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Limb wounds in horses are common, however healing is exceedingly slow and fraught with complications. Contrary to body wounds, limb wounds demonstrate only a small amount of wound contraction. The specialist procedure of applying split-thickness skin grafts to limb wounds stimulates wound contraction by unknown mechanisms. The objective of this project is to identify those mechanisms to develop a treatment strategy for equine limb wounds for use in general  practice. Limb wounds are severely impacting animal welfare due to an extended healing/treatment duration, and the risk of euthanasia due to a poor functional outcome. By stimulating wound contraction, healing time will be reduced, and the functional outcome improved, directly benefitting the welfare of wounded horse and reducing treatment cost for the owner. Aim: To identify dermal components stimulating wound contraction, and to develop this knowledge into future state-of-the-art treatment of equine limb wounds for use in general practice. Hypotheses: i) Application of dermal fractions to collagen gels seeded with equine fibroblasts will increase gel contraction in vitro; ii) Application of dermal fractions to experimental limb wounds in vivo, will increase wound contraction resulting in a faster healing time versus wounds treated by conventional methods. Methods: i) The contractile effect of different dermal components will be assessed in a collagen gel/ fibroblast model; ii) Identified dermal components will be tested in a standardized experimental limb wound model in vivo (n=5). Ultimately, results from this project are expected to improve wound treatment in horses, directly impacting animal welfare by reducing healing time and improving the functional outcome of wounded horses. This will also directly benefit horse owners and caretakers and making veterinarians able to offer better treatment solutions.

HESTEFORSK - Raskere og bedre sårheling hos hest med autologe hudkomponenter

Prosjektet «Wheelchair Activity Monitoring» (WHAM) sikter både på å øke fysisk aktivitet blant rullestolbrukere, og på å bidra til bredere mål om mangfold og inkludering av personer med nedsatt mobilitet, ved å fremme større tilgjengelighet og deltakelse gjennom innovativ teknologi og forskning.

Rullestolbrukere er tre til fem ganger mindre aktive enn den generelle befolkningen, noe som øker risikoen for å utvikle forebyggbare sykdommer. Selv om det finnes retningslinjer for fysisk aktivitet som er tilpasset rullestolbrukere, trenger vi fortsatt effektive måter å implementere disse på samt nøyaktig teknologi for å spore mulige endringer i fysisk aktivitet. WHAM har som mål å bidra til økt fysisk aktivitet blant rullestolbrukere ved å lage digitale verktøy for å monitorere og gi tilbakemelding på rullestolbrukerens aktivitet. WHAM består av tre faser: to år ved University of British Columbia (UBC), som inkluderer et samarbeid med eksperter innen atferdsendrings-intervensjoner for rullestolbrukere; ett år ved Norges teknisk-naturvitenskapelige universitet (NTNU) og et halvt år ved Maastricht Instruments - de to siste fasene er viet til å utvikle de digitale teknologiene. 

WHAMs mål er:
1)	Å teste effekten av et treningsprogram på fysisk aktivitetsnivå og fitness blant rullestolbrukere,
2)	Å utvikle nøyaktige algoritmer for monitorering av fysisk aktivitet blant rullestolbrukere,
3)	Å lage et system som både monitorerer og gir tilbakemelding på fysisk aktivitet blant rullestolbrukere.

Wheelchair users (WCU) are three to five times more inactive than the general population, leading to a high risk of developing preventable secondary conditions. Although physical activity (PA) guidelines have been specifically developed for WCU, we lack systematic approaches to implement them in practice, as well as valid algorithms to monitor PA change in WCU through sensor-based solutions. Accordingly, the overall scientific aim of the WHeelchair Activity Monitoring project (WHAM) is to advance PA research and practice in WCU by developing valid digital markers for monitoring of and providing feedback on PA, paving the way for implementation and intervention. I will accomplish this through combining the complementary research fields of 1) behavioral intervention studies focusing on increasing PA in WCU (core competence University of British Columbia, UBC; outgoing phase) and 2) sensor-based PA monitoring (core competence Norwegian University of Science and Technology, NTNU; returning phase – consolidated by non-academic placement at Maastricht Instruments, which develop research prototypes including PA monitors). WHAM’s scientific aim is achieved through three objectives: 1) Measure the effect of a pragmatic exercise intervention trial on self-reported physical activity levels and cardio-respiratory fitness, 2) Develop valid algorithms for tracking PA markers in WCU, and 3) Co-create
a framework that outlines how PA can be conjointly monitored and provided feedback on in WCU. This fellowship will enable me to become established as an internationally recognized researcher in the field of “physical activity and disability”, while bringing together ongoing national disjointed research activities in this field. Altogether, my overall ambition is to contribute to reducing inequalities in daily-life participation among WCU compared to the rest of the population.

