well as our own data all argue for follow-up studies of COVID-19 patients. 

In the proposed project, we will combine Norwegian Registries with a large cohort of COVID-19 patients and controls to characterize the long-term health of COVID-19 survivors.

The proposed project is based on a prospective cohort study that has already started. A group of committed researchers led by Arne Søraas have established a new cohort of 176.000 participants. All participants have completed an extensive baseline questionnaire and up to three follow-up questionnaires. The study has already obtained and used data from the Norwegian Surveillance System for Communicable Diseases (MSIS) and now plans to conduct a large-scale follow-up study of more than 4000 COVID-19 patients and controls through several other Norwegian registries. 

The project will thus provide high-quality, empirical knowledge about the long-term health consequences of COVID-19.

The project will be led by the principal investigator (PI) and specialist in Infectious diseases, Arne Søraas, MD, PhD, together with an epidemiology team from Imperial College, London, the Cancer Registry of Norway, and the epidemiologist in our group. In addition, the investigations of memory after COVID-19 will be led by the PI and a neurocognitive team from the Department of Psychology, University of Oslo.

Long-term health effects of COVID-19 - the Norwegian Corona Cohort

Et stort problem for kreftbehandling er at kreftceller slipper unna immunforsvaret. Flere behandlinger er utviklet som aktiverer immunforsvaret på nytt for å drepe kreftcellene. Disse behandlingene har revolusjonert kreftbehandlingen. Imidlertid ser det ut til at bare et mindretall av pasientene drar fordel av disse behandlingene, noe som i det minste delvis skyldes det faktum at hittil bare svært få immunbehandlinger er klinisk godkjent. Vi har tidligere identifisert en forbindelse som kan modulere immunresponsen. Dette prosjektet hadde som mål å videreutvikle denne forbindelsen. I korte trekk er funnene fra dette prosjektet at denne forbindelsen dreper et stort utvalg av tumorceller. Vi undersøkte dens virkningsmekanisme, og fant ut at den induserer raskt tap av c-Myc fra cellen, samtidig som vi aktiverte p53. c-Myc er et protein som er viktig for overlevelse og vekst av de fleste tumortyper, og som også er velkjent for å modulere følsomheten til kreftceller for immunsystemet; p53 er et protein som beskytter organismen mot kreft ved å indusere celledød av ondartede celler. Behandling av tumorceller med denne forbindelsen stoppet cellens vekst, induserte celledifferensiering og utløste celledød. Dypgående mekanistiske studier avslørte at forbindelsen kan sette seg inn i DNAet til celler (interkalering), og dermed forhindre syntese av c-Myc og aktivere p53.
På fysiologisk nivå har vi bestemt hvor godt forbindelsen tas opp av celler, hvor stabil den er, og hva den maksimale tolererte dosen er hos mus. De nøyaktige immunmodulerende egenskapene til denne forbindelsen er for tiden mindre klare, selv om de ser ut til å være avhengige av tumortypen. Dette må studeres nærmere i fremtidige studier. Til slutt undersøkte vi IPR for denne forbindelsen, og fant ut at det kommersielle potensialet til forbindelsen er begrenset av det faktum at det interkalerer DNA, noe som av mange farmasøytiske selskaper blir sett på som lavere prioritet.
I konklusjon, vi oppdaget en ny forbindelse som hemmer c-Myc og selektivt dreper tumorceller. Som sådan er denne forbindelsen et lovende utgangspunkt for utvikling av mer selektive forbindelser med antitumoraktivitet. For tiden tror vi det viktigste kommersielle potensialet sannsynligvis vil komme fra nytten som et forskningsverktøy i akademiske studier.

Immune checkpoint proteins regulate the duration and amplitude of physiological immune responses in normal tissues, which is crucial for self-tolerance and which prevents collateral damage from the immune system. Cancer cells co-opt certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. 

We have recently identified and characterized a small molecule hit compound from a 20K library screen that inhibits the expression of immune checkpoint proteins on the surface of cancer cells. Our preliminary data indicate that DJ34 is active against leukemic cells, including AML and ALL cells; other cancer have not yet been tested. This project is aimed at optimizing this compound and to explore its commercial potential as novel anti-immune checkpoint cancer therapy. 

