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HAVBRUKS-Havbruk - en næring i vekst
Platform for Viral Aquamedicine
Awarded: NOK 16.0 mill.
Source:
Project Manager:
Project Number:
185217
Application Type:
Project Period:
2008 - 2013
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Subject Fields:
This project gathers Norwegian expertise on both viral and host factors affecting viral disease progression. We focus on infectious salmon anaemia virus (ISAV) and infectious pancreatic necrosis virus (IPNV), both representing major disease problems in No rwegian aquaculture, as well as representing good models, as they differ in both innate and adaptive host defence strategies. The overall goal of the project is to advance the understanding of the virulence mechanisms of the viruses and host responses upo n infection. Understanding the complex network of cellular antiviral processes and virus host interactions will facilitate improved control strategies against virus infection in farmed fish. Reverse genetics systems for ISAV and IPNV will be developed as optimal tools for understanding viral virulence factors as well as enabling design of "safe" attenuated vaccines. Furthermore, studies of MHC peptide antigen presentation will provide knowledge about peptide epitopes optimal for targeted subunit vaccines. Technologies optimized for fish such as reverse genetics for ISAV and IPNV, and MHC class I tetramers will be developed in collaboration with national and international scientists.
Publications from Cristin
Atlantic salmon type I IFN subtypes show differences in antiviral activity and cell dependent expression - evidence for high IFNb/IFNc-producing cells in fish lymphoid tissues
Antiviral Activity of Salmonid Gamma Interferon against Infectious Pancreatic Necrosis Virus and Salmonid Alphavirus and Its Dependency on Type I Interferon
Regulation and function of interferon regulatory factors of Atlantic salmon
Atlantic salmon IPS-1 mediates induction of IFNa1 and activation of NF-kappa B and localizes to mitochondria
An antiserum against Atlantic salmon IFNa1 detects IFN and neutralizes antiviral activity produced by poly I:C stimulated cells
Identification of an Atlantic salmon IFN multigene cluster encoding three IFN subtypes with very different expression properties
Structural and functional studies of an IRF-7-like gene from Atlantic salmon
No publications found
Interferon a, b, c og d har ulike funksjoner i medfødt immunitet mot virus hos laks
Atlantisk laks har 12 interferon-gener som uttrykker 3 ulike IFN-typer
Genomic and functional studies of the Atlantic salmon interferon multigene family
Identification and functional studies of an interferon promoter stimulating protein (IPS-1) from Atlantic salmon
No publications found
Funding scheme:
HAVBRUKS-Havbruk - en næring i vekst
1.3BILL. NOKtotal funding in the programme period511PROJECTShave received funding in the programme period7SOURCEShave financed the programme
Funding Sources
Thematic Areas and Topics
MarinHavbrukLTP3 Marine bioressurser og havforvaltningLTP3 Samfunnsikkerhet, sårbarhet og konfliktLTP3 Et kunnskapsintensivt næringsliv i hele landetMatInternasjonaliseringInternasjonalt prosjektsamarbeidBransjer og næringerMatMat - Blå sektorLTP3 Høy kvalitet og tilgjengelighetInternasjonaliseringPortefølje ForskningssystemetPortefølje Banebrytende forskningLTP3 Muliggjørende og industrielle teknologierGlobale utfordringerGlobal matsikkerhetPortefølje Mat og bioressurserGlobale utfordringerPortefølje Muliggjørende teknologierMarinBransjer og næringerFiskeri og havbrukGrunnforskningNordområdeneLTP3 Fagmiljøer og talenterMatGlobal matsikkerhetLTP3 Samfunnssikkerhet og beredskapLTP3 Hav og kystLTP3 Styrket konkurransekraft og innovasjonsevneLTP3 Nano-, bioteknologi og teknologikonvergensBioteknologiNordområdeneMiljø og marine ressurser (utgår 2010)