Syntese av isotopmerkede narkotika og legemidler som standarder for forensisk og farmasøytisk analyse

Hovedfokus har vært i 2014 på skriving av oppgaven og publikasjon av artikler samt analyse av de ferdige produktene. Publikasjoner: Paper 1 ?Synthesis of [13C6]-labeled phenethylamine derivatives for drug quantification in biological samples? Morten K arlsen, Huiling Liu, Thomas Berg, Jon Eigill Johansen, Bård Helge Hoff Journal of Labelled Compounds and Radiopharmaceuticals (2014), 57, 378. Paper 2 ?Evaluation of 13C- and 2H-labeled internal standards for the determination of amphetamines in biolog ical samples, by reversed-phase ultra-high performance liquid chromatography?tandem mass spectrometry? Thomas Berg, Morten Karlsen, Åse Marit Leere Øiestad, Jon Eigill Johansen, Huiling Liu, Dag Helge Strand Journal of Chromatography A (2014), 1344, 83. Paper 3 ?Synthesis of [13C4]-labeled ?9-tetrahydrocannabinol and 11-nor-9-carboxy-?9-tetrahydrocannabinol as internal standards for reducing ion suppressing/alteration effects in LC/MS-MS quantification? Morten Karlsen, Huiling Liu, Thomas Berg, Jon E igill Johansen, Bård Helge Hoff Molecules, Submitted. Paper 4 ?Economical synthesis of 13C-labelled opiates, cocaine derivatives and selected urinary metabolites by derivatisation of the natural products? Morten Karlsen, Huiling Liu, Thomas Berg, Jon Eigill Johansen, Bård Helge Hoff Journal of Labelled Compounds and Radiopharmaceuticals, Submitted