0 antall prosjekter

Dato fra ny til gammel

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Mechanistic, structural and regulatory investigations of unusual and artificial variants of chorismate mutases

Chorismate mutases (CMs) are enzymes that catalyze an essential reaction at the branching point of the metabolic shikimate pathway for the production of aromatic amino acids. As this pathway is confined to bacteria, fungi and plants, CMs therefore represent potential targets for highly specific a...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2012-2014

Sted: Oslo

KLIMAFORSK-Stort program klima

Forest in south China: An important sink for reactive nitrogen and a regional hotspot for N2O?

Lystgass (N2O), en viktig klimagass, har vist økende konsentrasjoner i atmosfæren siden den industrielle revolusjonen. Lystgass dannes i jorda som et bi-produkt ved ulike nitrogen omsetninger. Det er først og fremst den globale intensiveringen av nitrogen omsetninger i jorda, både pga utstrakt br...

Tildelt: kr 8,5 mill.

Prosjektperiode: 2012-2015

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

ERC-MORTH Bicarbonate transporters in acid-base balance - A structural focus

All mammalian cells use oxygen as an electron acceptor to run oxidative phosphorylation. Oxidative phosphorylation is connected to the citric acid cycle and thus to the complete breakdown of nutrients, ultimately generating carbon dioxide (CO2) as the fin al waste product. When CO2 is solubilised...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2012-2016

Sted: Oslo

IS-TOPP-Toppfinans. av M.Curie-stipend

toppfinansiering til Fp7 People Marie Curie Action IEF grant Dr. Giorgio Zoppellaro

Marie Curie Action IEF grant Dr. Giorgio Zoppellaro need extra money to at least get Lønnstrinn 57 and 58. Dr. Giorgio Zoppellaro was earlier 2007-2008 at Lønnstrinn 57 at Univ of Oslo, but was forced down to Lønnstrinn 54 as an IEF, as founding is to low from a IEF MCA grant. The aim of the...

Tildelt: kr 0,11 mill.

Prosjektperiode: 2011-2011

Sted: Oslo

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Chemometric approaches for the analysis of LC-MS based metabolomics data

The main objective of the project is to establish chemometric approaches for the analysis of LS-MS based metabolomics data. The project will include work to provide a pipeline for robust data processing of LC-MS based metabolomics data, to facilitate mea ns for biological interpretation of LC-MS...

Tildelt: kr 0,14 mill.

Prosjektperiode: 2011-2012

Sted: Ukjent Fylke

IS-DAAD-Forskerutveksl. Norge-Tyskland

Molecular Identification of Porin Channels in Plant Peroxisomes by Electrophysiological Analyses

Plant biomass production needs to increase world-wide to feed the growing world population and to meet the demands for cellulose-based biofuels. However, plant photosynthesis is inefficient because it is accompanied by photorespiration, which releases up to 30% of fixed carbon as CO2 in higher p...

Tildelt: kr 13 257

Prosjektperiode: 2011-2012

Sted: Rogaland

IS-MOBIL-Mobilitetsprogr.f.utl.Ph.D-stu

Proteomics analysis of peroxisomes from pepper fruits: Functional analysis of antioxidant peroxisomal enzymes

Pepper (Capsicum annuum L.) is the second worldwide consumed vegetable and is characterized by its high levels of vitamin C (ascorbic acid), vitamin A (pro-carotene) and calcium. Mature pepper fruits are also rich in carotenoids, which are compounds with antioxidant and anticancinogenic capacity...

Tildelt: kr 33 999

Prosjektperiode: 2010-2010

Sted: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structure-function studies of chitinases and cellulases - the molecular mechanism of enzymatic conversion of crystalline polysaccharides

Despite years of research there are still major holes in our understanding of how enzymatic machineries acting on recalcitrant polysccharides such as cellulose and chitin accomplish their degradative tasks. Chitin and cellulose are structurally similar an d cellulases face the same challenges dur...

Tildelt: kr 4,3 mill.

Prosjektperiode: 2010-2014

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Human protein N-terminal acetyltransferases: A protein-modifying enzyme family essential for cell survival and peptide hormone regulation

Acetylation is a very common protein modification occurring both at lysine residues within proteins (N-epsilon-acetylation or lysine acetylation) and at N-termini of proteins (N-alpha-acetylation or N-terminal acetylation). Lysine acetylation has been stu died extensively and it provides importan...

