Physical activity (PA) and fitness are integral in the prevention and treatments of diseases and should be regularly assessed and treated as part of all healthcare. The purpose of the Cardiac Exercise Training Group (CERG)projects is to make the scientifically proven benefits of PA the standard in the Norwegian and international healthcare systems.Generation 100 is one such project. It is the first large randomized controlled trial, with the primary aim to study the effect of PA on mortality in an elderly population. In light of the aging population, this study adds new important knowledge on how older individuals can achieve more active and healthy years with self-reliance. The HUNT Study is one of the largest health studies ever performed. The fourth wave of HUNT testing (each wave 10 years apart),which includes fitness testing performed by CERG, is expected to commence this year (2017). The recent American Heart Association statement called for fitness to be a vital sign and be routinely assessed in the clinics . However, fitness is currently the only known major risk factor for lifestyle diseases not routinely assessed in clinical practice, most likely due to lack of reference values and consensus on clinically relevant cut-offs that associate with higher health risk for various populations. Furthermore, inclusion of fitness into the health risk assessment models is crucial and substantially improves the ability of medical professionals to identify individuals at high risk of premature death and improve patient management. As a result, the FRIEND Consortium, a cardiopulmonary exercise testing Core Laboratory at University of Illinois- Chicago, was established and currently contains fitness information on ca. 8000 individuals from the US. The goal is to expand the register and develop it into an international databank, with Generation 100 and HUNT fitness data contribution, serving to improve risk assessment and clinical practice in Norway and around the world.