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2023

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BOLD MINDS aspires to enhance the understanding of vulnerability factors underlying the emergence of borderline personality disorder (BPD), with an ultimate aim of increasing the potential for young individuals to receive early, evidence-based help when their mental health is at risk. BOLD MINDS will achieve this by investigating whether disruptions in two aspects of autobiographical memory (AM), narrative identity (NI) and involuntary AM (IAM), are associated with BPD features and problem behaviours in adolescents concurrently and over time. In doing so, BOLD MINDS will strengthen the understanding of mechanisms underlying the emergence of BPD in adolescence and lay a groundwork for developing evidence-based early interventions for BPD. While currently limited, the study of AM in this field is essential for two reasons. Firstly, because the aspects of AM under investigation, NI and IAM, are known to be involved in identity formation and emotion regulation which represent two key psychological processes that are disrupted in adults with BPD and are linked to problem behaviours such as self-harm and suicidality. Secondly, because promising research is emerging on the use of AM targets in the treatment of emotional disorder in adults, and provides a strong model for future treatment development with vulnerable adolescents. In addition, this timely research program aligns with calls from international organizations to prioritize early interventions to promote adolescent mental health. BOLD MINDS will adopt and adapt state-of-the-art ecological momentary assessment and analytical techniques and work at the crossroads of clinical and cognitive psychological perspectives, allowing for a multidimensional approach to understanding BPD vulnerability. Training-through-research and formalized training of the experienced researcher will prepare her for a permanent academic position and the founding of her own research lab specializing in AM and early interventions for BPD.

Borderline Personality Disorder: Memory and Identity in Adolescence

Bilingual Experiences, Cognitive Ageing and underlying Mechanisms

The goal of the Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME) project is to examine the functional neuroplastic mechanisms underlying mitigatory effects of bilingual experience on age-related cognitive decline. While evidence is available for structural brain changes supporting bilingualism-induced effects on cognitive aging (CA), functional mechanisms underlying such effects are not yet well understood. BECAME aims to fill this gap by investigating the trajectory of bilingualism-induced functional neuroplasticity across the adult lifespan (ages 18-85), crucially adopting an individual differences approach related to measurable degree of bilingual engagement. Importantly, although such benefits are thought to be rooted early in the lifespan, evidence for the timeframe and conditions of their early emergence is scarce. The choice of including the whole adult lifespan allows us to investigate these mechanisms and their emergence more directly from a lifespan perspective. I combine behavioral testing with brain recordings via electroencephalography (EEG). EEG is widely used in cognitive neuroscience to assess brain activity and the degree of communication between brain regions (functional connectivity) in response to stimuli and at rest. Combining behavioral and EEG modalities will allow me to test bilingualism’s effect on functional connectivity, as well as its consequences for functional efficiency, the minimum required neural activation to successfully perform a task. This will enable a detailed, evidence-based account of the protective effects observed in older-aged bilinguals, and how they are built from earlier life stages. By illuminating the relationship between multilingualism and resulting neurocognitive adaptations, BECAME will enable to capitalize on it as a health initiative, with manifold societal implications and the potential to be translated into actionable policies exploiting multilingualism to ameliorate effects of CA.

WHeelchair Activity Monitoring project (WHAM)

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioural intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Longitudinal Investigation of Visual and Numerical Perception in Preterm and Full-term Infants

The number of preterm births is on the rise -now more than 1 in 10 babies- and being born preterm is associated with having difficulties in two very important and related cognitive skills that we rely on daily: numerical and visual perception. However, a knowledge gap exists on neural and behavioural associations of numerical and visual perception in full-term and preterm infants. PrePER aims to uncover the underlying neural signatures of the cognitive dysfunctions that preterm infants might display in the first year of their lives and the role of parent-baby interaction to predict preterm infants that are at risk of developing these cognitive difficulties in the second year of their lives. The purpose is to establish criteria to identify infants (especially preterm) at-risk of having cognitive difficulties in numerical and visual perception. Shedding light on normal and impaired cognitive functions in infancy is an essential stepping stone that will pave the way for early diagnostic tools and interventions that would correct the cognitive dysfunctions more efficiently while the brain is still developing. The activities in PrePER will lead to original and innovative outcomes that are beneficial for four parties: 1) Scientific communities will be interested in the results as the ambitious research objectives address questions that have not been asked before. 2) Parents of preterm infants, health-care providers, and policy makers will be interested in the results as the overall aim is to establish criteria to identify infants at-risk of having cognitive-developmental difficulties in the first year of their lives. 3) The researcher will be accelerating her career progression as the training objectives meet her specific needs. 4) The supervisor will be enlarging her research interest and network as the research objectives include a topic within the researcher’s expertise.

