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H20-HEALTH-Health, demographic change and wellbeing

Soraprazan - a new regenerative therapy for Stargardt's disease

Awarded: NOK 14.6 mill.

Source:

Project Number:

779317

Application Type:

Project Period:

2017 - 2021

Location:

Soraprazan - a new regenerative therapy for Stargardt's disease

Soraprazan – a new regenerative therapy for Stargardt’s disease Abnormal accumulation of lipofuscin in the RPE cells is a hallmark in Stargardt's disease. As lipofuscin cannot be removed from the RPE cells in the eyes neither spontaneously nor with existing therapies, the accumulation of lipofuscin in the RPE cells of the eyes results in the degradation of the RPE cells and consequently in worsening of visual acuity and could lead to blindness. Soraprazan was able to show removal of lipofuscin in RPE cells. Aim of the phase II trial in this project is to evaluate savety and efficacy or orally taken Soraprazan treatment compared to placebo.

Funding scheme:

H20-HEALTH-Health, demographic change and wellbeing

Funding Sources