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NAERINGSPH-Nærings-phd

Formation of impurities in an industrial process - structure elucidation and mechanistic studies

Awarded: NOK 1.3 mill.

Project Manager:

Project Number:

201825

Project Period:

2010 - 2014

Funding received from:

Location:

-

In the production of iohexol and related contrast agents for X-ray investigations [1-3], minor amounts of several byproducts are formed. These products are almost completely removed in the purification process, but it would be an advantage if their format ion could be completely prevented. In order to achieve this elucidation of their structures and clarification of the mechanisms of the reactions involved in the formation of the products would be required. In this project these aspects will be studied for one compound of particular interest, the structure of which can not be publicly disclosed and therefore is given the notation RC(O)NHCH2CH(OH)CH2OH (to highlight the part of the molecule which is believed to be involved in the formation of the most impor tant byproducts). On the basis of this a project in three parts has been planned, see Prosjektets hovedmål og delmål.

Funding scheme:

NAERINGSPH-Nærings-phd