AQUASERV – RESEARCH INFRASTRUCTURE SERVICES FOR SUSTAINABLE AQUACULTURE, FISHERIES AND THE BLUE ECONOMY

The overarching objectives of AQUASERV are to bring together, enhance, integrate and customise RI capacities (including facilities, instruments and expertise) and through the provision of transnational access (on-site or remote) and/or virtual access, to significantly further scientific advance and promote and facilitate the implementation of European Common Fisheries Policy, the Farm to Fork Strategy, the Sustainable Blue Economy and the European Green Deal. 

AQUASERV will achieve these objectives by offering scientists from academia and business remote and on-site transnational (TA) and virtual (VA) access to an advanced set of European research infrastructures and its nodes related to research and management of marine and freshwater biological resources, food and biotechnology. These include the European Marine Biological Resource Centre ERIC (EMBRC), the Analysis and Experimentation on Ecosystems ERIC, The Aquaculture for Excellence for Aquaculture in Fish (Aquaexcel), and the Infrastructure for Promoting Metrology in Food and Nutrition (METROFOOD), as well as the International Council for Exploration of the Sea, both a service provider and stakeholder. It also includes the Research Infrastructure for Science and Innovation Policy Studies (RISIS) to bring contributions from the social sciences and to bring results nearer to policy makers ensuring societal impact. 

To enhance, integrate and customise RI capacities, collaboration between partners and new pipelines to meet the objectives of the project will be developed during the first 3 years and will make available  to users.  To ensure these capacities will not be lost, a sustainability work package involving stakeholders will address the project legacy.  

To maximize impact, AQUASERV will build a communication network among the partnership and develop a dissemination and outreach programme. Furthermore, an advanced training programme will be developed to capture future users and will be updated during the p

IMProving User experience, Long-term sustainability and Services of EU-OPENSCREEN

EU-OPENSCREEN (EU-OS), the distributed European Research Infrastructure for Chemical Biology and early drug discovery, provides world-class services in high-throughput compound screening and medicinal chemistry to users from academia and industry. As one of the largest open-access initiative globally, EU-OPENSCREEN plays an increasingly important role in facilitating early stage drug discovery in Europe. It recently integrated fragment-based drug discovery and chemoproteomics as two new services, but the increasing complexity of modern drug discovery projects requires an even more comprehensive portfolio and integration of emerging technologies. To ensure that EU-OS continues to offer a comprehensive suite of relevant services and support a growing user community to conduct forefront research, IMPULSE will develop, validate and integrate new services in AI/ML, new chemical modalities, and innovative disease-relevant cell models combined with CRISPR-Cas9/RNAi-based genetic screening. IMPULSE will work towards the implementation of common operational and data standards to increase data reproducibility and FAIRness. Bespoke outreach and training activities will raise awareness among key user groups of its new services and advance operational excellence and reproducibility in pre-clinical drug discovery. New models for pre-competitive drug discovery with industry or charities, and growing ERIC member community will reinforce the sustainability and accessibility of EU-OPENSCREEN.

Strengthening resilience and mental wellbeing through the Support4Resilience toolbox for leaders in elderly care

European elderly care experiences labor shortages, lack of qualified workers and a mismatch between capacity and demands, causing stress, burnout, and reduced mental wellbeing among healthcare workers and informal caregivers. Leaders are crucial in promoting supportive working conditions but lack research-based measures to act upon these challenges.

Support4Resilience (S4R) will develop, implement, and evaluate a research-based Toolbox to support healthcare leaders in improving healthcare workers’ and informal caregivers’ resilience and mental wellbeing in elderly care. S4R will identify resilience and mental wellbeing factors among healthcare workers and informal caregivers; explore their perspectives and needs; develop new theory on the relationship between individual and organizational resilience, and mental wellbeing; and develop recommendations and cost-effective interventions. The Toolbox with tailormade resources for policy and practical use will be available through an open access S4R Resource Bank.

The S4R Toolbox includes three main tools: 1) Mapping and identification, 2) Reflection and education, and 3) Reorganization. Measures are initiated at the organizational level and effects on mental wellbeing and resilience transpire at the frontline of elderly care. The Toolbox covers different situational contexts, types of healthcare providers and health system levels. Elderly care settings in six European countries will implement and evaluate the Toolbox through a process evaluation, effectiveness evaluation, and cost-effectiveness evaluation. 

