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KOSK-II-Katalyse og org.synt.kjemi II

Synthesis, molecular modelling and biological evaluation of protectin D1 and analogs

Awarded: NOK 2.8 mill.

Project Number:

197704

Application Type:

Project Period:

2010 - 2014

Location:

-

Epidemiological studies have linked fat fish consumption to lower rates of neurological diseases such as Alzheimer's disease. Fish contains high levels of omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. Recently several lines of evidence indicate that docosahexaenoic acid acts in the brain via anti-apoptotic, neurotrophic pathways and anti-inflammatory pathways. In the body and especially the brain, docosahexaenoic acid is converted to a class of molecules terme d protectins that have anti-inflammatory properties. The most potent compound was protectin D1. In this research proposal we will prepare this polyunsaturated fatty acid derived natural product named protectin D1, but also some of its analogs. The natural product and its analogs will be submitted to molecular modelling and biological testing, and the biological testing will inform us if protectin D1 and its analog may be potential drugs against neurological diseases, for example Alzheimer's disease. With full knowledge of the physiological role the protectins have on neuroinflammation, control of a number of maladies, such as Alzheimer's disease, disease may be possible.

Funding scheme:

KOSK-II-Katalyse og org.synt.kjemi II