Can simulation shed light on complex disease processes in cardiomyopathy? Collaborative extension between Simula and UCSD

Arrhythmogenic cardiomyopathy is likely more common than previously thought. This project aims to address the challenge of understanding these complex disease processes through the use of patient-specific, image based, multi-scale models. Specifically, th e collaborative visit will concentrate on an ongoing project related to the modeling of arrhythmogenic cardiomyopathy. In silico studies are well-suited to shed light onto the mechanisms that increase the vulnerability to arrhythmia in these patients. Joi nt patient-specific, multiscale modeling and simulation work between Simula and UCSD will focus on expanding this insight. The detailed research plan for the duration of the 3 month visit (to be approved at the host institution after the first week) will build upon models and simulations previously completed to address the above hypotheses. In essence, most collaborative modeling and simulation work pursuant to the above will be complete by the beginning of the research visit, and detailed, expert-level consultations will ensue at the visit's start. This will be followed by follow-up simulations, and the development of a manuscript centered around key results. Finally, the defined collaborative project team will jointly write a full manuscript aimed at p ublication in a top domain journal (as detailed below). Before the visit's conclusion, plans for continuing work and next steps will be finalized. In addition to the scientific and potential clinical contribution of the scientific components, the project will serve to further strengthen the research relationship between UCSD Bioengineering and Simula Computational Cardiac Modeling, increasing visibility of both Simula and the Center for Cardiological Innovation (SFI) and opening the possibility for futur e joint endeavors.