S4R provides policymakers, decisions-makers and leaders with solutions for taking action to solve specific risks for healthcare workers’ and informal caregivers’ resilience and mental wellbeing. Thus, pertinent to the work programme, S4R will support the development of resilient health systems in European elderly care through improved leadership capabilities, governance structures, and adaptive capacities.

NEXT GENERATION IMAGING FOR REAL-TIME DOSE VERIFICATION ENABLING ADAPTIVE PROTON THERAPY

The NOVO project will address a fundamental issue in proton radiotherapy (PT) of cancer, namely the lack of real-time dose verification (RDV) that significantly limits the potential of PT due to uncertainties in the precise delivery of the prescribed dose. In the NOVO project, we will develop the first proof-of-concept of an RDV technology adaptable to any PT treatment and bring the concept to TRL 4 by also considering integration into the PT clinical workflow. The RDV technology will be pivotal for enabling the next generation of adaptive PT therapy, i.e., dose-guided real-time adaptive therapy. Real-time measurement of the dose to targeted and non-targeted tissues will be the key to truly empower patient-centered, personalized cancer treatment, important to improve curation and quality-of-life post-treatment. As a high-risk/high-gain project, NOVO aims at a first-of-its-kind RDV technology through the unique synergy between (1) cutting-edge, inexpensive organic scintillator technology that can detect secondary radiation during treatment for non-invasive measurements, (2) novel and fast image reconstruction, artificial intelligence (AI)-accelerated models and AI-enhanced image reconstruction to allow simultaneous detection of multiple radiation species and tissue compositional analysis, (3) tumor-tracking and imaging of tissue radio-sensitivity based on oxygen levels, (4) intelligent automation of decision-making schemes for real-time dose-guided adaptive therapy. The project will essentially open a new era in PT that enables curing more cancer patients and reducing toxicity from treatment. The NOVO consortium covers the entire value chain of RDV development (technology providers, theory and modelling, technology integration and PT clinics) and optimally engages nuclear, medical, and high-energy physicists, chemists, mathematicians, computer scientists, oncologists, biologists, as well as European PT centers. 


Development of innovative proton and neutron therapies with high cancer specificity by 'hijacking' the intracellular chemistry of haem biosynthesis.

Deep-lying cancers, such as glioblastoma multiforme (GBM) brain cancer, are very difficult to access and incurable by the current standards of care. The fluorescence of photosensitive molecules (PSs) can precisely guide surgical resection of GBM. Nevertheless, photomedical treatments like photodynamic therapy (PDT) show limited efficacies due to the low penetration of light into tissue. Proton radiotherapy can reach deep-lying disease through therapeutic energy deposition in a spatially confined region called Bragg peak. Current neutron-based therapies, like Boron Neutron Capture Therapy (BNCT), have sufficient penetration depth but lack cancer specificity.
In NuCapCure, we propose to 'hijack' intracellular biosynthetic pathways and use them to produce custom-made drugs that will facilitate two genuinely new cancer treatments: i) "NuCapCure Proton", combining proton radiotherapy, protondynamic therapy through PS proton activation, and proton capture therapy (BPCT) through three produced alpha particles; and ii) "NuCapCure neutron", combining GBM specific BNCT and PS neutron activation as demonstrated in our FET-open project FRINGE.
The main scientific breakthroughs of NuCapCure will be to demonstrate the custom production of novel compounds through native intracellular biosynthesis but also to establish experimental proof-of-principle, both in vitro and in vivo, of the proposed two novel therapies. Our highly interdisciplinary project team comprises world-renowned experts from a unique combination of disciplines: proton and neutron physics, synthetic chemistry, photochemistry, photobiology, radiobiology, medical physics, nuclear reactor and particle accelerator technology and radio-oncology to lay the foundations for novel, targeted and curative therapies against currently fatal cancer indications like GBM.

