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EUROSTARS-EUROSTARS

E!1142997 PhagePow(d)er: Sustainable, Effectiv and Natural Inhibition of Food-Borne Pathogens by Advanced Phage Technology

Alternative title: E!1142997 Fagpudder - bærekraftig, effektiv og naturlig hemming av matbårne patogener med avansert fagteknologi

Awarded: NOK 3.0 mill.

The project goal is to establish a technology platform for development of next generation phages in enhanced formulations, to protect food against contamination with Listeria, Salmonella and STEC (Shiga toxin producing E. coli). Existing processing aids for food safety, while mostly effective, still cannot prevent antimicrobial resistance and disease outbreaks; imposing huge socio-economic burden due to morbidity, mortality, and product recalls. Further, customers are seeking new interventions for food safety that qualify as clean-label technologies. We aim to ensure food safety via bacteriophages (?phages?); the natural biological control agents of bacteria. Phages infect and replicate inside specific bacteria, ultimately killing them. By selecting phages that specifically target pathogens, yet are safe for beneficial bacteria, targeted products can be developed to eliminate harmful bacteria, preventing foodborne illnesses. The main results of the project will be a completed technology platform for next generation phages in improved phage formulations, and demonstration of three prototype products as food processing aids. To achieves this, we will select specific phages and develop prototype products which will be validated for efficacy. Prototype phage formulations will be validated in spice-blends/marinades and dry-salted cold-smoked salmon.

The project goal is to establish a technology platform for development of next generation phages in enhanced formulations, to protect food against contamination with Listeria, Salmonella and STEC (Shiga toxin producing E.coli). Existing processing aids for food safety, while mostly effective, still cannot prevent antimicrobial resistance and disease outbreaks; imposing huge socio-economic burden due to morbidity, mortality, and product recalls. For example, Salmonella typhi infections that are not susceptible to ciprofloxacin increased from 22% (1999) to 74% (2017). One in three foodborne outbreaks in the EU (2018) were caused by Salmonella. Further, customers are seeking new interventions for food safety that qualify as clean-label technologies. We aim to ensure food safety via bacteriophages (“phages”); the natural biological control agents of bacteria. Phages infect and replicate inside specific bacteria, ultimately killing them. By selecting phages that specifically target pathogens, yet are safe for beneficial bacteria, targeted products can be developed to eliminate harmful bacteria, preventing foodborne illnesses. The main results of the project will be a completed technology platform for next generation phages in improved phage formulations, and demonstration of three prototype products as food processing aids. To achieves this, (i) project coordinator Micreos Food Safety (MFS) will select specific phages and set up the phage technology platform for next generation phage formulations. (ii) MFS and Zurich University of Applied Science (ZHAW) will cooperate to develop a formulation technology powdered prototype products, which will be validated for efficacy in an experimental setup by NOFIMA. (iii) Prototype phage formulations will be validated in an operational setting by MFS in two use cases (spice-blends/marinades and dry-salted cold-smoked salmon).

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EUROSTARS-EUROSTARS