Topfinancing - WHeelchair Activity Monitoring project (WHAM)

Effektene av fysisk og seksuell vold på ofre og deres familier kan være ødeleggende og vedvarende, med potensielt langvarige konsekvenser for fysisk og mental helse, utdanning, sysselsetting og bruk av velferdstjenester. Mens strafferettssystemet anses som en viktig del av offerets gjenopprettingsprosess, er det begrenset empirisk forskning på hvorvidt strafferettslige prosesser hjelper og/eller hindrer bedring langs disse ulike dimensjonene. I dette prosjektet vil vi adressere dette kunnskapshullet ved å bruke en kombinasjon av kvantitative og kvalitative forskningsmetoder. I de kvantitative analysene vil vi bruke administrative registerdata som dekker hele befolkningen sammen med kvasi-eksperimentelle metoder for å kunne trekke kausale slutninger. Vi vil også benytte maskinlæringsteknikker for prediksjon. De kvalitative analysene vil supplere de kvantitative analysene ved å gi kontekst til et komplekst felt av saker og ofre og ved å identifisere potensielle mekanismer mellom strafferettslige prosesser og utfall for ofrene. Samlet vil disse metodene gi en mer robust, representativ og nyansert forståelse av hvordan kontakt med strafferettssystemet påvirker offeret på tvers av flere viktige livsområder både på kort og lang sikt. Prosjektet ledes av Folkehelseinstituttet (FHI) med Frischsenteret og Universitetet i Oslo som partnere. Prosjektet har et rådgivende utvalg med medlemmer fra Nasjonalt kunnskapssenter om vold og traumatisk stress (NKVTS), ETH Zurich, Universitetet i Oslo, Frischsenteret, Universitetet i Bergen, og OsloMet. Det er også tilknyttet en brukergruppe bestående av personer og organisasjoner som er i kontakt med ofre for vold og overgrep.

Victims of sexual and physical violence is one of the most vulnerable groups in our society. The criminal justice system (CJS) serves a critical role in providing assistance to victims of these crimes, enabling them to seek justice, protection, compensation, and closure. Yet, knowledge about whether the CJS helps or harms these victims is extremely limited. This project aims to remedy this by providing a comprehensive understanding of the role of the CJS in supporting and providing restoration for victims of physical and sexual violence in Norway. We will utilize a combination of quantitative and qualitative research methods across disciplines to study outcomes across multiple important life domains, both in the short and long run. For the quantitative analyses we will use exceptionally rich longitudinal administrative register data with full population coverage combined with state-of-the-art quasi-experimental methods for credible causal inference and predictive machine learning techniques. The qualitative analysis will be based on narrative interviews with victims, providing context and insights into how interactions with the CJS shape life stories. The results will yield a robust and nuanced understanding of how the different stages of the CJS impacts victims. This is particularly urgent given how the current emphasis on legal responses to assaults has caused a sense of obligation and civic duty for especially women to report incidents, while the chances of legal closure remain small. In addition to advancing the methods for quasi-experimental designs and machine learning within quantitative criminology, this project will provide valuable insights for policymakers, stakeholders, and practitioners working in the field of victim support and rehabilitation and may inform current legal reform efforts aimed at addressing these issues.

Helpful or harmful: The effects of criminal justice system contact on victims of sexual and physical violence