Despites dental pulp capping materials should meet the certain requirements, the available materials have one or more shortcomings—poor biocompatibility and rheological properties, fail to maintain pulp vitality and to simulate reparative dentine formation and expensive etc. Mineral trioxide aggregate (MTA) is widely used material because of its beneficial properties. However, its composition bismuth oxide, which is suspectable to toxicity, has an impact on rheological properties. This emphasizes the necessity of looking for inexpensive alternatives to materials that meet the specifications. This project's goal and novelty are to investigate the potential processing of the dental pulp capping cement, which is made of strontium silicate (SrSiO3), strontium fluoride (SrF2), piezoelectric material (PZM) and tricalcium silicate (Ca3O5Si) and its rheological properties and hemocompatibility. Because SrSiO3, SrF2, PZM and Ca3O5Si have the promising properties. This project's work packages are split into four categories based on the interdisciplinary approach since it involves the synthesis and characterization of PZM, the processing and characterization of cement, the identification of rheological parameters utilizing ISO standardizations, and hemocompatibility, and acquiring new transferrable skills. Additionally, the interactions among the selected compounds will be determined. The scientific impact of this project is comprehending the physical properties and the immune system's response to evaluate the cement's suitability as a replacement for existing materials, as well as resulting in further uses in dentistry and medicine. The societal impact is providing millions of patients in Europe with predictable and outstanding treatment outcomes each year to maintain pulp vitality and health. Eventually, it will ease the financial load on millions of patients who need dental care, will be avoiding inflated medical expenses and misuse of the patent (economic impact).

SrSiO3-based Dental Pulp Capping Cement

Midlene fra RBGRUNPRIM-M-Res.bas.grunnbev.prim.- marin fordelt på år

Midlene fra RBGRUNPRIM-M-Res.bas.grunnbev.prim.- marin fordelt på fylker

Midlene fra RBGRUNPRIM-M-Res.bas.grunnbev.prim.- marin fordelt på fagområde

Division Director

Grunnbevilgning - Nofima

Hvordan primitive celler oppstod og utviklet seg under den tidlige fasen til jordkloden, anses å være en av de uløste grunnleggende vitenskapelige problemene. De første primitive cellene, protocellene, betraktes vanligvis som sfæriske skall, fritt suspendert i vann og som på en eller annen måte har satt seg selv sammen fra fettmolekyler. Dette forklarer selve dannelsen, men ikke påfølgende utviklingstrinn. En mulig nøkkelrolle for faste overflater i dannelse og utvikling av protoceller har til nå ikke blitt grundig undersøkt. Mitt team gjorde nylig en gjennombruddsoppdagelse der enkle lipidsamlinger på en fast overflate spontant utvikler seg til et nettverk av avdelinger på størrelse med celler. Disse kan deretter vokse, dele seg og flytte på seg. Disse funnene åpner ikke bare dører for opprettelse av livlignende maskiner, kunstige celler og myke dataenheter, men tilbyr også en ny tilnærming til selve debatten rundt livets opprinnelse. SURIGINS tar sikte på å identifisere hvordan den lille energigevinsten som oppstår gjennom kontakt med naturlig forekommende overflater driver unike multitrinns transformasjoner av fettsamlinger til mer organiserte, dynamiske primitive celler samt å etablere mulige ruter til protocellestrukturer på stein og mineraloverflater knyttet til den tidlige jordkloden og Mars. Prosjektet og dets resultater kan fundamentalt endre måten vi tenker på livets opprinnelse på planeten vår og på andre deler av solsystemet, for eksempel Mars, og påvirke måten vi oppfatter og modellerer levende systemer på i dag.

Have the capabilities of biosurfactant assemblies to undergo shape transformations been much underestimated? My team recently made a breakthrough discovery that simple lipid assemblies can on a solid surface spontaneously develop into a network of microcompartments, then autonomously grow, divide, and relocate. These findings not only open doors to the creation of life-like machines, artificial cells and soft computing devices, they also offer a fresh approach to the origins of life debate. I propose a research line which can answer some of the pending big questions about the origins of life.
The first primitive cells are commonly viewed as spherical shells, freely suspended in aqueous medium that somehow self-assembled from fat molecules. This well explains initial, but not later steps, e.g. how containers divide autonomously. I intend to study how the tiny energy gain arising from contact with naturally occurring mineral and meteorite surfaces drive a unique multi-stage transformation of rough surfactant assemblies into organized nanotube-connected protocells.
The project addresses:
(i) which lipid species spontaneously form primitive cells on minerals and meteorites,
(ii) how surfaces promote colony formation and encapsulation of prebiotic chemicals,
(iii) If/how protocells communicate through nano-tubular interconnections.
The project outcome has ground-breaking transformative potential. It can fundamentally change the way we think about the origins of life on our planet and on other parts of the solar system, e.g. Mars, and impact the way we perceive and model living systems today.
Why me? Why now? Enabled by the latest interdisciplinary bionanotechnological and methodological developments, to which my team contributed significantly, the proposed hypothesis is ready to be tested. The subject of the development of life on Earth is of exceptionally broad interest, which puts SURIGINS at the forefront of research on a competitive international scale.