Tildelt: kr 10,9 mill.

Prosjektperiode: 2010-2014

Sted: Vestland

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Biogenesis of plant photoautotrophy

Fotosyntetiserende organismer som planter og alger stammer fra fotosyntetiserende bakterier. De begynte å høste lys energi for å gi energi til sine metabolske behov og bli autotrofe for mer enn tre milliarder år siden. Sentralt i prosessen for fotosyntese og autotrofi er klorofyll. Molekylet er s...

Tildelt: kr 10,3 mill.

Prosjektperiode: 2010-2015

Sted: Rogaland

IS-DAAD-Forskerutveksl. Norge-Tyskland

Coping with Oxidative Stress: Plant Peroxisomes as an Underestimated Player in Oxidative Stress Tolerance

Basic plant research lays the foundation to our understanding of plant adaptation to changing environmental conditions. Abiotic stress conditions generally disturb redox homeostasis and induce oxidative stress, which activates signaling pathways and adapt ive responses. This proposal focuses on t...

Tildelt: kr 22 808

Prosjektperiode: 2010-2011

Sted: Rogaland

SYNKNØYT-Progr.f.synkrotron- og nøytron

Microbial recognition investigated by membrane protein crystallography

The main goal of this project is to structurally and functionally characterize the molecular interactions underlying infection by the common gastric pathogen H. pylori. This will not only lead to a better understanding of the fundamental molecular recogni tion mechanisms, but also put us in a pos...

Tildelt: kr 3,6 mill.

Prosjektperiode: 2009-2013

Sted: Oslo

NORKLIMA-Klimaendringer og konsekvenser for Norge

N2O emissions from N saturated subtropical forest in South China

Surplus of reactive nitrogen (Nr) is one of China's most pressing environmental problems, and may cause a positive feedback to climate change through increased N2O emission. We previously found that forests in sub-tropical China receiving high atmogenic N loads (> 4g N m-2 yr-1) differ in their ...

Tildelt: kr 4,4 mill.

Prosjektperiode: 2009-2013

Sted: Akershus

IS-DAAD-Forskerutveksl. Norge-Tyskland

Egge-Jacobsen daadppp 09

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Tildelt: kr 30 000

Prosjektperiode: 2009-2011

Sted: Ukjent Fylke

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Dissecting molecular properties of honey bee vitellogenin (Vg): a protein acting at the intersection between social behavior and aging

The honey bee provides opportunities for cutting-edge studies of the molecular basis for complex social traits. Our group has made substantial contributions to the understanding of honey bee behavior and aging by identifying a socially controlled pathway that affects social activities and aging r...

Tildelt: kr 4,1 mill.

Prosjektperiode: 2008-2012

Sted: Akershus

IS-BILAT-Mobilitet Norge-USA /Canada

Reversible protein adsorption to membranes and nanoparticles

The delivery of protein-drugs using nanoparticles is an attractive therapeutic concept. The delivery would be greatly improved if the protein was firmly attached to the nanoparticle outside the target cell, and released when the nanoparticles enter the ce ll. Such a mechanism would rely on differ...

Tildelt: kr 0,19 mill.

Prosjektperiode: 2008-2008

Sted: Vestland

FUGE-Funksjonell genomforskn.i Norg

Structure based rules for protein kinase inhibitor selectivity

Protein kinase inhibitors are now emerging as a major class of new targeted drugs. Many diseases, especially cancers, are associated with disregulation of signalling pathways, and modulation of protein kinase activity is now a clearly validated approach f or therapy. Because there are over 500 pr...

Tildelt: kr 5,3 mill.

Prosjektperiode: 2007-2013

Sted: Troms - Romsa - Tromssa

IS-STP-Statsstipendprogram, utlendinger

Batioglu, Meric Tyrkia stp 07/08

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Tildelt: kr 0,13 mill.

Prosjektperiode: 2007-2008

Sted: Akershus

TU-Tungt utstyr

NTNU Sealab Biokjemisk Analyselaboratorium

NTNU Sealab er NTNUs nye tverrfaglige senter for akvakultur- og fiskeriteknologisk forskning og undervisning. En ny biokjemisk analyselab inngår i oppbyggingen av en moderne og hensiktsmessig forsknings-infrastruktur i forbindelse med etableringen av NTNU Sealab. For at det nyetablerte senteret ...

Tildelt: kr 1,1 mill.