The goal of the Bilingual Experiences, Cognitive Ageing and underlying Mechanisms (BECAME) project is to examine the functional neuroplastic mechanisms underlying mitigatory effects of bilingual experience on age-related cognitive decline. While evidence is available for structural brain changes supporting bilingualism-induced effects on cognitive aging (CA), functional mechanisms underlying such effects are not yet well understood. BECAME aims to fill this gap by investigating the trajectory of bilingualism-induced functional neuroplasticity across the adult lifespan (ages 18-85), crucially adopting an individual differences approach related to measurable degree of bilingual engagement. Importantly, although such benefits are thought to be rooted early in the lifespan, evidence for the timeframe and conditions of their early emergence is scarce. The choice of including the whole adult lifespan allows us to investigate these mechanisms and their emergence more directly from a lifespan perspective. I combine behavioral testing with brain recordings via electroencephalography (EEG). EEG is widely used in cognitive neuroscience to assess brain activity and the degree of communication between brain regions (functional connectivity) in response to stimuli and at rest. Combining behavioral and EEG modalities will allow me to test bilingualism’s effect on functional connectivity, as well as its consequences for functional efficiency, the minimum required neural activation to successfully perform a task. This will enable a detailed, evidence-based account of the protective effects observed in older-aged bilinguals, and how they are built from earlier life stages. By illuminating the relationship between multilingualism and resulting neurocognitive adaptations, BECAME will enable to capitalize on it as a health initiative, with manifold societal implications and the potential to be translated into actionable policies exploiting multilingualism to ameliorate effects of CA.

Bilingual Experiences, Cognitive Ageing and underlying Mechanisms

From the SEA to the SOLution. An integrative assessment of marine pollution in a changing Arctic

Marine chemical pollution poses known threats to human health and to biodiversity, ecosystem and societal services. The Arctic is a major sink of global mercury (Hg) pollution. Arctic sediments, sea and glacial ice constitute vast Hg reservoirs. Recent studies raise concerns about their increasing role as local Hg sources. In a rapidly warming Arctic, the consequences of potentially increased environmental Hg on marine biota remain unknown. The objective of SEASOL is to identify the pathway(s) of Hg bioaccumulation in marine food webs of the High Arctic Kongsfjorden (Svalbard). This changing glacial fjord is recognised as a ‘natural laboratory’ of climate change in the Arctic. The fellow’s earlier research has shown the sole measurement of Hg levels as insufficient to connect biotic Hg dynamics to environmental change, whereas the analysis of Hg stable isotopes proved to be a promising tool for source discrimination and biotic transfer. SEASOL will build on the novel application of stable isotope analysis to identify the sources of Hg within the fjord system and the pathways to Hg accumulation within sentinel marine species. On the short-term, the study will provide fundamental knowledge to help understand how emerging sources of Hg from rapid environmental change will impact Arctic marine predators. On the long-term, SEASOL will contribute to the development of early-warning, adaptive management strategies, including modelling, for mitigating the cumulative impact of pollutants and climate change on Arctic marine species. This multidisciplinary approach and the central position of the host institution (Norwegian Polar Institute) in the field of Polar Research will equip the Fellow with a broad set of new skills and lay the foundation for building her specific niche as a future leader in marine pollution science.

Reality-Connected Machine Simulation of Heavy Machinery

The RealSim project proposal aims to connect machine simulation to reality in the framework of heavy machinery, which is an interdisciplinary application. The results of this project are expected to optimize machine performance, accurately and reliably predict machine failure, and reduce overall development and operation costs, thus, serving the Europe’s priority of green transformation and the United Nation’s sustainable development goal 9. The RealSim project will close the gaps of: (1) Onboard estimations of force and pressure components of heavy machinery; (2) Estimating deformability, cylinder friction, leakage, and valve dynamics of heavy machinery using independent nonlinear Kalman filters; (3) Employing dependent nonlinear Kalman filters in state estimators of heavy machinery; (4) Tuning algorithms for the covariance matrix of plant noise in the state estimation of heavy machinery. 

I will consolidate and leverage my research career and position as a leading researcher in the field through integration in Assoc. Prof. Mohammad Poursina’s group at the Department of Engineering Sciences of the University of Agder (UiA), Norway. Here, I will acquire hands-on experience of working with actual mechatronic systems and develop efficient control algorithms. I will improve my knowledge of fluid power designing, control theory, instrumentation, and develop efficient coding skills. I will also develop entrepreneurial skills. The skills, knowledge, and international network that I will develop during this fellowship will put me in an excellent position to achieve my long-term goal of becoming a professor with my own independent research group at an esteemed university in EU. This fellowship will help me to prepare a strong ERC Starting Grant application in the future. It will also cater my additional goal of setting-up a research-related start-up in the future.

Information theory is a discipline at the intersection of statistics, engineering and computer science. As the study of information quantities, such as compression or communication capacities, information content or measures of statistical dependency, it is one of the theoretical underpinnings of data science.