DID SURFACES ENABLE THE ORIGINS OF LIFE? The role of interfaces in the emergence of primitive cells on the early Earth

I dette prosjektet produserte vi primitive syntetiske celler i et laboratoriemiljø og studerte deres oppførsel på overflater. Generelt har alle overflater energi. Disse energiene er så små at de bare er tilstrekkelige til å påvirke individuelle atomer. Kunstige celler kan settes sammen fra lipider, som er biologiske overflateaktive stoffer. Disse molekylene samhandler veldig spesifikt med overflater. Vi tok fordel av vårt sofistikerte mikromanipulasjonsutstyr som gjør oss i stand til å se på fenomener i den størrelsesskalaen, og oppdaget at våre kunstige celler kan endre form, ta nye former og danne fantastiske nettverk. Disse nettverkene består av våre kunstige celler og tunnelerende nanorør som forbinder dem som motorveier forbinder byer. Cellene i nettverkene kan sende molekyler til andre celler gjennom rørforbindelsene og også kjenne de fysiske forholdene til andre celler i nettverket, for eksempel belastningen på membranen. Hvis slike nettverk har overflødig lipidmateriale, kan de sende det til nettverket for å redusere stresset hos andre. Hvis det er en mild vannstrøm rundt de kunstige cellene, kan de løfte seg fra overflaten, flytte til andre områder og slå seg ned. Til vår forbauselse oppdaget vi at dette er ekstremt viktig for livets opprinnelse, fordi et slikt system er så enkelt at det lett kunne ha blitt dannet under tidlig jordtilstand. Vi innså at det bare kreves vann, biomolekyler og overflater som var i overflod tilgjengelig allerede for 4 milliarder år siden.
Prosjektet startet som en liten gruppe forskere ved UiO, en ph.d.-student, en postdoktor og en hovedetterforsker, og da det ble klart at dette prosjektet har en enorm innvirkning på livets opprinnelse, kom nye nasjonale og internasjonale samarbeidspartnere til og prosjektet ble en virkelig tverrfaglig innsats som kombinerer forskere fra molekylærbiologi, materialvitenskap, fysikk, geologi og planetariske vitenskaper. Det er ikke så vanlig at en original hypotese produseres som et resultat av et prosjekt som fører til dannelsen av et nytt forskningsfelt. Vi oppnådde dette og fikk mye oppmerksomhet fra internasjonale eksperter og media. Dette prosjektet bidro med et lite, men viktig nøkkelelement som kan hjelpe oss til å løse et av vår tids største vitenskapelige spørsmål. Hvordan ble den første levende cellen dannet? Vel, mest sannsynlig ved hjelp av overflater.

Biological cells migrate to perform tasks essential for life, and are associated with disease development. During development of an embryo, a special neuron, the growth cone, finds its matching neuron by migrating towards it. Wounds on our skin close by migration of cells at the circumference of the wound. The spreading of malignant tumors occurs through migration of cancer cells. Despite its key roles in these and many others processes, the biophysical mechanisms of cellular migration are currently not sufficiently understood. Many research groups investigate these problems exclusively from a molecular biology perspective, where they manipulate genetic mechanisms suspected of playing a role in migration; and observe if and how the genetically manipulated cells differ from the native ones.
Despite of remarkable progress achieved with this approach, one important component of migration has received little attention: the materials-associated processes at the interfaces between a migrating cell and its environment. While migration is occurring, cells continuously interact in a complex manner with the contact areas they establish on surfaces, and the surrounding chemical and physical environment. Migration is highly dependent on how cells perceive the interface they migrate at.
This research project adapts a new alternative route of investigation, focusing on the soft- and hard matter solid interfaces, and aims to engineer substrates at the nano- and microscale to study their interaction with simplified, minimal cell models. Learning from nature in this context is one of the most challenging, but also most rewarding targets for technology-oriented research. It has the possibility to address a wider range of health-related challenges associated with migration, and enables new research directions with high application value, such as preventing spreading of cancerous tumors.

RBGRUNPRIM-M-Res.bas.grunnbev.prim.- marin

Grunnbevilgning - Nofima

Awarded: NOK 190.7 mill.

Funding scheme:

RBGRUNPRIM-M-Res.bas.grunnbev.prim.- marin

Funding Sources

Thematic Areas and Topics