We will further characterize the physicochemical properties of this compound, determine its cancer cell sensitivity and demonstrate its efficacy in a relevant animal model of disease. We further aim to optimize the chemical template of the hit compound, to develop novel chemical entities with superior properties, with respect to ADME/PK, safety and efficacy.     

During the project, we will also seek to secure IPR protection for the hit compound and analogs/derivatives, perform market analysis to determine the competitive landscape and therapeutic fields of greatest unmet medical need, and engage both clinical key opinion leaders and relevant pharmaceutical industry. 

By the end of the project we aim to have demonstrated in vivo proof-of-concept, identified a preliminary lead suitable for further preclinical development, selected a preliminary primary target indication, and developed a strategy/plan for further commercial development of the novel therapeutic strategy.

Optimalisering: Development of small molecule cancer immunotherapy

International Symposium  on Personalized Cancer Care;
What have we achieved since 2012 in risk prediction, early diagnosis, progression, and therapy? 
Oslo,  May18-20, 2016, Holmenkollen Park Hotel Conference Center		
	
Opening keynote on P4 and Cancer: Leroy Hood,  Institute for Systems Biology, Seattle, USA
Speakers: 30 min followed by 10 min discussions to interact with the audience	
Session I: Genetic Profiling of Patients, Prediction of Risk and therapy response
	Bruce Ponder, Cancer Research Institute, Cambridge, UK
	Paul Pharoah, Strangeways Research Laboratory, Cambridge, UK
			
Session II: Molecular Profiling of Tumors and Metastases
Elaine Mardis, The Genome Inst., Washington Univ., St. Louis, Missouri, USA
	Zoltan Szallasi, Technical University of Denmark 
Carlos Caldas, Cancer Research Inst. Cambridge  UK.
Nicholas Navin, MD Anderson Cancr Center, Houston  USA
Peter van Loo, Crick Center, London, UK
						
Session III: Tumor-host Microenvironment Interaction and Metabolism
	Arnold Levine, Princeton University, USA
	Larry Norton, Memorial Sloan-Kettering Cancer Center, NY; USA.
Mina Bissell, Lawrence Berkeley National Laboratory, CA, USA
	Morag Park, McGill University, Montreal,  Canada
				
Session IV: Targeted Therapy
	Gordon Mills, MD Anderson Cancer Center,  Houston USA	
Rene Bernards, The Netherlands Cancer Institute, Netherlands
Joe Gray, Knight Cancer Inst. Oregon Health & Science Univ., Oregon  USA
	Alberto Bardelli,  University of Torino, Italy	
Soldano Ferrone, Massachusetts General Hospital, Harvard, Boston, USA
						
Session VI: Translation	
Olli Kallioniemi, FIMM, Helsinki, Finland
Laura van't Veer, University of California, San Francisco, USA
	Per Eystein Lønning, Univ Bergen, Norway
Anne-Lise Børresen-Dale, Oslo Univ Hopsital, Norway		
Session V: The impact of social and ethical issues on personalized medicine		
	Serena Nik-Zainal, Sanger Center,  Hinxton, Cambridge, UK
David Livingstone, Dana-Farber Cancer Institute; Boston, USA

International symposium on Personalized Cancer Care:
From risk prediction, early diagnosis, progression,  and therapy.

The Norwegian Center for Stem Cell Research organises the Annual Norwegian Stem Cell Networking Meeting at Soria Moria Hotel & Conference Center outside of Oslo. The meeting brings together Center core group members and associate members, non-Center stem cell researchers who had received funding from the Research Council’s Stem Cell Program, Research Council representatives, members of the Stem Cell Program Steering Committee, invited international speakers, and media representatives. The meeting provides an update on Norwegian stem cell research and serve to assemble the Norwegian stem cell research community to promote interaction and collaboration.

FUNN-3-Tilskudd til ulønnet FoU-innsats

32728 Lutefisk Filet

Awarded: NOK 67,400

Funding scheme:

FUNN-3-Tilskudd til ulønnet FoU-innsats

Thematic Areas and Topics