Computational problems in information theory are highly non-linear. The goal of this project is to transfer state-of-the-art methods of computational non-linear algebra to information theory, to study the inherent algebraic complexity of information-theoretical problems and to provide tools for solving them in practice. The algebraic point of view has proven to be fruitful in seemingly unrelated areas, as witnessed by a surge of recent work in algebraic statistics, in particular on likelihood geometry. However, maximizing the likelihood function is the same as minimizing relative entropy — a specific information quantity. Hence, this project also aims at generalizing the techniques developed in likelihood geometry.

One focus is on the practical computation of information quantities using numerical and differential algebraic geometry. Such quantities are defined via non-linear optimization problems and we aim to pinpoint the algebraic complexity of these problems in instances of general interest, such as common information measures. The final objective is finding fundamental laws and limits of data science imposed by non-linear inequalities constraining the entropic region. These inequalities provide, by duality, universal bounds for many of the optimization problems studied in information theory.

Algebraic Theory of Information Quantities

Enabling the next generation in search of blood cancer cures

The CarrerasPathfinder program is new a world-wide unique doctoral program that covers the entire spectrum of research and innovation in blood cancers from understanding disease biology to the implementation of novel processes in the clinical practice. The program will fund 14 excellent Doctoral Candidates (DCs) for a period of 48 months. DCs will perform collaborative PhD projects involving associated partners from different sectors, countries, and disciplines through secondments. DCs will improve their research capacity and transferable skills through high-quality supervision arrangements and a tailored training program.

The program has been designed and will be hosted by the Josep Carreras Leukaemia Research Institute (IJC) which is the first European non-profit institute exclusively devoted to blood cancers. By answering the European needs for human resources, it is fully aligned with the 13 recommendations of the EU Cancer Board’s Draft Mission  and the Europe’s Beating Cancer Plan (2021). The CarrerasPathfinder program has a strong triple-I dimension of internationality, inter-sectorality and interdisciplinarity in training, networking, co-supervision and research. Its specific objectives are:
•	To develop an excellent doctoral program in blood cancer research conceived as a pilot for a permanent international doctoral program
•	To equip DCs with a unique skill set boosting effectiveness and innovation capacity. 
•	To promote DCs’ career development and increase their employability in different sectors.
•	To establish the IJC as a European reference for research and training in blood cancers.
•	To provide Europe with a new generation of researchers able to address unmet needs and societal challenges of blood cancers.
•	To contribute to structuring the European research area by collaborating and synergizing with other European key opinion leaders.



Tenk på universet som en enorm ballong som alltid utvider seg. Jo lenger unna et punkt er på ballongen, jo raskere beveger det seg bort fra deg. Dette ligner på hvordan universet utvider seg, jo lenger unna en galakse er, jo raskere beveger den seg bort fra oss på jorden.

I mange år trodde forskerne at universets ekspansjon ble bremset. Begrunnelsen deres var at gravitasjonskraften fra all materie i universet virket mot denne utvidelsen. Imidlertid gjorde kosmologer i 1998 en overraskende oppdagelse gjennom studiet av fjerne supernovaer: utvidelsen av universet akselererer faktisk!

Dette betyr at avstanden mellom galaksene blir større og større i stadig økende hastighet. Det er som om ballongen blåses opp raskere og raskere.

Forskere vet ikke nøyaktig hva som får universet til å akselerere. De kaller den ukjente kraften som får dette til å skje "mørk energi". Mørk energi er overalt i universet, men den mørke energien vekselvirker ikke med materie i de formene som vi kan observere direkte.

NEVO-prosjektet er et nytt forsøk på å forstå egenskapene til mørk energi. NEVO vil bruke kraftige datamaskiner for å simulere universet og studere effekten av kandidater til den mørke energien på en måte som aldri har vært gjort før. Ved å studere disse simuleringene og utnytte høypresisjons-observasjonene fra Euclid-teleskopet som nylig er skutt opp i rommet, vil kosmologene være i stand til å bedre betydelig vår forståelse av den mørke energiens gåtefulle natur.

The Universe has entered an accelerating expansion phase in the last few billion years of its evolution, a phenomenon that is caused by the mysterious entity known as dark energy. Through the NEVO proposal, I aim to provide key insights about the properties of dark energy, which includes its time evolution and spatial distribution in the Universe. This objective will be achieved by utilizing cutting-edge cosmological N-body simulations and novel techniques to study cosmic EVOlution accurately.