Prosjektperiode: 2007-2007

Sted: Trøndelag - Trööndelage

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Applying advanced computational and experimental tools to explore surface electrostatics in chitinases

Understanding how proteins work is a major challenge in the post-genome era. Traditionally proteins have been studied by the use of numerous biochemical techniques, but as the number of proteins that needs to be characterized has increased, so has the num ber of in computo techniques to study pro...

Tildelt: kr 2,9 mill.

Prosjektperiode: 2007-2012

Sted: Akershus

IS-BILAT-Mobilitet Norge-USA /Canada

MCD and CD studies of di-iron cluster in R2 proteins of ribonucleotide reductases

The aim of the project is to investigate structural features of oxygen or electron reactions in proteins containing functionally important iron, copper, manganese and/or radical centers and some dinuclear iron clusters with mu-oxo (hydroxo) bridge. This t ype of di-iron cluster can perform severa...

Tildelt: kr 0,13 mill.

Prosjektperiode: 2007-2007

Sted: Oslo

FRIBIO-Biologi og biomedisin

Fe-S Cluster Biogenesis in Plastids and Mitochondria in Plants

Iron-sulfur (Fe-S) clusters are essential, inorganic cofactors of Fe-S proteins involved in numerous vital developmental processes. Although simple in structure Fe-S clusters are not formed spontaneously but require an intricate interplay of a number of p roteins and in plants Fe-S cluster biogen...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2007-2010

Sted: Rogaland

IS-NAD-Samarbeid med NORAD-land

Chen, Zhiqiang kinesisk statsstip 2006/07

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Tildelt: kr 0,12 mill.

Prosjektperiode: 2006-2007

Sted: Telemark

FRIBIO-Biologi og biomedisin

Protein - DNA interactions at atomic levels

The project aims at exploring protein-DNA interactions at atomic levels using novel DNA-binding proteins. Protein targets will be selected from the genomes of the extremophiles Deinococcus radiodurans and Vibrio salmonicida and produced recombinant in qua ntities necessary for structural and func...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2011

Sted: Troms - Romsa - Tromssa

FRIBIO-Biologi og biomedisin

Degradation of insoluble carbohydrate polymers: how do microbial chitinolytic machineries work?

Enzymatic degradation of abundant insoluble carbohydrate polymers such as cellulose and chitin is of tremendous biological and biotechnological importance. Microbes produce numerous enzymes to hydrolyze these polymers, but the question of how they manage to disrupt the crystalline structure of th...

Tildelt: kr 2,8 mill.

Prosjektperiode: 2006-2009

Sted: Akershus

FRIMEDBIO-Fri prosj.st. med.,helse,biol

Structural Glycobiology

The aim of the present research project is to structurally and functionally characterize the basis of protein carbohydrate recognition, with the long-term goal of engineering the carbohydrate specificity of carbohydrate binding proteins. This research fie ld is central to many cellular processes ...

Tildelt: kr 3,4 mill.

Prosjektperiode: 2006-2011

Sted: Oslo

FRIBIO-Biologi og biomedisin

The Biosynthesis of NAD in Humans: Isozymes and Subcellular Compartmentation

NAD is essential for energy transduction. It is also a key molecule in a variety of central signaling pathways. Nevertheless, surprisingly little is not known about its biosynthesis. Our recent research has established that NAD biosynthesis is absent from the cytosol: the three human isoforms of...

Tildelt: kr 3,1 mill.

Prosjektperiode: 2006-2009

Sted: Vestland

BIA-Brukerstyrt innovasjonsarena

A novel antimicrobial agent for topical treatment of challenging infections caused by drug-resistant bacteria.

"Once life-saving medicines are increasingly having as little effect as a sugar pill. Since 1970, no new classes of antibacterials have been developed to combat infectious diseases. Microbial resistance to treatment could bring the world back to a pre-an tibiotic age." WHO Report 2000: Overcomi...

Tildelt: kr 8,8 mill.

Prosjektperiode: 2006-2009

Sted: Oslo

IS-NAD-Samarbeid med NORAD-land

Sharma, Vijay K. indisk spes 2005

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Tildelt: kr 16 130

Prosjektperiode: 2005-2005

Sted: Rogaland

PES-EU-Prosjektetablererstøtte EU (bedrift)

STREP - Improved, affordable and more precise tests for kidney function, especially in childhood

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Tildelt: kr 99 999

Prosjektperiode: 2005-2006

Sted: Østfold

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