A comprehensive understanding of the nature of dark energy requires a thorough investigation of viable candidates and their impact on different stages of the Universe. However, the consistent and accurate modeling of dark energy candidates has been largely neglected so far. To address this gap, I propose the development of a novel, integrated framework that utilizes state-of-the-art relativistic N-body simulations along with the hi_class code, to accurately model dark energy candidates in both linear and non-linear scales.

NEVO: illuminating the dark cosmos

Global natur- og miljøforvaltning er en av vår tids mest sentralt og vanskellige mål. Mange av utfordringene skyldes motsetningene mellom vår fragmenterte politiske verden og økosystemer som ikke forholder seg til landegrenser eller politiske skillelinjer.
Ulike biologiske samfunn (biomer) som ligger i én stat, kan ikke løsrives fra et større økosystem. Derfor er flere «lokale» naturområder blitt del av den globale miljøforvaltningen.
Prosjektet RESOLVING skal se på politiske løsninger for en naturforvaltning som både er:
(i) lokal: som del av en stats territorium og hjem til ulike befolkningsgrupper
(ii) global: som kritiske deler av planetens økosystem
Hva betyr denne forvaltningen på flere nivåer for staters suverenitet?
Vi vet allerede mye om utfordringene nasjonalt oppdelt myndighet utgjør for effektiv forvaltning av jordens økosystemer. Vi vet derimot langt mindre om hvordan forsøkene på å styre jordens komplekse og grenseløse økosystemer faktisk kan endre selve systemet som forsinker den globale forvaltningen: statlig suverenitet.
RESOLVING vil prøve å forstå denne dynamikken ved å undersøke gruppene som faktisk utøver internasjonal naturforvaltning på vegne av eller parallelt med statene. Prosjektet vil her se nærmere på styringen av to områder som er viktige for hele verden: Amazonas-regnskogen og Guineabukta.
RESOLVING undersøker hvordan tiltak for å ta vare på disse områdene – laget på både internasjonalt, nasjonalt og lokalt nivå – fungerer sammen. Hvilke aktører får mer makt? Hvem blir inkludert i beslutningsprosessene og hvem blir utelatt?

The RESOLVING project asks: How does global governance of nature transform the exercise of sovereign power? Scientific evidence of the environment as a complex system of planetary dimensions has elevated several natural resources as objects of global governance. Primary forests and maritime biomes particularly capture global attention because of their systemic relevance for our planetary ecosystem. Still, international politics operates within a framework locating authority over nature indivisibly into territorially discrete and independent states. This project investigates the implications for sovereignty stemming from the construction of nature as a global governance object. We build on existing conceptualizations of sovereignty as a combination of de jure sovereign authority and bundles of de facto sovereign competence. In the case of nature, while permanent sovereignty over natural resources is an immutable property of state authority, a wider range of actors can be involved in defining the ways in which these resources are governed or even in governing them. RESOLVING will focus on two parcels of local nature especially entangled in global governance: the Amazon rainforest and the Gulf of Guinea. The project will investigate how networks of actors work across levels of governance to produce sovereign competence and exert sovereign power over nature in these regions. Sovereign power is the capacity to achieve de facto sovereign competence, here identified as the capacity to define and implement the rules of human–nature interaction. We look at multilevel governance from three angles: the global, the state, and the local. The comparative analysis of those networks across levels, regions, and regimes complexes will allow for identifying the mechanisms driving the rebundling of sovereign power with or away from the state, and a better understanding of the consequences of that process.

Rebundling sovereignty over local nature in global governance

Midlene fra PUBL-Publisering/prosjektinform fordelt på år

Midlene fra PUBL-Publisering/prosjektinform fordelt på fylker

Midlene fra PUBL-Publisering/prosjektinform fordelt på fagområde

Generalsekretær

Publisering av boka Spirits of Globalisation: Cross-cultural and Theological Perspectives on Pentecostalism and Experiential Spiritualities

Breast cancer can be divided into molecular subtypes, and we have chosen to categorize the disease into six groups. It has been suggested that factors that operate in utero and determine birth characteristics, such as birth weight, birth length and placental weight, are associated with breast cancer risk in adult life. In this project, we want to study whether these early life factors are associated with risk for breast cancer later in life, and whether these factors are differentially associated with different subtypes of breast cancer.

This project is part of a larger project, and the subtyping of breast cancer in this specific project has taken more time than originally anticipated. Although the subtyping is going on, and will shortly be completed, the PhD student has completed an analysis that was not described in the project description. That analysis used similar data on breast cancer subtypes that has already been completed, and the paper has recently been published in Cancer Epidemiology Biomarkers and Prevention, with the title "Molecular subtypes of breast cancer: long-term incidence trends and prognostic differences". The paper describes trends in breast cancer incidence according to molecular subtypes in Norwegian women born between 1887 and 1977, and in addition to incidence trends, it also includes an analysis of breast cancer survivial - according to molecular subtypes - where cases diagnosed before 1995 are compared with cases diagnosed in 1995 or later. The results remarkable differences in incidence over time between the subtypes; with strong increases in luminal subtypes and very moderate increases in the incidence of non-luminal subtypes. With respect to prognosis, there has been a consistent improvement in breast cancer survival since 1995, and this improvement is observed for all subtypes of breast cancer.

Molecular subtypes of breast cancer are typically classified as luminal A or B, HER-2 receptor positive and triple negative breast cancer. Adult risk factors, including age at menarche, age at first birth, parity, and body mass, have shown differential as sociations with these subtypes, and support a heterogeneous nature of the disease. The intrauterine environment is important for breast cancer development, but perinatal factors, including placental weight and birth size, have not been studied in relation  to molecular subtypes. Also, birth size is closely linked to maternal size, and maternal height may be associated with breast cancer risk among daughters, possibly mediated by perinatal factors. Maternal height may also be an effect modifier of the assoc iation of perinatal factors with breast cancer risk.  

Three specific hypotheses will be investigated: 
(1) Birth size (weight and length) is differentially associated with risk for different subtypes of breast cancer: we hypothesize that birth size is p ositively associated with luminal A and B breast cancer. 
(2) Placental weight, an indicator of placental function, is more strongly associated with breast cancer risk than birth size. Associations of placental weight are strongest for the luminal A and B  subtypes.  
(3) Maternal height is positively associated with breast cancer risk in daughters, and the positive associations of placental weight and birth size are most evident in daughters whose mothers were relatively tall. 
This research will be based  on a follow up of 23,478 Norwegian women (born 1920-1966), and will include at least 800 incident breast cancers (1961-2010). Molecular subtypes will be determined using tissue microarray technology applied to stored breast tissue. The results will advan ce our understanding of early roots of breast cancer, and be useful for developing specific prevention strategies for breast cancer, possibly aimed at particular subtypes.

The Epidemiology of Early Life Factors and Breast Cancer Risk by Molecular Subtype

Hormone therapy and mammographic density - important determinant of mammographic sensitivity and breast cancer risk

Det er kjent at brystkreftsykdommen kan inndeles i ulike undergrupper eller subtyper, men det er ikke kjent om "tradisjonelle" risikofaktorer har ulik sammenheng med ulike subtyper. Derfor har vi undersøkt sammenhengen mellom kjente risikofaktorer og seks  ulike subtyper av brystkreft, identifisert med såkalt "tissue micro array" (TMA)-metodikk. 

I tillegg er det ikke klart om prognosen (overlevelsen) etter diagnose er vesensforskjellig for de ulike subtypene av brystkreft. Derfor har vi også undersøkt  overlevelsen blant kvinner med brystkreft som ble diagnostisert for mange år siden, og deretter fulgt dem så lenge som mulig.

I forhold til risiko for å få sykdommen, har vi funnet at kjente risikofaktorer har særlig sammenheng med såkalte luminale svu lster, og med såkalte HR2 positive svulster, men vi fant lite eller ingen sammenheng med såkalte basal-like svulster og med andre ikke-luminale svulster uten spesielle kjennetegn.

I forhold til prognose har vi funnet at luminale svulster har en langt b edre overlevelse enn ikke-luminale svulster de første årene (5-10 år) etter diagnose, men luminale svulster fortsetter å ta liv lenge etter 10 års oppføging. De ikke-luminale svulstene har en dårlig prognose de første 5 år etter diagnose, men fra 5-10 år  etter diagnosen er det slik at overlevelsen for kvinner med ikke-luminale og luminale svulster konvergerer, og på meget lang sikt ser det ut som prognosen ikke er vesentlig forskjellig mellom subtypene. Det betyr også at for en viss andel kvinner med brys tkreft, uansett hvilken subtype de har, så er lang tids prognosen god. Hvorvidt det skyldes at disse kvinnene har hatt meget god nytte av behandlingen som de fikk, eller om de har hatt en relativt lite aggressiv sykdom, kan vi ikke vite, men dette er et m eget viktig forskningsspørsmål for framtidige studier.

This proposal describes 3 specific studies, each with several specific aims. 
The first is a case-control study nested within a cohort of 30,000 pregnant women who have been followed for 10 years after pregnancy. Blood was collected three times during pre gnancy, and we will compare pro- and anti-angiogenic factors in pregnancy and subsequent risk of breast cancer in 152 women who were diagnosed during follow-up and 300 age-matched controls. 

The second study is a cohort of 20,000 women who participated i n a breast cancer screening more than 45 years ago. Only a fraction of these women are alive, and more than 1500 have developed breast cancer. We want to use tissue micro array technology and determine three subtypes of breast cancer in these women. We wi ll assess the association of conventional (especially reproductive factors) risk factors with each subtype to find out if all subtypes of breast cancer are similarly associated with the established risk factors for this disease. In this study, we will als o investigate the prognosis of each subtype of breast cancer.

In the third study, we have followed approximately 35,000 women for 9 years, and 460 have developed breast cancer. These women have participated in an international consortium on genetic facto rs and breast cancer risk, and the association of 90 genetic variants with breast cancer risk have been determined. We want to use these genetic variants and study their interaction with conventional risk factors (reproductive factors, height, weight etc)  in relation to breast cancer risk. 
We also want to explore the possible gene-environment interactions in relation to breast cancer subtypes determined with tissue micro array. For this part of the proposal, we will attempt to analyse the data in collabo ration with other cohort studies, preferably the Nurses' Health Study, to increase the statistical power of the study.

Aspects of breast cancer risk: subtypes of breast cancer, relation to angiogenic factors and gene-environment interactions

Dette prosjektet inngår i evaluerinen av det norske mammografi-programmet. Hovedhensikten med dette prosjektet er å undersøke om mammografi-screeningen har påvirket dødeligheten av brystkreft i Norge. Forsker Harald Weedon-Fekjær har vært finansiert av midler fra NFR for å gjøre dette arbeidet sammen med prosjektleder Lars Vatten.
Analysene er nå ferdigstilt og foreligger i et utarbeidet manus som er publisert av det britiske tidsskriftet British Medical Journal.

This proposal describes 3 specific aims and briefly, how these aims are to be investigated: 
1. Most importantly, we want to determine effects of mammography on breast cancer mortality by comparing women with different exposures to mammographic screening.  
2. We will also assess changes in distributions of breast cancer by stage and size at diagnosis related to mammography; with particular emphasis on whether advanced disease is less prevalent after the introduction of mammography screening. 

To meet the se four aims we need to have access to data collected by the Norwegian Cancer Registry.

3. The third aim is to compare the Norwegian experience (trends in incidence, stage distribution and mortality) with that of other European countries. These analyses  will be conducted in collaboration with the International Agency for Research on Cancer, which is WHO's cancer research institute.

Mammography screening in Norway. Evaluation of health effects

In this proposal, we describe three separate studies. 
First, in a cohort study of more than 35,000 men and women born between 1920 and 1958, we propose to use historical data from birth records to study the association between perinatal factors (primaril y birth weight and birth length) and risk for several specified cancers (e.g. breast, cervix, prostate, colorectum). 

Second, in another cohort study of nearly 30,000 pregnant women, we will explore how pregnancy factors measured in maternal blood during  pregnancy may predict the occurrence of preeclampsia in the mother. Thereby, we hope to advance our understanding of how preeclampsia is related to reduced risk for breast cancer both in the mother, and in her female offspring. 

Third, using linked data  between women who have been recorded at delivery to the Medical Birth Registry and data on cancer incidence recorded by the Norwegian Cancer Registry, we propose to study the association between perinatal factors of the offspring (birth weight, birth len gth) and other pregnancy factors (length of gestation, pregnancy complications, e.g. preeclampsia) and subsequent risk for hormone related cancer (breast, ovary, endometrium, cervix) and colorectal cancer in the mother.

PUBL-Publisering/prosjektinform

Publisering av boka Spirits of Globalisation: Cross-cultural and Theological Perspectives on Pentecostalism and Experiential Spiritualities

Awarded: NOK 45,000

Funding scheme:

PUBL-Publisering/prosjektinform

Funding Sources

Thematic Areas and Topics